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A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds 期刊论文
NATURE, 2020, 580 (7803) : 409-+
作者:  Al-Shayeb, Basem;  Sachdeva, Rohan;  Chen, Lin-Xing;  Ward, Fred;  Munk, Patrick;  Devoto, Audra;  Castelle, Cindy J.;  Olm, Matthew R.;  Bouma-Gregson, Keith;  Amano, Yuki;  He, Christine;  Meheust, Raphael;  Brooks, Brandon;  Thomas, Alex;  Levy, Adi;  Matheus-Carnevali, Paula;  Sun, Christine;  Goltsman, Daniela S. A.;  Borton, Mikayla A.;  Sharrar, Allison;  Jaffe, Alexander L.;  Nelson, Tara C.;  Kantor, Rose;  Keren, Ray;  Lane, Katherine R.;  Farag, Ibrahim F.;  Lei, Shufei;  Finstad, Kari;  Amundson, Ronald;  Anantharaman, Karthik;  Zhou, Jinglie;  Probst, Alexander J.;  Power, Mary E.;  Tringe, Susannah G.;  Li, Wen-Jun;  Wrighton, Kelly;  Harrison, Sue;  Morowitz, Michael;  Relman, David A.;  Doudna, Jennifer A.;  Lehours, Anne-Catherine;  Warren, Lesley;  Cate, Jamie H. D.;  Santini, Joanne M.;  Banfield, Jillian F.
收藏  |  浏览/下载：37/0  |  提交时间：2020/07/03

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen and the causative agent of tuberculosis(1-3). Although Mtb can synthesize vitamin B-12 (cobalamin) de novo, uptake of cobalamin has been linked to pathogenesis of tuberculosis2. Mtb does not encode any characterized cobalamin transporter(4-6)  however, the gene rv1819c was found to be essential for uptake of cobalamin(1). This result is difficult to reconcile with the original annotation of Rv1819c as a protein implicated in the transport of antimicrobial peptides such as bleomycin(7). In addition, uptake of cobalamin seems inconsistent with the amino acid sequence, which suggests that Rv1819c has a bacterial ATP-binding cassette (ABC)-exporter fold1. Here, we present structures of Rv1819c, which reveal that the protein indeed contains the ABC-exporter fold, as well as a large water-filled cavity of about 7,700 angstrom(3), which enables the protein to transport the unrelated hydrophilic compounds bleomycin and cobalamin. On the basis of these structures, we propose that Rv1819c is a multi-solute transporter for hydrophilic molecules, analogous to the multidrug exporters of the ABC transporter family, which pump out structurally diverse hydrophobic compounds from cells(8-11).


  
Comment on "Global pattern of nest predation is disrupted by climate change in shorebirds" 期刊论文
SCIENCE, 2019, 364 (6445) : 1041-+
作者:  Bulla, Martin;  Reneerkens, Jeroen;  Weiser, Emily L.;  Sokolov, Aleksandr;  Taylor, Audrey R.;  Sittler, Benoit;  McCaffery, Brian J.;  Ruthrauff, Dan R.;  Catlin, Daniel H.;  Payer, David C.;  Ward, David H.;  Solovyeva, Diana V.;  Santos, Eduardo S. A.;  Rakhimberdiev, Eldar;  Nol, Erica;  Kwon, Eunbi;  Brown, Glen S.;  Hevia, Glenda D.;  etc
收藏  |  浏览/下载：10/0  |  提交时间：2019/11/27
Empowering Latina scientists 期刊论文
SCIENCE, 2019, 363 (6429) : 825-826
作者:  Bernal, Ximena E.;  Rojas, Bibiana;  Pinto-E, Maria Alejandra;  Mendoza-Henao, Angela M.;  Herrera-Montes, Adriana;  Isabel Herrera-Montes, Maria;  Caceres Franco, Andrea del Pilar;  Ceron-Souza, Ivania;  Paz, Andrea;  Vergara, Daniela;  Barragan Contreras, Leidy Alejandra;  Salazar, Camilo;  Bohorquez Alonso, Martha Lucia;  Guarnizo, Carlos E.;  Sanchez, Adriana;  Olaya-Castro, Alexandra;  Urbina-Cardona, Nicolas;  Guayasamin, Juan M.;  Uy, Floria Mora-Kepfer;  Feris, Faride Lamadrid;  Franco-Orozco, Barbara;  Munoz, Martha M.;  Patricia