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Observations of Electron Vortex at the Dipolarization Front 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (13)
作者:  Jiang, K.;  Huang, S. Y.;  Yuan, Z. G.;  Deng, X. H.;  Xu, S. B.;  Wei, Y. Y.;  He, L. H.;  Zhang, J.;  Zhang, Z. H.
收藏  |  浏览/下载:12/0  |  提交时间:2020/06/22
dipolarization front  electron vortex  small-scale plateau  asymmetric electric field  
A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds 期刊论文
NATURE, 2020, 580 (7803) : 409-+
作者:  Al-Shayeb, Basem;  Sachdeva, Rohan;  Chen, Lin-Xing;  Ward, Fred;  Munk, Patrick;  Devoto, Audra;  Castelle, Cindy J.;  Olm, Matthew R.;  Bouma-Gregson, Keith;  Amano, Yuki;  He, Christine;  Meheust, Raphael;  Brooks, Brandon;  Thomas, Alex;  Levy, Adi;  Matheus-Carnevali, Paula;  Sun, Christine;  Goltsman, Daniela S. A.;  Borton, Mikayla A.;  Sharrar, Allison;  Jaffe, Alexander L.;  Nelson, Tara C.;  Kantor, Rose;  Keren, Ray;  Lane, Katherine R.;  Farag, Ibrahim F.;  Lei, Shufei;  Finstad, Kari;  Amundson, Ronald;  Anantharaman, Karthik;  Zhou, Jinglie;  Probst, Alexander J.;  Power, Mary E.;  Tringe, Susannah G.;  Li, Wen-Jun;  Wrighton, Kelly;  Harrison, Sue;  Morowitz, Michael;  Relman, David A.;  Doudna, Jennifer A.;  Lehours, Anne-Catherine;  Warren, Lesley;  Cate, Jamie H. D.;  Santini, Joanne M.;  Banfield, Jillian F.
收藏  |  浏览/下载:37/0  |  提交时间:2020/07/03

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen and the causative agent of tuberculosis(1-3). Although Mtb can synthesize vitamin B-12 (cobalamin) de novo, uptake of cobalamin has been linked to pathogenesis of tuberculosis2. Mtb does not encode any characterized cobalamin transporter(4-6)  however, the gene rv1819c was found to be essential for uptake of cobalamin(1). This result is difficult to reconcile with the original annotation of Rv1819c as a protein implicated in the transport of antimicrobial peptides such as bleomycin(7). In addition, uptake of cobalamin seems inconsistent with the amino acid sequence, which suggests that Rv1819c has a bacterial ATP-binding cassette (ABC)-exporter fold1. Here, we present structures of Rv1819c, which reveal that the protein indeed contains the ABC-exporter fold, as well as a large water-filled cavity of about 7,700 angstrom(3), which enables the protein to transport the unrelated hydrophilic compounds bleomycin and cobalamin. On the basis of these structures, we propose that Rv1819c is a multi-solute transporter for hydrophilic molecules, analogous to the multidrug exporters of the ABC transporter family, which pump out structurally diverse hydrophobic compounds from cells(8-11).


  
Using Short-Term CO/CO2 Ratios to Assess Air Mass Differences Over the Korean Peninsula During KORUS-AQ 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2019
作者:  Halliday, H. S.;  DiGangi, J. P.;  Choi, Y.;  Diskin, G. S.;  Pusede, S. E.;  Rana, M.;  Nowak, J. B.;  Knote, C.;  Ren, X.;  He, H.;  Dickerson, R. R.;  Li, Z.
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27
carbon monoxide  carbon dioxide  CO  CO2 ratios  Korean air quality  air mass characterization  tracer ratios  
Mid-21st century ozone air quality and health burden in China under emissions scenarios and climate change 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2019, 14 (7)
作者:  Westervelt, D. M.;  Ma, C. T.;  He, M. Z.;  Fiore, A. M.;  Kinney, P. L.;  Kioumourtzoglou, M-A;  Wang, S.;  Xing, J.;  Ding, D.;  Correa, G.
