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Global maps of soil temperature 期刊论文
Global Change Biology, 2022
作者:  Jonas J. Lembrechts;  Johan van den Hoogen;  Juha Aalto;  Michael B. Ashcroft;  Pieter De Frenne;  Julia Kemppinen;  Martin Kopecký;  Miska Luoto;  Ilya M. D. Maclean;  Thomas W. Crowther;  Joseph J. Bailey;  Stef Haesen;  David H. Klinges;  Pekka Niittynen;  Brett R. Scheffers;  Koenraad Van Meerbeek;  Peter Aartsma;  Otar Abdalaze;  Mehdi Abedi;  Rien Aerts;  Negar Ahmadian;  Antje Ahrends;  Juha M. Alatalo;  Jake M. Alexander;  Camille Nina Allonsius;  Jan Altman;  Christof Ammann;  Christian Andres;  Christopher Andrews;  Jonas Ardö;  Nicola Arriga;  Alberto Arzac;  Valeria Aschero;  Rafael L. Assis;  Jakob Johann Assmann;  Maaike Y. Bader;  Khadijeh Bahalkeh;  Peter Baranč;  ok;  Isabel C. Barrio;  Agustina Barros;  Matti Barthel;  Edmund W. Basham;  Marijn Bauters;  Manuele Bazzichetto;  Luca Belelli Marchesini;  Michael C. Bell;  Juan C. Benavides;  José;  Luis Benito Alonso;  Bernd J. Berauer;  Jarle W. Bjerke;  Robert G. Bjö;  rk;  Mats P. Bjö;  rkman;  Katrin Bjö;  rnsdó;  ttir;  Benjamin Blonder;  Pascal Boeckx;  Julia Boike;  Stef Bokhorst;  ;  rbara N. S. Brum;  Josef Brů;  na;  Nina Buchmann;  Pauline Buysse;  José;  Luí;  s Camargo;  Otá;  vio C. Campoe;  Onur Candan;  Rafaella Canessa;  Nicoletta Cannone;  Michele Carbognani;  Jofre Carnicer;  Angé;  lica Casanova-Katny;  Simone Cesarz;  Bogdan Chojnicki;  Philippe Choler;  Steven L. Chown;  Edgar F. Cifuentes;  Marek Č;  iliak;  Tamara Contador;  Peter Convey;  Elisabeth J. Cooper;  Edoardo Cremonese;  Salvatore R. Curasi;  Robin Curtis;  Maurizio Cutini;  C. Johan Dahlberg;  Gergana N. Daskalova;  Miguel Angel de Pablo;  Stefano Della Chiesa;  ;  rgen Dengler;  Bart Deronde;  Patrice Descombes;  Valter Di Cecco;  Michele Di Musciano;  Jan Dick;  Romina D. Dimarco;  Jiri Dolezal;  Ellen Dorrepaal;  Jiř;  í;  Duš;  ek;  Nico Eisenhauer;  Lars Eklundh;  Todd E. Erickson;  Brigitta Erschbamer;  Werner Eugster;  Robert M. Ewers;  Dan A. Exton;  Nicolas Fanin;  Fatih Fazlioglu;  Iris Feigenwinter;  Giuseppe Fenu;  Olga Ferlian;  M. Rosa Ferná;  ndez Calzado;  Eduardo Ferná;  ndez-Pascual;  Manfred Finckh;  Rebecca Finger Higgens;  T'ai G. W. Forte;  Erika C. Freeman;  Esther R. Frei;  Eduardo Fuentes-Lillo;  Rafael A. Garcí;  a;  Marí;  a B. Garcí;  a;  Charly Gé;  ron;  Mana Gharun;  Dany Ghosn;  Khatuna Gigauri;  Anne Gobin;  Ignacio Goded;  Mathias Goeckede;  Felix Gottschall;  Keith Goulding;  Sanne Govaert;  Bente Jessen Graae;  Sarah Greenwood;  Caroline Greiser;  Achim Grelle;  Benoit Gué;  nard;  Mauro Guglielmin;  Joannè;  s Guillemot;  Peter Haase;  Sylvia Haider;  Aud H. Halbritter;  Maroof Hamid;  Albin Hammerle;  Arndt Hampe;  Siri V. Haugum;  Lucia Hederová;  Bernard Heinesch;  Carole Helfter;  Daniel Hepenstrick;  Maximiliane Herberich;  Mathias Herbst;  Luise Hermanutz;  David S. Hik;  Raú;  l Hoffré;  n;  ;  rgen Homeier;  Lukas Hö;  rtnagl;  Toke T. Hø;  ye;  