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Atmospheric reactivity and oxidation capacity during summer at a suburban site between Beijing and Tianjin 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (13) : 8181-8200
作者:  Yang, Yuan;  Wang, Yonghong;  Zhou, Putian;  Yao, Dan;  Ji, Dongsheng;  Sun, Jie;  Wang, Yinghong;  Zhao, Shuman;  Huang, Wei;  Yang, Shuanghong;  Chen, Dean;  Gao, Wenkang;  Liu, Zirui;  Hu, Bo;  Zhang, Renjian;  Zeng, Limin;  Ge, Maofa;  Petaja, Tuukka;  Kerminen, Veli-Matti;  Kulmala, Markku;  Wang, Yuesi
收藏  |  浏览/下载:17/0  |  提交时间:2020/08/18
Economics in the Age of COVID-19 期刊论文
NATURE, 2020, 581 (7809) : 375-377
作者:  Yin, Juan;  Li, Yu-Huai;  Liao, Sheng-Kai;  Yang, Meng;  Cao, Yuan;  Zhang, Liang;  Ren, Ji-Gang;  Cai, Wen-Qi;  Liu, Wei-Yue;  Li, Shuang-Lin;  Shu, Rong;  Huang, Yong-Mei;  Deng, Lei;  Li, Li;  Zhang, Qiang;  Liu, Nai-Le
收藏  |  浏览/下载:25/0  |  提交时间:2020/07/03

Breakneck triage nails many diagnoses, but deeper treatment is needed.


Breakneck triage nails many diagnoses, but deeper treatment is needed.


  
DNA-repair enzyme turns to translation 期刊论文
NATURE, 2020, 579 (7798) : 198-199
作者:  Bian, Zhilei;  Gong, Yandong;  Huang, Tao;  Lee, Christopher Z. W.;  Bian, Lihong;  Bai, Zhijie;  Shi, Hui;  Zeng, Yang;  Liu, Chen;  He, Jian;  Zhou, Jie;  Li, Xianlong;  Li, Zongcheng;  Ni, Yanli;  Ma, Chunyu;  Cui, Lei;  Zhang, Rui;  Chan, Jerry K. Y.;  Ng, Lai Guan;  Lan, Yu;  Ginhoux, Florent;  Liu, Bing
收藏  |  浏览/下载:13/0  |  提交时间:2020/07/03

A key DNA-repair enzyme has a surprising role during the early steps in the assembly of ribosomes - the molecular machines that translate the genetic code into protein.


  
Spatial-temporal variations and process analysis of O-3 pollution in Hangzhou during the G20 summit 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (10) : 5963-5976
作者:  Ni, Zhi-Zhen;  Luo, Kun;  Gao, Yang;  Gao, Xiang;  Jiang, Fei;  Huang, Cheng;  Fan, Jian-Ren;  Fu, Joshua S.;  Chen, Chang-Hong
收藏  |  浏览/下载:7/0  |  提交时间:2020/05/20
Changes in the summer extreme precipitation in the Jianghuai plum rain area and their relationship with the intensity anomalies of the south Asian high 期刊论文
ATMOSPHERIC RESEARCH, 2020, 236
作者:  Yin, Yixing;  Han, Cui;  Yang, Guanying;  Huang, Yihan;  Liu, Mengyang;  Wang, Xiaojun
收藏  |  浏览/下载:11/0  |  提交时间:2020/07/02
extreme precipitation  south Asian high  circulation anomaly  atmospheric heat source  Jianghuai plum rain area  
A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1 期刊论文
NATURE, 2020, 577 (7788) : 109-+
作者:  Tao, Panfeng;  Sun, Jinqiao;  Wu, Zheming;  Wang, Shihao;  Wang, Jun;  Li, Wanjin;  Pan, Heling;  Bai, Renkui;  Zhang, Jiahui;  Wang, Ying;  Lee, Pui Y.;  Ying, Wenjing;  Zhou, Qinhua;  Hou, Jia;  Wang, Wenjie;  Sun, Bijun;  Yang, Mi;  Liu, Danru;  Fang, Ran;  Han, Huan;  Yang, Zhaohui;  Huang, Xin;  Li, Haibo;  Deuitch, Natalie;  Zhang, Yuan;  Dissanayake, Dilan;  Haude, Katrina;  McWalter, Kirsty;  Roadhouse, Chelsea;  MacKenzie, Jennifer J.;  Laxer, Ronald M.;  Aksentijevich, Ivona;  Yu, Xiaomin;  Wang, Xiaochuan;  Yuan, Junying;  Zhou, Qing
收藏  |  浏览/下载:26/0  |  提交时间:2020/07/03

