GSTDTAP

浏览/检索结果: 共8条,第1-8条 帮助

限定条件    
已选(0)清除 条数/页:   排序方式:
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms 期刊论文
Science, 2020
作者:  David E. Gordon;  Joseph Hiatt;  Mehdi Bouhaddou;  Veronica V. Rezelj;  Svenja Ulferts;  Hannes Braberg;  Alexander S. Jureka;  Kirsten Obernier;  Jeffrey Z. Guo;  Jyoti Batra;  Robyn M. Kaake;  Andrew R. Weckstein;  Tristan W. Owens;  Meghna Gupta;  Sergei Pourmal;  Erron W. Titus;  Merve Cakir;  Margaret Soucheray;  Michael McGregor;  Zeynep Cakir;  Gwendolyn Jang;  Matthew J. O’Meara;  Tia A. Tummino;  Ziyang Zhang;  Helene Foussard;  Ajda Rojc;  Yuan Zhou;  Dmitry Kuchenov;  Ruth Hüttenhain;  Jiewei Xu;  Manon Eckhardt;  Danielle L. Swaney;  Jacqueline M. Fabius;  Manisha Ummadi;  Beril Tutuncuoglu;  Ujjwal Rathore;  Maya Modak;  Paige Haas;  Kelsey M. Haas;  Zun Zar Chi Naing;  Ernst H. Pulido;  Ying Shi;  Inigo Barrio-Hernandez;  Danish Memon;  Eirini Petsalaki;  Alistair Dunham;  Miguel Correa Marrero;  David Burke;  Cassandra Koh;  Thomas Vallet;  Jesus A. Silvas;  Caleigh M. Azumaya;  Christian Billesbølle;  Axel F. Brilot;  Melody G. Campbell;  Amy Diallo;  Miles Sasha Dickinson;  Devan Diwanji;  Nadia Herrera;  Nick Hoppe;  Huong T. Kratochvil;  Yanxin Liu;  Gregory E. Merz;  Michelle Moritz;  Henry C. Nguyen;  Carlos Nowotny;  Cristina Puchades;  Alexandrea N. Rizo;  Ursula Schulze-Gahmen;  Amber M. Smith;  Ming Sun;  Iris D. Young;  Jianhua Zhao;  Daniel Asarnow;  Justin Biel;  Alisa Bowen;  Julian R. Braxton;  Jen Chen;  Cynthia M. Chio;  Un Seng Chio;  Ishan Deshpande;  Loan Doan;  Bryan Faust;  Sebastian Flores;  Mingliang Jin;  Kate Kim;  Victor L. Lam;  Fei Li;  Junrui Li;  Yen-Li Li;  Yang Li;  Xi Liu;  Megan Lo;  Kyle E. Lopez;  Arthur A. Melo;  Frank R. Moss;  Phuong Nguyen;  Joana Paulino;  Komal Ishwar Pawar;  Jessica K. Peters;  Thomas H. Pospiech;  Maliheh Safari;  Smriti Sangwan;  Kaitlin Schaefer;  Paul V. Thomas;  Aye C. Thwin;  Raphael Trenker;  Eric Tse;  Tsz Kin Martin Tsui;  Feng Wang;  Natalie Whitis;  Zanlin Yu;  Kaihua Zhang;  Yang Zhang;  Fengbo Zhou;  Daniel Saltzberg;  QCRG Structural Biology Consortium12†;  Anthony J. Hodder;  Amber S. Shun-Shion;  Daniel M. Williams;  Kris M. White;  Romel Rosales;  Thomas Kehrer;  Lisa Miorin;  Elena Moreno;  Arvind H. Patel;  Suzannah Rihn;  Mir M. Khalid;  Albert Vallejo-Gracia;  Parinaz Fozouni;  Camille R. Simoneau;  Theodore L. Roth;  David Wu;  Mohd Anisul Karim;  Maya Ghoussaini;  Ian Dunham;  Francesco Berardi;  Sebastian Weigang;  Maxime Chazal;  Jisoo Park;  James Logue;  Marisa McGrath;  Stuart Weston;  Robert Haupt;  C. James Hastie;  Matthew Elliott;  Fiona Brown;  Kerry A. Burness;  Elaine Reid;  Mark Dorward;  Clare Johnson;  Stuart G. Wilkinson;  Anna Geyer;  Daniel M. Giesel;  Carla Baillie;  Samantha Raggett;  Hannah Leech;  Rachel Toth;  Nicola Goodman;  Kathleen C. Keough;  Abigail L. Lind;  Zoonomia Consortium‡;  Reyna J. Klesh;  Kafi R. Hemphill;  Jared Carlson-Stevermer;  Jennifer Oki;  Kevin Holden;  Travis Maures;  Katherine S. Pollard;  Andrej Sali;  David A. Agard;  