Fundamental bounds on the fidelity of sensory cortical coding

doi:10.1038/s41586-020-2130-2

GSTDTAP > 地球科学

DOI	10.1038/s41586-020-2130-2
	Fundamental bounds on the fidelity of sensory cortical coding
	Rempel, S.1,2,8; Gati, C.3,4; Nijland, M.1,2; Thangaratnarajah, C.1,2; Karyolaimos, A.5; de Gier, J. W.5; Guskov, A.1,2,6; Slotboom, D. J.1,2,7
	2020-03-25
发表期刊	NATURE
ISSN	0028-0836
EISSN	1476-4687
出版年	2020
文章类型	Article;Early Access
语种	英语
国家	USA
英文关键词	How the brain processes information accurately despite stochastic neural activity is a longstanding question(1). For instance, perception is fundamentally limited by the information that the brain can extract from the noisy dynamics of sensory neurons. Seminal experiments(2,3) suggest that correlated noise in sensory cortical neural ensembles is what limits their coding accuracy(4-6), although how correlated noise affects neural codes remains debated(7-11). Recent theoretical work proposes that how a neural ensemble' s sensory tuning properties relate statistically to its correlated noise patterns is a greater determinant of coding accuracy than is absolute noise strength(12-14). However, without simultaneous recordings from thousands of cortical neurons with shared sensory inputs, it is unknown whether correlated noise limits coding fidelity. Here we present a 16-beam, two-photon microscope to monitor activity across the mouse primary visual cortex, along with analyses to quantify the information conveyed by large neural ensembles. We found that, in the visual cortex, correlated noise constrained signalling for ensembles with 800-1,300 neurons. Several noise components of the ensemble dynamics grew proportionally to the ensemble size and the encoded visual signals, revealing the predicted information-limiting correlations(12-14). Notably, visual signals were perpendicular to the largest noise mode, which therefore did not limit coding fidelity. The information-limiting noise modes were approximately ten times smaller and concordant with mouse visual acuity(15). Therefore, cortical design principles appear to enhance coding accuracy by restricting around 90% of noise fluctuations to modes that do not limit signalling fidelity, whereas much weaker correlated noise modes inherently bound sensory discrimination. A microscopy system that enables simultaneous recording from hundreds of neurons in the mouse visual cortex reveals that the brain enhances its coding capacity by representing visual inputs in dimensions perpendicular to correlated noise.
领域	地球科学 ; 气候变化 ; 资源环境
收录类别	SCI-E
WOS记录号	WOS:000520398000002
WOS关键词	FIELD-OF-VIEW ; NOISE CORRELATIONS ; NEURONAL-ACTIVITY ; VISUAL-CORTEX ; POPULATION ; INFORMATION ; MICE ; TEMPERATURE ; DIVERSITY ; RESPONSES
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/281518
专题	地球科学资源环境科学气候变化
作者单位	1.Univ Groningen, Groningen Biomol Sci, Groningen, Netherlands; 2.Univ Groningen, Biotechnol Inst GBB, Groningen, Netherlands; 3.SLAC Natl Accelerator Lab, Menlo Pk, CA USA; 4.Stanford Univ, Sch Med, Dept Struct Biol, Palo Alto, CA 94304 USA; 5.Stockholm Univ, Dept Biochem & Biophys, Stockholm, Sweden; 6.Moscow Inst Phys & Technol, Dolgoprudnyi, Russia; 7.Univ Groningen, Zernike Inst Adv Mat, Groningen, Netherlands; 8.Univ Basel, Biozentrum, Struct Biol & Biophys, Basel, Switzerland
推荐引用方式 GB/T 7714	Rempel, S.,Gati, C.,Nijland, M.,et al. Fundamental bounds on the fidelity of sensory cortical coding[J]. NATURE,2020.
APA	Rempel, S..,Gati, C..,Nijland, M..,Thangaratnarajah, C..,Karyolaimos, A..,...&Slotboom, D. J..(2020).Fundamental bounds on the fidelity of sensory cortical coding.NATURE.
MLA	Rempel, S.,et al."Fundamental bounds on the fidelity of sensory cortical coding".NATURE (2020).