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Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 期刊论文
Science, 2020
作者:  Qian Zhang;  Paul Bastard;  Zhiyong Liu;  Jérémie Le Pen;  Marcela Moncada-Velez;  Jie Chen;  Masato Ogishi;  Ira K. D. Sabli;  Stephanie Hodeib;  Cecilia Korol;  Jérémie Rosain;  Kaya Bilguvar;  Junqiang Ye;  Alexandre Bolze;  Benedetta Bigio;  Rui Yang;  Andrés Augusto Arias;  Qinhua Zhou;  Yu Zhang;  Fanny Onodi;  Sarantis Korniotis;  Léa Karpf;  Quentin Philippot;  Marwa Chbihi;  Lucie Bonnet-Madin;  Karim Dorgham;  Nikaïa Smith;  William M. Schneider;  Brandon S. Razooky;  Hans-Heinrich Hoffmann;  Eleftherios Michailidis;  Leen Moens;  Ji Eun Han;  Lazaro Lorenzo;  Lucy Bizien;  Philip Meade;  Anna-Lena Neehus;  Aileen Camille Ugurbil;  Aurélien Corneau;  Gaspard Kerner;  Peng Zhang;  Franck Rapaport;  Yoann Seeleuthner;  Jeremy Manry;  Cecile Masson;  Yohann Schmitt;  Agatha Schlüter;  Tom Le Voyer;  Taushif Khan;  Juan Li;  Jacques Fellay;  Lucie Roussel;  Mohammad Shahrooei;  Mohammed F. Alosaimi;  Davood Mansouri;  Haya Al-Saud;  Fahd Al-Mulla;  Feras Almourfi;  Saleh Zaid Al-Muhsen;  Fahad Alsohime;  Saeed Al Turki;  Rana Hasanato;  Diederik van de Beek;  Andrea Biondi;  Laura Rachele Bettini;  Mariella D’Angio’;  Paolo Bonfanti;  Luisa Imberti;  Alessandra Sottini;  Simone Paghera;  Eugenia Quiros-Roldan;  Camillo Rossi;  Andrew J. Oler;  Miranda F. Tompkins;  Camille Alba;  Isabelle Vandernoot;  Jean-Christophe Goffard;  Guillaume Smits;  Isabelle Migeotte;  Filomeen Haerynck;  Pere Soler-Palacin;  Andrea Martin-Nalda;  Roger Colobran;  Pierre-Emmanuel Morange;  Sevgi Keles;  Fatma Çölkesen;  Tayfun Ozcelik;  Kadriye Kart Yasar;  Sevtap Senoglu;  Şemsi Nur Karabela;  Carlos Rodríguez-Gallego;  Giuseppe Novelli;  Sami Hraiech;  Yacine Tandjaoui-Lambiotte;  Xavier Duval;  Cédric Laouénan;  COVID-STORM Clinicians†;  COVID Clinicians†;  Imagine COVID Group†;  French COVID Cohort Study Group†;  CoV-Contact Cohort†;  Amsterdam UMC Covid-19 Biobank†;  COVID Human Genetic Effort†;  NIAID-USUHS/TAGC COVID Immunity Group†;  Andrew L. Snow;  Clifton L. Dalgard;  Joshua D. Milner;  Donald C. Vinh;  Trine H. Mogensen;  Nico Marr;  András N. Spaan;  Bertrand Boisson;  Stéphanie Boisson-Dupuis;  Jacinta Bustamante;  Anne Puel;  Michael J. Ciancanelli;  Isabelle Meyts;  Tom Maniatis;  Vassili Soumelis;  Ali Amara;  Michel Nussenzweig;  Adolfo García-Sastre;  Florian Krammer;  Aurora Pujol;  Darragh Duffy;  Richard P. Lifton;  Shen-Ying Zhang;  Guy Gorochov;  Vivien Béziat;  Emmanuelle Jouanguy;  Vanessa Sancho-Shimizu;  Charles M. Rice;  Laurent Abel;  Luigi D. Notarangelo;  Aurélie Cobat;  Helen C. Su;  Jean-Laurent Casanova
收藏  |  浏览/下载:51/0  |  提交时间:2020/10/26
Black phosphorus composites with engineered interfaces for high-rate high-capacity lithium storage 期刊论文
Science, 2020
作者:  Hongchang Jin;  Sen Xin;  Chenghao Chuang;  Wangda Li;  Haiyun Wang;  Jian Zhu;  Huanyu Xie;  Taiming Zhang;  Yangyang Wan;  Zhikai Qi;  Wensheng Yan;  Ying-Rui Lu;  Ting-Shan Chan;  Xiaojun Wu;  John B. Goodenough;  Hengxing Ji;  Xiangfeng Duan
收藏  |  浏览/下载:42/0  |  提交时间:2020/10/12
Long‐term nitrogen loading alleviates phosphorus limitation in terrestrial ecosystems 期刊论文
Global Change Biology, 2020
作者:  Ji Chen;  Kees J. van Groenigen;  Bruce A. Hungate;  ;  sar Terrer;  Jan‐;  Willem van Groenigen;  Fernando T. Maestre;  Samantha C. Ying;  Yiqi Luo;  Uffe Jø;  rgensen;  Robert L. Sinsabaugh;  ;  rgen E. Olesen;  Lars Elsgaard
收藏  |  浏览/下载:30/0  |  提交时间:2020/07/06
Structure of the RNA-dependent RNA polymerase from COVID-19 virus 期刊论文
Science, 2020
作者:  Yan Gao;  Liming Yan;  Yucen Huang;  Fengjiang Liu;  Yao Zhao;  Lin Cao;  Tao Wang;  Qianqian Sun;  Zhenhua Ming;  Lianqi Zhang;  Ji Ge;  Litao Zheng;  Ying Zhang;  Haofeng Wang;  Yan Zhu;  Chen Zhu;  Tianyu Hu;  Tian Hua;  Bing Zhang;  Xiuna Yang;  Jun Li;  Haitao Yang;  Zhijie Liu;  Wenqing Xu;  Luke W. Guddat;  Quan Wang;  Zhiyong Lou;  Zihe Rao
收藏  |  浏览/下载:44/0  |  提交时间:2020/05/20
Improved protein structure prediction using potentials from deep learning 期刊论文
NATURE, 2020, 577 (7792) : 706-+