Yifan Cheng;  James S. Fraser;  Adam Frost;  Natalia Jura;  Tanja Kortemme;  Aashish Manglik;  Daniel R. Southworth;  Robert M. Stroud;  Dario R. Alessi;  Paul Davies;  Matthew B. Frieman;  Trey Ideker;  Carmen Abate;  Nolwenn Jouvenet;  Georg Kochs;  Brian Shoichet;  Melanie Ott;  Massimo Palmarini;  Kevan M. Shokat;  Adolfo García-Sastre;  Jeremy A. Rassen;  Robert Grosse;  Oren S. Rosenberg;  Kliment A. Verba;  Christopher F. Basler;  Marco Vignuzzi;  Andrew A. Peden;  Pedro Beltrao;  Nevan J. Krogan
收藏  |  浏览/下载:27/0  |  提交时间:2020/12/07
Anomalous circulation in July 2019 resulting in mass loss on the Greenland Ice Sheet 期刊论文
Geophysical Research Letters, 2020
作者:  Richard I. Cullather;  Lauren C. Andrews;  Michael J. Croteau;  Nicolo E. Digirolamo;  Dorothy K. Hall;  Young‐;  Kwon Lim;  Bryant D. Loomis;  Christopher A. Shuman;  Sophie M. J. Nowicki
收藏  |  浏览/下载:14/0  |  提交时间:2020/09/08
International evaluation of an AI system for breast cancer screening 期刊论文
NATURE, 2020, 577 (7788) : 89-+
作者:  McKinney, Scott Mayer;  Sieniek, Marcin;  Godbole, Varun;  Godwin, Jonathan;  Antropova, Natasha;  Ashrafian, Hutan;  Back, Trevor;  Chesus, Mary;  Corrado, Greg C.;  Darzi, Ara;  Etemadi, Mozziyar;  Garcia-Vicente, Florencia;  Gilbert, Fiona J.;  Halling-Brown, Mark;  Hassabis, Demis;  Jansen, Sunny;  Karthikesalingam, Alan;  Kelly, Christopher J.;  King, Dominic;  Ledsam, Joseph R.;  Melnick, David;  Mostofi, Hormuz;  Peng, Lily;  Reicher, Joshua Jay;  Romera-Paredes, Bernardino;  Sidebottom, Richard;  Suleyman, Mustafa;  Tse, Daniel;  Young, Kenneth C.;  De Fauw, Jeffrey;  Shetty, Shravya
收藏  |  浏览/下载:15/0  |  提交时间:2020/07/03

Screening mammography aims to identify breast cancer at earlier stages of the disease, when treatment can be more successful(1). Despite the existence of screening programmes worldwide, the interpretation of mammograms is affected by high rates of false positives and false negatives(2). Here we present an artificial intelligence (AI) system that is capable of surpassing human experts in breast cancer prediction. To assess its performance in the clinical setting, we curated a large representative dataset from the UK and a large enriched dataset from the USA. We show an absolute reduction of 5.7% and 1.2% (USA and UK) in false positives and 9.4% and 2.7% in false negatives. We provide evidence of the ability of the system to generalize from the UK to the USA. In an independent study of six radiologists, the AI system outperformed all of the human readers: the area under the receiver operating characteristic curve (AUC-ROC) for the AI system was greater than the AUC-ROC for the average radiologist by an absolute margin of 11.5%. We ran a simulation in which the AI system participated in the double-reading process that is used in the UK, and found that the AI system maintained non-inferior performance and reduced the workload of the second reader by 88%. This robust assessment of the AI system paves the way for clinical trials to improve the accuracy and efficiency of breast cancer screening.