Filip Hrbacek;  Kristoffer Hylander;  Hiroki Iwata;  Marcin Antoni Jackowicz-Korczynski;  Hervé;  Jactel;  ;  rvi Jä;  rveoja;  Szymon Jastrzę;  bowski;  Anke Jentsch;  Juan J. Jimé;  nez;  Ingibjö;  rg S. Jó;  nsdó;  ttir;  Tommaso Jucker;  Alistair S. Jump;  Radoslaw Juszczak;  ;  bert Kanka;  ;  t Kaš;  par;  George Kazakis;  Julia Kelly;  Anzar A. Khuroo;  Leif Klemedtsson;  Marcin Klisz;  Natascha Kljun;  Alexander Knohl;  Johannes Kobler;  Jozef Kollá;  r;  Martyna M. Kotowska;  Bence Ková;  cs;  Juergen Kreyling;  Andrea Lamprecht;  Simone I. Lang;  Christian Larson;  Keith Larson;  Kamil Laska;  Guerric le Maire;  Rachel I. Leihy;  Luc Lens;  Bengt Liljebladh;  Annalea Lohila;  Juan Lorite;  Benjamin Loubet;  Joshua Lynn;  Martin Macek;  Roy Mackenzie;  Enzo Magliulo;  Regine Maier;  Francesco Malfasi;  Františ;  ek Má;  liš;  Matě;  j Man;  Giovanni Manca;  Antonio Manco;  Tanguy Manise;  Paraskevi Manolaki;  Felipe Marciniak;  Radim Matula;  Ana Clara Mazzolari;  Sergiy Medinets;  Volodymyr Medinets;  Camille Meeussen;  Sonia Merinero;  Rita de Cá;  ssia Guimarã;  es Mesquita;  Katrin Meusburger;  Filip J. R. Meysman;  Sean T. Michaletz;  Ann Milbau;  Dmitry Moiseev;  Pavel Moiseev;  Andrea Mondoni;  Ruth Monfries;  Leonardo Montagnani;  Mikel Moriana-Armendariz;  Umberto Morra di Cella;  Martin Mö;  rsdorf;  Jonathan R. Mosedale;  Lena Muffler;  Miriam Muñ;  oz-Rojas;  Jonathan A. Myers;  Isla H. Myers-Smith;  Laszlo Nagy;  Marianna Nardino;  Ilona Naujokaitis-Lewis;  Emily Newling;  Lena Nicklas;  Georg Niedrist;  Armin Niessner;  Mats B. Nilsson;  Signe Normand;  Marcelo D. Nosetto;  Yann Nouvellon;  Martin A. Nuñ;  ez;  Romà;  Ogaya;  ;  ;  me Ogé;  e;  Joseph Okello;  Janusz Olejnik;  ;  rgen Eivind Olesen;  Ø;  ystein H. Opedal;  Simone Orsenigo;  Andrej Palaj;  Timo Pampuch;  Alexey V. Panov;  Meelis Pä;  rtel;  Ada Pastor;  Aní;  bal Pauchard;  Harald Pauli;  Marian Pavelka;  William D. Pearse;  Matthias Peichl;  Loï;  c Pellissier;  Rachel M. Penczykowski;  Josep Penuelas;  Matteo Petit Bon;  Alessandro Petraglia;  Shyam S. Phartyal;  Gareth K. Phoenix;  Casimiro Pio;  Andrea Pitacco;  Camille Pitteloud;  Roman Plichta;  Francesco Porro;  Miguel Portillo-Estrada;  ;  ;  me Poulenard;  Rafael Poyatos;  Anatoly S. Prokushkin;  Radoslaw Puchalka;  Mihai Puș;  caș;  Dajana Radujković;  Krystal Randall;  Amanda Ratier Backes;  Sabine Remmele;  Wolfram Remmers;  David Renault;  Anita C. Risch;  Christian Rixen;  Sharon A. Robinson;  Bjorn J. M. Robroek;  Adrian V. Rocha;  Christian Rossi;  Graziano Rossi;  Olivier Roupsard;  Alexey V. Rubtsov;  Patrick Saccone;  Clotilde Sagot;  Jhonatan Sallo Bravo;  Cinthya C. Santos;  Judith M. Sarneel;  Tobias Scharnweber;  Jonas Schmeddes;  Marius Schmidt;  Thomas Scholten;  Max Schuchardt;  Naomi Schwartz;  Tony Scott;  Julia Seeber;  Ana Cristina Segalin de Andrade;  Tim Seipel;  Philipp Semenchuk;  Rebecca A. Senior;  Josep M. Serra-Diaz;  Piotr Sewerniak;  Ankit Shekhar;  Nikita V. Sidenko;  Lukas Siebicke;  