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Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice 期刊论文
Science, 2021
作者:  David R. Martinez;  Alexandra Schäfer;  Sarah R. Leist;  Gabriela De la Cruz;  Ande West;  Elena N. Atochina-Vasserman;  Lisa C. Lindesmith;  Norbert Pardi;  Robert Parks;  Maggie Barr;  Dapeng Li;  Boyd Yount;  Kevin O. Saunders;  Drew Weissman;  Barton F. Haynes;  Stephanie A. Montgomery;  Ralph S. Baric
收藏  |  浏览/下载:38/0  |  提交时间:2021/08/30
Analysis of multispectral imaging with the AstroPath platform informs efficacy of PD-1 blockade 期刊论文
Science, 2021
作者:  Sneha Berry;  Nicolas A. Giraldo;  Benjamin F. Green;  Tricia R. Cottrell;  Julie E. Stein;  Elizabeth L. Engle;  Haiying Xu;  Aleksandra Ogurtsova;  Charles Roberts;  Daphne Wang;  Peter Nguyen;  Qingfeng Zhu;  Sigfredo Soto-Diaz;  Jose Loyola;  Inbal B. Sander;  Pok Fai Wong;  Shlomit Jessel;  Joshua Doyle;  Danielle Signer;  Richard Wilton;  Jeffrey S. Roskes;  Margaret Eminizer;  Seyoun Park;  Joel C. Sunshine;  Elizabeth M. Jaffee;  Alexander Baras;  Angelo M. De Marzo;  Suzanne L. Topalian;  Harriet Kluger;  Leslie Cope;  Evan J. Lipson;  Ludmila Danilova;  Robert A. Anders;  David L. Rimm;  Drew M. Pardoll;  Alexander S. Szalay;  Janis M. Taube
收藏  |  浏览/下载:43/0  |  提交时间:2021/06/15
Classifying ecosystem stressor interactions: Theory highlights the data limitations of the additive null model and the difficulty in revealing ecological surprises 期刊论文
Global Change Biology, 2021
作者:  Benjamin J. Burgess;  Drew Purves;  Georgina Mace;  David J. Murrell
收藏  |  浏览/下载:13/0  |  提交时间:2021/05/14
Guidelines for Modeling and Reporting Health Effects of Climate Change Mitigation Actions 期刊论文
Environmental Health Perspectives, 2020
作者:  Jeremy J. Hess;  Nikhil Ranadive;  Chris Boyer;  Lukasz Aleksandrowicz;  Susan C. Anenberg;  Kristin Aunan;  Kristine Belesova;  Michelle L. Bell;  Sam Bickersteth;  Kathryn Bowen;  Marci Burden;  Diarmid Campbell-Lendrum;  Elizabeth Carlton;  Guéladio Cissé;  Francois Cohen;  Hancheng Dai;  Alan David Dangour;  Purnamita Dasgupta;  Howard Frumkin;  Peng Gong;  Robert J. Gould;  Andy Haines;  Simon Hales;  Ian Hamilton;  Tomoko Hasegawa;  Masahiro Hashizume;  Yasushi Honda;  Daniel E. Horton;  Alexandra Karambelas;  Ho Kim;  Satbyul Estella Kim;  Patrick L. Kinney;  Inza Kone;  Kim Knowlton;  Jos Lelieveld;  Vijay S. Limaye;  Qiyong Liu;  Lina Madaniyazi;  Micaela Elvira Martinez;  Denise L. Mauzerall;  James Milner;  Tara Neville;  Mark Nieuwenhuijsen;  Shonali Pachauri;  Frederica Perera;  Helen Pineo;  Justin V. Remais;  Rebecca K. Saari;  Jon Sampedro;  Pauline Scheelbeek;  Joel Schwartz;  Drew Shindell;  Priya Shyamsundar;  Timothy J. Taylor;  Cathryn Tonne;  Detlef Van Vuuren;  Can Wang;  Nicholas Watts;  J. Jason West;  Paul Wilkinson;  Stephen A. Wood;  James Woodcock;  Alistair Woodward;  Yang Xie;  Ying Zhang;  Kristie L. Ebi
收藏  |  浏览/下载:55/0  |  提交时间:2020/11/20
Rapid implementation of mobile technology for real-time epidemiology of COVID-19 期刊论文
Science, 2020
作者:  David A. Drew;  Long H. Nguyen;  Claire J. Steves;  Cristina Menni;  Maxim Freydin;  Thomas Varsavsky;  Carole H. Sudre;  M. Jorge Cardoso;  Sebastien Ourselin;  Jonathan Wolf;  Tim D. Spector;  Andrew T. Chan;  COPE Consortium§
收藏  |  浏览/下载:26/0  |  提交时间:2020/06/22
Sex-specific adipose tissue imprinting of regulatory T cells 期刊论文
NATURE, 2020, 579 (7800) : 581-+
作者:  Qureshi, Abdul Aziz;  Suades, Albert;  Matsuoka, Rei;  Brock, Joseph;  McComas, Sarah E.;  Nji, Emmanuel;  Orellana, Laura;  Claesson, Magnus;  Delemotte, Lucie;  Drew, David
收藏  |  浏览/下载:20/0  |  提交时间:2020/07/03