  
Long-term thermal sensitivity of Earth’s tropical forests 期刊论文
Science, 2020
作者:  Martin J. P. Sullivan;  Simon L. Lewis;  Kofi Affum-Baffoe;  Carolina Castilho;  Flávia Costa;  Aida Cuni Sanchez;  Corneille E. N. Ewango;  Wannes Hubau;  Beatriz Marimon;  Abel Monteagudo-Mendoza;  Lan Qie;  Bonaventure Sonké;  Rodolfo Vasquez Martinez;  Timothy R. Baker;  Roel J. W. Brienen;  Ted R. Feldpausch;  David Galbraith;  Manuel Gloor;  Yadvinder Malhi;  Shin-Ichiro Aiba;  Miguel N. Alexiades;  Everton C. Almeida;  Edmar Almeida de Oliveira;  Esteban Álvarez Dávila;  Patricia Alvarez Loayza;  Ana Andrade;  Simone Aparecida Vieira;  Luiz E. O. C. Aragão;  Alejandro Araujo-Murakami;  Eric J. M. M. Arets;  Luzmila Arroyo;  Peter Ashton;  Gerardo Aymard C.;  Fabrício B. Baccaro;  Lindsay F. Banin;  Christopher Baraloto;  Plínio Barbosa Camargo;  Jos Barlow;  Jorcely Barroso;  Jean-François Bastin;  Sarah A. Batterman;  Hans Beeckman;  Serge K. Begne;  Amy C. Bennett;  Erika Berenguer;  Nicholas Berry;  Lilian Blanc;  Pascal Boeckx;  Jan Bogaert;  Damien Bonal;  Frans Bongers;  Matt Bradford;  Francis Q. Brearley;  Terry Brncic;  Foster Brown;  Benoit Burban;  José Luís Camargo;  Wendeson Castro;  Carlos Céron;  Sabina Cerruto Ribeiro;  Victor Chama Moscoso;  Jerôme Chave;  Eric Chezeaux;  Connie J. Clark;  Fernanda Coelho de Souza;  Murray Collins;  James A. Comiskey;  Fernando Cornejo Valverde;  Massiel Corrales Medina;  Lola da Costa;  Martin Dančák;  Greta C. Dargie;  Stuart Davies;  Nallaret Davila Cardozo;  Thales de Haulleville;  Marcelo Brilhante de Medeiros;  Jhon del Aguila Pasquel;  Géraldine Derroire;  Anthony Di Fiore;  Jean-Louis Doucet;  Aurélie Dourdain;  Vincent Droissant;  Luisa Fernanda Duque;  Romeo Ekoungoulou;  Fernando Elias;  Terry Erwin;  Adriane Esquivel-Muelbert;  Sophie Fauset;  Joice Ferreira;  Gerardo Flores Llampazo;  Ernest Foli;  Andrew Ford;  Martin Gilpin;  Jefferson S. Hall;  Keith C. Hamer;  Alan C. Hamilton;  David J. Harris;  Terese B. Hart;  Radim Hédl;  Bruno Herault;  Rafael Herrera;  Niro Higuchi;  Annette Hladik;  Eurídice Honorio Coronado;  Isau Huamantupa-Chuquimaco;  Walter Huaraca Huasco;  Kathryn J. Jeffery;  Eliana Jimenez-Rojas;  Michelle Kalamandeen;  Marie Noël Kamdem Djuikouo;  Elizabeth Kearsley;  Ricardo Keichi Umetsu;  Lip Khoon Kho;  Timothy Killeen;  Kanehiro Kitayama;  Bente Klitgaard;  Alexander Koch;  Nicolas Labrière;  William Laurance;  Susan Laurance;  Miguel E. Leal;  Aurora Levesley;  Adriano J. N. Lima;  Janvier Lisingo;  Aline P. Lopes;  Gabriela Lopez-Gonzalez;  Tom Lovejoy;  Jon C. Lovett;  Richard Lowe;  William E. Magnusson;  Jagoba Malumbres-Olarte;  Ângelo Gilberto Manzatto;  Ben Hur Marimon;  Andrew R. Marshall;  Toby Marthews;  Simone Matias de Almeida Reis;  Colin Maycock;  