Rincon-Diaz, Martha;  Sanchez Herrera, Melissa;  Betancourth-Cundar, Mileidy;  Tarvin, Rebecca D.;  Marquez, Roberto;  Lopez-Aguirre, Camilo;  Ron, Santiago R.;  Ramirez, Santiago;  Paez-Vacas, Monica;  Gaitan-Espitia, Juan Diego;  Navarrete-Mendez, Maria J.;  Vianna, Juliana A.;  Varela-Jaramillo, Andrea;  Sanchez-Martinez, Paola M.;  Caminer Rodriguez, Marcel Adrian;  Garcia-Robledo, Carlos;  Kuprewicz, Erin K.;  Gomez-Bahamon, Valentina;  Chacon-Vargas, Katherine;  Trillo, Alex;  Ramirez Castaneda, Valeria;  Buenaventura, Eliana;  Carolina Monmany-Garzia, A.;  Carolina Carnaval, Ana;  Dick, Christopher W.;  Jose Andrade-Nunez, Maria;  Carvajal Castro, Juan David;  Marcela Pinto, Diana;  Camargo-Sanabria, Angela A.;  Lips, Karen R.;  Motta-Gonzalez, Diana;  Canedo, Clarissa;  Melissa Diaz, Jhandra;  Navarro-Suarez, Adriana M.;  Corredor, Karen;  Roa-Varon, Adela;  Flechas, Sandra V.;  Andres Martinez-Lanfranco, Juan;  Chiarioni Thome, Maria Tereza;  Caldwell, Michael S.;  Ballestas, Onil;  Mejia M, Carolina;  Chaverri, Gloriana;  Rossi, Alejandra;  Bonaccorso, Elisa;  Pimiento, Catalina;  Guerrero, Rafael F.;  Warkentin, Karen M.;  Montoya-Pachongo, Carolina;  Alvarez, Silvia J.;  Gonzalez-Duran, Gustavo;  Anganoy-Criollo, Marvin;  Martinez-Habibe, Maria Cristina;  Ramirez, Juan P.;  Burrowes, Patricia;  Catenazzi, Alessandro;  Riveros, Andre J.;  Targino, Mariane;  Velez, Alejandro;  Vargas, Oscar M.;  Zapata, Felipe;  Waltrick, Camilla Spengler;  Ceron, Karoline;  Segovia Salcedo, Claudia;  Silva-Velasco, Martha;  Ochoa-Herrera, Valeria;  Medina, Iliana;  Narins, Peter M.;  Alves Saccol, Suelen da Silva;  de Castro Godinho, Marcela Brasil;  Velasquez Escobar, Beatriz Eugenia;  Velasco, Julian A.;  Lomascolo, Silvia;  Hoke, Kim;  Zeidemann, Vivian;  Almeida-Santos, Patricia;  Paola Ferraro, Daiana;  Araujo-Vieira, Katyuscia;  da Rocha, Sabine Borges;  Torres, Maria Fernanda;  Daniel Cadena, Carlos;  Collevatti, Rosane Garcia;  Vasconcellos, Mariana Mira;  Recart, Wilnelia;  Mitchell Aide, T.;  Bacon, Christine;  Jeckel, Adriana Moriguchi;  Diele-Viegas, Luisa Maria;  Calijorne Lourenco, Ana Carolina;  Santos, Danusy Lopes;  Rieder Cholak, Luiza;  Mendes, Roberta Graboski;  Silva, Fernanda Magalhaes;  Guedes, Thais;  Lopez-Perilla, Yeny R.;  Fusinatto, Luciana Ardenghi;  Terra, Juliana de Souza;  Rodriguez Brenes, Sofia;  Narvaez, Andrea E.;  Zina, Juliana;  Calderon-Espinosa, Martha L.;  Pardo-Diaz, Carolina;  Abadie, Michelle;  Maldonado-Chaparro, Adriana;  Cespedes Arias, Laura N.;  Montesinos, Rachel;  Fenker, Jessica;  Brunes, Tuliana Oliveira;  Ferreira Lantyer Silva, Amanda Santiago;  Vallejos, Johana Goyes;  Costa Rodrigues, Ana Paula V.;  Friol, Natalia Rizzo;  Herrera-Alvarez, Santiago;  de Souza, Eletra;  Araujo, Olivia G. S.;  Citeli, Nathalie Q. K.;  Ruggeri, Joice;  Fierro-Calderon, Eliana;  Acevedo-Charry, Orlando;  Barato, Paola;  Campos-Cerqueira, Marconi;  Mazzini, Flavia;  Beltran, Ivan;  Alejandra Meneses-Giorgi, Maria;  Jerez, Adriana;  Clavijo, Andrea P.;  Neira Jimenez, Carolina;  Dantas, Gisele P. M.;  Nascimento, Luciana Barreto;  Caballero, Susana J.;  Henao Sepulveda, A. Carolina;  Wolff, Marta;  Barnabe, Paula Cristina;  Quinones-Lebron, Shakira G.;  Bressan, Raissa Fries;  Gomez-Montoya, Nataly;  Gomez, Camila;  Colon-Pineiro, Zuania;  Esquivel Dobles, Carolina;  Bloch, Natasha;  Stynoski, Jennifer L.;  Arango, Daniel;  Marisol