作者:  Ma, Runze;  Cao, Duanyun;  Zhu, Chongqin;  Tian, Ye;  Peng, Jinbo;  Guo, Jing;  Chen, Ji;  Li, Xin-Zheng;  Francisco, Joseph S.;  Zeng, Xiao Cheng;  Xu, Li-Mei;  Wang, En-Ge;  Jiang, Ying
收藏  |  浏览/下载:156/0  |  提交时间:2020/07/03

Protein structure prediction can be used to determine the three-dimensional shape of a protein from its amino acid sequence(1). This problem is of fundamental importance as the structure of a protein largely determines its function(2)  however, protein structures can be difficult to determine experimentally. Considerable progress has recently been made by leveraging genetic information. It is possible to infer which amino acid residues are in contact by analysing covariation in homologous sequences, which aids in the prediction of protein structures(3). Here we show that we can train a neural network to make accurate predictions of the distances between pairs of residues, which convey more information about the structure than contact predictions. Using this information, we construct a potential of mean force(4) that can accurately describe the shape of a protein. We find that the resulting potential can be optimized by a simple gradient descent algorithm to generate structures without complex sampling procedures. The resulting system, named AlphaFold, achieves high accuracy, even for sequences with fewer homologous sequences. In the recent Critical Assessment of Protein Structure Prediction(5) (CASP13)-a blind assessment of the state of the field-AlphaFold created high-accuracy structures (with template modelling (TM) scores(6) of 0.7 or higher) for 24 out of 43 free modelling domains, whereas the next best method, which used sampling and contact information, achieved such accuracy for only 14 out of 43 domains. AlphaFold represents a considerable advance in protein-structure prediction. We expect this increased accuracy to enable insights into the function and malfunction of proteins, especially in cases for which no structures for homologous proteins have been experimentally determined(7).


  
Dissecting primate early post-implantation development using long-term in vitro embryo culture 期刊论文
SCIENCE, 2019, 366 (6467) : 837-+
作者:  Niu, Yuyu;  Sun, Nianqin;  Li, Chang;  Lei, Ying;  Huang, Zhihao;  Wu, Jun;  Si, Chenyang;  Dai, Xi;  Liu, Chuanyu;  Wei, Jingkuan;  Liu, Longqi;  Feng, Su;  Kang, Yu;  Si, Wei;  Wang, Hong;  Zhang, E.;  Zhao, Lu;  Li, Ziwei;  Luo, Xi;  Cui, Guizhong;  Peng, Guangdun;  Belmonte, Juan Carlos Izpisua;  Ji, Weizhi;  Tan, Tao
收藏  |  浏览/下载:38/0  |  提交时间:2020/02/17
Palmitoylation of NOD1 and NOD2 is required for bacterial sensing 期刊论文
SCIENCE, 2019, 366 (6464) : 460-+
作者:  Lu, Yan;  Zheng, Yuping;  Coyaud, Etienne;  Zhang, Chao;  Selvabaskaran, Apiraam;  Yu, Yuyun;  Xu, Zizhen;  Weng, Xialian;  Chen, Ji Shun;  Meng, Ying;  Warner, Neil;  Cheng, Xiawei;  Liu, Yangyang;  Yao, Bingpeng;  Hu, Hu;  Xia, Zonping;  Muise, Aleixo M.;  Klip, Amira;  Brumell, John H.;  Girardin, Stephen E.;  Ying, Songmin;  Fairn, Gregory D.;  Raught, Brian;  Sun, Qiming;  Neculai, Dante
收藏  |  浏览/下载:35/0  |  提交时间:2019/11/27
HNRNPK maintains epidermal progenitor function through transcription of proliferation genes and degrading differentiation promoting mRNAs 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Li, Jingting;  Chen, Yifang;  Xu, Xiaojun;  Jones, Jackson;  Tiwari, Manisha;  Ling, Ji;  Wang, Ying;  Harismendy, Olivier;  Sen, George L.
收藏  |  浏览/下载:14/0  |  提交时间:2019/11/27
Comparison of Environmental and Mesoscale Characteristics of Two Types of Mountain-to-Plain Precipitation Systems in the Beijing Region, China 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2019, 124 (13) : 6856-6872
作者:  Xiao, Xian;  Sun, Juanzhen;  Chen, Mingxuan;  Qie, Xiushu;  Ying, Zhuming;  Wang, Yingchun;  Ji, Lei
收藏  |  浏览/下载:12/0  |  提交时间:2019/11/27
radar  storm  convective system  mesoscale analysis  data assimilation  
The impact of OPEC on East Asian oil import security: A multidimensional analysis 期刊论文
ENERGY POLICY, 2019, 126: 99-107
作者:  Ji, Qiang;  Zhang, Hai-Ying;  Zhang, Dayong
收藏  |  浏览/下载:10/0  |  提交时间:2019/04/09
DEA-like model  Energy security  OPEC  Regional trade  Sustainable growth