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African climate response to orbital and glacial forcing in 140,000-y simulation with implications for early modern human environments 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (5) : 2255-2264
作者:  Kutzbach, John E.;  Guan, Jian;  He, Feng;  Cohen, Andrew S.;  Orland, Ian J.;  Chen, Guangshan
收藏  |  浏览/下载：15/0  |  提交时间：2020/05/13
paleoclimate  Africa  climate modeling  glacial and orbital forcing  human dispersal  
A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds 期刊论文
NATURE, 2020, 580 (7803) : 409-+
作者:  Al-Shayeb, Basem;  Sachdeva, Rohan;  Chen, Lin-Xing;  Ward, Fred;  Munk, Patrick;  Devoto, Audra;  Castelle, Cindy J.;  Olm, Matthew R.;  Bouma-Gregson, Keith;  Amano, Yuki;  He, Christine;  Meheust, Raphael;  Brooks, Brandon;  Thomas, Alex;  Levy, Adi;  Matheus-Carnevali, Paula;  Sun, Christine;  Goltsman, Daniela S. A.;  Borton, Mikayla A.;  Sharrar, Allison;  Jaffe, Alexander L.;  Nelson, Tara C.;  Kantor, Rose;  Keren, Ray;  Lane, Katherine R.;  Farag, Ibrahim F.;  Lei, Shufei;  Finstad, Kari;  Amundson, Ronald;  Anantharaman, Karthik;  Zhou, Jinglie;  Probst, Alexander J.;  Power, Mary E.;  Tringe, Susannah G.;  Li, Wen-Jun;  Wrighton, Kelly;  Harrison, Sue;  Morowitz, Michael;  Relman, David A.;  Doudna, Jennifer A.;  Lehours, Anne-Catherine;  Warren, Lesley;  Cate, Jamie H. D.;  Santini, Joanne M.;  Banfield, Jillian F.
收藏  |  浏览/下载：37/0  |  提交时间：2020/07/03

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen and the causative agent of tuberculosis(1-3). Although Mtb can synthesize vitamin B-12 (cobalamin) de novo, uptake of cobalamin has been linked to pathogenesis of tuberculosis2. Mtb does not encode any characterized cobalamin transporter(4-6)  however, the gene rv1819c was found to be essential for uptake of cobalamin(1). This result is difficult to reconcile with the original annotation of Rv1819c as a protein implicated in the transport of antimicrobial peptides such as bleomycin(7). In addition, uptake of cobalamin seems inconsistent with the amino acid sequence, which suggests that Rv1819c has a bacterial ATP-binding cassette (ABC)-exporter fold1. Here, we present structures of Rv1819c, which reveal that the protein indeed contains the ABC-exporter fold, as well as a large water-filled cavity of about 7,700 angstrom(3), which enables the protein to transport the unrelated hydrophilic compounds bleomycin and cobalamin. On the basis of these structures, we propose that Rv1819c is a multi-solute transporter for hydrophilic molecules, analogous to the multidrug exporters of the ABC transporter family, which pump out structurally diverse hydrophobic compounds from cells(8-11).


  
The earliest human occupation of the high-altitude Tibetan Plateau 40 thousand to 30 thousand years ago 期刊论文
SCIENCE, 2018, 362 (6418) : 1049-+
作者:  Zhang, X. L.;  Ha, B. B.;  Wang, S. J.;  Chen, Z. J.;  Ge, J. Y.;  Long, H.;  He, W.;  Da, W.;  Nian, X. M.;  Yi, M. J.;  Zhou, X. Y.;  Zhang, P. Q.;  Jin, Y. S.;  Bar-Yosef, O.;  Olsen, J. W.;  Gao, X.
收藏  |  浏览/下载：21/0  |  提交时间：2019/11/27
Rapid change of superconductivity and electron-phonon coupling through critical doping in Bi-2212 期刊论文
SCIENCE, 2018, 362 (6410) : 62-+
作者:  He, Y.;  Hashimoto, M.;  Song, D.;  Chen, S. -D.;  He, J.;  Vishik, I. M.;  Moritz, B.;  Lee, D. -H.;  Nagaosa, N.;  Zaanen, J.;  Devereaux, T. P.;  Yoshida, Y.;  Eisaki, H.;  Lu, D. H.;  Shen, Z. -X.
收藏  |  浏览/下载：10/0  |  提交时间：2019/11/27
Scale-invariant magnetoresistance in a cuprate superconductor 期刊论文
SCIENCE, 2018, 361 (6401) : 479-481
作者:  Giraldo-Gallo, P.;  Galvis, J. A.;  Stegen, Z.;  Modic, K. A.;  Balakirev, F. F.;  Betts, J. B.;  Lian, X.;  Moir, C.;  Riggs, S. C.;  Wu, J.;  Bollinger, A. T.;  He, X.;  Bozovic, I.;  Ramshaw, B. J.;  McDonald, R. D.;  Boebinger, G. S.;  Shekhter, A.
