Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1289/EHP6012 |
Exposure to Drinking Water Chlorination by-Products and Fetal Growth and Prematurity: A Nationwide Register-Based Prospective Study | |
Melle Säve-Söderbergh; Jonas Toljander; Carolina Donat-Vargas; Marika Berglund; Agneta Åkesson | |
2020-05-18 | |
发表期刊 | Environmental Health Perspectives |
出版年 | 2020 |
英文摘要 | AbstractBackground:Chlorination is globally used to produce of safe drinking water. Chlorination by-products are easily formed, and there are indications that these are associated with adverse reproductive outcomes. Objectives:We conducted a nationwide register-based prospective study to assess whether gestational exposure to the four most common chlorination by-products [total trihalomethanes (TTHMs)] via tap water was associated with risk of small for gestational age (SGA), preterm delivery, and very preterm delivery. To date, this is one of the largest studies assessing drinking water TTHM-associated adverse reproductive outcomes. Methods:We included all singleton births 2005–2015 (live and stillbirths) of mothers residing in Swedish localities having inhabitants, operating waterworks, adequate information on chlorination treatment, and a sufficient number of routine TTHM measurements in tap water. Individual maternal second and third trimester exposure was obtained by linking TTHM measurements to residential history, categorized into no chlorination, , 5–15, and TTHM/L. Outcomes and covariates were obtained via the linkage to Swedish health and administrative registers. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by logistic regression using inverse probability weighting. We stratified the analyses by chlorination treatment (chloramine, hypochlorite). Results:Based on approximately 500,000 births, we observed a TTHM dose-dependent association with increased risk of SGA, confined to treatment with hypochlorite, corresponding to a multivariable-adjusted 1.20 (95% CI: 1.08, 1.33) comparing drinking water TTHM to the unexposed. Similar results were obtained when, instead of unexposed, the lowest exposure category ( TTHM) was used as reference. No clear associations were observed for preterm delivery and very preterm delivery. Discussion:Chlorination by-products exposure via drinking water was associated with increased risk of SGA in areas with hypochlorite treatment. https://doi.org/10.1289/EHP6012 |
领域 | 资源环境 |
URL | 查看原文 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/267540 |
专题 | 资源环境科学 |
推荐引用方式 GB/T 7714 | Melle Säve-Söderbergh,Jonas Toljander,Carolina Donat-Vargas,et al. Exposure to Drinking Water Chlorination by-Products and Fetal Growth and Prematurity: A Nationwide Register-Based Prospective Study[J]. Environmental Health Perspectives,2020. |
APA | Melle Säve-Söderbergh,Jonas Toljander,Carolina Donat-Vargas,Marika Berglund,&Agneta Åkesson.(2020).Exposure to Drinking Water Chlorination by-Products and Fetal Growth and Prematurity: A Nationwide Register-Based Prospective Study.Environmental Health Perspectives. |
MLA | Melle Säve-Söderbergh,et al."Exposure to Drinking Water Chlorination by-Products and Fetal Growth and Prematurity: A Nationwide Register-Based Prospective Study".Environmental Health Perspectives (2020). |
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