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SARS-CoV-2 Mpro inhibitors with antiviral activity in a transgenic mouse model 期刊论文
Science, 2021
作者:  Jingxin Qiao;  Yue-Shan Li;  Rui Zeng;  Feng-Liang Liu;  Rong-Hua Luo;  Chong Huang;  Yi-Fei Wang;  Jie Zhang;  Baoxue Quan;  Chenjian Shen;  Xin Mao;  Xinlei Liu;  Weining Sun;  Wei Yang;  Xincheng Ni;  Kai Wang;  Ling Xu;  Zi-Lei Duan;  Qing-Cui Zou;  Hai-Lin Zhang;  Wang Qu;  Yang-Hao-Peng Long;  Ming-Hua Li;  Rui-Cheng Yang;  Xiaolong Liu;  Jing You;  Yangli Zhou;  Rui Yao;  Wen-Pei Li;  Jing-Ming Liu;  Pei Chen;  Yang Liu;  Gui-Feng Lin;  Xin Yang;  Jun Zou;  Linli Li;  Yiguo Hu;  Guang-Wen Lu;  Wei-Min Li;  Yu-Quan Wei;  Yong-Tang Zheng;  Jian Lei;  Shengyong Yang
收藏  |  浏览/下载：18/0  |  提交时间：2021/04/06
Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody 期刊论文
Science, 2020
作者:  Zhe Lv;  Yong-Qiang Deng;  Qing Ye;  Lei Cao;  Chun-Yun Sun;  Changfa Fan;  Weijin Huang;  Shihui Sun;  Yao Sun;  Ling Zhu;  Qi Chen;  Nan Wang;  Jianhui Nie;  Zhen Cui;  Dandan Zhu;  Neil Shaw;  Xiao-Feng Li;  Qianqian Li;  Liangzhi Xie;  Youchun Wang;  Zihe Rao;  Cheng-Feng Qin;  Xiangxi Wang
收藏  |  浏览/下载：17/0  |  提交时间：2020/09/22
Giant piezoelectricity in oxide thin films with nanopillar structure 期刊论文
Science, 2020
作者:  Huajun Liu;  Haijun Wu;  Khuong Phuong Ong;  Tiannan Yang;  Ping Yang;  Pranab Kumar Das;  Xiao Chi;  Yang Zhang;  Caozheng Diao;  Wai Kong Alaric Wong;  Eh Piew Chew;  Yi Fan Chen;  Chee Kiang Ivan Tan;  Andrivo Rusydi;  Mark B. H. Breese;  David J. Singh;  Long-Qing Chen;  Stephen J. Pennycook;  Kui Yao
收藏  |  浏览/下载：15/0  |  提交时间：2020/07/21
Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation 期刊论文
NATURE, 2020, 580 (7803) : 391-+
作者:  Zhang, Zhibin;  Zhang, Ying;  Xia, Shiyu;  Kong, Qing;  Li, Shunying;  Liu, Xing;  Junqueira, Caroline;  Meza-Sosa, Karla F.;  Mok, Temy Mo Yin;  Ansara, James;  Sengupta, Satyaki;  Yao, Yandan;  Wu, Hao;  Lieberman, Judy
收藏  |  浏览/下载：12/0  |  提交时间：2020/07/03

The biological function of Z-DNA and Z-RNA, nucleic acid structures with a left-handed double helix, is poorly understood(1-3). Z-DNA-binding protein 1 (ZBP1  also known as DAI or DLM-1) is a nucleic acid sensor that contains two Z alpha domains that bind Z-DNA(4,5) and Z-RNA(6-8). ZBP1 mediates host defence against some viruses(6,7,9-14) by sensing viral nucleic acids(6,7,10). RIPK1 deficiency, or mutation of its RIP homotypic interaction motif (RHIM), triggers ZBP1-dependent necroptosis and inflammation in mice(15,16). However, the mechanisms that induce ZBP1 activation in the absence of viral infection remain unknown. Here we show that Z alpha-dependent sensing of endogenous ligands induces ZBP1-mediated perinatal lethality in mice expressing RIPK1 with mutated RHIM (Ripk1(mR/mR)), skin inflammation in mice with epidermis-specific RIPK1 deficiency (RIPK1(E-KO)) and colitis in mice with intestinal epithelial-specific FADD deficiency (FADD(IEC-KO)). Consistently, functional Z alpha domains were required for ZBP1-induced necroptosis in fibroblasts that were treated with caspase inhibitors or express RIPK1 with mutated RHIM. Inhibition of nuclear export triggered the Z alpha-dependent activation of RIPK3 in the nucleus resulting in cell death, which suggests that ZBP1 may recognize nuclear Z-form nucleic acids. We found that ZBP1 constitutively bound cellular double-stranded RNA in a Z alpha-dependent manner. Complementary reads derived from endogenous retroelements were detected in epidermal RNA, which suggests that double-stranded RNA derived from these retroelements may act as a Z alpha-domain ligand that triggers the activation of ZBP1. Collectively, our results provide evidence that the sensing of endogenous Z-form nucleic acids by ZBP1 triggers RIPK3-dependent necroptosis and inflammation, which could underlie the development of chronic inflammatory conditions-particularly in individuals with mutations in RIPK1 and CASP8(17-20).