收藏  |  浏览/下载：12/0  |  提交时间：2019/11/27
Response to Comment on "Plant diversity increases with the strength of negative density dependence at the global scale" 期刊论文
SCIENCE, 2018, 360 (6391)
作者:  LaManna, Joseph A.;  Mangan, Scott A.;  Alonso, Alfonso;  Bourg, Norman A.;  Brockelman, Warren Y.;  Bunyavejchewin, Sarayudh;  Chang, Li-Wan;  Chiang, Jyh-Min;  Chuyong, George B.;  Clay, Keith;  Cordell, Susan;  Davies, Stuart J.;  Furniss, Tucker J.;  Giardina, Christian P.;  Gunatilleke, I. A. U. Nimal;  Gunatilleke, C. V. Savitri;  He, Fangliang;  Howe, Robert W.;  Hubbell, Stephen P.;  Hsieh, Chang-Fu;  Inman-Narahari, Faith M.;  Janik, David;  Johnson, Daniel J.;  Kenfack, David;  Korte, Lisa;  Kral, Kamil;  Larson, Andrew J.;  Lutz, James A.;  McMahon, Sean M.;  McShea, William J.;  Memiaghe, Herve R.;  Nathalang, Anuttara;  Novotny, Vojtech;  Ong, Perry S.;  Orwig, David A.;  Ostertag, Rebecca;  Parker, Geoffrey G.;  Phillips, Richard P.;  Sack, Lawren;  Sun, I-Fang;  Tello, J. Sebastian;  Thomas, Duncan W.;  Turner, Benjamin L.;  Diaz, Dilys M. Vela;  Vrska, Tomas;  Weiblen, George D.;  Wolf, Amy;  Yap, Sandra;  Myers, Jonathan A.
收藏  |  浏览/下载：18/0  |  提交时间：2019/11/27
Response to Comment on "Plant diversity increases with the strength of negative density dependence at the global scale" 期刊论文
SCIENCE, 2018, 360 (6391)
作者:  LaManna, Joseph A.;  Mangan, Scott A.;  Alonso, Alfonso;  Bourg, Norman A.;  Brockelman, Warren Y.;  Bunyavejchewin, Sarayudh;  Chang, Li-Wan;  Chiang, Jyh-Min;  Chuyong, George B.;  Clay, Keith;  Cordell, Susan;  Davies, Stuart J.;  Furniss, Tucker J.;  Giardina, Christian P.;  Gunatilleke, I. A. U. Nimal;  Gunatilleke, C. V. Savitri;  He, Fangliang;  Howe, Robert W.;  Hubbell, Stephen P.;  Hsieh, Chang-Fu;  Inman-Narahari, Faith M.;  Janik, David;  Johnson, Daniel J.;  Kenfack, David;  Korte, Lisa;  Kral, Kamil;  Larson, Andrew J.;  Lutz, James A.;  McMahon, Sean M.;  McShea, William J.;  Memiaghe, Herve R.;  Nathalang, Anuttara;  Novotny, Vojtech;  Ong, Perry S.;  Orwig, David A.;  Ostertag, Rebecca;  Parker, Geoffrey G.;  Phillips, Richard P.;  Sack, Lawren;  Sun, I-Fang;  Tello, J. Sebastian;  Thomas, Duncan W.;  Turner, Benjamin L.;  Diaz, Dilys M. Vela;  Vrska, Tomas;  Weiblen, George D.;  Wolf, Amy;  Yap, Sandra;  Myers, Jonathan A.
收藏  |  浏览/下载：14/0  |  提交时间：2019/11/27
Plant diversity increases with the strength of negative density dependence at the global scale 期刊论文
SCIENCE, 2017, 356 (6345) : 1389-1392
作者:  LaManna, Joseph A.;  Mangan, Scott A.;  Alonso, Alfonso;  Bourg, Norman A.;  Brockelman, Warren Y.;  Bunyavejchewin, Sarayudh;  Chang, Li-Wan;  Chiang, Jyh-Min;  Chuyong, George B.;  Clay, Keith;  Condit, Richard;  Cordell, Susan;  Davies, Stuart J.;  Furniss, Tucker J.;  Giardina, Christian P.;  Gunatilleke, I. A. U. Nimal;  Gunatilleke, C. V. Savitri;  He, Fangliang;  Howe, Robert W.;  Hubbell, Stephen P.;  Hsieh, Chang-Fu;  Inman-Narahari, Faith M.;  Janik, David;  Johnson, Daniel J.;  Kenfack, David;  Korte, Lisa;  Kral, Kamil;  Larson, Andrew J.;  Lutz, James A.;  McMahon, Sean M.;  McShea, William J.;  Memiaghe, Herve R.;  Nathalang, Anuttara;  Novotny, Vojtech;  Ong, Perry S.;  Orwig, David A.;  Ostertag, Rebecca;  Parker, Geoffrey G.;  Phillips, Richard P.;  Sack, Lawren;  Sun, I-Fang;  Tello, J. Sebastian;  Thomas, Duncan W.;  Turner, Benjamin L.;  Diaz, Dilys M. Vela;  Vrska, Tomas;  Weiblen, George D.;  Wolf, Amy;  Yap, Sandra;  Myers, Jonathan A.
收藏  |  浏览/下载：10/0  |  提交时间：2019/11/27
CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells 期刊论文
Science, 2017, 355 (6320)
作者:  S. John Liu;  Max A. Horlbeck;  Seung Woo Cho;  Harjus S. Birk;  Martina Malatesta;  Daniel He;  Frank J. Attenello;  Jacqueline E. Villalta;  Min Y. Cho;  Yuwen Chen;  Mohammad A. Mandegar;  Michael P. Olvera;  Luke A. Gilbert;  Bruce R. Conklin;  Howard Y. Chang;  Jonathan S. Weissman;  Daniel A. Lim
收藏  |  浏览/下载：10/0  |  提交时间：2020/04/17
CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells 期刊论文
SCIENCE, 2017, 355 (6320)
作者:  Liu, S. John;  Horlbeck, Max A.;  Cho, Seung Woo;  Birk, Harjus S.;  Malatesta, Martina;  He, Daniel;  Attenello, Frank J.;  Villalta, Jacqueline E.;  Cho, Min Y.;  Chen, Yuwen;  Mandegar, Mohammad A.;  Olvera, Michael P.;  Gilbert, Luke A.;  Conklin, Bruce R.;  Chang, Howard Y.;  Weissman, Jonathan S.;  Lim, Daniel A.
收藏  |  浏览/下载：14/0  |  提交时间：2019/11/27