Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP2152 |
The Association of Long-Term Exposure to Particulate Matter Air Pollution with Brain MRI Findings: The ARIC Study | |
Power, Melinda C.1; Lamichhane, Archana P.2,3; Liao, Duanping4; Xu, Xiaohui5; Jack, Clifford R., Jr.6; Gottesman, Rebecca F.7; Mosley, Thomas8; Stewart, James D.2,9; Yanosky, Jeff D.4; Whitsel, Eric A.10 | |
2018-02-01 | |
发表期刊 | ENVIRONMENTAL HEALTH PERSPECTIVES
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ISSN | 0091-6765 |
EISSN | 1552-9924 |
出版年 | 2018 |
卷号 | 126期号:2 |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | Background: Increasing evidence links higher particulate matter (PM) air pollution exposure to late-life cognitive impairment. However, few studies have considered associations between direct estimates of long-term past exposures and brain MRI findings indicative of neurodegeneration or cerebrovascular disease. Objective: Our objective was to quantify the association between brain MRI findings and PM exposures approximately 5 to 20 y prior to MRI in the Atherosclerosis Risk in Communities (ARIC) study. Methods: ARIC is based in four U.S. sites: Washington County, Maryland; Minneapolis suburbs, Minnesota; Forsyth County, North Carolina; and Jackson, Mississippi. A subset of ARIC participants underwent 3T brain MRI in 2011-2013 (n=1,753). We estimated mean exposures to PM with an aerodynamic diameter less than 10 or 2.5 mu m (PM10 and PM2.5) in 1990-1998, 1999-2007, and 1990-2007 at the residential addresses of eligible participants with MRI data. We estimated site-specific associations between PM and brain MRI findings and used random-effect, inverse variance-weighted meta-analysis to combine them. Results: In pooled analyses, higher mean PM2.5 and PM10 exposure in all time periods were associated with smaller deep-gray brain volumes, but not other MRI markers. Higher PM2.5 exposures were consistently associated with smaller total and regional brain volumes in Minnesota, but not elsewhere. Conclusions: Long-term past PM exposure in was not associated with markers of cerebrovascular disease. Higher long-term past PM exposures were associated with smaller deep-gray volumes overall, and higher PM2.5 exposures were associated with smaller brain volumes in the Minnesota site. Further work is needed to understand the sources of heterogeneity across sites. |
领域 | 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000427382800004 |
WOS关键词 | SMALL VESSEL DISEASE ; COGNITIVE FUNCTION ; RESIDENTIAL PROXIMITY ; MAJOR ROADS ; FINE ; DEMENTIA ; ADULTS ; NEURODEGENERATION ; POPULATION ; MODELS |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/24068 |
专题 | 资源环境科学 |
作者单位 | 1.George Washington Univ, Milken Inst Sch Publ Hlth, Washington, DC 20052 USA; 2.Univ N Carolina, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA; 3.RTI Int, Res Triangle Pk, NC USA; 4.Penn State Univ, Sch Med, Hershey, PA USA; 5.Texas A&M Hlth Sci Ctr, Sch Publ Hlth, College Stn, TX USA; 6.Mayo Clin, Rochester, MN USA; 7.Johns Hopkins Univ, Baltimore, MD USA; 8.Univ Mississippi, Med Ctr, Jackson, MS 39216 USA; 9.Univ N Carolina, Carolina Populat Ctr, Chapel Hill, NC USA; 10.Univ N Carolina, Sch Med, Chapel Hill, NC USA |
推荐引用方式 GB/T 7714 | Power, Melinda C.,Lamichhane, Archana P.,Liao, Duanping,et al. The Association of Long-Term Exposure to Particulate Matter Air Pollution with Brain MRI Findings: The ARIC Study[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2018,126(2). |
APA | Power, Melinda C..,Lamichhane, Archana P..,Liao, Duanping.,Xu, Xiaohui.,Jack, Clifford R., Jr..,...&Whitsel, Eric A..(2018).The Association of Long-Term Exposure to Particulate Matter Air Pollution with Brain MRI Findings: The ARIC Study.ENVIRONMENTAL HEALTH PERSPECTIVES,126(2). |
MLA | Power, Melinda C.,et al."The Association of Long-Term Exposure to Particulate Matter Air Pollution with Brain MRI Findings: The ARIC Study".ENVIRONMENTAL HEALTH PERSPECTIVES 126.2(2018). |
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