Karina Melgaço;  Casimiro Mendoza;  Faizah Metali;  Vianet Mihindou;  William Milliken;  Edward T. A. Mitchard;  Paulo S. Morandi;  Hannah L. Mossman;  Laszlo Nagy;  Henrique Nascimento;  David Neill;  Reuben Nilus;  Percy Núñez Vargas;  Walter Palacios;  Nadir Pallqui Camacho;  Julie Peacock;  Colin Pendry;  Maria Cristina Peñuela Mora;  Georgia C. Pickavance;  John Pipoly;  Nigel Pitman;  Maureen Playfair;  Lourens Poorter;  John R. Poulsen;  Axel Dalberg Poulsen;  Richard Preziosi;  Adriana Prieto;  Richard B. Primack;  Hirma Ramírez-Angulo;  Jan Reitsma;  Maxime Réjou-Méchain;  Zorayda Restrepo Correa;  Thaiane Rodrigues de Sousa;  Lily Rodriguez Bayona;  Anand Roopsind;  Agustín Rudas;  Ervan Rutishauser;  Kamariah Abu Salim;  Rafael P. Salomão;  Juliana Schietti;  Douglas Sheil;  Richarlly C. Silva;  Javier Silva Espejo;  Camila Silva Valeria;  Marcos Silveira;  Murielle Simo-Droissart;  Marcelo Fragomeni Simon;  James Singh;  Yahn Carlos Soto Shareva;  Clement Stahl;  Juliana Stropp;  Rahayu Sukri;  Terry Sunderland;  Martin Svátek;  Michael D. Swaine;  Varun Swamy;  Hermann Taedoumg;  Joey Talbot;  James Taplin;  David Taylor;  Hans ter Steege;  John Terborgh;  Raquel Thomas;  Sean C. Thomas;  Armando Torres-Lezama;  Peter Umunay;  Luis Valenzuela Gamarra;  Geertje van der Heijden;  Peter van der Hout;  Peter van der Meer;  Mark van Nieuwstadt;  Hans Verbeeck;  Ronald Vernimmen;  Alberto Vicentini;  Ima Célia Guimarães Vieira;  Emilio Vilanova Torre;  Jason Vleminckx;  Vincent Vos;  Ophelia Wang;  Lee J. T. White;  Simon Willcock;  John T. Woods;  Verginia Wortel;  Kenneth Young;  Roderick Zagt;  Lise Zemagho;  Pieter A. Zuidema;  Joeri A. Zwerts;  Oliver L. Phillips
收藏  |  浏览/下载:35/0  |  提交时间:2020/05/25
Inner ear sensory system changes as extinct crocodylomorphs transitioned from land to water 期刊论文
Proceedings of the National Academy of Science, 2020
作者:  Julia A. Schwab;  Mark T. Young;  James M. Neenan;  Stig A. Walsh;  Lawrence M. Witmer;  Yanina Herrera;  Ronan Allain;  Christopher A. Brochu;  Jonah N. Choiniere;  James M. Clark;  Kathleen N. Dollman;  Steve Etches;  Guido Fritsch;  Paul M. Gignac;  Alexander Ruebenstahl;  Sven Sachs;  Alan H. Turner;  Patrick Vignaud;  Eric W. Wilberg;  Xing Xu;  Lindsay E. Zanno;  Stephen L. Brusatte
收藏  |  浏览/下载:11/0  |  提交时间:2020/05/13
Inner ear sensory system changes as extinct crocodylomorphs transitioned from land to water 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (19) : 10422-10428
作者:  Schwab, Julia A.;  Young, Mark T.;  Neenan, James M.;  Walsh, Stig A.;  Witmer, Lawrence M.;  Herrera, Yanina;  Allain, Ronan;  Brochu, Christopher A.;  Choiniere, Jonah N.;  Clark, James M.;  Dollman, Kathleen N.;  Etches, Steve;  Fritsch, Guido;  Gignac, Paul M.;  Ruebenstahl, Alexander;  Sachs, Sven;  Turner, Alan H.;  Vignaud, Patrick;  Wilberg, Eric W.;  Xu, Xing;  Zanno, Lindsay E.;  Brusatte, Stephen L.
