Primary exposure to SARS-CoV-2 protects against reinfection in rhesus macaques

doi:10.1126/science.abc5343

GSTDTAP > 气候变化

DOI	10.1126/science.abc5343
	Primary exposure to SARS-CoV-2 protects against reinfection in rhesus macaques
	Wei Deng; Linlin Bao; Jiangning Liu; Chong Xiao; Jiayi Liu; Jing Xue; Qi Lv; Feifei Qi; Hong Gao; Pin Yu; Yanfeng Xu; Yajin Qu; Fengdi Li; Zhiguang Xiang; Haisheng Yu; Shuran Gong; Mingya Liu; Guanpeng Wang; Shunyi Wang; Zhiqi Song; Ying Liu; Wenjie Zhao; Yunlin Han; Linna Zhao; Xing Liu; Qiang Wei; Chuan Qin
	2020-08-14
发表期刊	Science
出版年	2020
英文摘要	One of the many open questions about severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is whether an individual who has cleared the virus can be infected a second time and get sick. Chandrashekar et al. and Deng et al. generated rhesus macaque models of SARS-CoV-2 infection and tested whether natural SARS-CoV-2 infection could result in immunity to viral rechallenge. They found that animals indeed developed immune responses that protected against a second infection. Although there are differences between SARS-CoV-2 infection in macaques and in humans, these findings have key implications for public health and economic initiatives if validated in human studies. Science , this issue p. [812][1], p. [818][2] Coronavirus disease 2019 (COVID-19), which is caused by infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic. It is unclear whether convalescing patients have a risk of reinfection. We generated a rhesus macaque model of SARS-CoV-2 infection that was characterized by interstitial pneumonia and systemic viral dissemination mainly in the respiratory and gastrointestinal tracts. Rhesus macaques reinfected with the identical SARS-CoV-2 strain during the early recovery phase of the initial SARS-CoV-2 infection did not show detectable viral dissemination, clinical manifestations of viral disease, or histopathological changes. Comparing the humoral and cellular immunity between primary infection and rechallenge revealed notably enhanced neutralizing antibody and immune responses. Our results suggest that primary SARS-CoV-2 exposure protects against subsequent reinfection in rhesus macaques. [1]: /lookup/doi/10.1126/science.abc4776 [2]: /lookup/doi/10.1126/science.abc5343
领域	气候变化 ; 资源环境
URL	查看原文
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/288086
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Wei Deng,Linlin Bao,Jiangning Liu,et al. Primary exposure to SARS-CoV-2 protects against reinfection in rhesus macaques[J]. Science,2020.
APA	Wei Deng.,Linlin Bao.,Jiangning Liu.,Chong Xiao.,Jiayi Liu.,...&Chuan Qin.(2020).Primary exposure to SARS-CoV-2 protects against reinfection in rhesus macaques.Science.
MLA	Wei Deng,et al."Primary exposure to SARS-CoV-2 protects against reinfection in rhesus macaques".Science (2020).