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Senolytics reduce coronavirus-related mortality in old mice 期刊论文
Science, 2021
作者:  Christina D. Camell;  Matthew J. Yousefzadeh;  Yi Zhu;  Larissa G. P. Langhi Prata;  Matthew A. Huggins;  Mark Pierson;  Lei Zhang;  Ryan D. O’Kelly;  Tamar Pirtskhalava;  Pengcheng Xun;  Keisuke Ejima;  Ailing Xue;  Utkarsh Tripathi;  Jair Machado Espindola-Netto;  Nino Giorgadze;  Elizabeth J. Atkinson;  Christina L. Inman;  Kurt O. Johnson;  Stephanie H. Cholensky;  Timothy W. Carlson;  Nathan K. LeBrasseur;  Sundeep Khosla;  M. Gerard O’Sullivan;  David B. Allison;  Stephen C. Jameson;  Alexander Meves;  Ming Li;  Y. S. Prakash;  Sergio E. Chiarella;  Sara E. Hamilton;  Tamara Tchkonia;  Laura J. Niedernhofer;  James L. Kirkland;  Paul D. Robbins
收藏  |  浏览/下载:16/0  |  提交时间:2021/07/27
Haplotype-resolved diverse human genomes and integrated analysis of structural variation 期刊论文
Science, 2021
作者:  Peter Ebert;  Peter A. Audano;  Qihui Zhu;  Bernardo Rodriguez-Martin;  David Porubsky;  Marc Jan Bonder;  Arvis Sulovari;  Jana Ebler;  Weichen Zhou;  Rebecca Serra Mari;  Feyza Yilmaz;  Xuefang Zhao;  PingHsun Hsieh;  Joyce Lee;  Sushant Kumar;  Jiadong Lin;  Tobias Rausch;  Yu Chen;  Jingwen Ren;  Martin Santamarina;  Wolfram Höps;  Hufsah Ashraf;  Nelson T. Chuang;  Xiaofei Yang;  Katherine M. Munson;  Alexandra P. Lewis;  Susan Fairley;  Luke J. Tallon;  Wayne E. Clarke;  Anna O. Basile;  Marta Byrska-Bishop;  André Corvelo;  Uday S. Evani;  Tsung-Yu Lu;  Mark J. P. Chaisson;  Junjie Chen;  Chong Li;  Harrison Brand;  Aaron M. Wenger;  Maryam Ghareghani;  William T. Harvey;  Benjamin Raeder;  Patrick Hasenfeld;  Allison A. Regier;  Haley J. Abel;  Ira M. Hall;  Paul Flicek;  Oliver Stegle;  Mark B. Gerstein;  Jose M. C. Tubio;  Zepeng Mu;  Yang I. Li;  Xinghua Shi;  Alex R. Hastie;  Kai Ye;  Zechen Chong;  Ashley D. Sanders;  Michael C. Zody;  Michael E. Talkowski;  Ryan E. Mills;  Scott E. Devine;  Charles Lee;  Jan O. Korbel;  Tobias Marschall;  Evan E. Eichler
收藏  |  浏览/下载:28/0  |  提交时间:2021/04/06
Detection of two interstellar polycyclic aromatic hydrocarbons via spectral matched filtering 期刊论文
Science, 2021
作者:  Brett A. McGuire;  Ryan A. Loomis;  Andrew M. Burkhardt;  Kin Long Kelvin Lee;  Christopher N. Shingledecker;  Steven B. Charnley;  Ilsa R. Cooke;  Martin A. Cordiner;  Eric Herbst;  Sergei Kalenskii;  Mark A. Siebert;  Eric R. Willis;  Ci Xue;  Anthony J. Remijan;  Michael C. McCarthy
收藏  |  浏览/下载:8/0  |  提交时间:2021/03/29
Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth 期刊论文
Science, 2021
