中文版 | English

在结果中检索

GSTDTAP

浏览/检索结果: 共9条，第1-9条 帮助

限定条件            
已选(0)清除 条数/页：   排序方式：
Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation 期刊论文
NATURE, 2020, 580 (7803) : 391-+
作者:  Zhang, Zhibin;  Zhang, Ying;  Xia, Shiyu;  Kong, Qing;  Li, Shunying;  Liu, Xing;  Junqueira, Caroline;  Meza-Sosa, Karla F.;  Mok, Temy Mo Yin;  Ansara, James;  Sengupta, Satyaki;  Yao, Yandan;  Wu, Hao;  Lieberman, Judy
收藏  |  浏览/下载：12/0  |  提交时间：2020/07/03

The biological function of Z-DNA and Z-RNA, nucleic acid structures with a left-handed double helix, is poorly understood(1-3). Z-DNA-binding protein 1 (ZBP1  also known as DAI or DLM-1) is a nucleic acid sensor that contains two Z alpha domains that bind Z-DNA(4,5) and Z-RNA(6-8). ZBP1 mediates host defence against some viruses(6,7,9-14) by sensing viral nucleic acids(6,7,10). RIPK1 deficiency, or mutation of its RIP homotypic interaction motif (RHIM), triggers ZBP1-dependent necroptosis and inflammation in mice(15,16). However, the mechanisms that induce ZBP1 activation in the absence of viral infection remain unknown. Here we show that Z alpha-dependent sensing of endogenous ligands induces ZBP1-mediated perinatal lethality in mice expressing RIPK1 with mutated RHIM (Ripk1(mR/mR)), skin inflammation in mice with epidermis-specific RIPK1 deficiency (RIPK1(E-KO)) and colitis in mice with intestinal epithelial-specific FADD deficiency (FADD(IEC-KO)). Consistently, functional Z alpha domains were required for ZBP1-induced necroptosis in fibroblasts that were treated with caspase inhibitors or express RIPK1 with mutated RHIM. Inhibition of nuclear export triggered the Z alpha-dependent activation of RIPK3 in the nucleus resulting in cell death, which suggests that ZBP1 may recognize nuclear Z-form nucleic acids. We found that ZBP1 constitutively bound cellular double-stranded RNA in a Z alpha-dependent manner. Complementary reads derived from endogenous retroelements were detected in epidermal RNA, which suggests that double-stranded RNA derived from these retroelements may act as a Z alpha-domain ligand that triggers the activation of ZBP1. Collectively, our results provide evidence that the sensing of endogenous Z-form nucleic acids by ZBP1 triggers RIPK3-dependent necroptosis and inflammation, which could underlie the development of chronic inflammatory conditions-particularly in individuals with mutations in RIPK1 and CASP8(17-20).


  
How transit scaling shapes cities 期刊论文
NATURE SUSTAINABILITY, 2019, 2 (12) : 1142-1148
作者:  Wu, Hao;  Levinson, David;  Sarkar, Somwrita
收藏  |  浏览/下载：2/0  |  提交时间：2020/02/16
Structure of the RSC complex bound to the nucleosome 期刊论文
SCIENCE, 2019, 366 (6467) : 838-+
作者:  Ye, Youpi;  Wu, Hao;  Chen, Kangjing;  Clapier, Cedric R.;  Verma, Naveen;  Zhang, Wenhao;  Deng, Haiteng;  Cairns, Bradley R.;  Gao, Ning;  Chen, Zhucheng
收藏  |  浏览/下载：11/0  |  提交时间：2020/02/17
Boltzmann generators: Sampling equilibrium states of many-body systems with deep learning 期刊论文
SCIENCE, 2019, 365 (6457) : 1001-+
作者:  Noe, Frank;  Olsson, Simon;  Koehler, Jonas;  Wu, Hao
收藏  |  浏览/下载：6/0  |  提交时间：2019/11/27
Protein-peptide association kinetics beyond the seconds timescale from atomistic simulations (vol 8, 2017) 期刊论文
NATURE COMMUNICATIONS, 2018, 9
作者:  Paul, Fabian;  Wehmeyer, Christoph;  Abualrous, Esam T.;  Wu, Hao;  Crabtree, Michael D.;  Schoneberg, Johannes;  Clarke, Jane;  Freund, Christian;  Weikl, Thomas R.;  Noe, Frank
收藏  |  浏览/下载：8/0  |  提交时间：2019/11/27
Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWPI inhibitory pathway 期刊论文
SCIENCE, 2019, 364 (6441) : 651-+
作者:  Lee, Yu-Ru;  Chen, Ming;  Lee, Jonathan D.;  Zhang, Jinfang;  Lin, Shu-Yu;  Fu, Tian-Min;  Chen, Hao;  Ishikawa, Tomold;  Chiang, Shang-Yin;  Katon, Jesse;  Zhang, Yang;  Shulga, Yulia V.;  Bester, Assaf C.;  Fung, Jacqueline;  Monteleone, Emanuele;  Wan, Lixin;  Shen, Chen;  Hsu, Chil-Hung;  Papa, Antonella;  Clohessy, John G.;  Teruya-Feldstein, Julie;  Jain, Suresh;  Wu, Hao;  Matesic, Lydia;  Chen, Ruey-Hwa;  Wei, Wenyi;  Pandolfi, Pier Paolo
收藏  |  浏览/下载：12/0  |  提交时间：2019/11/27
Structures and gating mechanism of human TRPM2 期刊论文
SCIENCE, 2018, 362 (6421) : 1377-+
作者:  Wang, Longfei;  Fu, Tian-Min;  Zhou, Yiming;  Xia, Shiyu;  Greka, Anna;  Wu, Hao
收藏  |  浏览/下载：13/0  |  提交时间：2019/11/27
Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death 期刊论文
SCIENCE, 2018, 362 (6418) : 1064-+
作者:  Orning, Pontus;  Weng, Dan;  Starheim, Kristian;  Ratner, Dmitry;  Best, Zachary;  Lee, Bettina;  Brooks, Alexandria;  Xia, Shiyu;  Wu, Hao;  Kelliher, Michelle A.;  Berger, Scott B.;  Gough, Peter J.;  Bertin, John;  Proulx, Megan M.;  Goguen, Jon D.;  Kayagaki, Nobuhiko;  Fitzgerald, Katherine A.;  Lien, Egil
收藏  |  浏览/下载：12/0  |  提交时间：2019/11/27
VAMPnets for deep learning of molecular kinetics 期刊论文
NATURE COMMUNICATIONS, 2018, 9
作者:  Mardt, Andreas;  Pasquali, Luca;  Wu, Hao;  Noe, Frank
收藏  |  浏览/下载：5/0  |  提交时间：2019/11/27