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Active construction of southernmost Tibet revealed by deep seismic imaging 期刊论文
Nature Communications, 2022
作者:  Lu, Zhanwu;  Guo, Xiaoyu;  Gao, Rui;  Murphy, Michael Andrew;  Huang, Xingfu;  Xu, Xiao;  Li, Sanzhong;  Li, Wenhui;  Zhao, Junmeng;  Li, Chunsen;  Xiang, Bo
收藏  |  浏览/下载:52/0  |  提交时间:2022/06/24
Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity 期刊论文
Science, 2021
作者:  Parsa Akbari;  Ankit Gilani;  Olukayode Sosina;  Jack A. Kosmicki;  Lori Khrimian;  Yi-Ya Fang;  Trikaldarshi Persaud;  Victor Garcia;  Dylan Sun;  Alexander Li;  Joelle Mbatchou;  Adam E. Locke;  Christian Benner;  Niek Verweij;  Nan Lin;  Sakib Hossain;  Kevin Agostinucci;  Jonathan V. Pascale;  Ercument Dirice;  Michael Dunn;  Regeneron Genetics Center‡;  DiscovEHR Collaboration‡;  William E. Kraus;  Svati H. Shah;  Yii-Der I. Chen;  Jerome I. Rotter;  Daniel J. Rader;  Olle Melander;  Christopher D. Still;  Tooraj Mirshahi;  David J. Carey;  Jaime Berumen-Campos;  Pablo Kuri-Morales;  Jesus Alegre-Díaz;  Jason M. Torres;  Jonathan R. Emberson;  Rory Collins;  Suganthi Balasubramanian;  Alicia Hawes;  Marcus Jones;  Brian Zambrowicz;  Andrew J. Murphy;  Charles Paulding;  Giovanni Coppola;  John D. Overton;  Jeffrey G. Reid;  Alan R. Shuldiner;  Michael Cantor;  Hyun M. Kang;  Goncalo R. Abecasis;  Katia Karalis;  Aris N. Economides;  Jonathan Marchini;  George D. Yancopoulos;  Mark W. Sleeman;  Judith Altarejos;  Giusy Della Gatta;  Roberto Tapia-Conyer;  Michal L. Schwartzman;  Aris Baras;  Manuel A. R. Ferreira;  Luca A. Lotta
收藏  |  浏览/下载:63/0  |  提交时间:2021/07/27
Targeting a neoantigen derived from a common TP53 mutation 期刊论文
Science, 2021
作者:  Emily Han-Chung Hsiue;  Katharine M. Wright;  Jacqueline Douglass;  Michael S. Hwang;  Brian J. Mog;  Alexander H. Pearlman;  Suman Paul;  Sarah R. DiNapoli;  Maximilian F. Konig;  Qing Wang;  Annika Schaefer;  Michelle S. Miller;  Andrew D. Skora;  P. Aitana Azurmendi;  Michael B. Murphy;  Qiang Liu;  Evangeline Watson;  Yana Li;  Drew M. Pardoll;  Chetan Bettegowda;  Nickolas Papadopoulos;  Kenneth W. Kinzler;  Bert Vogelstein;  Sandra B. Gabelli;  Shibin Zhou
收藏  |  浏览/下载:36/0  |  提交时间:2021/03/12
Cholangiocyte organoids can repair bile ducts after transplantation in the human liver 期刊论文
Science, 2021
作者:  Fotios Sampaziotis;  Daniele Muraro;  Olivia C. Tysoe;  Stephen Sawiak;  Timothy E. Beach;  Edmund M. Godfrey;  Sara S. Upponi;  Teresa Brevini;  Brandon T. Wesley;  Jose Garcia-Bernardo;  Krishnaa Mahbubani;  Giovanni Canu;  Richard Gieseck;  Natalie L. Berntsen;  Victoria L. Mulcahy;  Keziah Crick;  Corrina Fear;  Sharayne Robinson;  Lisa Swift;  Laure Gambardella;  Johannes Bargehr;  Daniel Ortmann;  Stephanie E. Brown;  Anna Osnato;  Michael P. Murphy;  Gareth Corbett;  William T. H. Gelson;  George F. Mells;  Peter Humphreys;  Susan E. Davies;  Irum Amin;  Paul Gibbs;  Sanjay Sinha;  Sarah A. Teichmann;  Andrew J. Butler;  Teik Choon See;  Espen Melum;  Christopher J. E. Watson;  Kourosh Saeb-Parsy;  Ludovic Vallier
收藏  |  浏览/下载:59/0  |  提交时间:2021/02/22
Monumental architecture at Aguada Fenix and the rise of Maya civilization 期刊论文
NATURE, 2020
作者:  Bedding, Timothy R.;  Murphy, Simon J.;  Hey, Daniel R.;  Huber, Daniel;  Li, Tanda;  Smalley, Barry;  Stello, Dennis;  White, Timothy R.;  Ball, Warrick H.;  Chaplin, William J.;  Colman, Isabel L.;  Fuller, Jim;  Gaidos, Eric;  Harbeck, Daniel R.;  Hermes, J. J.;  Holdsworth, Daniel L.;  Li, Gang;  Li, Yaguang;  Mann, Andrew W.;  Reese, Daniel R.;  Sekaran, Sanjay;  Yu, Jie;  Antoci, Victoria;  Bergmann, Christoph;  Brown, Timothy M.;  Howard, Andrew W.;  Ireland, Michael J.;  Isaacson, Howard;  Jenkins, Jon M.;  Kjeldsen, Hans;  McCully, Curtis;  Rabus, Markus;  Rains, Adam D.;  Ricker, George R.;  Tinney, Christopher G.;  Vanderspek, Roland K.
收藏  |  浏览/下载:62/0  |  提交时间:2020/07/03

