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Van Allen Probes Observations of Oxygen Ion Cyclotron Harmonic Waves: Statistical Study 期刊论文
Geophysical Research Letters, 2022
作者:  Yan Wang;  Kaijun Liu;  Kyungguk Min;  Fei Yao;  Ying Xiong;  Kun Cheng;  Yuqi Liu;  Xianming Zheng;  Jingyi Zhou
收藏  |  浏览/下载：59/0  |  提交时间：2022/02/23
The synergistic role of sulfuric acid, bases, and oxidized organics governing new‐particle formation in Beijing 期刊论文
Geophysical Research Letters, 2021
作者:  Chao Yan;  Rujing Yin;  Yiqun Lu;  Lubna Dada;  Dongsen Yang;  Yueyun Fu;  Jenni Kontkanen;  Chenjuan Deng;  Olga Garmash;  Jiaxin Ruan;  Rima Baalbaki;  Meredith Schervish;  Runlong Cai;  Matthew Bloss;  Tommy Chan;  Tianzeng Chen;  Qi Chen;  Xuemeng Chen;  Yan Chen;  Biwu Chu;  Kaspar Dä;  llenbach;  Benjamin Foreback;  Xucheng He;  Liine Heikkinen;  Tuija Jokinen;  Heikki Junninen;  Juha Kangasluoma;  Tom Kokkonen;  Mona Kurppa;  Katrianne Lehtipalo;  Haiyan Li;  Hui Li;  Xiaoxiao Li;  Yiliang Liu;  Qingxin Ma;  Pauli Paasonen;  Pekka Rantala;  Rosaria E. Pileci;  Anton Rusanen;  Nina Sarnela;  Pauli Simonen;  Shixian Wang;  Weigang Wang;  Yonghong Wang;  Mo Xue;  Gan Yang;  Lei Yao;  Ying Zhou;  Joni Kujansuu;  Tuukka Petä;  jä;  Wei Nie;  Yan Ma;  Maofa Ge;  Hong He;  Neil M. Donahue;  Douglas R. Worsnop;  Veli‐;  Matti Kerminen;  Lin Wang;  Yongchun Liu;  Jun Zheng;  Markku Kulmala;  Jingkun Jiang;  Federico Bianchi
收藏  |  浏览/下载：56/0  |  提交时间：2021/04/06
Structure of the RNA-dependent RNA polymerase from COVID-19 virus 期刊论文
Science, 2020
作者:  Yan Gao;  Liming Yan;  Yucen Huang;  Fengjiang Liu;  Yao Zhao;  Lin Cao;  Tao Wang;  Qianqian Sun;  Zhenhua Ming;  Lianqi Zhang;  Ji Ge;  Litao Zheng;  Ying Zhang;  Haofeng Wang;  Yan Zhu;  Chen Zhu;  Tianyu Hu;  Tian Hua;  Bing Zhang;  Xiuna Yang;  Jun Li;  Haitao Yang;  Zhijie Liu;  Wenqing Xu;  Luke W. Guddat;  Quan Wang;  Zhiyong Lou;  Zihe Rao
收藏  |  浏览/下载：46/0  |  提交时间：2020/05/20
Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation 期刊论文
NATURE, 2020, 580 (7803) : 391-+
作者:  Zhang, Zhibin;  Zhang, Ying;  Xia, Shiyu;  Kong, Qing;  Li, Shunying;  Liu, Xing;  Junqueira, Caroline;  Meza-Sosa, Karla F.;  Mok, Temy Mo Yin;  Ansara, James;  Sengupta, Satyaki;  Yao, Yandan;  Wu, Hao;  Lieberman, Judy
收藏  |  浏览/下载：30/0  |  提交时间：2020/07/03

The biological function of Z-DNA and Z-RNA, nucleic acid structures with a left-handed double helix, is poorly understood(1-3). Z-DNA-binding protein 1 (ZBP1  also known as DAI or DLM-1) is a nucleic acid sensor that contains two Z alpha domains that bind Z-DNA(4,5) and Z-RNA(6-8). ZBP1 mediates host defence against some viruses(6,7,9-14) by sensing viral nucleic acids(6,7,10). RIPK1 deficiency, or mutation of its RIP homotypic interaction motif (RHIM), triggers ZBP1-dependent necroptosis and inflammation in mice(15,16). However, the mechanisms that induce ZBP1 activation in the absence of viral infection remain unknown. Here we show that Z alpha-dependent sensing of endogenous ligands induces ZBP1-mediated perinatal lethality in mice expressing RIPK1 with mutated RHIM (Ripk1(mR/mR)), skin inflammation in mice with epidermis-specific RIPK1 deficiency (RIPK1(E-KO)) and colitis in mice with intestinal epithelial-specific FADD deficiency (FADD(IEC-KO)). Consistently, functional Z alpha domains were required for ZBP1-induced necroptosis in fibroblasts that were treated with caspase inhibitors or express RIPK1 with mutated RHIM. Inhibition of nuclear export triggered the Z alpha-dependent activation of RIPK3 in the nucleus resulting in cell death, which suggests that ZBP1 may recognize nuclear Z-form nucleic acids. We found that ZBP1 constitutively bound cellular double-stranded RNA in a Z alpha-dependent manner. Complementary reads derived from endogenous retroelements were detected in epidermal RNA, which suggests that double-stranded RNA derived from these retroelements may act as a Z alpha-domain ligand that triggers the activation of ZBP1. Collectively, our results provide evidence that the sensing of endogenous Z-form nucleic acids by ZBP1 triggers RIPK3-dependent necroptosis and inflammation, which could underlie the development of chronic inflammatory conditions-particularly in individuals with mutations in RIPK1 and CASP8(17-20).


