中文版 | English

在结果中检索

GSTDTAP

浏览/检索结果: 共5条，第1-5条 帮助

限定条件                    
已选(0)清除 条数/页：   排序方式：
A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds 期刊论文
NATURE, 2020, 580 (7803) : 409-+
作者:  Al-Shayeb, Basem;  Sachdeva, Rohan;  Chen, Lin-Xing;  Ward, Fred;  Munk, Patrick;  Devoto, Audra;  Castelle, Cindy J.;  Olm, Matthew R.;  Bouma-Gregson, Keith;  Amano, Yuki;  He, Christine;  Meheust, Raphael;  Brooks, Brandon;  Thomas, Alex;  Levy, Adi;  Matheus-Carnevali, Paula;  Sun, Christine;  Goltsman, Daniela S. A.;  Borton, Mikayla A.;  Sharrar, Allison;  Jaffe, Alexander L.;  Nelson, Tara C.;  Kantor, Rose;  Keren, Ray;  Lane, Katherine R.;  Farag, Ibrahim F.;  Lei, Shufei;  Finstad, Kari;  Amundson, Ronald;  Anantharaman, Karthik;  Zhou, Jinglie;  Probst, Alexander J.;  Power, Mary E.;  Tringe, Susannah G.;  Li, Wen-Jun;  Wrighton, Kelly;  Harrison, Sue;  Morowitz, Michael;  Relman, David A.;  Doudna, Jennifer A.;  Lehours, Anne-Catherine;  Warren, Lesley;  Cate, Jamie H. D.;  Santini, Joanne M.;  Banfield, Jillian F.
收藏  |  浏览/下载：37/0  |  提交时间：2020/07/03

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen and the causative agent of tuberculosis(1-3). Although Mtb can synthesize vitamin B-12 (cobalamin) de novo, uptake of cobalamin has been linked to pathogenesis of tuberculosis2. Mtb does not encode any characterized cobalamin transporter(4-6)  however, the gene rv1819c was found to be essential for uptake of cobalamin(1). This result is difficult to reconcile with the original annotation of Rv1819c as a protein implicated in the transport of antimicrobial peptides such as bleomycin(7). In addition, uptake of cobalamin seems inconsistent with the amino acid sequence, which suggests that Rv1819c has a bacterial ATP-binding cassette (ABC)-exporter fold1. Here, we present structures of Rv1819c, which reveal that the protein indeed contains the ABC-exporter fold, as well as a large water-filled cavity of about 7,700 angstrom(3), which enables the protein to transport the unrelated hydrophilic compounds bleomycin and cobalamin. On the basis of these structures, we propose that Rv1819c is a multi-solute transporter for hydrophilic molecules, analogous to the multidrug exporters of the ABC transporter family, which pump out structurally diverse hydrophobic compounds from cells(8-11).


