Bladder Cancer and Water Disinfection By-product Exposures through Multiple Routes: A Population-Based Case Control Study (New England, USA)

doi:10.1289/EHP89

GSTDTAP > 资源环境科学

DOI	10.1289/EHP89
	Bladder Cancer and Water Disinfection By-product Exposures through Multiple Routes: A Population-Based Case Control Study (New England, USA)
	Freeman, Laura E. Beane 1; Cantor, Kenneth P.2; Baris, Dalsu 1; Nuckols, John R.3,4; Johnson, Alison 5; Colt, Joanne S.1; Schwenn, Molly 6; Ward, Mary H.1; Lubin, Jay H.7; Waddell, Richard 8; Hosain, G. Monawar 9; Paulu, Chris 10; Mccoy, Richard 5; Moore, Lee E.1; Huang, An-Tsun 1; Rothman, Nat 1; Karagas, Margaret R.8; Silverman, Debra T.1
	2017-06-01
发表期刊	ENVIRONMENTAL HEALTH PERSPECTIVES
ISSN	0091-6765
EISSN	1552-9924
出版年	2017
卷号	125 期号:6
文章类型	Article
语种	英语
国家	USA
英文摘要	BACKGROUND: Ingestion of disinfection byproducts has been associated with bladder cancer in multiple studies. Although associations with other routes of exposure have been suggested, epidemiologic evidence is limited. OBJECTIVES: We evaluated the relationship between bladder cancer and total, chlorinated, and brominated trihalomethanes (THMs) through various exposure routes. METHODS: In a population-based case control study in New England (n = 1,213 cases; n = 1,418 controls), we estimated lifetime exposure to THMs from ingestion, showering/bathing, and hours of swimming pool use. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) using unconditional logistic regression adjusted for confounders. RESULTS: Adjusted ORs for bladder cancer comparing participants with exposure above the 95th percentile with those in the lowest quartile of exposure (based on the distribution in controls) were statistically significant for average daily intake mg/g of total THMs [OR = 1.53 (95% CI: 1.01, 2.32), p-trend = 0.16] and brominated THMs [OR = 1.98 (95% CI: 1.19, 3.29), p-trend = 0.03]. For cumulative intake mg, the OR at the 95th percentile of total THMs was 1.45 (95% CI: 0.95, 2.2), p-trend = 0.13; the ORs at the 95th percentile for chlorinated and brominated THMs were 1.77 (95% CI: 1.05, 2,.99), p-trend = 0.07 and 1.78 (95% CI: 1.05, 3.00), p-trend = 0.02, respectively. The OR in the highest category of showering/bathing for brominated THMs was 1.43 (95% CI: 0.80, 2.42), p-trend = 0.10. We found no evidence of an association for bladder cancer and hours of swimming pool use. CONCLUSIONS: We observed a modest association between ingestion of water with higher THAT. (>95th percentile vs. <25th percentile) and bladder cancer. Brominated THMs have been a particular concern based on toxicologic evidence, and our suggestive findings for multiple metrics require further study in a population with higher levels of these exposures. Data from this population do not support an association between swimming pool use and bladder cancer.
领域	资源环境
收录类别	SCI-E
WOS记录号	WOS:000413788400019
WOS关键词	DRINKING-WATER ; TRIHALOMETHANE EXPOSURE ; ALVEOLAR AIR ; INDOOR ; SWIMMERS ; POOL ; RISK ; METHYLATION ; CHLOROFORM ; DNA
WOS类目	Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology
WOS研究方向	Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/22949
专题	资源环境科学
作者单位	1.NCI, Occupat & Environm Epidemiol Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA; 2.KP Cantor Environm LLC, Silver Spring, MD USA; 3.Colorado State Univ, Ft Collins, CO 80523 USA; 4.JRN Environm Hlth Sci, North Bethesda, MD USA; 5.Vermont Dept Hlth, Burlington, VT 05402 USA; 6.Maine Canc Registry, Augusta, ME USA; 7.NCI, Biostat Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA; 8.Dartmouth Coll, Dept Epidemiol, Geisel Sch Med, Hanover, NH 03755 USA; 9.New Hampshire Canc Registry, Concord, NH USA; 10.Univ Southern Maine, Muskie Sch Publ Serv, Grad Program Publ Hlth, Portland, ME USA
推荐引用方式 GB/T 7714	Freeman, Laura E. Beane,Cantor, Kenneth P.,Baris, Dalsu,et al. Bladder Cancer and Water Disinfection By-product Exposures through Multiple Routes: A Population-Based Case Control Study (New England, USA)[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(6).
APA	Freeman, Laura E. Beane.,Cantor, Kenneth P..,Baris, Dalsu.,Nuckols, John R..,Johnson, Alison.,...&Silverman, Debra T..(2017).Bladder Cancer and Water Disinfection By-product Exposures through Multiple Routes: A Population-Based Case Control Study (New England, USA).ENVIRONMENTAL HEALTH PERSPECTIVES,125(6).
MLA	Freeman, Laura E. Beane,et al."Bladder Cancer and Water Disinfection By-product Exposures through Multiple Routes: A Population-Based Case Control Study (New England, USA)".ENVIRONMENTAL HEALTH PERSPECTIVES 125.6(2017).