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Drivers of the fungal spore bioaerosol budget: observational analysis and global modelling 期刊论文
Atmospheric Chemistry and Physics, 2020
作者:  Ruud H. H. Janssen, Colette L. Heald, Allison L. Steiner, Anne E. Perring, J. Alex Huffman, Ellis S. Robinson, Cynthia H. Twohy, and Luke D. Ziemba
收藏  |  浏览/下载：16/0  |  提交时间：2020/07/21
A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds 期刊论文
NATURE, 2020, 580 (7803) : 409-+
作者:  Al-Shayeb, Basem;  Sachdeva, Rohan;  Chen, Lin-Xing;  Ward, Fred;  Munk, Patrick;  Devoto, Audra;  Castelle, Cindy J.;  Olm, Matthew R.;  Bouma-Gregson, Keith;  Amano, Yuki;  He, Christine;  Meheust, Raphael;  Brooks, Brandon;  Thomas, Alex;  Levy, Adi;  Matheus-Carnevali, Paula;  Sun, Christine;  Goltsman, Daniela S. A.;  Borton, Mikayla A.;  Sharrar, Allison;  Jaffe, Alexander L.;  Nelson, Tara C.;  Kantor, Rose;  Keren, Ray;  Lane, Katherine R.;  Farag, Ibrahim F.;  Lei, Shufei;  Finstad, Kari;  Amundson, Ronald;  Anantharaman, Karthik;  Zhou, Jinglie;  Probst, Alexander J.;  Power, Mary E.;  Tringe, Susannah G.;  Li, Wen-Jun;  Wrighton, Kelly;  Harrison, Sue;  Morowitz, Michael;  Relman, David A.;  Doudna, Jennifer A.;  Lehours, Anne-Catherine;  Warren, Lesley;  Cate, Jamie H. D.;  Santini, Joanne M.;  Banfield, Jillian F.
收藏  |  浏览/下载：37/0  |  提交时间：2020/07/03

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen and the causative agent of tuberculosis(1-3). Although Mtb can synthesize vitamin B-12 (cobalamin) de novo, uptake of cobalamin has been linked to pathogenesis of tuberculosis2. Mtb does not encode any characterized cobalamin transporter(4-6)  however, the gene rv1819c was found to be essential for uptake of cobalamin(1). This result is difficult to reconcile with the original annotation of Rv1819c as a protein implicated in the transport of antimicrobial peptides such as bleomycin(7). In addition, uptake of cobalamin seems inconsistent with the amino acid sequence, which suggests that Rv1819c has a bacterial ATP-binding cassette (ABC)-exporter fold1. Here, we present structures of Rv1819c, which reveal that the protein indeed contains the ABC-exporter fold, as well as a large water-filled cavity of about 7,700 angstrom(3), which enables the protein to transport the unrelated hydrophilic compounds bleomycin and cobalamin. On the basis of these structures, we propose that Rv1819c is a multi-solute transporter for hydrophilic molecules, analogous to the multidrug exporters of the ABC transporter family, which pump out structurally diverse hydrophobic compounds from cells(8-11).


  
Crowther et al. reply 期刊论文
Nature, 2018, 554: E7-E8
作者:  T. W. Crowther;  M. B. Machmuller;  J. C. Carey;  S. D. Allison;  J. M. Blair;  S. D. Bridgham;  A. J. Burton;  F. A. Dijkstra;  B. Elberling;  M. Estiarte;  K. S. Larsen;  H. Laudon;  M. Lupascu;  S. Marhan;  J. Mohan;  S. Niu;  J. J. Pe帽uelas;  I. K. Schmidt;  P. H. Templer;  G. Kr枚el-Dulay;  S. Frey;  M. A. Bradford
收藏  |  浏览/下载：16/0  |  提交时间：2019/11/27
Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients 期刊论文
SCIENCE, 2018, 359 (6371) : 97-103
作者:  Gopalakrishnan, V.;  Spencer, C. N.;  Nezi, L.;  Reuben, A.;  Andrews, M. C.;  Karpinets, T. V.;  Prieto, P. A.;  Vicente, D.;  Hoffman, K.;  Wei, S. C.;  Cogdill, A. P.;  Zhao, L.;  Hudgens, C. W.;  Hutchinson, D. S.;  Manzo, T.;  de Macedo, M. Petaccia;  Cotechini, T.;  Kumar, T.;  Chen, W. S.;  Reddy, S. M.;  Sloane, R. Szczepaniak;  Galloway-Pena, J.;  Jiang, H.;  Chen, P. L.;  Shpall, E. J.;  Rezvani, K.;  Alousi, A. M.;  Chemaly, R. F.;  Shelburne, S.;  Vence, L. M.;  Okhuysen, P. C.;  Jensen, V. B.;  Swennes, A. G.;  McAllister, F.;  Sanchez, E. Marcelo Riquelme;  Zhang, Y.;  Le Chatelier, E.;  Zitvogel, L.;  Pons, N.;  Austin-Breneman, J. L.;  Haydu, L. E.;  Burton, E. M.;  Gardner, J. M.;  Sirmans, E.;  Hu, J.;  Lazar, A. J.;  Tsujikawa, T.;  Diab, A.;  Tawbi, H.;  Glitza, I. C.;  Hwu, W. J.;  Patel, S. P.;  Woodman, S. E.;  Amaria, R. N.;  Davies, M. A.;  Gershenwald, J. E.;  Hwu, P.;  Lee, J. E.;  Zhang, J.;  Coussens, L. M.;  Cooper, Z. A.;  Futreal, P. A.;  Daniel, C. R.;  Ajami, N. J.;  Petrosino, J. F.;  Tetzlaff, M. T.;  Sharma, P.;  Allison, J. P.;  Jenq, R. R.;  Wargo, J. A.