Laura Siegwart Collier;  Elizabeth Simpson;  David P. Siqueira;  Zuzana Sitková;  Johan Six;  Marko Smiljanic;  Stuart W. Smith;  Sarah Smith-Tripp;  Ben Somers;  Mia Vedel Sø;  rensen;  José;  Joã;  o L. L. Souza;  Bartolomeu Israel Souza;  Arildo Souza Dias;  Marko J. Spasojevic;  James D. M. Speed;  Fabien Spicher;  Angela Stanisci;  Klaus Steinbauer;  Rainer Steinbrecher;  Michael Steinwandter;  Michael Stemkovski;  ;  rg G. Stephan;  Christian Stiegler;  Stefan Stoll;  Martin Svá;  tek;  Miroslav Svoboda;  Torbern Tagesson;  Andrew J. Tanentzap;  Franziska Tanneberger;  Jean-Paul Theurillat;  Haydn J. D. Thomas;  Andrew D. Thomas;  Katja Tielbö;  rger;  Marcello Tomaselli;  Urs Albert Treier;  Mario Trouillier;  Pavel Dan Turtureanu;  Rosamond Tutton;  Vilna A. Tyystjä;  rvi;  Masahito Ueyama;  Karol Ujhá;  zy;  Mariana Ujhá;  zyová;  Domas Uogintas;  Anastasiya V. Urban;  Josef Urban;  Marek Urbaniak;  Tudor-Mihai Ursu;  Francesco Primo Vaccari;  Stijn Van de Vondel;  Liesbeth van den Brink;  Maarten Van Geel;  Vigdis Vandvik;  Pieter Vangansbeke;  Andrej Varlagin;  G. F. Veen;  Elmar Veenendaal;  Susanna E. Venn;  Hans Verbeeck;  Erik Verbrugggen;  Frank G. A. Verheijen;  Luis Villar;  Luca Vitale;  Pascal Vittoz;  Maria Vives-Ingla;  Jonathan von Oppen;  Josefine Walz;  Runxi Wang;  Yifeng Wang;  Robert G. Way;  Ronja E. M. Wedegä;  rtner;  Robert Weigel;  Jan Wild;  Matthew Wilkinson;  Martin Wilmking;  Lisa Wingate;  Manuela Winkler;  Sonja Wipf;  Georg Wohlfahrt;  Georgios Xenakis;  Yan Yang;  Zicheng Yu;  Kailiang Yu;  Florian Zellweger;  Jian Zhang;  Zhaochen Zhang;  Peng Zhao;  Klaudia Ziembliń;  ska;  Reiner Zimmermann;  Shengwei Zong;  Viacheslav I. Zyryanov;  Ivan Nijs;  Jonathan Lenoir
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A systematic global stocktake of evidence on human adaptation to climate change 科技报告
来源:Climate Analytics. 出版年: 2021
作者:  Lea Berrang-Ford;  A. R. Siders;  Alexandra Lesnikowski;  Alexandra Paige Fischer;  Max W. Callaghan;  Neal R. Haddaway;  Katharine J. Mach;  Malcolm Araos;  Mohammad Aminur Rahman Shah;  Mia Wannewitz;  Deepal Doshi;  Timo Leiter;  Custodio Matavel;  Justice Issah Musah-Surugu;  Gabrielle Wong-Parodi;  Philip Antwi-Agyei;  Idowu Ajibade;  Neha Chauhan;  William Kakenmaster;  Caitlin Grady;  Vasiliki I. Chalastani;  Kripa Jagannathan;  Eranga K. Galappaththi;  Asha Sitati;  Giulia Scarpa;  Edmond Totin;  Katy Davis;  Nikita Charles Hamilton;  Christine J. Kirchhoff;  Praveen Kumar;  Brian Pentz;  Nicholas P. Simpson;  Emily Theokritoff;  Delphine Deryng;  Diana Reckien;  Carol Zavaleta-Cortijo;  Nicola Ulibarri;  Alcade C. Segnon;  Vhalinavho Khavhagali;  Yuanyuan Shang;  Luckson Zvobgo;  Zinta Zommers;  Jiren Xu;  Portia Adade Williams;  Ivan Villaverde Canosa;  Nicole van Maanen;  Bianca van Bavel;  Maarten van Aalst;  Lynée L. Turek-Hankins;  Hasti Trivedi;  Christopher H. Trisos;  Adelle Thomas;  Shinny Thakur;  Sienna Templeman;  Lindsay C. Stringer;  Garry Sotnik;  Kathryn Dana