收藏  |  浏览/下载:9/0  |  提交时间:2020/05/13
bony labyrinth  vestibular system  morphology  thalattosuchia  CT scanning  
APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline 期刊论文
NATURE, 2020, 581 (7806) : 70-+
作者:  Doherty, Tiarnan A. S.;  Winchester, Andrew J.;  Macpherson, Stuart;  Johnstone, Duncan N.;  Pareek, Vivek;  Tennyson, Elizabeth M.;  Kosar, Sofiia;  Kosasih, Felix U.;  Anaya, Miguel;  Abdi-Jalebi, Mojtaba;  Andaji-Garmaroudi, Zahra;  Wong, E. Laine;  Madeo, Julien;  Chiang, Yu-Hsien;  Park, Ji-Sang;  Jung, Young-Kwang;  Petoukhoff, Christopher E.;  Divitini, Giorgio;  Man, Michael K. L.;  Ducati, Caterina;  Walsh, Aron;  Midgley, Paul A.;  Dani, Keshav M.;  Stranks, Samuel D.
收藏  |  浏览/下载:25/0  |  提交时间:2020/07/03

Breakdown of the blood-brain barrier in individuals carrying the epsilon 4 allele of the APOE gene, but not the epsilon 3 allele, increases with and predicts cognitive impairment and is independent of amyloid beta or tau pathology.


Vascular contributions to dementia and Alzheimer'  s disease are increasingly recognized(1-6). Recent studies have suggested that breakdown of the blood-brain barrier (BBB) is an early biomarker of human cognitive dysfunction(7), including the early clinical stages of Alzheimer'  s disease(5,8-10). The E4 variant of apolipoprotein E (APOE4), the main susceptibility gene for Alzheimer'  s disease(11-14), leads to accelerated breakdown of the BBB and degeneration of brain capillary pericytes(15-19), which maintain BBB integrity(20-22). It is unclear, however, whether the cerebrovascular effects of APOE4 contribute to cognitive impairment. Here we show that individuals bearing APOE4 (with the epsilon 3/epsilon 4 or epsilon 4/epsilon 4 alleles) are distinguished from those without APOE4 (epsilon 3/epsilon 3) by breakdown of the BBB in the hippocampus and medial temporal lobe. This finding is apparent in cognitively unimpaired APOE4 carriers and more severe in those with cognitive impairment, but is not related to amyloid-beta or tau pathology measured in cerebrospinal fluid or by positron emission tomography(23). High baseline levels of the BBB pericyte injury biomarker soluble PDGFR beta(7,8) in the cerebrospinal fluid predicted future cognitive decline in APOE4 carriers but not in non-carriers, even after controlling for amyloid-beta and tau status, and were correlated with increased activity of the BBB-degrading cyclophilin A-matrix metalloproteinase-9 pathway(19) in cerebrospinal fluid. Our findings suggest that breakdown of the BBB contributes to APOE4-associated cognitive decline independently of Alzheimer'  s disease pathology, and might be a therapeutic target in APOE4 carriers.


