Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP527 |
Association between Exposure to p,p'-DDT and Its Metabolite p,p'-DDE with Obesity: Integrated Systematic Review and Meta-Analysis | |
Cano-Sancho, German1; Salmon, Andrew G.2; La Merrill, Michele A.1 | |
2017-09-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES
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ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2017 |
卷号 | 125期号:9 |
文章类型 | Review |
语种 | 英语 |
国家 | USA |
英文摘要 | BACKGROUND: The prevalence of obesity is increasing in all countries, becoming a substantial public health concern worldwide, Increasing evidence has associated obesity with persistent pollutants such as the pesticide DDT and its metabolite p,p'-DDE. OBJECTIVES: Our objective was to systematically review the literature on the association between exposure to the pesticide DDT and its metabolites and obesity to develop hazard identification conclusions. METHODS: We applied a systematic review-based strategy to identify and integrate evidence from epidemiological, in vivo, and in vitro studies. The evidence from prospective epidemiological studies was quantitatively synthesized by meta-analysis. We rated the body of evidence and integrated the streams of evidence to systematically develop hazard identification conclusions. RESULTS: We identified seven epidemiological studies reporting prospective associations between exposure to p p'-DDE and adiposity assessed by body mass index (BMI) z-score. The results from the meta-analysis revealed positive associations between exposure to p,p'-DDE and HMI z-score (beta = 0.13 BMI z-scare (95% CI: 0.01, 0.25) per log increase of p,p'-DDE). Two studies constituted the primary in vivo evidence. Both studies reported positive associations between exposure to p,p'-DDT and increased adiposity in rodents. We identified 19 in vivo studies and 7 in vitro studies that supported the biological plausibility of the obesogenic effects of p,p'-DDT and p,p'-DDE. CONCLUSIONS: We classified pp'-DDT and pp'-DDE as "presumed" to be obesogenic for humans, based on a moderate level of primary human evidence, a moderate level of primary in vivo evidence, and a moderate level of supporting evidence from in vivo and in vitro studies, |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000413792800010 |
WOS关键词 | PERSISTENT ORGANIC POLLUTANTS ; EVIDENCE-BASED MEDICINE ; ENDOCRINE-DISRUPTING CHEMICALS ; ENVIRONMENTAL-HEALTH SCIENCE ; BODY-MASS INDEX ; PRENATAL EXPOSURE ; LIPID ADJUSTMENT ; CONSENSUS STATEMENT ; ENERGY-EXPENDITURE ; DDT EXPOSURE |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/23567 |
专题 | 资源环境科学 |
作者单位 | 1.Univ Calif Davis, Dept Environm Toxicol, 1 Shields Ave,4245 Meyer Hall, Davis, CA 95616 USA; 2.Calif Environm Protect Agcy, Off Environm Hlth Hazard Assessment, Oakland, CA USA |
推荐引用方式 GB/T 7714 | Cano-Sancho, German,Salmon, Andrew G.,La Merrill, Michele A.. Association between Exposure to p,p'-DDT and Its Metabolite p,p'-DDE with Obesity: Integrated Systematic Review and Meta-Analysis[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(9). |
APA | Cano-Sancho, German,Salmon, Andrew G.,&La Merrill, Michele A..(2017).Association between Exposure to p,p'-DDT and Its Metabolite p,p'-DDE with Obesity: Integrated Systematic Review and Meta-Analysis.ENVIRONMENTAL HEALTH PERSPECTIVES,125(9). |
MLA | Cano-Sancho, German,et al."Association between Exposure to p,p'-DDT and Its Metabolite p,p'-DDE with Obesity: Integrated Systematic Review and Meta-Analysis".ENVIRONMENTAL HEALTH PERSPECTIVES 125.9(2017). |
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