Sjostrom;  Chandni Singh;  Mariella Z. Siña;  Roopam Shukla;  Jordi Sardans;  Eunice A. Salubi;  Lolita Shaila Safaee Chalkasra;  Raquel Ruiz-Díaz;  Carys Richards;  Pratik Pokharel;  Jan Petzold;  Josep Penuelas;  Julia Pelaez Avila;  Julia B. Pazmino Murillo;  Souha Ouni;  Jennifer Niemann;  Miriam Nielsen;  Mark New;  Patricia Nayna Schwerdtle;  Gabriela Nagle Alverio;  Cristina A. Mullin;  Joshua Mullenite;  Anuszka Mosurska;  Mike D. Morecroft;  Jan C. Minx;  Gina Maskell;  Abraham Marshall Nunbogu;  Alexandre K. Magnan;  Shuaib Lwasa;  Megan Lukas-Sithole;  Tabea Lissner;  Oliver Lilford;  Steven F. Koller;  Matthew Jurjonas;  Elphin Tom Joe;  Lam T. M. Huynh;  Avery Hill;  Rebecca R. Hernandez;  Greeshma Hegde;  Tom Hawxwell;  Sherilee Harper;  Alexandra Harden;  Marjolijn Haasnoot;  Elisabeth A. Gilmore;  Leah Gichuki;  Alyssa Gatt;  Matthias Garschagen;  James D. Ford;  Andrew Forbes;  Aidan D. Farrell;  Carolyn A. F. Enquist;  Susan Elliott;  Emily Duncan;  Erin Coughlan de Perez;  Shaugn Coggins;  Tara Chen;  Donovan Campbell;  Katherine E. Browne;  Kathryn J. Bowen;  Robbert Biesbroek;  Indra D. Bhatt;  Rachel Bezner Kerr;  Stephanie L. Barr;  Emily Baker;  Stephanie E. Austin;  Ingrid Arotoma-Rojas;  Christa Anderson;  Warda Ajaz;  Tanvi Agrawal;  Thelma Zulfawu Abu
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A warm jet in a cold ocean 期刊论文
Nature Communications, 2021
作者:  Jennifer A. MacKinnon;  Harper L. Simmons;  John Hargrove;  Jim Thomson;  Thomas Peacock;  Matthew H. Alford;  Benjamin I. Barton;  Samuel Boury;  Samuel D. Brenner;  Nicole Couto;  Seth L. Danielson;  Elizabeth C. Fine;  Hans C. Graber;  John Guthrie;  Joanne E. Hopkins;  Steven R. Jayne;  Chanhyung Jeon;  Thilo Klenz;  Craig M. Lee;  Yueng-Djern Lenn;  Andrew J. Lucas;  Bjö;  rn Lund;  Claire Mahaffey;  Louisa Norman;  Luc Rainville;  Madison M. Smith;  Leif N. Thomas;  Sinhué;  Torres-Valdé;  s;  Kevin R. Wood
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Ecological insights from three decades of animal movement tracking across a changing Arctic 期刊论文
Science, 2020
作者:  Sarah C. Davidson;  Gil Bohrer;  Eliezer Gurarie;  Scott LaPoint;  Peter J. Mahoney;  Natalie T. Boelman;  Jan U. H. Eitel;  Laura R. Prugh;  Lee A. Vierling;  Jyoti Jennewein;  Emma Grier;  Ophélie Couriot;  Allicia P. Kelly;  Arjan J. H. Meddens;  Ruth Y. Oliver;  Roland Kays;  Martin Wikelski;  Tomas Aarvak;  Joshua T. Ackerman;  José A. Alves;  Erin Bayne;  Bryan Bedrosian;  Jerrold L. Belant;  Andrew M. Berdahl;  Alicia M. Berlin;  Dominique Berteaux;  Joël Bêty;  Dmitrijs Boiko;  Travis L. Booms;  Bridget L. Borg;  Stan Boutin;  W. Sean Boyd;  Kane Brides;  Stephen Brown;  Victor N. Bulyuk;  Kurt K. Burnham;  David Cabot;  Michael Casazza;  Katherine Christie;  Erica H. Craig;  Shanti E. Davis;  Tracy Davison;  Dominic Demma;  Christopher R. DeSorbo;  Andrew Dixon;  Robert Domenech;  Götz Eichhorn;  Kyle Elliott;  Joseph R. Evenson;  Klaus-Michael Exo;  Steven H. Ferguson;  Wolfgang Fiedler;  