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Targeting a neoantigen derived from a common TP53 mutation 期刊论文
Science, 2021
作者:  Emily Han-Chung Hsiue;  Katharine M. Wright;  Jacqueline Douglass;  Michael S. Hwang;  Brian J. Mog;  Alexander H. Pearlman;  Suman Paul;  Sarah R. DiNapoli;  Maximilian F. Konig;  Qing Wang;  Annika Schaefer;  Michelle S. Miller;  Andrew D. Skora;  P. Aitana Azurmendi;  Michael B. Murphy;  Qiang Liu;  Evangeline Watson;  Yana Li;  Drew M. Pardoll;  Chetan Bettegowda;  Nickolas Papadopoulos;  Kenneth W. Kinzler;  Bert Vogelstein;  Sandra B. Gabelli;  Shibin Zhou
收藏  |  浏览/下载：37/0  |  提交时间：2021/03/12
Hydrothermal (NN)-N-15-N-15 abundances constrain the origins of mantle nitrogen 期刊论文
NATURE, 2020, 580 (7803) : 367-+
作者:  Zhao, Steven;  Jang, Cholsoon;  Liu, Joyce;  Uehara, Kahealani;  Gilbert, Michael;  Izzo, Luke;  Zeng, Xianfeng;  Trefely, Sophie;  Fernandez, Sully;  Carrer, Alessandro;  Miller, Katelyn D.;  Schug, Zachary T.;  Snyder, Nathaniel W.;  Gade, Terence P.;  Titchenell, Paul M.;  Rabinowitz, Joshua D.;  Wellen, Kathryn E.
收藏  |  浏览/下载：36/0  |  提交时间：2020/05/13

Nitrogen is the main constituent of the Earth'  s atmosphere, but its provenance in the Earth'  s mantle remains uncertain. The relative contribution of primordial nitrogen inherited during the Earth'  s accretion versus that subducted from the Earth'  s surface is unclear(1-6). Here we show that the mantle may have retained remnants of such primordial nitrogen. We use the rare (NN)-N-15-N-15 isotopologue of N-2 as a new tracer of air contamination in volcanic gas effusions. By constraining air contamination in gases from Iceland, Eifel (Germany) and Yellowstone (USA), we derive estimates of mantle delta N-15 (the fractional difference in N-15/N-14 from air), N-2/Ar-36 and N-2/He-3. Our results show that negative delta N-15 values observed in gases, previously regarded as indicating a mantle origin for nitrogen(7-10), in fact represent dominantly air-derived N-2 that experienced N-15/N-14 fractionation in hydrothermal systems. Using two-component mixing models to correct for this effect, the (NN)-N-15-N-15 data allow extrapolations that characterize mantle endmember delta N-15, N-2/Ar-36 and N-2/He-3 values. We show that the Eifel region has slightly increased delta N-15 and N-2/Ar-36 values relative to estimates for the convective mantle provided by mid-ocean-ridge basalts(11), consistent with subducted nitrogen being added to the mantle source. In contrast, we find that whereas the Yellowstone plume has delta N-15 values substantially greater than that of the convective mantle, resembling surface components(12-15), its N-2/Ar-36 and N-2/He-3 ratios are indistinguishable from those of the convective mantle. This observation raises the possibility that the plume hosts a primordial component. We provide a test of the subduction hypothesis with a two-box model, describing the evolution of mantle and surface nitrogen through geological time. We show that the effect of subduction on the deep nitrogen cycle may be less important than has been suggested by previous investigations. We propose instead that high mid-ocean-ridge basalt and plume delta N-15 values may both be dominantly primordial features.


