GSTDTAP  > 资源环境科学
DOI10.1289/EHP527
Association between Exposure to p,p'-DDT and Its Metabolite p,p'-DDE with Obesity: Integrated Systematic Review and Meta-Analysis
Cano-Sancho, German1; Salmon, Andrew G.2; La Merrill, Michele A.1
2017-09-01
发表期刊ENVIRONMENTAL HEALTH PERSPECTIVES
ISSN0091-6765
EISSN1552-9924
出版年2017
卷号125期号:9
文章类型Review
语种英语
国家USA
英文摘要

BACKGROUND: The prevalence of obesity is increasing in all countries, becoming a substantial public health concern worldwide, Increasing evidence has associated obesity with persistent pollutants such as the pesticide DDT and its metabolite p,p'-DDE.


OBJECTIVES: Our objective was to systematically review the literature on the association between exposure to the pesticide DDT and its metabolites and obesity to develop hazard identification conclusions.


METHODS: We applied a systematic review-based strategy to identify and integrate evidence from epidemiological, in vivo, and in vitro studies. The evidence from prospective epidemiological studies was quantitatively synthesized by meta-analysis. We rated the body of evidence and integrated the streams of evidence to systematically develop hazard identification conclusions.


RESULTS: We identified seven epidemiological studies reporting prospective associations between exposure to p p'-DDE and adiposity assessed by body mass index (BMI) z-score. The results from the meta-analysis revealed positive associations between exposure to p,p'-DDE and HMI z-score (beta = 0.13 BMI z-scare (95% CI: 0.01, 0.25) per log increase of p,p'-DDE). Two studies constituted the primary in vivo evidence. Both studies reported positive associations between exposure to p,p'-DDT and increased adiposity in rodents. We identified 19 in vivo studies and 7 in vitro studies that supported the biological plausibility of the obesogenic effects of p,p'-DDT and p,p'-DDE.


CONCLUSIONS: We classified pp'-DDT and pp'-DDE as "presumed" to be obesogenic for humans, based on a moderate level of primary human evidence, a moderate level of primary in vivo evidence, and a moderate level of supporting evidence from in vivo and in vitro studies,


领域资源环境
收录类别SCI-E
WOS记录号WOS:000413792800010
WOS关键词PERSISTENT ORGANIC POLLUTANTS ; EVIDENCE-BASED MEDICINE ; ENDOCRINE-DISRUPTING CHEMICALS ; ENVIRONMENTAL-HEALTH SCIENCE ; BODY-MASS INDEX ; PRENATAL EXPOSURE ; LIPID ADJUSTMENT ; CONSENSUS STATEMENT ; ENERGY-EXPENDITURE ; DDT EXPOSURE
WOS类目Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology
WOS研究方向Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology
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文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/23567
专题资源环境科学
作者单位1.Univ Calif Davis, Dept Environm Toxicol, 1 Shields Ave,4245 Meyer Hall, Davis, CA 95616 USA;
2.Calif Environm Protect Agcy, Off Environm Hlth Hazard Assessment, Oakland, CA USA
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Cano-Sancho, German,Salmon, Andrew G.,La Merrill, Michele A.. Association between Exposure to p,p'-DDT and Its Metabolite p,p'-DDE with Obesity: Integrated Systematic Review and Meta-Analysis[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2017,125(9).
APA Cano-Sancho, German,Salmon, Andrew G.,&La Merrill, Michele A..(2017).Association between Exposure to p,p'-DDT and Its Metabolite p,p'-DDE with Obesity: Integrated Systematic Review and Meta-Analysis.ENVIRONMENTAL HEALTH PERSPECTIVES,125(9).
MLA Cano-Sancho, German,et al."Association between Exposure to p,p'-DDT and Its Metabolite p,p'-DDE with Obesity: Integrated Systematic Review and Meta-Analysis".ENVIRONMENTAL HEALTH PERSPECTIVES 125.9(2017).
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