Aaron Fisk;  Jérôme Fort;  Alastair Franke;  Mark R. Fuller;  Stefan Garthe;  Gilles Gauthier;  Grant Gilchrist;  Petr Glazov;  Carrie E. Gray;  David Grémillet;  Larry Griffin;  Michael T. Hallworth;  Autumn-Lynn Harrison;  Holly L. Hennin;  J. Mark Hipfner;  James Hodson;  James A. Johnson;  Kyle Joly;  Kimberly Jones;  Todd E. Katzner;  Jeff W. Kidd;  Elly C. Knight;  Michael N. Kochert;  Andrea Kölzsch;  Helmut Kruckenberg;  Benjamin J. Lagassé;  Sandra Lai;  Jean-François Lamarre;  Richard B. Lanctot;  Nicholas C. Larter;  A. David M. Latham;  Christopher J. Latty;  James P. Lawler;  Don-Jean Léandri-Breton;  Hansoo Lee;  Stephen B. Lewis;  Oliver P. Love;  Jesper Madsen;  Mark Maftei;  Mark L. Mallory;  Buck Mangipane;  Mikhail Y. Markovets;  Peter P. Marra;  Rebecca McGuire;  Carol L. McIntyre;  Emily A. McKinnon;  Tricia A. Miller;  Sander Moonen;  Tong Mu;  Gerhard J. D. M. Müskens;  Janet Ng;  Kerry L. Nicholson;  Ingar Jostein Øien;  Cory Overton;  Patricia A. Owen;  Allison Patterson;  Aevar Petersen;  Ivan Pokrovsky;  Luke L. Powell;  Rui Prieto;  Petra Quillfeldt;  Jennie Rausch;  Kelsey Russell;  Sarah T. Saalfeld;  Hans Schekkerman;  Joel A. Schmutz;  Philipp Schwemmer;  Dale R. Seip;  Adam Shreading;  Mónica A. Silva;  Brian W. Smith;  Fletcher Smith;  Jeff P. Smith;  Katherine R. S. Snell;  Aleksandr Sokolov;  Vasiliy Sokolov;  Diana V Solovyeva;  Mathew S. Sorum;  Grigori Tertitski;  J. F. Therrien;  Kasper Thorup;  T. Lee Tibbitts;  Ingrid Tulp;  Brian D. Uher-Koch;  Rob S. A. van Bemmelen;  Steven Van Wilgenburg;  Andrew L. Von Duyke;  Jesse L. Watson;  Bryan D. Watts;  Judy A. Williams;  Matthew T. Wilson;  James R. Wright;  Michael A. Yates;  David J. Yurkowski;  Ramūnas Žydelis;  Mark Hebblewhite
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Increasing contribution of peatlands to boreal evapotranspiration in a warming climate 期刊论文
NATURE CLIMATE CHANGE, 2020, 10 (6) : 555-+
作者:  Helbig, Manuel;  Waddington, James Michael;  Alekseychik, Pavel;  Amiro, Brian D.;  Aurela, Mika;  Barr, Alan G.;  Black, T. Andrew;  Blanken, Peter D.;  Carey, Sean K.;  Chen, Jiquan;  Chi, Jinshu;  Desai, Ankur R.;  Dunn, Allison;  Euskirchen, Eugenie S.;  Flanagan, Lawrence B.;  Forbrich, Inke;  Friborg, Thomas;  Grelle, Achim;  Harder, Silvie;  Heliasz, Michal;  Humphreys, Elyn R.;  Ikawa, Hiroki;  Isabelle, Pierre-Erik;  Iwata, Hiroki;  Jassal, Rachhpal;  Korkiakoski, Mika;  Kurbatova, Juliya;  Kutzbach, Lars;  Lindroth, Anders;  Lofvenius, Mikaell Ottosson;  Lohila, Annalea;  Mammarella, Ivan;  Marsh, Philip;  Maximov, Trofim;  Melton, Joe R.;  Moore, Paul A.;  Nadeau, Daniel F.;  Nicholls, Erin M.;  Nilsson, Mats B.;  Ohta, Takeshi;  Peichl, Matthias;  Petrone, Richard M.;  Petrov, Roman;  Prokushkin, Anatoly;  Quinton, William L.;  Reed, David E.;  Roulet, Nigel T.;  Runkle, Benjamin R. K.;  Sonnentag, Oliver;  Strachan, Ian B.;  Taillardat, Pierre;  Tuittila, Eeva-Stiina;  Tuovinen, Juha-Pekka;  Turner, Jessica;  Ueyama, Masahito;  Varlagin, Andrej;  Wilmking, Martin;  Wofsy, Steven C.;  Zyrianov, Vyacheslav