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/27
ozone  climate change  China  health  model  
Large-Amplitude Electromagnetic Ion Cyclotron Waves and Density Fluctuations in the Flank of the Earth's Magnetosheath 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2019, 46 (9) : 4545-4553
作者:  Zhao, J. S.;  Wang, T. Y.;  Dunlop, M. W.;  Shi, C.;  He, J. S.;  Dong, X. C.;  Wu, D. J.;  Giles, B.;  Russell, C. T.
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/26
Source Contributions to Carbon Monoxide Concentrations During KORUS-AQ Based on CAM-chem Model Applications 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2019, 124 (5) : 2796-2822
作者:  Tang, Wenfu;  Emmons, Louisa K.;  Arellano, Avelino F., Jr.;  Gaubert, Benjamin;  Knote, Christoph;  Tilmes, Simone;  Buchholz, Rebecca R.;  Pfister, Gabriele G.;  Diskin, Glenn S.;  Blake, Donald R.;  Blake, Nicola J.;  Meinardi, Simone;  DiGangi, Joshua P.;  Choi, Yonghoon;  Woo, Jung-Hun;  He, Cenlin;  Schroeder, Jason R.;  Suh, Inseon;  Lee, Hyo-Jung;  Jo, Hyun-Young;  Kanaya, Yugo;  Jung, Jinsang;  Lee, Youngjae;  Kim, Danbi
收藏  |  浏览/下载:13/0  |  提交时间:2019/11/26
KORUS-AQ  source contribution  carbon monoxide  CAM-chem  emissions  model evaluation  
Observations of Flux Ropes With Strong Energy Dissipation in the Magnetotail 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2019, 46 (2) : 580-589
作者:  Huang, S. Y.;  Jiang, K.;  Yuan, Z. G.;  Zhou, M.;  Sahraoui, F.;  Fu, H. S.;  Deng, X. H.;  Khotyaintsev, Yu. V.;  Yu, X. D.;  He, L. H.;  Deng, D.;  Pollock, C. J.;  Torbert, R. B.;  Burch, J. L.
收藏  |  浏览/下载:15/0  |  提交时间:2019/04/09
The earliest human occupation of the high-altitude Tibetan Plateau 40 thousand to 30 thousand years ago 期刊论文
SCIENCE, 2018, 362 (6418) : 1049-+
作者:  Zhang, X. L.;  Ha, B. B.;  Wang, S. J.;  Chen, Z. J.;  Ge, J. Y.;  Long, H.;  He, W.;  Da, W.;  Nian, X. M.;  Yi, M. J.;  Zhou, X. Y.;  Zhang, P. Q.;  Jin, Y. S.;  Bar-Yosef, O.;  Olsen, J. W.;  Gao, X.
收藏  |  浏览/下载:21/0  |  提交时间:2019/11/27
Rapid change of superconductivity and electron-phonon coupling through critical doping in Bi-2212 期刊论文
SCIENCE, 2018, 362 (6410) : 62-+
作者:  He, Y.;  Hashimoto, M.;  Song, D.;  Chen, S. -D.;  He, J.;  Vishik, I. M.;  Moritz, B.;  Lee, D. -H.;  Nagaosa, N.;  Zaanen, J.;  Devereaux, T. P.;  Yoshida, Y.;  Eisaki, H.;  Lu, D. H.;  Shen, Z. -X.
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27
Characteristics of Water-Heat Exchanges and Inconsistent Surface Temperature Changes at an Elevational Permafrost Site on the Qinghai-Tibet Plateau 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2018, 123 (18) : 10404-10422
作者:  Luo, D. L.;  Jin, H. J.;  He, R. X.;  Wang, X. F.;  Muskett, R. R.;  Marchenko, S. S.;  Romanovsky, V. E.
收藏  |  浏览/下载:4/0  |  提交时间:2019/04/09
elevational permafrost  surface temperature  soil heat flux  radiation budget  hydrothermal processes  albedo