  
Global airborne sampling reveals a previously unobserved dimethyl sulfide oxidation mechanism in the marine atmosphere 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (9) : 4505-4510
作者:  Veres, Patrick R.;  Neuman, J. Andrew;  Bertram, Timothy H.;  Assaf, Emmanuel;  Wolfe, Glenn M.;  Williamson, Christina J.;  Weinzierl, Bernadett;  Tilmes, Simone;  Thompson, Chelsea R.;  Thames, Alexander B.;  Schroder, Jason C.;  Saiz-Lopez, Alfonso;  Rollins, Andrew W.;  Roberts, James M.;  Price, Derek;  Peischl, Jeff;  Nault, Benjamin A.;  Moller, Kristian H.;  Miller, David O.;  Meinardi, Simone;  Li, Qinyi;  Lamarque, Jean-Francois;  Kupc, Agnieszka;  Kjaergaard, Henrik G.;  Kinnison, Douglas;  Jimenez, Jose L.;  Jernigan, Christopher M.;  Hornbrook, Rebecca S.;  Hills, Alan;  Dollner, Maximilian;  Day, Douglas A.;  Cuevas, Carlos A.;  Campuzano-Jost, Pedro;  Burkholder, James;  Bui, T. Paul;  Brune, William H.;  Brown, Steven S.;  Brock, Charles A.;  Bourgeois, Ilann;  Blake, Donald R.;  Apel, Eric C.;  Ryerson, Thomas B.
收藏  |  浏览/下载：59/0  |  提交时间：2020/05/13
dimethyl sulfide  marine sulfur  autoxidation  marine aerosols  aerosol sulfate  
BIOMEDICINE Multivascular networks and functional intravascular topologies within biocompatible hydrogels 期刊论文
SCIENCE, 2019, 364 (6439) : 458-+
作者:  Grigoryan, Bagrat;  Paulsen, Samantha J.;  Corbett, Daniel C.;  Sazer, Daniel W.;  Fortin, Chelsea L.;  Zaita, Alexander J.;  Greenfield, Paul T.;  Calafat, Nicholas J.;  Gounley, John P.;  Ta, Anderson H.;  Johansson, Fredrik;  Randles, Amanda;  Rosenkrantz, Jessica E.;  Louis-Rosenberg, Jesse D.;  Galie, Peter A.;  Stevens, Kelly R.;  Miller, Jordan S.
收藏  |  浏览/下载：36/0  |  提交时间：2019/11/27
Global estimates of mortality associated with long-term exposure to outdoor fine particulate matter 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (38) : 9592-9597
作者:  Burnett, Richard;  Chen, Hong;  Szyszkowicz, Mieczyslaw;  Fann, Neal;  Hubbell, Bryan;  Pope, C. Arden;  Apte, Joshua S.;  Brauer, Michael;  Cohen, Aaron;  Weichenthal, Scott;  Coggins, Jay;  Di, Qian;  Brunekreef, Bert;  Frostad, Joseph;  Lim, Stephen S.;  Kan, Haidong;  Walker, Katherine D.;  Thurston, George D.;  Hayes, Richard B.;  Lim, Chris C.;  Turner, Michelle C.;  Jerrett, Michael;  Krewski, Daniel;  Gapstur, Susan M.;  Diver, W. Ryan;  Ostro, Bart;  Goldberg, Debbie;  Crouse, Daniel L.;  Martin, Randall V.;  Peters, Paul;  Pinault, Lauren;  Tjepkema, Michael;  van Donkelaar, Aaron;  Villeneuve, Paul J.;  Miller, Anthony B.;  Yin, Peng;  Zhou, Maigeng;  Wang, Lijun;  Janssen, Nicole A. H.;  Marra, Marten;  Atkinson, Richard W.;  Tsang, Hilda;  Thuan Quoc Thach;  Cannon, John B.;  Allen, Ryan T.;  Hart, Jaime E.;  Laden, Francine;  Cesaroni, Giulia;  Forastiere, Francesco;  Weinmayr, Gudrun;  Jaensch, Andrea;  Nagel, Gabriele;  Concin, Hans;  Spadaro, Joseph V.
