The immune system's first steps

doi:10.1126/science.abc3140

GSTDTAP > 气候变化

DOI	10.1126/science.abc3140
	The immune system's first steps
	Seth Thomas Scanlon
	2020-05-08
发表期刊	Science
出版年	2020
英文摘要	In the early 1950s, Peter Medwar and colleagues showed that transplant tolerance could be induced in adult mice by inoculating them in utero with cells from a donor strain. This elegant experiment revealed that the immune system in early life is functionally distinct and responsive to programming that persists into adulthood. Nearly 70 years later, the complexity and developmental trajectory of the fetal–neonatal immune system are much better understood. We have also begun to appreciate that the immune system in early life does not develop in isolation but is instead strongly infl uenced by maternal cells, commensal microbes, and pathogens. This special issue surveys recent advances in the fi eld of early life immunology. Review articles highlight distinctive features of human fetal immune system development elucidated by unbiased multi-omics analysis, the impact of commensal metabolites and xenobiotics on immunity before and after birth, how maternal and fetal immune components work together to combat viral infections during pregnancy (and what happens when these mechanisms fail), and the potential of vaccination approaches to boost fetal–maternal immunity and protect neonates against the pathogens that most frequently cause them harm. These discoveries should inform future public health initiatives and draw renewed attention to the vulnerability of children in early life, laying the groundwork for vaccination strategies to target pathogens that cause congenital and neonatal infections as well as therapies to treat disorders such as stillbirth and prematurity. Evidence is also mounting that immune system programming that starts in early life may influence the risk of developing conditions such as allergic, autoimmune, reproductive, and neuropsychiatric disorders in later life, further underscoring the translational implications of this kind of research.
领域	气候变化 ; 资源环境
URL	查看原文
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/249713
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Seth Thomas Scanlon. The immune system's first steps[J]. Science,2020.
APA	Seth Thomas Scanlon.(2020).The immune system's first steps.Science.
MLA	Seth Thomas Scanlon."The immune system's first steps".Science (2020).