Adipose tissue is an energy store and a dynamic endocrine organ(1,2). In particular, visceral adipose tissue (VAT) is critical for the regulation of systemic metabolism(3,4). Impaired VAT function-for example, in obesity-is associated with insulin resistance and type 2 diabetes(5,6). Regulatory T (T-reg) cells that express the transcription factor FOXP3 are critical for limiting immune responses and suppressing tissue inflammation, including in the VAT(7-9). Here we uncover pronounced sexual dimorphism in T-reg cells in the VAT. Male VAT was enriched for T-reg cells compared with female VAT, and T-reg cells from male VAT were markedly different from their female counterparts in phenotype, transcriptional landscape and chromatin accessibility. Heightened inflammation in the male VAT facilitated the recruitment of T-reg cells via the CCL2-CCR2 axis. Androgen regulated the differentiation of a unique IL-33-producing stromal cell population specific to the male VAT, which paralleled the local expansion of T-reg cells. Sex hormones also regulated VAT inflammation, which shaped the transcriptional landscape of VAT-resident T-reg cells in a BLIMP1 transcription factor-dependent manner. Overall, we find that sex-specific differences in T-reg cells from VAT are determined by the tissue niche in a sex-hormone-dependent manner to limit adipose tissue inflammation.


Visceral adipose tissue contains populations of regulatory T cells that exhibit sexual dimorphism, determined by the surrounding niche, and differ between male and female mice in terms of cell number, phenotype, transcriptional landscape and chromatin accessibility.


  
Species-specific and elevation-differentiated responses of tree growth to rapid warming in a mixed forest lead to a continuous growth enhancement in semi-humid Northeast Asia 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2019, 448: 76-84
作者:  Cap, Jing;  Liu, Hongyan;  Zhao, Bo;  Li, Zongshan;  Drew, David M.;  Zhao, Xiuhai
收藏  |  浏览/下载:20/0  |  提交时间:2019/11/27
Species-specific  Elevation  Mixed forest  Tree growth  Global climate warming  Semi-humid region  
Peroxy acetyl nitrate (PAN) measurements at northern midlatitude mountain sites in April: a constraint on continental source-receptor relationships 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2018, 18 (20) : 15345-15361
作者:  Fiore, Arlene M.;  Fischer, Emily, V;  Milly, George P.;  Deolal, Shubha Pandey;  Wild, Oliver;  Jaffe, Daniel A.;  Staehelin, Johannes;  Clifton, Olivia E.;  Bergmann, Dan;  Collins, William;  Dentener, Frank;  Doherty, Ruth M.;  Duncan, Bryan N.;  Fischer, Bernd;  Gilge, Stefan;  Hess, Peter G.;  Horowitz, Larry W.;  Lupu, Alexandru;  MacKenzie, Ian A.;  Park, Rokjin;  Ries, Ludwig;  Sanderson, Michael G.;  Schultz, Martin G.;  Shindell, Drew T.;  Steinbacher, Martin;  Stevenson, David S.;  Szopa, Sophie;  Zellweger, Christoph;  Zeng, Guang
收藏  |  浏览/下载:37/0  |  提交时间:2019/04/09
Single-cell profiling of the developing mouse brain and spinal cord with split-pool barcoding 期刊论文
SCIENCE, 2018, 360 (6385) : 176-+
作者:  Rosenberg, Alexander B.;  Roco, Charles M.;  Muscat, Richard A.;  Kuchina, Anna;  Sample, Paul;  Yao, Zizhen;  Graybuck, Lucas T.;  Peeler, David J.;  Mukherjee, Sumit;  Chen, Wei;  Pun, Suzie H.;  Sellers, Drew L.;  Tasic, Bosiljka;  Seelig, Georg
收藏  |  浏览/下载:28/0  |  提交时间:2019/11/27
Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria 期刊论文
SCIENCE, 2018, 359 (6375) : 592-+
作者:  Dejea, Christine M.;  Fathi, Payam;  Craig, John M.;  Boleij, Annemarie;  Taddese, Rahwa;  Geis, Abby L.;  Wu, Xinqun;  Shields, Christina E. DeStefano;  Hechenbleikner, Elizabeth M.;  Huso, David L.;  Anders, Robert A.;  Giardiello, Francis M.;  Wick, Elizabeth C.;  Wang, Hao;  Wu, Shaoguang;  Pardoll, Drew M.;  Housseau, Franck;  Sears, Cynthia L.
收藏  |  浏览/下载:29/0  |  提交时间:2019/11/27