Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP38 |
Lower Placental Leptin Promoter Methylation in Association with Fine Particulate Matter Air Pollution during Pregnancy and Placental Nitrosative Stress at Birth in the ENVIRONAGE Cohort | |
Saenen, Nelly D.1; Vrijens, Karen1; Janssen, Bram G.1; Roels, Harry A.1,2; Neven, Kristof Y.1; Berghe, Wim Vanden3; Gyselaers, Wilfried4,5; Vanpoucke, Charlotte6; Lefebvre, Wouter7; De Boever, Patrick1,7; Nawrot, Tim S.1,8 | |
2017-02-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES |
ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:2 |
文章类型 | Article |
语种 | 英语 |
国家 | Belgium |
英文摘要 | BACKGROUND: Particulate matter with a diameter <= 2.5 mu m (PM2.5) affects human fetal development during pregnancy. Oxidative stress is a putative mechanism by which PM2.5 may exert its effects. Leptin (LEP) is an energy-regulating hormone involved in fetal growth and development. Objectives: We investigated in placental tissue whether DNA methylation of the LEP promoter is associated with PM2.5 and whether the oxidative/nitrosative stress biomarker 3-nitrotyrosine (3-NTp) is involved. METHODS: LEP DNA methylation status of 361 placentas from the ENVIRONAGE birth cohort was assessed using bisulfite-PCR-pyrosequencing. Placental 3-NTp (n = 313) was determined with an ELISA assay. Daily PM2.5 exposure levels were estimated for each mother's residence, accounting for residential mobility during pregnancy, using a spatiotemporal interpolation model. RESULTS: After adjustment for a priori chosen covariates, placental LEP methylation was 1.4% lower (95% CI: -2.7, -0.19%) in association with an interquartile range increment (7.5 mu g/m(3)) in second-trimester PM2.5 exposure and 0.43% lower (95% CI: -0.85, -0.02%) in association with a doubling of placental 3-NTp content. CONCLUSIONS: LEP methylation status in the placenta was negatively associated with PM2.5 exposure during the second trimester, and with placental 3-NTp, a marker of oxidative/nitrosative stress. Additional research is needed to confirm our findings and to assess whether oxidative/nitrosative stress might contribute to associations between PM2.5 and placental epigenetic events. Potential consequences for health during the neonatal period and later in life warrant further exploration. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000394004000021 |
WOS关键词 | TUMOR-NECROSIS-FACTOR ; DNA METHYLATION ; OXIDATIVE STRESS ; EARLY-LIFE ; GENE-EXPRESSION ; GENOME BROWSER ; CORD BLOOD ; EXPOSURE ; DISEASE ; HYPOMETHYLATION |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/23335 |
专题 | 资源环境科学 |
作者单位 | 1.Hasselt Univ, Ctr Environm Sci, Hasselt, Belgium; 2.Catholic Univ Louvain, Louvain Ctr Toxicol & Appl Pharmacol, LTAP, Brussels, Belgium; 3.Univ Antwerp, Dept Biomed Sci, PPES, Lab Prot Chem Prote & Epigenet Signaling, Antwerp, Belgium; 4.Hasselt Univ, Biomed Res Inst, Hasselt, Belgium; 5.East Limburg Hosp, Dept Obstet, Genk, Belgium; 6.Belgian Interreg Environm Agcy, Brussels, Belgium; 7.Flemish Inst Technol Res, Mol, Belgium; 8.Leuven Univ, Ctr Environm & Hlth, Leuven, Belgium |
推荐引用方式 GB/T 7714 | Saenen, Nelly D.,Vrijens, Karen,Janssen, Bram G.,et al. Lower Placental Leptin Promoter Methylation in Association with Fine Particulate Matter Air Pollution during Pregnancy and Placental Nitrosative Stress at Birth in the ENVIRONAGE Cohort[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(2). |
APA | Saenen, Nelly D..,Vrijens, Karen.,Janssen, Bram G..,Roels, Harry A..,Neven, Kristof Y..,...&Nawrot, Tim S..(2017).Lower Placental Leptin Promoter Methylation in Association with Fine Particulate Matter Air Pollution during Pregnancy and Placental Nitrosative Stress at Birth in the ENVIRONAGE Cohort.ENVIRONMENTAL HEALTH PERSPECTIVES,125(2). |
MLA | Saenen, Nelly D.,et al."Lower Placental Leptin Promoter Methylation in Association with Fine Particulate Matter Air Pollution during Pregnancy and Placental Nitrosative Stress at Birth in the ENVIRONAGE Cohort".ENVIRONMENTAL HEALTH PERSPECTIVES 125.2(2017). |
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