Translating genetic risk of Alzheimer’s disease into mechanistic insight and drug targets

doi:10.1126/science.abb8575

GSTDTAP > 气候变化

DOI	10.1126/science.abb8575
	Translating genetic risk of Alzheimer’s disease into mechanistic insight and drug targets
	Annerieke Sierksma; Valentina Escott-Price; Bart De Strooper
	2020-10-02
发表期刊	Science
出版年	2020
英文摘要	To provide better prevention and treatment, we need to understand the environmental and genetic risks of Alzheimer’s disease (AD). However, the definition of AD has been confounded with dementia in many studies. Thus, overinterpretation of genetic findings with regard to mechanisms and drug targets may explain, in part, controversies in the field. Here, we analyze the different forms of genetic risk of AD and how these can be used to model disease. We stress the importance of studying gene variants in the right cell types and in the right pathological context. The lack of mechanistic understanding of genetic variation has become the major bottleneck in the search for new drug targets for AD.
领域	气候变化 ; 资源环境
URL	查看原文
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/298024
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Annerieke Sierksma,Valentina Escott-Price,Bart De Strooper. Translating genetic risk of Alzheimer’s disease into mechanistic insight and drug targets[J]. Science,2020.
APA	Annerieke Sierksma,Valentina Escott-Price,&Bart De Strooper.(2020).Translating genetic risk of Alzheimer’s disease into mechanistic insight and drug targets.Science.
MLA	Annerieke Sierksma,et al."Translating genetic risk of Alzheimer’s disease into mechanistic insight and drug targets".Science (2020).