  
Effects of western Pacific intraseasonal convection on surface air temperature anomalies over North America 期刊论文
INTERNATIONAL JOURNAL OF CLIMATOLOGY, 2019
作者:  Yang, Ying;  Zhu, Zhiwei;  Li, Tim;  Yao, Mengying
收藏  |  浏览/下载：21/0  |  提交时间：2020/02/17
convection  mid-to-high latitude Rossby wave train  North American surface air temperature  western Pacific intraseasonal oscillation  
Palmitoylation of NOD1 and NOD2 is required for bacterial sensing 期刊论文
SCIENCE, 2019, 366 (6464) : 460-+
作者:  Lu, Yan;  Zheng, Yuping;  Coyaud, Etienne;  Zhang, Chao;  Selvabaskaran, Apiraam;  Yu, Yuyun;  Xu, Zizhen;  Weng, Xialian;  Chen, Ji Shun;  Meng, Ying;  Warner, Neil;  Cheng, Xiawei;  Liu, Yangyang;  Yao, Bingpeng;  Hu, Hu;  Xia, Zonping;  Muise, Aleixo M.;  Klip, Amira;  Brumell, John H.;  Girardin, Stephen E.;  Ying, Songmin;  Fairn, Gregory D.;  Raught, Brian;  Sun, Qiming;  Neculai, Dante
收藏  |  浏览/下载：36/0  |  提交时间：2019/11/27
Summertime aerosol volatility measurements in Beijing, China 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2019, 19 (15)
作者:  Xu, Weiqi;  Xie, Conghui;  Karnezi, Eleni;  Zhang, Qi;  Wang, Junfeng;  Pandis, Spyros N.;  Ge, Xinlei;  Zhang, Jingwei;  An, Junling;  Wang, Qingqing;  Zhao, Jian;  Du, Wei;  Qiu, Yanmei;  Zhou, Wei;  He, Yao;  Li, Ying;  Li, Jie;  Fu, Pingqing;  Wang, Zifa;  Worsnop, Douglas R.;  Sun, Yele
收藏  |  浏览/下载：33/0  |  提交时间：2019/11/27
Resetting histone modifications during human parental-to-zygotic transition 期刊论文
SCIENCE, 2019, 365 (6451) : 353-+
作者:  Xia, Weikun;  Xu, Jiawei;  Yu, Guang;  Yao, Guidong;  Xu, Kai;  Ma, Xueshan;  Zhang, Nan;  Liu, Bofeng;  Li, Tong;  Lin, Zili;  Chen, Xia;  Li, Lijia;  Wang, Qiujun;  Shi, Dayuan;  Shi, Senlin;  Zhang, Yile;  Song, Wenyan;  Jin, Haixia;  Hu, Linli;  Bu, Zhiqin;  Wang, Yang;  Na, Jie;  Xie, Wei;  Sun, Ying-Pu
收藏  |  浏览/下载：36/0  |  提交时间：2019/11/27
Targeting a ceramide double bond improves insulin resistance and hepatic steatosis 期刊论文
SCIENCE, 2019, 365 (6451) : 386-+
作者:  Chaurasia, Bhagirath;  Tippetts, Trevor S.;  Monibas, Rafael Mayoral;  Liu, Jinqi;  Li, Ying;  Wang, Liping;  Wilkerson, Joseph L.;  Sweeney, C. Rufus;  Pereira, Renato Felipe;  Sumida, Doris Hissako;  Maschek, J. Alan;  Cox, James E.;  Kaddai, Vincent;  Lancaster, Graeme Iain;  Siddique, Monowarul Mobin;  Poss, Annelise;  Pearson, Mackenzie;  Satapati, Santhosh;  Zhou, Heather;  McLaren, David G.;  Previs, Stephen F.;  Chen, Ying;  Qian, Ying;  Petrov, Aleksandr;  Wu, Margaret;  Shen, Xiaolan;  Yao, Jun;  Nunes, Christian N.;  Howard, Andrew D.;  Wang, Liangsu;  Erion, Mark D.;  Rutter, Jared;  Holland, William L.;  Kelley, David E.;  Summers, Scott A.
收藏  |  浏览/下载：36/0  |  提交时间：2019/11/27
Tropical Indian Ocean warming contributions to China winter climate trends since 1960 期刊论文
CLIMATE DYNAMICS, 2018, 51: 2965-2987
作者:  Wu, Qigang;  Yao, Yonghong;  Liu, Shizuo;  Cao, DanDan;  Cheng, Luyao;  Hu, Haibo;  Sun, Leng;  Yao, Ying;  Yang, Zhiqi;  Gao, Xuxu;  Schroeder, Steven R.
收藏  |  浏览/下载：27/0  |  提交时间：2019/04/09
Tropical Indian Ocean  Sea surface temperature  AMIP  Climate trends  East Asian Winter Monsoon  Precipitation  China