收藏  |  浏览/下载：96/0  |  提交时间：2019/11/27
mortality  exposure  risk  concentration  fine particulate matter  
An anatomic transcriptional atlas of human glioblastoma 期刊论文
SCIENCE, 2018, 360 (6389) : 660-663
作者:  Puchalski, Ralph B.;  Shah, Nameeta;  Miller, Jeremy;  Dalley, Rachel;  Nomura, Steve R.;  Yoon, Jae-Guen;  Smith, Kimberly A.;  Lankerovich, Michael;  Bertagnolli, Darren;  Bickley, Kris;  Boe, Andrew F.;  Brouner, Krissy;  Butler, Stephanie;  Caldejon, Shiella;  Chapin, Mike;  Datta, Suvro;  Dee, Nick;  Desta, Tsega;  Dolbeare, Tim;  Dotson, Nadezhda;  Ebbert, Amanda;  Feng, David;  Feng, Xu;  Fisher, Michael;  Gee, Garrett;  Goldy, Jeff;  Gourley, Lindsey;  Gregor, Benjamin W.;  Gu, Guangyu;  Hejazinia, Nika;  Hohmann, John;  Hothi, Parvinder;  Howard, Robert;  Joines, Kevin;  Kriedberg, Ali;  Kuan, Leonard;  Lau, Chris;  Lee, Felix;  Lee, Hwahyung;  Lemon, Tracy;  Long, Fuhui;  Mastan, Naveed;  Mott, Erika;  Murthy, Chantal;  Ngo, Kiet;  Olson, Eric;  Reding, Melissa;  Riley, Zack;  Rosen, David;  Sandman, David;  Shapovalova, Nadiya;  Slaughterbeck, Clifford R.;  Sodt, Andrew;  Stockdale, Graham;  Szafer, Aaron;  Wakeman, Wayne;  Wohnoutka, Paul E.;  White, Steven J.;  Marsh, Don;  Rostomily, Robert C.;  Ng, Lydia;  Dang, Chinh;  Jones, Allan;  Keogh, Bart;  Gittleman, Haley R.;  Barnholtz-Sloan, Jill S.;  Cimino, Patrick J.;  Uppin, Megha S.;  Keene, C. Dirk;  Farrokhi, Farrokh R.;  Lathia, Justin D.;  Berens, Michael E.;  Iavarone, Antonio;  Bernard, Amy;  Lein, Ed;  Phillips, John W.;  Rostad, Steven W.;  Cobbs, Charles;  Hawrylycz, Michael J.;  Foltz, Greg D.
收藏  |  浏览/下载：49/0  |  提交时间：2019/11/27
Eastern national parks protect greater tree species diversity than unprotected matrix forests 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2018, 414: 74-84
作者:  Miller, Kathryn M.;  McGill, Brian J.;  Mitchell, Brian R.;  Comiskey, Jim;  Dieffenbach, Fred W.;  Matthews, Elizabeth R.;  Perles, Stephanie J.;  Schmit, John Paul;  Weed, Aaron S.
收藏  |  浏览/下载：19/0  |  提交时间：2019/04/09
Tree species diversity  Forest management  Climate change  Alpha and beta diversity  Forest Inventory and Analysis  National Park Service Inventory and Monitoring  
A 42 year inference of cloud base height trends in the Luquillo Mountains of northeastern Puerto Rico 期刊论文
CLIMATE RESEARCH, 2018, 76 (1) : 87-94
作者:  Miller, Paul W.;  Mote, Thomas L.;  Ramseyer, Craig A.;  Van Beusekom, Ashley E.;  Scholl, Martha;  Gonzalez, Grizelle
收藏  |  浏览/下载：16/0  |  提交时间：2019/04/09
Cloud base height  Luquillo Mountains  Cloud forest  Lifted condensation level  Tropical rainforest  Caribbean  
The Saharan Air Layer as an Early Rainfall Season Suppressant in the Eastern Caribbean: The 2015 Puerto Rico Drought 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2017, 122 (20)
作者:  Mote, Thomas L.;  Ramseyer, Craig A.;  Miller, Paul W.