Gonzalez, Tania;  Luque Moreno, Francisco;  Taylor, Ryan;  Lawrence, J. P.;  Briscoe, Adriana Darielle Mejia;  Ortiz-Barrientos, Daniel;  Elena Salerno, Patricia;  Restrepo, Silvia;  Pasukonis, Andrius;  Damasceno, Roberta Pacheco;  Cecilia Dalton, Maria;  Proehl, Heike;  Valdez-Ward, Evelyn;  Andrea Rodriguez, Sabrina;  Marquez Garcia, Marcela;  Bianca Bonaparte, Eugenia;  Molina Escobar, Jorge Alberto;  Brown, Jason L.;  Yeager, Justin;  Kikuchi, David;  Ringler, Max;  Duran, Linda Hernandez;  Schulte, Lisa M.;  Vaira, Marcos;  Pereyra, Laura;  Astudillo Bravo, Diana;  Jose Salica, Maria;  Varga, Sandra;  Eguren, Antonieta;  Grattarola, Florencia;  Bernal, Moises A.;  Soledad Gaston, Maria;  Ortega Chinchilla, Jesus Eduardo;  Burdfield-Steel, Emily;  Valencia, Lina M.;  Ringler, Eva;  Rada, Marco;  Melendez-Ackerman, Elvia;  Botero, Carlos A.;  Estrada-Villegas, Sergio;  Orizaola, German;  Pinto, Brendan J.;  Gonzalez-Bellido, Paloma;  Hunter, Kimberly L.;  Rueda Solano, Luis Alberto;  Gordon, Swanne;  Guerra, Monica A.;  Jose Albo, Maria;  Vega-Frutis, Rocio;  Blundo, Cecilia;  Castaneda-Gomez, Laura;  Donnelly, Maureen A.;  Escobar, Betsabe D. Castro;  Isabel Moreno, Maria;  Crawford, Andrew J.;  Jiggins, Chris D.;  Roessler, Daniela C.;  Bravo Valencia, Laura;  Sarmiento, Carolina;  Munoz, Karen A.;  Galeano, Sandra P.;  del Rosario Castaneda, Maria;  Caro Cardenas, Cindy Jeanet;  Zalamea, Paul-Camilo;  Arias, Monica;  Zank, Caroline;  Suarez-Mayorga, Angela M.;  Colombo, Patrick;  Cuervo, Andres M.;  Coriolano, Iara Reinaldo;  de Melo, Lilian Sayuri Ouchi;  Buitrago Cardona, Alexandra;  Elias, Marianne;  Gonzalez, Mabel;  Maria Aldana, Ana;  Gubert, Carolina;  Luis Parra, Juan;  Contador, Tamara;  Coelho, Lorena;  Trillo, Mariana;  Bordin, Kauane;  Zulian, Viviane;  Moreno Arias, Rafael;  Loretto, Matthias-Claudio;  Alejandra Medina, Claudia;  Lyra, Mariana L.;  Pulido-Santacruz, Paola;  Rosser, Neil;  Waldron, Talia;  Moreno Duran, Carmen Helena;  Pizano, Camila;  Hoedl, Walter;  Fratani, Jessica;  Duport Bru, Ana Sofia;  Grosso, Jimena;  Vera Candioti, Florencia;  Adarve Rengifo, Isabel
收藏  |  浏览/下载：24/0  |  提交时间：2019/11/27
Biomass burning emissions in north Australia during the early dry season: an overview of the 2014 SAFIRED campaign 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2017, 17 (22)
作者:  Mallet, Marc D.;  Desservettaz, Maximilien J.;  Miljevic, Branka;  Milic, Andelija;  Ristovski, Zoran D.;  Alroe, Joel;  Cravigan, Luke T.;  Jayaratne, E. Rohan;  Paton-Walsh, Clare;  Griffith, David W. T.;  Wilson, Stephen R.;  Kettlewell, Graham;  van der Schoot, Marcel V.;  Selleck, Paul;  Reisen, Fabienne;  Lawson, Sarah J.;  Ward, Jason;  Harnwell, James;  Cheng, Min;  Gillett, Rob W.;  Molloy, Suzie B.;  Howard, Dean;  Nelson, Peter F.;  Morrison, Anthony L.;  Edwards, Grant C.;  Williams, Alastair G.;  Chambers, Scott D.;  Werczynski, Sylvester;  Williams, Leah R.;  Winton, V. Holly L.;  Atkinson, Brad;  Wang, Xianyu;  Keywood, Melita D.
收藏  |  浏览/下载：8/0  |  提交时间：2019/04/09
Effects of Electromagnetic Fields on Fish and Invertebrates: Task 2.1.3: Effects on Aquatic Organisms - Fiscal Year 2011 Progress Report - Environmental Effects of Marine and Hydrokinetic Energy 科技报告
来源：US Department of Energy (DOE). 出版年： 2012
作者:  Woodruff, Dana L.;  Schultz, Irvin R.;  Marshall, Kathryn E.;  Ward, Jeffrey A.;  Cullinan, Valerie I.
收藏  |  浏览/下载：8/0  |  提交时间：2019/04/05