  
Electrical manipulation of a topological antiferromagnetic state 期刊论文
NATURE, 2020, 580 (7805) : 608-+
作者:  Chabon, Jacob J.;  Hamilton, Emily G.;  Kurtz, David M.;  Esfahani, Mohammad S.;  Moding, Everett J.;  Stehr, Henning;  Schroers-Martin, Joseph;  Nabet, Barzin Y.;  Chen, Binbin;  Chaudhuri, Aadel A.;  Liu, Chih Long;  Hui, Angela B.;  Jin, Michael C.;  Azad, Tej D.;  Almanza, Diego;  Jeon, Young-Jun;  Nesselbush, Monica C.;  Keh, Lyron Co Ting;  Bonilla, Rene F.;  Yoo, Christopher H.;  Ko, Ryan B.;  Chen, Emily L.;  Merriott, David J.;  Massion, Pierre P.;  Mansfield, Aaron S.;  Jen, Jin;  Ren, Hong Z.;  Lin, Steven H.;  Costantino, Christina L.;  Burr, Risa;  Tibshirani, Robert;  Gambhir, Sanjiv S.;  Berry, Gerald J.;  Jensen, Kristin C.;  West, Robert B.;  Neal, Joel W.;  Wakelee, Heather A.;  Loo, Billy W., Jr.;  Kunder, Christian A.;  Leung, Ann N.;  Lui, Natalie S.;  Berry, Mark F.;  Shrager, Joseph B.;  Nair, Viswam S.;  Haber, Daniel A.;  Sequist, Lecia V.;  Alizadeh, Ash A.;  Diehn, Maximilian
收藏  |  浏览/下载:37/0  |  提交时间:2020/07/03

Room-temperature electrical switching of a topological antiferromagnetic state in polycrystalline Mn3Sn thin films is demonstrated using the same protocol as that used for conventional ferromagnetic metals.


Electrical manipulation of phenomena generated by nontrivial band topology is essential for the development of next-generation technology using topological protection. A Weyl semimetal is a three-dimensional gapless system that hosts Weyl fermions as low-energy quasiparticles(1-4). It has various exotic properties, such as a large anomalous Hall effect (AHE) and chiral anomaly, which are robust owing to the topologically protected Weyl nodes(1-16). To manipulate such phenomena, a magnetic version of Weyl semimetals would be useful for controlling the locations of Weyl nodes in the Brillouin zone. Moreover, electrical manipulation of antiferromagnetic Weyl metals would facilitate the use of antiferromagnetic spintronics to realize high-density devices with ultrafast operation(17,18). However, electrical control of a Weyl metal has not yet been reported. Here we demonstrate the electrical switching of a topological antiferromagnetic state and its detection by the AHE at room temperature in a polycrystalline thin film(19) of the antiferromagnetic Weyl metal Mn3Sn9,10,12,20, which exhibits zero-field AHE. Using bilayer devices composed of Mn3Sn and nonmagnetic metals, we find that an electrical current density of about 10(10) to 10(11) amperes per square metre induces magnetic switching in the nonmagnetic metals, with a large change in Hall voltage. In addition, the current polarity along the bias field and the sign of the spin Hall angle of the nonmagnetic metals-positive for Pt (ref. (21)), close to 0 for Cu and negative for W (ref. (22))-determines the sign of the Hall voltage. Notably, the electrical switching in the antiferromagnet is achieved with the same protocol as that used for ferromagnetic metals(23,24). Our results may lead to further scientific and technological advances in topological magnetism and antiferromagnetic spintronics.