收藏  |  浏览/下载：16/0  |  提交时间：2019/04/09
Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution 期刊论文
NATURE, 2017, 545 (7655) : 446-+
作者:  Abbosh, Christopher;  Birkbak, Nicolai J.;  Wilson, Gareth A.;  Jamal-Hanjani, Mariam;  Constantin, Tudor;  Salari, Raheleh;  Le Quesne, John;  Moore, David A.;  Veeriah, Selvaraju;  Rosenthal, Rachel;  Marafioti, Teresa;  Kirkizlar, Eser;  Watkins, Thomas B. K.;  McGranahan, Nicholas;  Ward, Sophia;  Martinson, Luke;  Riley, Joan;  Fraioli, Francesco;  Al Bakir, Maise;  Gronroos, Eva;  Zambrana, Francisco;  Endozo, Raymondo;  Bi, Wenya Linda;  Fennessy, Fiona M.;  Sponer, Nicole;  Johnson, Diana;  Laycock, Joanne;  Shafi, Seema;  Czyzewska-Khan, Justyna;  Rowan, Andrew;  Chambers, Tim;  Matthews, Nik;  Turajlic, Samra;  Hiley, Crispin;  Lee, Siow Ming;  Forster, Martin D.;  Ahmad, Tanya;  Falzon, Mary;  Borg, Elaine;  Lawrence, David;  Hayward, Martin;  Kolvekar, Shyam;  Panagiotopoulos, Nikolaos;  Janes, Sam M.;  Thakrar, Ricky;  Ahmed, Asia;  Blackhall, Fiona;  Summers, Yvonne;  Hafez, Dina;  Naik, Ashwini;  Ganguly, Apratim;  Kareht, Stephanie;  Shah, Rajesh;  Joseph, Leena;  Quinn, Anne Marie;  Crosbie, Phil A.;  Naidu, Babu;  Middleton, Gary;  Langman, Gerald;  Trotter, Simon;  Nicolson, Marianne;  Remmen, Hardy;  Kerr, Keith;  Chetty, Mahendran;  Gomersall, Lesley;  Fennell, Dean A.;  Nakas, Apostolos;  Rathinam, Sridhar;  Anand, Girija;  Khan, Sajid;  Russell, Peter;  Ezhil, Veni;  Ismail, Babikir;  Irvin-Sellers, Melanie;  Prakash, Vineet;  Lester, Jason F.;  Kornaszewska, Malgorzata;  Attanoos, Richard;  Adams, Haydn;  Davies, Helen;  Oukrif, Dahmane;  Akarca, Ayse U.;  Hartley, John A.;  Lowe, Helen L.;  Lock, Sara;  Iles, Natasha;  Bell, Harriet;  Ngai, Yenting;  Elgar, Greg;  Szallasi, Zoltan;  Schwarz, Roland F.;  Herrero, Javier;  Stewart, Aengus;  Quezada, Sergio A.;  Peggs, Karl S.;  Van Loo, Peter;  Dive, Caroline;  Lin, C. Jimmy;  Rabinowitz, Matthew;  Aerts, Hugo J. W. L.;  Hackshaw, Allan;  Shaw, Jacqui A.;  Zimmermann, Bernhard G.;  Swanton, Charles;  Jamal-Hanjani, Mariam;  Abbosh, Christopher;  Veeriah, Selvaraju;  Shafi, Seema;  Czyzewska-Khan, Justyna;  Johnson, Diana;  Laycock, Joanne;  Bosshard-Carter, Leticia;  Goh, Gerald;  Rosenthal, Rachel;  Gorman, Pat;  Murugaesu, Nirupa;  Hynds, Robert E.;  Wilson, Gareth A.;  Birkbak, Nicolai J.;  Watkins, Thomas B. K.;  McGranahan, Nicholas;  Horswell, Stuart;  Al Bakir, Maise;  Gronroos, Eva;  Mitter, Richard;  Escudero, Mickael;  Stewart, Aengus;  Van Loo, Peter;  Rowan, Andrew;  Xu, Hang;  Turajlic, Samra;  Hiley, Crispin;  Goldman, Jacki;  Stone, Richard Kevin;  Denner, Tamara;  Matthews, Nik;  Elgar, Greg;  Ward, Sophia;  Biggs, Jennifer;  Costa, Marta;  Begum, Sharmin;  Phillimore, Ben;  Chambers, Tim;  Nye, Emma;  Graca, Sofia;  Joshi, Kroopa;  Furness, Andrew;  Ben Aissa, Assma;  Wong, Yien Ning Sophia;  Georgiou, Andy;  Quezada, Sergio A.;  Peggs, Karl S.;  Hartley, John A.;  Lowe, Helen L.;  Herrero, Javier;  Lawrence, David;  Hayward, Martin;  Panagiotopoulos, Nikolaos;  Kolvekar, Shyam;  