Residential Proximity to Major Roadways at Birth, DNA Methylation at Birth and Midchildhood, and Childhood Cognitive Test Scores: Project Viva (Massachusetts, USA)

doi:10.1289/EHP2034

GSTDTAP > 资源环境科学

DOI	10.1289/EHP2034
	Residential Proximity to Major Roadways at Birth, DNA Methylation at Birth and Midchildhood, and Childhood Cognitive Test Scores: Project Viva (Massachusetts, USA)
	Peng, Cheng 1; den Dekker, Martijn 2,3,4; Cardenas, Andres 5,6; Rifas-Shiman, Sheryl L.5,6; Gibson, Heike 7; Agha, Golareh 8; Harris, Maria H.9; Coull, Brent A.10; Schwartz, Joel 1,7; Litonjua, Augusto A.1; DeMeo, Dawn L.1; Hivert, Marie-France 5,6,11; Gilman, Matthew W.5,6,12; Sagiv, Sharon K.9; de Kluizenaar, Yvonne 13; Felix, Janine F.2,4,14; Jaddoe, Vincent W.2,4,14; Oken, Emily 5,6; Duijts, Liesbeth 2,3,15; Gold, Diane R.1,7; Baccarelli, AndreaA.1,8
	2018-09-01
发表期刊	ENVIRONMENTAL HEALTH PERSPECTIVES
ISSN	0091-6765
EISSN	1552-9924
出版年	2018
卷号	126 期号:9
文章类型	Article
语种	英语
国家	USA; Netherlands
英文摘要	BACKGROUND: Epigenetic variability is hypothesized as a regulatory pathway through which prenatal exposures may influence child development and health. OBJECTIVE: We sought to examine the associations of residential proximity to roadways at birth and epigenome-wide DNA methylation. We also assessed associations of differential methylation with child cognitive outcomes. METHODS: We estimated residential proximity to roadways at birth using a geographic information system (GIS) and cord blood methylation using Illumina's HumanMethylation450-array in 482 mother child pairs in Project Viva. We identified individual CpGs associated with residential proximity-to-roadways at birth using robust linear regression [false discover), rate (FDR) <0.05]. We also estimated association between proximity-to-roadways at birth and methylation of the same sites in blood samples collected at age 7-11 y = 415). We ran the same analyses in the Generation R Study for replication (N =641). In Project Viva, we investigated associations of differential methylation at birth with midchildhood cognition using linear regression. RESULTS: Living closer to major roadways at birth was associated with higher cord blood (and-more weakly-midchildhood blood) methylation of four sites in LAMB2. For each halving of residential-proximity-to-major-roadways, we observed a 0.82% increase in DNA methylation at cg05654765 [95% confidence interval (CI): (0.54%, 1.10%)], 0.88% at cg14099457 [95% CI: (0.56%, 1.19%)], 0.19% at cg03732535 [95% CI: (0.11%, 0.28)], and 1.08% at cg02954987 [95% CI: (0.65%, 1.51%)]. Higher cord blood methylation of these sites was associated with lower midchildhood nonverbal cognitive scores. Our results did not replicate in the Generation R Study. CONCLUSIONS: Our discovery results must be interpreted with caution, given that they were not replicated in a separate cohort. However, living close to major roadways at birth was associated with cord blood methylation of sites in LAMB2 a gene known to he linked to axonal development-in our U.S. cohort. Higher methylation of these sites associated with lower nonverbal cognitive scores at age 7-11 y in the same children.
领域	资源环境
收录类别	SCI-E
WOS记录号	WOS:000449118800004
WOS关键词	POLYCYCLIC AROMATIC-HYDROCARBONS ; AIR-POLLUTION EXPOSURE ; UMBILICAL-CORD BLOOD ; PRENATAL EXPOSURE ; MATERNAL SMOKING ; CIGARETTE-SMOKING ; ARSENIC EXPOSURE ; SYNAPTIC CLEFT ; S-LAMININ ; EXPRESSION
WOS类目	Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology
WOS研究方向	Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/22959
专题	资源环境科学
作者单位	1.Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA; 2.Univ Med Ctr Rotterdam, Erasmus MC, Generat R Study Grp, Rotterdam, Netherlands; 3.Univ Med Ctr Rotterdam, Erasmus MC, Dept Pediat, Div Resp Med & Allergol, Rotterdam, Netherlands; 4.Univ Med Ctr Rotterdam, Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands; 5.Harvard Med Sch, Dept Populat Med, Div Chron Dis Res Lifecourse, Boston, MA USA; 6.Harvard Pilgrim Hlth Care Inst, Boston, MA USA; 7.Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA; 8.Columbia Univ, Mailman Sch Publ Hlth, Dept Environm Hlth, New York, NY USA; 9.Univ Calif Berkeley, Sch Publ Hlth, Dept Epidemiol, Berkeley, CA 94720 USA; 10.Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA USA; 11.Massachusetts Gen Hosp, Diabet Unit, Boston, MA 02114 USA; 12.NIH, Environm Influences Child Hlth Outcomes ECHO Prog, Off Director, Bldg 10, Bethesda, MD 20892 USA; 13.Netherlands Org Appl Sci Res TNO, Delft, Netherlands; 14.Univ Med Ctr Rotterdam, Erasmus MC, Dept Pediat, Rotterdam, Netherlands; 15.Univ Med Ctr Rotterdam, Erasmus MC, Dept Pediat, Div Neonatol, Rotterdam, Netherlands
推荐引用方式 GB/T 7714	Peng, Cheng,den Dekker, Martijn,Cardenas, Andres,et al. Residential Proximity to Major Roadways at Birth, DNA Methylation at Birth and Midchildhood, and Childhood Cognitive Test Scores: Project Viva (Massachusetts, USA)[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2018,126(9).
APA	Peng, Cheng.,den Dekker, Martijn.,Cardenas, Andres.,Rifas-Shiman, Sheryl L..,Gibson, Heike.,...&Baccarelli, AndreaA..(2018).Residential Proximity to Major Roadways at Birth, DNA Methylation at Birth and Midchildhood, and Childhood Cognitive Test Scores: Project Viva (Massachusetts, USA).ENVIRONMENTAL HEALTH PERSPECTIVES,126(9).
MLA	Peng, Cheng,et al."Residential Proximity to Major Roadways at Birth, DNA Methylation at Birth and Midchildhood, and Childhood Cognitive Test Scores: Project Viva (Massachusetts, USA)".ENVIRONMENTAL HEALTH PERSPECTIVES 126.9(2018).