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Divergence of Arctic shrub growth associated with sea ice decline 期刊论文
Proceedings of the National Academy of Sciences, 2020
作者:  Agata Buchwal;  Patrick F. Sullivan;  Marc Macias-Fauria;  Eric Post;  Isla H. Myers-Smith;  Julienne C. Stroeve;  Daan Blok;  Ken D. Tape;  Bruce C. Forbes;  Pascale Ropars;  Esther Lévesque;  Bo Elberling;  Sandra Angers-Blondin;  Joseph S. Boyle;  Stéphane Boudreau;  Noémie Boulanger-Lapointe;  Cassandra Gamm;  Martin Hallinger;  Grzegorz Rachlewicz;  Amanda Young;  Pentti Zetterberg;  Jeffrey M. Welker
收藏  |  浏览/下载:30/0  |  提交时间:2020/12/22
A new coronavirus associated with human respiratory disease in China (vol 579, pg 265, 2020) 期刊论文
NATURE, 2020, 580 (7803) : E7-E7
作者:  Jiao, Huipeng;  Wachsmuth, Laurens;  Kumari, Snehlata;  Schwarzer, Robin;  Lin, Juan;  Eren, Remzi Onur;  Fisher, Amanda;  Lane, Rebecca;  Young, George R.;  Kassiotis, George;  Kaiser, William J.;  Pasparakis, Manolis
收藏  |  浏览/下载:37/0  |  提交时间:2020/07/03
Structural basis for catalysis and substrate specificity of human ACAT1 期刊论文
NATURE, 2020, 581 (7808) : 333-+
作者:  Jiao, Huipeng;  Wachsmuth, Laurens;  Kumari, Snehlata;  Schwarzer, Robin;  Lin, Juan;  Eren, Remzi Onur;  Fisher, Amanda;  Lane, Rebecca;  Young, George R.;  Kassiotis, George;  Kaiser, William J.;  Pasparakis, Manolis
收藏  |  浏览/下载:16/0  |  提交时间:2020/07/03

The structure of human ACAT1, which catalyses the transfer of an acyl group from acyl-coenzyme A to cholesterol to form cholesteryl ester, is resolved by cryo-electron microscopy.


As members of the membrane-bound O-acyltransferase (MBOAT) enzyme family, acyl-coenzyme A:cholesterol acyltransferases (ACATs) catalyse the transfer of an acyl group from acyl-coenzyme A to cholesterol to generate cholesteryl ester, the primary form in which cholesterol is stored in cells and transported in plasma(1). ACATs have gained attention as potential drug targets for the treatment of diseases such as atherosclerosis, Alzheimer'  s disease and cancer(2-7). Here we present the cryo-electron microscopy structure of human ACAT1 as a dimer of dimers. Each protomer consists of nine transmembrane segments, which enclose a cytosolic tunnel and a transmembrane tunnel that converge at the predicted catalytic site. Evidence from structure-guided mutational analyses suggests that acyl-coenzyme A enters the active site through the cytosolic tunnel, whereas cholesterol may enter from the side through the transmembrane tunnel. This structural and biochemical characterization helps to rationalize the preference of ACAT1 for unsaturated acyl chains, and provides insight into the catalytic mechanism of enzymes within the MBOAT family(8).


  
Spatial and temporal dynamics of 20th century carbon storage and emissions after wildfire in an old-growth forest landscape 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2019, 449
作者:  Harris, Lucas B.;  Scholl, Andrew E.;  Young, Amanda B.;  Estes, Becky L.;  Taylor, Alan H.
收藏  |  浏览/下载:20/0  |  提交时间:2019/11/27
Carbon storage  Carbon emissions  Carbon stability  Forest reconstruction  Wildfire  Old growth  Yosemite National Park  
Iron hits the mark 期刊论文
SCIENCE, 2019, 363 (6424) : 225-226
作者:  Young, Elizabeth R.;  Oldacre, Amanda
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/27
Key drivers of ozone change and its radiative forcing over the 21st century 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2018, 18 (9) : 6121-6139
作者:  Iglesias-Suarez, Fernando;  Kinnison, Douglas E.;  Rap, Alexandru;  Maycock, Amanda C.;  Wild, Oliver;  Young, Paul J.
收藏  |  浏览/下载:14/0  |  提交时间:2019/04/09