Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP2322 |
Epigenetic Applications in Adverse Outcome Pathways and Environmental Risk Evaluation | |
Angrish, Michelle M.1; Allard, Patrick2; McCullough, Shaun D.3; Druwe, Ingrid L.1; Chadwick, Lisa Helbling4; Hines, Erin1; Chorley, Brian N.2 | |
2018-04-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2018 |
卷号 | 126期号:4 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | BACKGROUND: The epigenome may be an important nterface between environmental chemical exposures and human health. However, the links between epigenetic modifications and health outcomes are often correlative and do not distinguish between cause and effect or common-cause relationships. The Adverse Outcome Pathway (AOP) framework has the potential to demonstrate, by way of an inference-and science-based analysis, the causal relationship between chemical exposures, epigenome, and adverse health outcomes, OBJECTIVE: The objective of this work is to discuss the epigenome as a modifier of exposure effects and risk, perspectives for integrating toxicoepigenetic data into an AOP framework, tools for the exploration of epigenetic toxicity, and integration of AOP-guided epigenetic information into science and risk-assessment processes. DISCUSSION: Organizing epigenetic information into the topology of a qualitative AOP network may help describe how a system will respond to epigenetic modifications caused by environmental chemical exposures. However, understanding the biological plausibility, linking epigenetic effects to short-and long-term health outcomes, and including epigenetic studies in the risk assessment process is met by substantive challenges. These obstacles include understanding the complex range of epigenetic modifications and their combinatorial effects, the large number of environmental chemicals to he tested, and the lack of data that quantitatively evaluate the epigenetic effects of environmental exposure. CONCLUSION: We anticipate that epigenetic information organized into AOP frameworks can he consistently used to support biological plausibility and to identify data gaps that will accelerate the pace at which epigenetic information is applied in chemical evaluation and risk-assessment paradigms. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000431396900007 |
WOS关键词 | HISTONE MODIFICATIONS ; TRANSGENERATIONAL INHERITANCE ; DEVELOPMENTAL EXPOSURE ; EVALUATION CRITERIA ; CHROMATIN-STRUCTURE ; ARSENIC EXPOSURE ; DNA METHYLATION ; DOWN-REGULATION ; CIRCULAR RNAS ; SKIN-CANCER |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/22713 |
专题 | 资源环境科学 |
作者单位 | 1.US EPA, Natl Ctr Environm Assessment, ORD, Res Triangle Pk, NC 27711 USA; 2.Univ Calif Los Angeles, Inst Soc & Genet, Los Angeles, CA USA; 3.US EPA, Natl Hlth & Environm Effects Res Lab, ORD, Res Triangle Pk, NC 27711 USA; 4.NIEHS, Div Extramural Res & Training, NIH, Dept Hlth & Human Serv, POB 12233, Res Triangle Pk, NC 27709 USA |
推荐引用方式 GB/T 7714 | Angrish, Michelle M.,Allard, Patrick,McCullough, Shaun D.,et al. Epigenetic Applications in Adverse Outcome Pathways and Environmental Risk Evaluation[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2018,126(4). |
APA | Angrish, Michelle M..,Allard, Patrick.,McCullough, Shaun D..,Druwe, Ingrid L..,Chadwick, Lisa Helbling.,...&Chorley, Brian N..(2018).Epigenetic Applications in Adverse Outcome Pathways and Environmental Risk Evaluation.ENVIRONMENTAL HEALTH PERSPECTIVES,126(4). |
MLA | Angrish, Michelle M.,et al."Epigenetic Applications in Adverse Outcome Pathways and Environmental Risk Evaluation".ENVIRONMENTAL HEALTH PERSPECTIVES 126.4(2018). |
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