Falzon, Mary;  Borg, Elaine;  Marafioti, Teresa;  Simeon, Celia;  Hector, Gemma;  Smith, Amy;  Aranda, Marie;  Novelli, Marco;  Oukrif, Dahmane;  Akarca, Ayse U.;  Janes, Sam M.;  Thakrar, Ricky;  Forster, Martin D.;  Ahmad, Tanya;  Lee, Siow Ming;  Papadatos-Pastos, Dionysis;  Carnell, Dawn;  Mendes, Ruheena;  George, Jeremy;  Navani, Neal;  Ahmed, Asia;  Taylor, Magali;  Choudhary, Junaid;  Summers, Yvonne;  Califano, Raffaele;  Taylor, Paul;  Shah, Rajesh;  Krysiak, Piotr;  Rammohan, Kendadai;  Fontaine, Eustace;  Booton, Richard;  Evison, Matthew;  Crosbie, Phil A.;  Moss, Stuart;  Idries, Faiza;  Joseph, Leena;  Bishop, Paul;  Chaturvedi, Anshuman;  Quinn, Anne Marie;  Doran, Helen;  Leek, Angela;  Harrison, Phil;  Moore, Katrina;  Waddington, Rachael;  Novasio, Juliette;  Blackhall, Fiona;  Rogan, Jane;  Smith, Elaine;  Dive, Caroline;  Tugwood, Jonathan;  Brady, Ged;  Rothwell, Dominic G.;  Chemi, Francesca;  Pierce, Jackie;  Gulati, Sakshi;  Naidu, Babu;  Langman, Gerald;  Trotter, Simon;  Bellamy, Mary;  Bancroft, Hollie;  Kerr, Amy;  Kadiri, Salma;  Webb, Joanne;  Middleton, Gary;  Djearaman, Madava;  Fennell, Dean A.;  Shaw, Jacqui A.;  Le Quesne, John;  Moore, David A.;  Thomas, Anne;  Walter, Harriet;  Riley, Joan;  Martinson, Luke;  Nakas, Apostolos;  Rathinam, Sridhar;  Monteiro, William;  Marshall, Hilary;  Nelson, Louise;  Bennett, Jonathan;  Primrose, Lindsay;  Anand, Girija;  Khan, Sajid;  Amadi, Anita;  Nicolson, Marianne;  Kerr, Keith;  Palmer, Shirley;  Remmen, Hardy;  Miller, Joy;  Buchan, Keith;  Chetty, Mahendran;  Gomersall, Lesley;  Lester, Jason F.;  Edwards, Alison;  Morgan, Fiona;  Adams, Haydn;  Davies, Helen;  Kornaszewska, Malgorzata;  Attanoos, Richard;  Lock, Sara;  Verjee, Azmina;  MacKenzie, Mairead;  Wilcox, Maggie;  Bell, Harriet;  Iles, Natasha;  Hackshaw, Allan;  Ngai, Yenting;  Smith, Sean;  Gower, Nicole;  Ottensmeier, Christian;  Chee, Serena;  Johnson, Benjamin;  Alzetani, Aiman;  Shaw, Emily;  Lim, Eric;  De Sousa, Paulo;  Barbosa, Monica Tavares;  Bowman, Alex;  Jordan, Simon;  Rice, Alexandra;  Raubenheimer, Hilgardt;  Proli, Chiara;  Cufari, Maria Elena;  Ronquillo, John Carlo;  Kwayie, Angela;  Bhayani, Harshil;  Hamilton, Morag;  Bakar, Yusura;  Mensah, Natalie;  Ambrose, Lyn;  Devaraj, Anand;  Buderi, Silviu;  Finch, Jonathan;  Azcarate, Leire;  Chavan, Hema;  Green, Sophie;  Mashinga, Hillaria;  Nicholson, Andrew G.;  Lau, Kelvin;  Sheaff, Michael;  Schmid, Peter;  Conibear, John;  Ezhil, Veni;  Ismail, Babikir;  Irvin-Sellers, Melanie;  Prakash, Vineet;  Russell, Peter;  Light, Teresa;  Horey, Tracey;  Danson, Sarah;  Bury, Jonathan;  Edwards, John;  Hill, Jennifer;  Matthews, Sue;  Kitsanta, Yota;  Suvarna, Kim;  Fisher, Patricia;  Keerio, Allah Dino;  Shackcloth, Michael;  Gosney, John;  Postmus, Pieter;  Feeney, Sarah;  Asante-Siaw, Julius;  Constantin, Tudor;  Salari, Raheleh;  Sponer, Nicole;  Naik, Ashwini;  Zimmermann, Bernhard G.;  Rabinowitz, Matthew;  Aerts, Hugo J. W. L.;  Dentro, Stefan;  Dessimoz, Christophe
收藏  |  浏览/下载：65/0  |  提交时间：2019/04/09