作者:  Ryan S. Roark;  Hui Li;  Wilton B. Williams;  Hema Chug;  Rosemarie D. Mason;  Jason Gorman;  Shuyi Wang;  Fang-Hua Lee;  Juliette Rando;  Mattia Bonsignori;  Kwan-Ki Hwang;  Kevin O. Saunders;  Kevin Wiehe;  M. Anthony Moody;  Peter T. Hraber;  Kshitij Wagh;  Elena E. Giorgi;  Ronnie M. Russell;  Frederic Bibollet-Ruche;  Weimin Liu;  Jesse Connell;  Andrew G. Smith;  Julia DeVoto;  Alexander I. Murphy;  Jessica Smith;  Wenge Ding;  Chengyan Zhao;  Neha Chohan;  Maho Okumura;  Christina Rosario;  Yu Ding;  Emily Lindemuth;  Anya M. Bauer;  Katharine J. Bar;  David Ambrozak;  Cara W. Chao;  Gwo-Yu Chuang;  Hui Geng;  Bob C. Lin;  Mark K. Louder;  Richard Nguyen;  Baoshan Zhang;  Mark G. Lewis;  Donald D. Raymond;  Nicole A. Doria-Rose;  Chaim A. Schramm;  Daniel C. Douek;  Mario Roederer;  Thomas B. Kepler;  Garnett Kelsoe;  John R. Mascola;  Peter D. Kwong;  Bette T. Korber;  Stephen C. Harrison;  Barton F. Haynes;  Beatrice H. Hahn;  George M. Shaw
收藏  |  浏览/下载:24/0  |  提交时间:2021/01/15
Fisheries rely on threatened salt marshes 期刊论文
Science, 2020
作者:  Ronald Baker;  Matthew D. Taylor;  Kenneth W. Able;  Michael W. Beck;  Just Cebrian;  Denise D. Colombano;  Rod M. Connolly;  Carolyn Currin;  Linda A. Deegan;  Ilka C. Feller;  Ben L. Gilby;  Matthew E. Kimball;  Thomas J. Minello;  Lawrence P. Rozas;  Charles Simenstad;  R. Eugene Turner;  Nathan J. Waltham;  Michael P. Weinstein;  Shelby L. Ziegler;  Philine S.E. zu Ermgassen;  Caitlin Alcott;  Scott B. Alford;  Myriam A. Barbeau;  Sarah C. Crosby;  Kate Dodds;  Alyssa Frank;  Janelle Goeke;  Lucy A. Goodridge Gaines;  Felicity E. Hardcastle;  Christopher J. Henderson;  W. Ryan James;  Matthew D. Kenworthy;  Justin Lesser;  Debbrota Mallick;  Charles W. Martin;  Ashley E. McDonald;  Catherine McLuckie;  Blair H. Morrison;  James A. Nelson;  Gregory S. Norris;  Jeff Ollerhead;  James W. Pahl;  Sarah Ramsden;  Jennifer S. Rehage;  James F. Reinhardt;  Ryan J. Rezek;  L. Mark Risse;  Joseph A.M. Smith;  Eric L. Sparks;  Lorie W. Staver
收藏  |  浏览/下载:17/0  |  提交时间:2020/11/09
Global status and conservation potential of reef sharks 期刊论文
Nature, 2020
作者:  M. Aaron MacNeil;  Demian D. Chapman;  Michelle Heupel;  Colin A. Simpfendorfer;  Michael Heithaus;  Mark Meekan;  Euan Harvey;  Jordan Goetze;  Jeremy Kiszka;  Mark E. Bond;  Leanne M. Currey-Randall;  Conrad W. Speed;  C. Samantha Sherman;  Matthew J. Rees;  Vinay Udyawer;  Kathryn I. Flowers;  Gina Clementi;  Jasmine Valentin-Albanese;  Taylor Gorham;  M. Shiham Adam;  Khadeeja Ali;  Fabiá;  n Pina-Amargó;  s;  Jorge A. Angulo-Valdé;  s;  Jacob Asher;  Laura Garcí;  a Barcia;  Océ;  ane Beaufort;  Cecilie Benjamin;  Anthony T. F. Bernard;  Michael L. Berumen;  Stacy Bierwagen;  Erika Bonnema;  Rosalind M. K. Bown;  Darcey Bradley;  Edd Brooks;  J. Jed Brown;  Dayne Buddo;  Patrick Burke;  Camila Cá;  ceres;  Diego Cardeñ;  osa;  Jeffrey C. Carrier;  Jennifer E. Caselle;  Venkatesh Charloo;  Thomas Claverie;  Eric Clua;  Jesse E. M. Cochran;  Neil Cook;  Jessica Cramp;  Brooke D’;  Alberto;  Martin de Graaf;  Mareike Dornhege;  Andy Estep;  Lanya Fanovich;  Naomi F. Farabough;  Daniel Fernando;  Anna L. Flam;  Camilla Floros;  Virginia Fourqurean;  