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Vaccine trials among recipients of £20 million coronavirus research investment | |
admin | |
2020-03-23 | |
发布年 | 2020 |
语种 | 英语 |
国家 | 英国 |
领域 | 气候变化 |
正文(英文) | Press release Vaccine trials among recipients of £20 million coronavirus research investmentTrials of new coronavirus vaccine among 6 projects to receive share of £20 million. ![]()
Six coronavirus research projects, including 2 focused on vaccination trials, will be the first to benefit from a share of £20 million in government investment, Business Secretary Alok Sharma today (23 March) announced. Two government-backed projects will receive new funding, enabling pre-clinical and clinical vaccine trials, as well as supporting researchers to develop manufacturing processes to produce a vaccine at a million-dose scale. Other projects receiving funding examine how existing treatments could be repurposed to treat coronavirus, developing antibodies to help target the virus, and examining how people at greatest risk of catching it could be identified. Business Secretary Alok Sharma said:
Health Secretary Matt Hancock said:
The 6 projects receiving funding today are supporting and encouraging the UK’s world-class researchers and experts to speed up coronavirus research including developing new vaccines and treatments. Alongside the clinical trials, other projects include:
Chief Scientific Adviser Patrick Vallance said:
Chief Medical Officer Professor Chris Whitty said:
UK Research and Innovation Chief Executive, Professor Sir Mark Walport said:
Today’s announcement builds on the UK’s world-class expertise and capability in global health and infectious disease, and supports the government’s efforts to save lives, protect the vulnerable and support the NHS. It follows £30 million of new government funding for the National Institute for Health Research to enable further rapid research into COVID-19, and an additional £10 million to increase Public Health England’s ability to test people and monitor the virus, announced in the Budget (11 March). The research projectsDr Kenneth Baillie, University of Edinburgh, Professor Peter Openshaw, Imperial College London, and Professor Calum Semple University of Liverpool - £4.9 millionThe project involves collecting samples and data from COVID-19 patients in the UK to answer many urgent questions about the virus and provide real-time information, which could help to control the outbreak and improve treatment for patients. Their questions include:
They will recruit at least the first 1,300 UK patients who agree to take part over the next year and aim to start communicating their initial results in months. The team’s capacity builds on planning over the past 8 years as part of the International Severe Acute Respiratory Infection Consortium, and it includes co-investigators from 6 UK universities and Public Health England. Professor Sarah Gilbert, University of Oxford - £2.2 millionThe team are already developing a new vaccine against the COVID-19, as they initiated vaccine development as soon as the genetic sequence of the novel coronavirus was released. This funding will support preclinical testing of the new vaccine, vaccine manufacturing and then clinical trials in people. The first stage of human testing will be in adults aged 18-50, later expanding the trial to adults over 50 years and school age children. The vaccine is made from a harmless virus, an adenovirus, which has been altered to produce the surface spike protein of the coronavirus after vaccination, to prime the immune system to recognise and attack the coronavirus. If the vaccine is shown to be safe and effective in these earlier trials, vaccine manufacturing will be scaled up for larger studies. The vaccine utilises the same technique as a vaccine the team previously developed for the closely related MERS coronavirus, which showed promise in animal and early-stage human testing. This earlier research was funded by the UK Vaccines Network (a DHSC and UKRI initiative) in 2018. Professor Peter Horby, University of Oxford - £2.1 millionA clinical trial has started in the UK to test if existing or new drugs can help patients hospitalised with confirmed COVID-19. The drugs will be tested to see if they are safe and effective when added to the usual standard of care. The trial will have an ‘adaptive’ design, meaning it can test new therapies as they become available. The first 2 therapies to be tested will be HIV drugs: lopinavir-ritonavir and low-dose corticosteroids. The trial is called Randomised Evaluation of COVID-19 Therapy (RECOVERY). The research team’s ambitious aim is to have data available to inform patient treatment within 3 months. Professor Xiao-Ning Xu, Chelsea and Westminster Hospital, Imperial College London - £0.6 millionThis research aims to develop antibodies that target the novel coronavirus with the aim of developing a new therapy for COVID-19. Antibodies are molecules produced by the body’s immune system that can specifically recognise and bind to structures, such as those on the surface of a virus, to block the virus entry and instruct the immune system to destroy it. They have already identified some antibodies that might bind to proteins from the COVID-19 coronavirus. In collaboration with China, the scientists will use these in this project to develop a potential antibody therapy, with the aim of getting the therapy to the stage where it is ready to enter clinical trials to determine if it can treat a range of coronavirus infections including the COVID-19 coronavirus. Dr Sandy Douglas, University of Oxford – £0.4 millionThe team are aiming to develop manufacturing processes for producing harmless virus, adenovirus vaccines at a million-dose scale, so that - if clinical trials are successful - a vaccine could be made available to high-risk groups as quickly as possible. They are working with Professor Sarah Gilbert’s team, who are developing promising novel coronavirus vaccines by modifying harmless adenoviruses. Professor Ultan Power and Professor Ken Mills, Queens University Belfast – £0.3 millionThis project will test a library of approximately 1,000 drugs on cells in the laboratory to determine if any can reduce the toxic effects of novel coronavirus infection. The drugs are already approved for use in humans. They will be tested on airway epithelial cells grown in the lab and infected with novel coronavirus to determine if the drugs can reduce virus infection or replication and virus-induced inflammatory responses. This could identify promising drugs for further testing and clinical trials in 12 months. Notes to editorsThis announcement is part of a £20 million research response funded by the Department of Health and Social Care through the National Institute for Health Research, and by UK Research and Innovation. The funding call has 2 rounds, the results of the first are announced today. The call was announced in February - find out more on the UKRI site. The projects will run over a maximum 18-month period, ensuring timely insights into the current epidemic. This research funding has been coordinated with other funders and the World Health Organization (WHO) to ensure there is no duplication of effort and expertise is applied strategically. The funding is in addition and complementary to £20 million funding announced by the Health Secretary in February for the Coalition for Epidemic Preparedness Innovations (CEPI). In January, the Medical Research Council (part of UKRI) directly funded £0.5 million each to 2 centres:
About the National Institute for Health Research (NIHR)The National Institute for Health Research (NIHR) is the nation’s largest funder of health and care research. The NIHR:
The NIHR was established in 2006 to improve the health and wealth of the nation through research, and is funded by the Department of Health and Social Care. In addition to its national role, the NIHR supports applied health research for the direct and primary benefit of people in low- and middle-income countries, using UK aid from the UK government.
Published 23 March 2020
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来源平台 | GOV.UK - Department for Business, Energy & Industrial Strategy |
文献类型 | 新闻 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/229487 |
专题 | 气候变化 |
推荐引用方式 GB/T 7714 | admin. Vaccine trials among recipients of £20 million coronavirus research investment. 2020. |
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