Activation of RIPK1 controls TNF-mediated apoptosis, necroptosis and inflammatory pathways(1). Cleavage of human and mouse RIPK1 after residues D324 and D325, respectively, by caspase-8 separates the RIPK1 kinase domain from the intermediate and death domains. The D325A mutation in mouse RIPK1 leads to embryonic lethality during mouse development(2,3). However, the functional importance of blocking caspase-8-mediated cleavage of RIPK1 on RIPK1 activation in humans is unknown. Here we identify two families with variants in RIPK1 (D324V and D324H) that lead to distinct symptoms of recurrent fevers and lymphadenopathy in an autosomaldominant manner. Impaired cleavage of RIPK1 D324 variants by caspase-8 sensitized patients'  peripheral blood mononuclear cells to RIPK1 activation, apoptosis and necroptosis induced by TNF. The patients showed strong RIPK1-dependent activation of inflammatory signalling pathways and overproduction of inflammatory cytokines and chemokines compared with unaffected controls. Furthermore, we show that expression of the RIPK1 mutants D325V or D325H in mouse embryonic fibroblasts confers not only increased sensitivity to RIPK1 activation-mediated apoptosis and necroptosis, but also induction of pro-inflammatory cytokines such as IL-6 and TNF. By contrast, patient-derived fibroblasts showed reduced expression of RIPK1 and downregulated production of reactive oxygen species, resulting in resistance to necroptosis and ferroptosis. Together, these data suggest that human non-cleavable RIPK1 variants promote activation of RIPK1, and lead to an autoinflammatory disease characterized by hypersensitivity to apoptosis and necroptosis and increased inflammatory response in peripheral blood mononuclear cells, as well as a compensatory mechanism to protect against several pro-death stimuli in fibroblasts.


  
Brain control of humoral immune responses amenable to behavioural modulation 期刊论文
NATURE, 2020, 581 (7807)
作者:  Yang, C. H.;  Leon, R. C. C.;  Hwang, J. C. C.;  Saraiva, A.;  Tanttu, T.;  Huang, W.;  Lemyre, J. Camirand;  Chan, K. W.;  Tan, K. Y.;  Hudson, F. E.;  Itoh, K. M.;  Morello, A.;  Pioro-Ladriere, M.;  Laucht, A.;  Dzurak, A. S.
收藏  |  浏览/下载:12/0  |  提交时间:2020/07/03

It has been speculated that brain activities might directly control adaptive immune responses in lymphoid organs, although there is little evidence for this. Here we show that splenic denervation in mice specifically compromises the formation of plasma cells during a T cell-dependent but not T cell-independent immune response. Splenic nerve activity enhances plasma cell production in a manner that requires B-cell responsiveness to acetylcholine mediated by the alpha 9 nicotinic receptor, and T cells that express choline acetyl transferase(1,2) probably act as a relay between the noradrenergic nerve and acetylcholine-responding B cells. We show that neurons in the central nucleus of the amygdala (CeA) and the paraventricular nucleus (PVN) that express corticotropin-releasing hormone (CRH) are connected to the splenic nerve  ablation or pharmacogenetic inhibition of these neurons reduces plasma cell formation, whereas pharmacogenetic activation of these neurons increases plasma cell abundance after immunization. In a newly developed behaviour regimen, mice are made to stand on an elevated platform, leading to activation of CeA and PVN CRH neurons and increased plasma cell formation. In immunized mice, the elevated platform regimen induces an increase in antigen-specific IgG antibodies in a manner that depends on CRH neurons in the CeA and PVN, an intact splenic nerve, and B cell expression of the alpha 9 acetylcholine receptor. By identifying a specific brain-spleen neural connection that autonomically enhances humoral responses and demonstrating immune stimulation by a bodily behaviour, our study reveals brain control of adaptive immunity and suggests the possibility to enhance immunocompetency by behavioural intervention.


Neuronal activities in the central amygdala and paraventricular nucleus are transmitted via the splenic nerve to increase plasma cell formation after immunization, and this process can be behaviourally enhanced in mice.


  
Assessing the sensitivity of land-atmosphere coupling strength to boundary and surface layer parameters in the WRF model over Amazon 期刊论文
ATMOSPHERIC RESEARCH, 2020, 234
作者:  Wang, Chen;  Qian, Yun;  Duan, Qingyun;  Huang, Maoyi;  Berg, Larry K.;  Shin, Hyeyum H.;  Feng, Zhe;  Yang, Ben;  Quan, Jiping;  Hong, Songyou;  Yan, Junhua
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/02
L-A coupling strength  Amazon region  WRF model  Model uncertainties  Parameter sensitivity analysis  
Description and Evaluation of the specified-dynamics experiment in the Chemistry-Climate Model Initiative 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (6) : 3809-3840
作者:  Orbe, Clara;  Plummer, David A.;  Waugh, Darryn W.;  Yang, Huang;  Jocke, Patrick;  Kinnison, Douglas E.;  Josse, Beatrice;  Marecal, Virginie;  Deushi, Makoto;  Abraham, Nathan Luke;  Archibald, Alexander T.;  Chipperfield, Martyn P.;  Dhomse, Sandip;  Feng, Wuhu;  Bekki, Slimane
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/02
Extreme weather events recorded by daily to hourly resolution biogeochemical proxies of marine giant clam shells 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (13) : 7038-7043
作者:  Yan, Hong;  Liu, Chengcheng;  An, Zhisheng;  Yang, Wei;  Yang, Yuanjian;  Huang, Ping;  Qiu, Shican;  Zhou, Pengchao;  Zhao, Nanyu;  Fei, Haobai;  Ma, Xiaolin;  Shi, Ge;  Dodson, John;  Hao, Jialong;  Yu, Kefu;  Wei, Gangjian;  Yang, Yanan;  Jin, Zhangdong;  Zhou, Weijian
收藏  |  浏览/下载:14/0  |  提交时间:2020/05/13
Tridacna shell  daily growth bands  ultra-high resolution  biogeochemical proxies  weather-timescale extreme events