Ricardo Garla;  Kirk Gastrich;  Lachlan George;  Rory Graham;  Tristan Guttridge;  Royale S. Hardenstine;  Stephen Heck;  Aaron C. Henderson;  Heidi Hertler;  Robert Hueter;  Mohini Johnson;  Stacy Jupiter;  Devanshi Kasana;  Steven T. Kessel;  Benedict Kiilu;  Taratu Kirata;  Baraka Kuguru;  Fabian Kyne;  Tim Langlois;  Elodie J. I. Lé;  ;  e;  Steve Lindfield;  Andrea Luna-Acosta;  Jade Maggs;  B. Mabel Manjaji-Matsumoto;  Andrea Marshall;  Philip Matich;  Erin McCombs;  Dianne McLean;  Llewelyn Meggs;  Stephen Moore;  Sushmita Mukherji;  Ryan Murray;  Muslimin Kaimuddin;  Stephen J. Newman;  Josep Nogué;  s;  Clay Obota;  Owen O’;  Shea;  Kennedy Osuka;  Yannis P. Papastamatiou;  Nishan Perera;  Bradley Peterson;  Alessandro Ponzo;  Andhika Prasetyo;  L. M. Sjamsul Quamar;  Jessica Quinlan;  Alexei Ruiz-Abierno;  Enric Sala;  Melita Samoilys;  Michelle Schä;  rer-Umpierre;  Audrey Schlaff;  Nikola Simpson;  Adam N. H. Smith;  Lauren Sparks;  Akshay Tanna;  Rubé;  n Torres;  Michael J. Travers;  Maurits van Zinnicq Bergmann;  Laurent Vigliola;  Juney Ward;  Alexandra M. Watts;  Colin Wen;  Elizabeth Whitman;  Aaron J. Wirsing;  Aljoscha Wothke;  Esteban Zarza-Gonzâ;  lez;  Joshua E. Cinner
收藏  |  浏览/下载:18/0  |  提交时间:2020/08/09
Holocene earthquake history and slip rate of the southern Teton fault, Wyoming, USA 期刊论文
GEOLOGICAL SOCIETY OF AMERICA BULLETIN, 2020, 132 (7-8) : 1566-1586
作者:  DuRoss, Christopher B.;  Gold, Ryan D.;  Briggs, Richard W.;  Delano, Jaime E.;  Ostenaa, Dean A.;  Zellman, Mark S.;  Cholewinski, Nicole;  Wittke, Seth J.;  Mahan, Shannon A.
收藏  |  浏览/下载:7/0  |  提交时间:2020/08/18
Electrical manipulation of a topological antiferromagnetic state 期刊论文
NATURE, 2020, 580 (7805) : 608-+
作者:  Chabon, Jacob J.;  Hamilton, Emily G.;  Kurtz, David M.;  Esfahani, Mohammad S.;  Moding, Everett J.;  Stehr, Henning;  Schroers-Martin, Joseph;  Nabet, Barzin Y.;  Chen, Binbin;  Chaudhuri, Aadel A.;  Liu, Chih Long;  Hui, Angela B.;  Jin, Michael C.;  Azad, Tej D.;  Almanza, Diego;  Jeon, Young-Jun;  Nesselbush, Monica C.;  Keh, Lyron Co Ting;  Bonilla, Rene F.;  Yoo, Christopher H.;  Ko, Ryan B.;  Chen, Emily L.;  Merriott, David J.;  Massion, Pierre P.;  Mansfield, Aaron S.;  Jen, Jin;  Ren, Hong Z.;  Lin, Steven H.;  Costantino, Christina L.;  Burr, Risa;  Tibshirani, Robert;  Gambhir, Sanjiv S.;  Berry, Gerald J.;  Jensen, Kristin C.;  West, Robert B.;  Neal, Joel W.;  Wakelee, Heather A.;  Loo, Billy W., Jr.;  Kunder, Christian A.;  Leung, Ann N.;  Lui, Natalie S.;  Berry, Mark F.;  Shrager, Joseph B.;  Nair, Viswam S.;  Haber, Daniel A.;  Sequist, Lecia V.;  Alizadeh, Ash A.;  Diehn, Maximilian
收藏  |  浏览/下载:38/0  |  提交时间:2020/07/03

Room-temperature electrical switching of a topological antiferromagnetic state in polycrystalline Mn3Sn thin films is demonstrated using the same protocol as that used for conventional ferromagnetic metals.