收藏  |  浏览/下载：13/0  |  提交时间：2019/11/27
Illuminating gravitational waves: A concordant picture of photons from a neutron star merger 期刊论文
SCIENCE, 2017, 358 (6370) : 1559-+
作者:  Kasliwal, M. M.;  Nakar, E.;  Singer, L. P.;  Kaplan, D. L.;  Cook, D. O.;  Van Sistine, A.;  Lau, R. M.;  Fremling, C.;  Gottlieb, O.;  Jencson, J. E.;  Adams, S. M.;  Feindt, U.;  Hotokezaka, K.;  Ghosh, S.;  Perley, D. A.;  Yu, P-C.;  Piran, T.;  Allison, J. R.;  Anupama, G. C.;  Balasubramanian, A.;  WBannister, K.;  Bally, J.;  Barnes, J.;  Barway, S.;  Bellm, E.;  Bhalerao, V.;  Bhattacharya, D.;  Blagorodnova, N.;  Bloom, J. S.;  Brady, P. R.;  Cannella, C.;  Chatterjee, D.;  Cenko, S. B.;  Cobb, B. E.;  Copperwheat, C.;  Corsi, A.;  De, K.;  Dobie, D.;  Emery, S. W. K.;  Evans, P. A.;  Fox, O. D.;  Frail, D. A.;  Frohmaier, C.;  Goobar, A.;  Hallinan, G.;  Harrison, F.;  Helou, G.;  Hinderer, T.;  Ho, A. Y. Q.;  Horesh, A.;  Ip, W-H.;  Itoh, R.;  Kasen, D.;  Kim, H.;  Kuin, N. P. M.;  Kupfer, T.;  Lynch, C.;  Madsen, K.;  Mazzali, P. A.;  Miller, A. A.;  Mooley, K.;  Murphy, T.;  Ngeow, C-C.;  Nichols, D.;  Nissanke, S.;  Nugent, P.;  Ofek, E. O.;  Qi, H.;  Quimby, R. M.;  Rosswog, S.;  Rusu, F.;  Sadler, E. M.;  Schmidt, P.;  Sollerman, J.;  Steele, I.;  Williamson, A. R.;  Xu, Y.;  Yan, L.;  Yatsu, Y.;  Zhang, C.;  Zhao, W.
收藏  |  浏览/下载：15/0  |  提交时间：2019/11/27
A radio counterpart to a neutron star merger 期刊论文
SCIENCE, 2017, 358 (6370) : 1579-+
作者:  Hallinan, G.;  Corsi, A.;  Mooley, K. P.;  Hotokezaka, K.;  Nakar, E.;  Kasliwal, M. M.;  Kaplan, D. L.;  Frail, D. A.;  Myers, S. T.;  Murphy, T.;  De, K.;  Dobie, D.;  Allison, J. R.;  Bannister, K. W.;  Bhalerao, V.;  Chandra, P.;  Clarke, T. E.;  Giacintucci, S.;  Ho, A. Y. Q.;  Horesh, A.;  Kassim, N. E.;  Kulkarni, S. R.;  Lenc, E.;  Lockman, F. J.;  Lynch, C.;  Nichols, D.;  Nissanke, S.;  Palliyaguru, N.;  Peters, W. M.;  Piran, T.;  Rana, J.;  Sadler, E. M.;  Singer, L. P.
收藏  |  浏览/下载：10/0  |  提交时间：2019/11/27
Jupiter's interior and deep atmosphere: The initial pole-to-pole passes with the Juno spacecraft 期刊论文
SCIENCE, 2017, 356 (6340) : 821-825
作者:  Bolton, S. J.;  Adriani, A.;  Adumitroaie, V.;  Allison, M.;  Anderson, J.;  Atreya, S.;  Bloxham, J.;  Brown, S.;  Connerney, J. E. P.;  DeJong, E.;  Folkner, W.;  Gautier, D.;  Grassi, D.;  Gulkis, S.;  Guillot, T.;  Hansen, C.;  Hubbard, W. B.;  Iess, L.;  Ingersoll, A.;  Janssen, M.;  Jorgensen, J.;  Kaspi, Y.;  Levin, S. M.;  Li, C.;  Lunine, J.;  Miguel, Y.;  Mura, A.;  Orton, G.;  Owen, T.;  Ravine, M.;  Smith, E.;  Steffes, P.;  Stone, E.;  Stevenson, D.;  Thorne, R.;  Waite, J.;  Durante, D.;  Ebert, R. W.;  Greathouse, T. K.;  Hue, V.;  Parisi, M.;  Szalay, J. R.;  Wilson, R.
收藏  |  浏览/下载：9/0  |  提交时间：2019/11/27