Archaeologists have traditionally thought that the development of Maya civilization was gradual, assuming that small villages began to emerge during the Middle Preclassic period (1000-350 bc  dates are calibrated throughout) along with the use of ceramics and the adoption of sedentism(1). Recent finds of early ceremonial complexes are beginning to challenge this model. Here we describe an airborne lidar survey and excavations of the previously unknown site of Aguada Fenix (Tabasco, Mexico) with an artificial plateau, which measures 1,400 m in length and 10 to 15 m in height and has 9 causeways radiating out from it. We dated this construction to between 1000 and 800 bc using a Bayesian analysis of radiocarbon dates. To our knowledge, this is the oldest monumental construction ever found in the Maya area and the largest in the entire pre-Hispanic history of the region. Although the site exhibits some similarities to the earlier Olmec centre of San Lorenzo, the community of Aguada Fenix probably did not have marked social inequality comparable to that of San Lorenzo. Aguada Fenix and other ceremonial complexes of the same period suggest the importance of communal work in the initial development of Maya civilization.


Lidar survey of the Maya lowlands uncovers the monumental site of Aguada Fenix, which dates to around 1000-800 bc and points to the role of communal construction in the development of Maya civilization.


  
Pan-tumor genomic biomarkers for PD-1 checkpoint blockade-based immunotherapy 期刊论文
SCIENCE, 2018, 362 (6411) : 197-+
作者:  Cristescu, Razvan;  Mogg, Robin;  Ayers, Mark;  Albright, Andrew;  Murphy, Erin;  Yearley, Jennifer;  Sher, Xinwei;  Liu, Xiao Qiao;  Lu, Hongchao;  Nebozhyn, Michael;  Zhang, Chunsheng;  Lunceford, Jared;  Joe, Andrew;  Cheng, Jonathan;  Webber, Andrea L.;  Ibrahim, Nageatte;  Plimack, Elizabeth R.;  Ott, Patrick A.;  Seiwert, Tanguy;  Ribas, Antoni;  McClanahan, Terrill K.;  Tomassini, Joanne E.;  Loboda, Andrey;  Kaufman, David
收藏  |  浏览/下载:25/0  |  提交时间:2019/11/27