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Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease 期刊论文
NATURE, 2020, 577 (7788) : 103-+
作者:  Lalaoui, Najoua;  Boyden, Steven E.;  Oda, Hirotsugu;  Wood, Geryl M.;  Stone, Deborah L.;  Chau, Diep;  Liu, Lin;  Stoffels, Monique;  Kratina, Tobias;  Lawlor, Kate E.;  Zaal, Kristien J. M.;  Hoffmann, Patrycja M.;  Etemadi, Nima;  Shield-Artin, Kristy;  Biben, Christine;  Tsai, Wanxia Li;  Blake, Mary D.;  Kuehn, Hye Sun;  Yang, Dan;  Anderton, Holly;  Silke, Natasha;  Wachsmuth, Laurens;  Zheng, Lixin;  Moura, Natalia Sampaio;  Beck, David B.;  Gutierrez-Cruz, Gustavo;  Ombrello, Amanda K.;  Pinto-Patarroyo, Gineth P.;  Kueh, Andrew J.;  Herold, Marco J.;  Hall, Cathrine;  Wang, Hongying;  Chae, Jae Jin;  Dmitrieva, Natalia I.;  McKenzie, Mark;  Light, Amanda;  Barham, Beverly K.;  Jones, Anne;  Romeo, Tina M.;  Zhou, Qing;  Aksentijevich, Ivona;  Mullikin, James C.;  Gross, Andrew J.;  Shum, Anthony K.;  Hawkins, Edwin D.;  Masters, Seth L.;  Lenardo, Michael J.;  Boehm, Manfred;  Rosenzweig, Sergio D.;  Pasparakis, Manolis;  Voss, Anne K.;  Gadina, Massimo;  Kastner, Daniel L.;  Silke, John
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RIPK1 is a key regulator of innate immune signalling pathways. To ensure an optimal inflammatory response, RIPK1 is regulated post-translationally by well-characterized ubiquitylation and phosphorylation events, as well as by caspase-8-mediated cleavage1-7. The physiological relevance of this cleavage event remains unclear, although it is thought to inhibit activation of RIPK3 and necroptosis8. Here we show that the heterozygous missense mutations D324N, D324H and D324Y prevent caspase cleavage of RIPK1 in humans and result in an early-onset periodic fever syndrome and severe intermittent lymphadenopathy-a condition we term '  cleavage-resistant RIPK1-induced autoinflammatory syndrome'  . To define the mechanism for this disease, we generated a cleavage-resistant Ripk1(D325A) mutant mouse strain. Whereas Ripk1(-/-) mice died postnatally from systemic inflammation, Ripk1(D325A/D325A) mice died during embryogenesis. Embryonic lethality was completely prevented by the combined loss of Casp8 and Ripk3, but not by loss of Ripk3 or Mlkl alone. Loss of RIPK1 kinase activity also prevented Ripk1(D325A/D325A) embryonic lethality, although the mice died before weaning from multi-organ inflammation in a RIPK3-dependent manner. Consistently, Ripk1(D325A/D325A) and Ripk1(D325A/+) cells were hypersensitive to RIPK3-dependent TNF-induced apoptosis and necroptosis. Heterozygous Ripk1(D325A/+) mice were viable and grossly normal, but were hyper-responsive to inflammatory stimuli in vivo. Our results demonstrate the importance of caspase-mediated RIPK1 cleavage during embryonic development and show that caspase cleavage of RIPK1 not only inhibits necroptosis but also maintains inflammatory homeostasis throughout life.