  
Super-elastic ferroelectric single-crystal membrane with continuous electric dipole rotation 期刊论文
SCIENCE, 2019, 366 (6464) : 475-+
作者:  Dong, Guohua;  Li, Suzhi;  Yao, Mouteng;  Zhou, Ziyao;  Zhang, Yong-Qiang;  Han, Xu;  Luo, Zhenlin;  Yao, Junxiang;  Peng, Bin;  Hu, Zhongqiang;  Huang, Houbing;  Jia, Tingting;  Li, Jiangyu;  Ren, Wei;  Ye, Zuo-Guang;  Ding, Xiangdong;  Sun, Jun;  Nan, Ce-Wen;  Chen, Long-Qing;  Li, Ju;  Liu, Ming
收藏  |  浏览/下载：10/0  |  提交时间：2019/11/27
Ultrahigh-energy density lead-free dielectric films via polymorphic nanodomain design 期刊论文
SCIENCE, 2019, 365 (6453) : 578-582
作者:  Pan, Hao;  Li, Fei;  Liu, Yao;  Zhang, Qinghua;  Wang, Meng;  Lan, Shun;  Zheng, Yunpeng;  Ma, Jing;  Gu, Lin;  Shen, Yang;  Yu, Pu;  Zhang, Shujun;  Chen, Long-Qing;  Lin, Yuan-Hua;  Nan, Ce-Wen
收藏  |  浏览/下载：13/0  |  提交时间：2019/11/27
VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma 期刊论文
SCIENCE, 2018, 361 (6399) : 290-295
作者:  Zhang, Jing;  Wu, Tao;  Simon, Jeremy;  Takada, Mamoru;  Saito, Ryoichi;  Fan, Cheng;  Liu, Xian-De;  Jonasch, Eric;  Xie, Ling;  Chen, Xian;  Yao, Xiaosai;  Teh, Bin Tean;  Tan, Patrick;  Zheng, Xingnan;  Li, Mingjie;  Lawrence, Cortney;  Fan, Jie;  Geng, Jiang;  Liu, Xijuan;  Hu, Lianxin;  Wang, Jun;  Liao, Chengheng;  Hong, Kai;  Zurlo, Giada;  Parker, Joel S.;  Auman, J. Todd;  Perou, Charles M.;  Rathmell, W. Kimryn;  Kim, William Y.;  Kirschner, Marc W.;  Kaelin, William G., Jr.;  Baldwin, Albert S.;  Zhang, Qing
收藏  |  浏览/下载：12/0  |  提交时间：2019/11/27
A single mutation in the prM protein of Zika virus contributes to fetal microcephaly 期刊论文
SCIENCE, 2017, 358 (6365) : 933-+
作者:  Yuan, Ling;  Huang, Xing-Yao;  Liu, Zhong-Yu;  Zhang, Feng;  Zhu, Xing-Liang;  Yu, Jiu-Yang;  Ji, Xue;  Xu, Yan-Peng;  Li, Guanghui;  Li, Cui;  Wang, Hong-Jiang;  Deng, Yong-Qiang;  Wu, Menghua;  Cheng, Meng-Li;  Ye, Qing;  Xie, Dong-Yang;  Li, Xiao-Feng;  Wang, Xiangxi;  Shi, Weifeng;  Hu, Baoyang;  Shi, Pei-Yong;  Xu, Zhiheng;  Qin, Cheng-Feng
收藏  |  浏览/下载：12/0  |  提交时间：2019/11/27
Response to Comment on "Molecular and neural basis of contagious itch behavior in mice" 期刊论文
SCIENCE, 2017, 357 (6347)
作者:  Barry, Devin M.;  Yu, Yao-Qing;  Hao, Yan;  Liu, Xue-Ting;  Chen, Zhou-Feng
收藏  |  浏览/下载：4/0  |  提交时间：2019/11/27
Molecular and neural basis of contagious itch behavior in mice 期刊论文
SCIENCE, 2017, 355 (6329)
作者:  Yu, Yao-Qing;  Barry, Devin M.;  Hao, Yan;  Liu, Xue-Ting;  Chen, Zhou-Feng
收藏  |  浏览/下载：4/0  |  提交时间：2019/11/27