Electrical manipulation of phenomena generated by nontrivial band topology is essential for the development of next-generation technology using topological protection. A Weyl semimetal is a three-dimensional gapless system that hosts Weyl fermions as low-energy quasiparticles(1-4). It has various exotic properties, such as a large anomalous Hall effect (AHE) and chiral anomaly, which are robust owing to the topologically protected Weyl nodes(1-16). To manipulate such phenomena, a magnetic version of Weyl semimetals would be useful for controlling the locations of Weyl nodes in the Brillouin zone. Moreover, electrical manipulation of antiferromagnetic Weyl metals would facilitate the use of antiferromagnetic spintronics to realize high-density devices with ultrafast operation(17,18). However, electrical control of a Weyl metal has not yet been reported. Here we demonstrate the electrical switching of a topological antiferromagnetic state and its detection by the AHE at room temperature in a polycrystalline thin film(19) of the antiferromagnetic Weyl metal Mn3Sn9,10,12,20, which exhibits zero-field AHE. Using bilayer devices composed of Mn3Sn and nonmagnetic metals, we find that an electrical current density of about 10(10) to 10(11) amperes per square metre induces magnetic switching in the nonmagnetic metals, with a large change in Hall voltage. In addition, the current polarity along the bias field and the sign of the spin Hall angle of the nonmagnetic metals-positive for Pt (ref. (21)), close to 0 for Cu and negative for W (ref. (22))-determines the sign of the Hall voltage. Notably, the electrical switching in the antiferromagnet is achieved with the same protocol as that used for ferromagnetic metals(23,24). Our results may lead to further scientific and technological advances in topological magnetism and antiferromagnetic spintronics.


  
Measuring and forecasting progress towards the education-related SDG targets 期刊论文
NATURE, 2020, 580 (7805) : 636-+
作者:  Hindell, Mark A.;  Reisinger, Ryan R.;  Ropert-Coudert, Yan;  Huckstadt, Luis A.;  Trathan, Philip N.;  Bornemann, Horst;  Charrassin, Jean-Benoit;  Chown, Steven L.;  Costa, Daniel P.;  Danis, Bruno;  Lea, Mary-Anne;  Thompson, David;  Torres, Leigh G.;  Van de Putte, Anton P.
收藏  |  浏览/下载:20/0  |  提交时间:2020/07/03

Education is a key dimension of well-being and a crucial indicator of development(1-4). The Sustainable Development Goals (SDGs) prioritize progress in education, with a new focus on inequality(5-7). Here we model the within-country distribution of years of schooling, and use this model to explore educational inequality since 1970 and to forecast progress towards the education-related 2030 SDG targets. We show that although the world is largely on track to achieve near-universal primary education by 2030, substantial challenges remain in the completion rates for secondary and tertiary education. Globally, the gender gap in schooling had nearly closed by 2018 but gender disparities remained acute in parts of sub-Saharan Africa, and North Africa and the Middle East. It is predicted that, by 2030, females will have achieved significantly higher educational attainment than males in 18 countries. Inequality in education reached a peak globally in 2017 and is projected to decrease steadily up to 2030. The distributions and inequality metrics presented here represent a framework that can be used to track the progress of each country towards the SDG targets and the level of inequality over time. Reducing educational inequality is one way to promote a fairer distribution of human capital and the development of more equitable human societies.


Great progress toward the education-related SDG targets has been made  however, global estimates of within-country distributions of education reveal gender disparities and high levels of total inequality in many parts of the world.


  
Computational design of a modular protein sense-response system 期刊论文
SCIENCE, 2019, 366 (6468) : 1024-+
作者:  Glasgow, Anum A.;  Huang, Yao-Ming;  Mandell, Daniel J.;  Thompson, Michael;  Ritterson, Ryan;  Loshbaugh, Amanda L.;  Pellegrino, Jenna;  Krivacic, Cody;  Pache, Roland A.;  Barlow, Kyle A.;  Ollikainen, Noah;  Jeon, Deborah;  Kelly, Mark J. S.;  Fraser, James S.;  Kortemme, Tanja
收藏  |  浏览/下载:16/0  |  提交时间:2020/02/17