  
Neuronal programming by microbiota regulates intestinal physiology 期刊论文
NATURE, 2020, 578 (7794) : 284-+
作者:  Li, Yilong;  Roberts, Nicola D.;  Wala, Jeremiah A.;  Shapira, Ofer;  Schumacher, Steven E.;  Kumar, Kiran;  Khurana, Ekta;  Waszak, Sebastian;  Korbel, Jan O.;  Haber, James E.;  Imielinski, Marcin;  Weischenfeldt, Joachim;  Beroukhim, Rameen;  Campbell, Peter J.;  Akdemir, Kadir C.;  Alvarez, Eva G.;  Baez-Ortega, Adrian;  Boutros, Paul C.;  Bowtell, David D. L.;  Brors, Benedikt;  Burns, Kathleen H.;  Chan, Kin;  Chen, Ken;  Cortes-Ciriano, Isidro;  Dueso-Barroso, Ana;  Dunford, Andrew J.;  Edwards, Paul A.;  Estivill, Xavier;  Etemadmoghadam, Dariush;  Feuerbach, Lars;  Fink, J. Lynn;  Frenkel-Morgenstern, Milana;  Garsed, Dale W.;  Gerstein, Mark;  Gordenin, Dmitry A.;  Haan, David;  Hess, Julian M.;  Hutter, Barbara;  Jones, David T. W.;  Ju, Young Seok;  Kazanov, Marat D.;  Klimczak, Leszek J.;  Koh, Youngil;  Lee, Eunjung Alice;  Lee, Jake June-Koo;  Lynch, Andy G.;  Macintyre, Geoff;  Markowetz, Florian;  Martincorena, Inigo;  Martinez-Fundichely, Alexander;  Meyerson, Matthew;  Miyano, Satoru;  Nakagawa, Hidewaki;  Navarro, Fabio C. P.;  Ossowski, Stephan;  Park, Peter J.;  Pearson, John, V;  Puiggros, Montserrat;  Rippe, Karsten;  Roberts, Steven A.;  Rodriguez-Martin, Bernardo;  Scully, Ralph;  Shackleton, Mark;  Sidiropoulos, Nikos;  Sieverling, Lina;  Stewart, Chip;  Torrents, David;  Tubio, Jose M. C.;  Villasante, Izar;  Waddell, Nicola;  Yang, Lixing;  Yao, Xiaotong;  Yoon, Sung-Soo;  Zamora, Jorge;  Zhang, Cheng-Zhong
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Neural control of the function of visceral organs is essential for homeostasis and health. Intestinal peristalsis is critical for digestive physiology and host defence, and is often dysregulated in gastrointestinal disorders(1). Luminal factors, such as diet and microbiota, regulate neurogenic programs of gut motility(2-5), but the underlying molecular mechanisms remain unclear. Here we show that the transcription factor aryl hydrocarbon receptor (AHR) functions as a biosensor in intestinal neural circuits, linking their functional output to the microbial environment of the gut lumen. Using nuclear RNA sequencing of mouse enteric neurons that represent distinct intestinal segments and microbiota states, we demonstrate that the intrinsic neural networks of the colon exhibit unique transcriptional profiles that are controlled by the combined effects of host genetic programs and microbial colonization. Microbiota-induced expression of AHR in neurons of the distal gastrointestinal tract enables these neurons to respond to the luminal environment and to induce expression of neuron-specific effector mechanisms. Neuron-specific deletion of Ahr, or constitutive overexpression of its negative feedback regulator CYP1A1, results in reduced peristaltic activity of the colon, similar to that observed in microbiota-depleted mice. Finally, expression of Ahr in the enteric neurons of mice treated with antibiotics partially restores intestinal motility. Together, our experiments identify AHR signalling in enteric neurons as a regulatory node that integrates the luminal environment with the physiological output of intestinal neural circuits to maintain gut homeostasis and health.


