GSTDTAP  > 资源环境科学
DOI10.1289/EHP2152
The Association of Long-Term Exposure to Particulate Matter Air Pollution with Brain MRI Findings: The ARIC Study
Power, Melinda C.1; Lamichhane, Archana P.2,3; Liao, Duanping4; Xu, Xiaohui5; Jack, Clifford R., Jr.6; Gottesman, Rebecca F.7; Mosley, Thomas8; Stewart, James D.2,9; Yanosky, Jeff D.4; Whitsel, Eric A.10
2018-02-01
发表期刊ENVIRONMENTAL HEALTH PERSPECTIVES
ISSN0091-6765
EISSN1552-9924
出版年2018
卷号126期号:2
文章类型Article
语种英语
国家USA
英文摘要

Background: Increasing evidence links higher particulate matter (PM) air pollution exposure to late-life cognitive impairment. However, few studies have considered associations between direct estimates of long-term past exposures and brain MRI findings indicative of neurodegeneration or cerebrovascular disease.


Objective: Our objective was to quantify the association between brain MRI findings and PM exposures approximately 5 to 20 y prior to MRI in the Atherosclerosis Risk in Communities (ARIC) study.


Methods: ARIC is based in four U.S. sites: Washington County, Maryland; Minneapolis suburbs, Minnesota; Forsyth County, North Carolina; and Jackson, Mississippi. A subset of ARIC participants underwent 3T brain MRI in 2011-2013 (n=1,753). We estimated mean exposures to PM with an aerodynamic diameter less than 10 or 2.5 mu m (PM10 and PM2.5) in 1990-1998, 1999-2007, and 1990-2007 at the residential addresses of eligible participants with MRI data. We estimated site-specific associations between PM and brain MRI findings and used random-effect, inverse variance-weighted meta-analysis to combine them.


Results: In pooled analyses, higher mean PM2.5 and PM10 exposure in all time periods were associated with smaller deep-gray brain volumes, but not other MRI markers. Higher PM2.5 exposures were consistently associated with smaller total and regional brain volumes in Minnesota, but not elsewhere.


Conclusions: Long-term past PM exposure in was not associated with markers of cerebrovascular disease. Higher long-term past PM exposures were associated with smaller deep-gray volumes overall, and higher PM2.5 exposures were associated with smaller brain volumes in the Minnesota site. Further work is needed to understand the sources of heterogeneity across sites.


领域资源环境
收录类别SCI-E
WOS记录号WOS:000427382800004
WOS关键词SMALL VESSEL DISEASE ; COGNITIVE FUNCTION ; RESIDENTIAL PROXIMITY ; MAJOR ROADS ; FINE ; DEMENTIA ; ADULTS ; NEURODEGENERATION ; POPULATION ; MODELS
WOS类目Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology
WOS研究方向Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology
引用统计
文献类型期刊论文
条目标识符http://119.78.100.173/C666/handle/2XK7JSWQ/24068
专题资源环境科学
作者单位1.George Washington Univ, Milken Inst Sch Publ Hlth, Washington, DC 20052 USA;
2.Univ N Carolina, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA;
3.RTI Int, Res Triangle Pk, NC USA;
4.Penn State Univ, Sch Med, Hershey, PA USA;
5.Texas A&M Hlth Sci Ctr, Sch Publ Hlth, College Stn, TX USA;
6.Mayo Clin, Rochester, MN USA;
7.Johns Hopkins Univ, Baltimore, MD USA;
8.Univ Mississippi, Med Ctr, Jackson, MS 39216 USA;
9.Univ N Carolina, Carolina Populat Ctr, Chapel Hill, NC USA;
10.Univ N Carolina, Sch Med, Chapel Hill, NC USA
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Power, Melinda C.,Lamichhane, Archana P.,Liao, Duanping,et al. The Association of Long-Term Exposure to Particulate Matter Air Pollution with Brain MRI Findings: The ARIC Study[J]. ENVIRONMENTAL HEALTH PERSPECTIVES,2018,126(2).
APA Power, Melinda C..,Lamichhane, Archana P..,Liao, Duanping.,Xu, Xiaohui.,Jack, Clifford R., Jr..,...&Whitsel, Eric A..(2018).The Association of Long-Term Exposure to Particulate Matter Air Pollution with Brain MRI Findings: The ARIC Study.ENVIRONMENTAL HEALTH PERSPECTIVES,126(2).
MLA Power, Melinda C.,et al."The Association of Long-Term Exposure to Particulate Matter Air Pollution with Brain MRI Findings: The ARIC Study".ENVIRONMENTAL HEALTH PERSPECTIVES 126.2(2018).
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