gamma delta T cells and adipocyte IL-17RC control fat innervation and thermogenesis

doi:10.1038/s41586-020-2028-z

GSTDTAP > 地球科学

DOI	10.1038/s41586-020-2028-z
	gamma delta T cells and adipocyte IL-17RC control fat innervation and thermogenesis
	Staus, Dean P.1,2; Hu, Hongli 3,8; Robertson, Michael J.3,4; Kleinhenz, Alissa L. W.1,2,9; Wingler, Laura M.1,2; Capel, William D.1; Latorraca, Naomi R.3,5,6; Lefkowitz, Robert J.1,2,7; Skiniotis, Georgios 3,4
	2020-03-01
发表期刊	NATURE
ISSN	0028-0836
EISSN	1476-4687
出版年	2020
卷号	578 期号:7796 页码:610-+
文章类型	Article
语种	英语
国家	USA
英文关键词	V gamma 6(+) V delta 1(+) gamma delta T cells control tolerance to cold by activating adipocyte IL-17RC and promoting sympathetic innervation of thermogenic adipose tissue in mice. The sympathetic nervous system innervates peripheral organs to regulate their function and maintain homeostasis, whereas target cells also produce neurotrophic factors to promote sympathetic innervation(1,2). The molecular basis of this bi-directional communication remains to be fully determined. Here we use thermogenic adipose tissue from mice as a model system to show that T cells, specifically gamma delta T cells, have a crucial role in promoting sympathetic innervation, at least in part by driving the expression of TGF beta 1 in parenchymal cells via the IL-17 receptor C (IL-17RC). Ablation of IL-17RC specifically in adipose tissue reduces expression of TGF beta 1 in adipocytes, impairs local sympathetic innervation and causes obesity and other metabolic phenotypes that are consistent with defective thermogenesis innervation can be fully rescued by restoring TGF beta 1 expression. Ablating gamma delta tau cells and the IL-17RC signalling pathway also impairs sympathetic innervation in other tissues such as salivary glands. These findings demonstrate coordination between T cells and parenchymal cells to regulate sympathetic innervation.
领域	地球科学 ; 气候变化 ; 资源环境
收录类别	SCI-E
WOS记录号	WOS:000518176200003
WOS关键词	BROWN ADIPOSE-TISSUE ; RNA-SEQ ; BETA ; THERMOREGULATION ; CYTOKINE
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/281135
专题	地球科学资源环境科学气候变化
作者单位	1.Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA; 2.Duke Univ, Med Ctr, Howard Hughes Med Inst, Durham, NC 27710 USA; 3.Stanford Univ, Sch Med, Dept Mol & Cellular Physiol, Stanford, CA 94305 USA; 4.Stanford Univ, Sch Med, Dept Struct Biol, Stanford, CA 94305 USA; 5.Stanford Univ, Dept Comp Sci, Stanford, CA 94305 USA; 6.Stanford Univ, Biophys Program, Stanford, CA 94305 USA; 7.Duke Univ, Med Ctr, Dept Biochem, Durham, NC 27710 USA; 8.Chinese Univ Hong Kong, Kobilka Inst Innovat Drug Discovery, Sch Life & Hlth Sci, Shenzhen, Peoples R China; 9.Univ Michigan, Sch Med, Ann Arbor, MI USA
推荐引用方式 GB/T 7714	Staus, Dean P.,Hu, Hongli,Robertson, Michael J.,et al. gamma delta T cells and adipocyte IL-17RC control fat innervation and thermogenesis[J]. NATURE,2020,578(7796):610-+.
APA	Staus, Dean P..,Hu, Hongli.,Robertson, Michael J..,Kleinhenz, Alissa L. W..,Wingler, Laura M..,...&Skiniotis, Georgios.(2020).gamma delta T cells and adipocyte IL-17RC control fat innervation and thermogenesis.NATURE,578(7796),610-+.
MLA	Staus, Dean P.,et al."gamma delta T cells and adipocyte IL-17RC control fat innervation and thermogenesis".NATURE 578.7796(2020):610-+.