  
De novo design of tunable, pH-driven conformational changes 期刊论文
SCIENCE, 2019, 364 (6441) : 658-+
作者:  Boyken, Scott E.;  Benhaim, Mark A.;  Busch, Florian;  Jia, Mengxuan;  Bick, Matthew J.;  Choi, Heejun;  Klima, Jason C.;  Chen, Zibo;  Walkey, Carl;  Mileant, Alexander;  Sahasrabuddhe, Aniruddha;  Wei, Kathy Y.;  Hodge, Edgar A.;  Byron, Sarah;  Quijano-Rubio, Alfredo;  Sankaran, Banumathi;  King, Neil P.;  Lippincott-Schwartz, Jennifer;  Wysocki, Vicki H.;  Lee, Kelly K.;  Baker, David
收藏  |  浏览/下载：17/0  |  提交时间：2019/11/27
Amphibian fungal panzootic causes catastrophic and ongoing loss of biodiversity 期刊论文
SCIENCE, 2019, 363 (6434) : 1459-+
作者:  Scheele, Ben C.;  Pasmans, Frank;  Skerratt, Lee F.;  Berger, Lee;  Martel, An;  Beukema, Wouter;  Acevedo, Aldemar A.;  Burrowes, Patricia A.;  Carvalho, Tamilie;  Catenazzi, Alessandro;  De la Riva, Ignacio;  Fisher, Matthew C.;  Flechas, Sandra V.;  Foster, Claire N.;  Frias-Alvarez, Patricia;  Garner, Trenton W. J.;  Gratwicke, Brian;  Guayasamin, Juan M.;  Hirschfeld, Mareike;  Kolby, Jonathan E.;  Kosch, Tiffany A.;  La Marca, Enrique;  Lindenmayer, David B.;  Lips, Karen R.;  Longo, Ana V.;  Maneyro, Raul;  McDonald, Cait A.;  Mendelson, Joseph, III;  Palacios-Rodriguez, Pablo;  Parra-Olea, Gabriela;  Richards-Zawacki, Corinne L.;  Roedel, Mark-Oliver;  Rovito, Sean M.;  Soto-Azat, Claudio;  Toledo, Luis Felipe;  Voyles, Jamie;  Weldon, Che;  Whitfield, Steven M.;  Wilkinson, Mark;  Zamudio, Kelly R.;  Canessa, Stefano
收藏  |  浏览/下载：36/0  |  提交时间：2019/11/27
The Ozone Monitoring Instrument: overview of 14 years in space 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2018, 18 (8) : 5699-5745
作者:  Levelt, Pieternel F.;  Joiner, Joanna;  Tamminen, Johanna;  Veefkind, J. Pepijn;  Bhartia, Pawan K.;  Zweers, Deborah C. Stein;  Duncan, Bryan N.;  Streets, David G.;  Eskes, Henk;  van der A, Ronald;  McLinden, Chris;  Fioletov, Vitali;  Carn, Simon;  de laat, Jos;  DeLand, Matthew;  Marchenko, Sergey;  McPeters, Richard;  Ziemke, Jerald;  Fu, Dejian;  Liu, Xiong;  Pickering, Kenneth;  Apituley, Arnoud;  Abad, Gonzalo Gonzalez;  Arola, Antti;  Boersma, Folkert;  Miller, Christopher Chan;  Chance, Kelly;  de Graaf, Martin;  Hakkarainen, Janne;  Hassinen, Seppo;  Ialongo, Iolanda;  Kleipool, Quintus;  Krotkov, Nickolay;  Li, Can;  Lamsal, Lok;  Newman, Paul;  Nowlan, Caroline;  Suleiman, Raid;  Tilstra, Lieuwe Gijsbert;  Torres, Omar;  Wang, Huiqun;  Wargan, Krzysztof
收藏  |  浏览/下载：16/0  |  提交时间：2019/04/09
Loci associated with skin pigmentation identified in African populations 期刊论文
SCIENCE, 2017, 358 (6365) : 887-+
作者:  Crawford, Nicholas G.;  Kelly, Derek E.;  Hansen, Matthew E. B.;  Beltrame, Marcia H.;  Fan, Shaohua;  Bowman, Shanna L.;  Jewett, Ethan;  Ranciaro, Alessia;  Thompson, Simon;  Lo, Yancy;  Pfeifer, Susanne P.;  Jensen, Jeffrey D.;  Campbell, Michael C.;  Beggs, William;  Hormozdiari, Farhad;  Mpoloka, Sununguko Wata;  Mokone, Gaonyadiwe George;  Nyambo, Thomas;  Meskel, Dawit Wolde;  Belay, Gurja;  Haut, Jake;  Rothschild, Harriet;  Zon, Leonard;  Zhou, Yi;  Kovacs, Michael A.;  Xu, Mai;  Zhang, Tongwu;  Bishop, Kevin;  Sinclair, Jason;  Rivas, Cecilia;  Elliot, Eugene;  Choi, Jiyeon;  Li, Shengchao A.;  Hicks, Belynda;  Burgess, Shawn;  Abnet, Christian;  Watkins-Chow, Dawn E.;  Oceana, Elena;  Song, Yun S.;  Eskin, Eleazar;  Brown, Kevin M.;  Marks, Michael S.;  Loftus, Stacie K.;  Pavan, William J.;  Yeager, Meredith;  Chanock, Stephen;  Tishkoff, Sarah A.
收藏  |  浏览/下载：13/0  |  提交时间：2019/11/27