In a mouse model, aryl hydrocarbon receptor signalling in enteric neurons is revealed as a mechanism that helps to maintain gut homeostasis by integrating the luminal environment with the physiology of intestinal neural circuits.


  
Comparison of Airborne Reactive Nitrogen Measurements During WINTER 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2019
作者:  Sparks, Tamara L.;  Ebben, Carlena J.;  Wooldridge, Paul J.;  Lopez-Hilfiker, Felipe D.;  Lee, Ben H.;  Thornton, Joel A.;  McDuffie, Erin E.;  Fibiger, Dorothy L.;  Brown, Steven S.;  Montzka, Denise D.;  Weinheimer, Andrew J.;  Schroder, Jason C.;  Campuzano-Jost, Pedro;  Jimenez, Jose L.;  Cohen, Ronald C.
收藏  |  浏览/下载:32/0  |  提交时间:2019/11/27
Spatiotemporal immune zonation of the human kidney 期刊论文
SCIENCE, 2019, 365 (6460) : 1461-+
作者:  Stewart, Benjamin J.;  Ferdinand, John R.;  Young, Matthew D.;  Mitchell, Thomas J.;  Laudon, Kevin W.;  Riding, Alexandra M.;  Richoz, Nathan;  Frazer, Gordon L.;  Staniforth, Joy U. L.;  Braga, Felipe A. Vieira;  Botting, Rachel A.;  Popeseu, Dorin-Mirel;  Vento-Tormo, Baser;  Stephenson, Emily;  Cagan, Alex;  Farndon, Sarah J.;  Polanski, Krzysztof;  Efremova, Mirjana;  Green, Kile;  Velasco-Herrera, Martin Del Castillo;  Guzzo, Charlotte;  Collord, Grace;  Mamanova, Lira;  Aho, Tevita;  Armitage, James N.;  Riddick, Antony C. P.;  Mushtanq, Hnran;  Farrell, Stephen;  Rampling, Dyamte;  Nicholson, James;  Filby, Andrew;  Burge, Johanna;  Lisgo, Steven;  Lindsay, Susan;  Bajenoff, Marc;  Warren, Anne Y.;  Stewart, Grant D.;  Sebire, Neil;  Coleman, Nicholas;  Haniffa, Muzlifah;  Teichmann, Sarah A.;  Behjati, Sam;  Clatworthy, Menna R.
收藏  |  浏览/下载:66/0  |  提交时间:2019/11/27
Rates of Wintertime Atmospheric SO2 Oxidation based on Aircraft Observations during Clear-Sky Conditions over the Eastern United States 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2019, 124 (12) : 6630-6649
作者:  Green, Jaime R.;  Fiddler, Marc N.;  Holloway, John S.;  Fibiger, Dorothy L.;  McDuffie, Erin E.;  Campuzano-Jost, Pedro;  Schroder, Jason C.;  Jimenez, Jose L.;  Weinheimer, Andrew J.;  Aquino, Janine;  Montzka, D. D.;  Hall, Samuel R.;  Ullmann, Kirk;  Shah, Viral;  Jaegle, Lyatt;  Thornton, Joel A.;  Bililign, Solomon;  Brown, Steven S.
收藏  |  浏览/下载:38/0  |  提交时间:2019/11/26
SO2 oxidation  power plant emissions  urban emissions  wintertime rates