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美科学院为改善美国轻型车辆燃油经济性提出建议 快报文章
气候变化快报,2021年第8期
作者:  董利苹
Microsoft Word(16Kb)  |  收藏  |  浏览/下载:439/0  |  提交时间:2021/04/20
Improving  Light-duty Vehicle  Fuel Economy  
Preparation of cyclohexene isotopologues and stereoisotopomers from benzene 期刊论文
NATURE, 2020, 581 (7808) : 288-+
作者:  Shimazaki, Yuya;  Schwartz, Ido;  Watanabe, Kenji;  Taniguchi, Takashi;  Kroner, Martin;  Imamoglu, Atac
收藏  |  浏览/下载:33/0  |  提交时间:2020/07/03

The hydrogen isotopes deuterium (D) and tritium (T) have become essential tools in chemistry, biology and medicine(1). Beyond their widespread use in spectroscopy, mass spectrometry and mechanistic and pharmacokinetic studies, there has been considerable interest in incorporating deuterium into drug molecules(1). Deutetrabenazine, a deuterated drug that is promising for the treatment of Huntington'  s disease(2), was recently approved by the United States'  Food and Drug Administration. The deuterium kinetic isotope effect, which compares the rate of a chemical reaction for a compound with that for its deuterated counterpart, can be substantial(1,3,4). The strategic replacement of hydrogen with deuterium can affect both the rate of metabolism and the distribution of metabolites for a compound(5), improving the efficacy and safety of a drug. The pharmacokinetics of a deuterated compound depends on the location(s) of deuterium. Although methods are available for deuterium incorporation at both early and late stages of the synthesis of a drug(6,7), these processes are often unselective and the stereoisotopic purity can be difficult to measure(7,8). Here we describe the preparation of stereoselectively deuterated building blocks for pharmaceutical research. As a proof of concept, we demonstrate a four-step conversion of benzene to cyclohexene with varying degrees of deuterium incorporation, via binding to a tungsten complex. Using different combinations of deuterated and proteated acid and hydride reagents, the deuterated positions on the cyclohexene ring can be controlled precisely. In total, 52 unique stereoisotopomers of cyclohexene are available, in the form of ten different isotopologues. This concept can be extended to prepare discrete stereoisotopomers of functionalized cyclohexenes. Such systematic methods for the preparation of pharmacologically active compounds as discrete stereoisotopomers could improve the pharmacological and toxicological properties of drugs and provide mechanistic information related to their distribution and metabolism in the body.


Cyclohexene isotopologues and stereoisotopomers with varying degrees of deuteration are formed by binding a tungsten complex to benzene, which facilitates the selective incorporation of deuterium into any position on the ring.


  
Coupling of Indo-Pacific climate variability over the last millennium 期刊论文
NATURE, 2020
作者:  Chow, Brian W.;  Nunez, Vicente;  Kaplan, Luke;  Granger, Adam J.;  Bistrong, Karina;  Zucker, Hannah L.;  Kumar, Payal;  Sabatini, Bernardo L.;  Gu, Chenghua
收藏  |  浏览/下载:57/0  |  提交时间:2020/05/13

Coral records indicate that the variability of the Indian Ocean Dipole over the last millennium is strongly coupled to variability in the El Nino/Southern Oscillation and that recent extremes are unusual but not unprecedented.


The Indian Ocean Dipole (IOD) affects climate and rainfall across the world, and most severely in nations surrounding the Indian Ocean(1-4). The frequency and intensity of positive IOD events increased during the twentieth century(5) and may continue to intensify in a warming world(6). However, confidence in predictions of future IOD change is limited by known biases in IOD models(7) and the lack of information on natural IOD variability before anthropogenic climate change. Here we use precisely dated and highly resolved coral records from the eastern equatorial Indian Ocean, where the signature of IOD variability is strong and unambiguous, to produce a semi-continuous reconstruction of IOD variability that covers five centuries of the last millennium. Our reconstruction demonstrates that extreme positive IOD events were rare before 1960. However, the most extreme event on record (1997) is not unprecedented, because at least one event that was approximately 27 to 42 per cent larger occurred naturally during the seventeenth century. We further show that a persistent, tight coupling existed between the variability of the IOD and the El Nino/Southern Oscillation during the last millennium. Indo-Pacific coupling was characterized by weak interannual variability before approximately 1590, which probably altered teleconnection patterns, and by anomalously strong variability during the seventeenth century, which was associated with societal upheaval in tropical Asia. A tendency towards clustering of positive IOD events is evident in our reconstruction, which-together with the identification of extreme IOD variability and persistent tropical Indo-Pacific climate coupling-may have implications for improving seasonal and decadal predictions and managing the climate risks of future IOD variability.


  
Cell stress in cortical organoids impairs molecular subtype specification 期刊论文
NATURE, 2020, 578 (7793) : 142-+
作者:  Chen, Tao;  van Gelder, Jeroen;  van de Ven, Bram;  Amitonov, Sergey V.;  de Wilde, Bram;  Euler, Hans-Christian Ruiz;  Broersma, Hajo;  Bobbert, Peter A.;  Zwanenburg, Floris A.;  van der Wiel, Wilfred G.
收藏  |  浏览/下载:31/0  |  提交时间:2020/07/03

Cortical organoids are self-organizing three-dimensional cultures that model features of the developing human cerebral cortex(1,2). However, the fidelity of organoid models remains unclear(3-5). Here we analyse the transcriptomes of individual primary human cortical cells from different developmental periods and cortical areas. We find that cortical development is characterized by progenitor maturation trajectories, the emergence of diverse cell subtypes and areal specification of newborn neurons. By contrast, organoids contain broad cell classes, but do not recapitulate distinct cellular subtype identities and appropriate progenitor maturation. Although the molecular signatures of cortical areas emerge in organoid neurons, they are not spatially segregated. Organoids also ectopically activate cellular stress pathways, which impairs cell-type specification. However, organoid stress and subtype defects are alleviated by transplantation into the mouse cortex. Together, these datasets and analytical tools provide a framework for evaluating and improving the accuracy of cortical organoids as models of human brain development.


Single-cell RNA sequencing clarifies the development and specification of neurons in the human cortex and shows that cell stress impairs this process in cortical organoids.


  
Environmental licensing challenges for the implementation of photovoltaic solar energy projects in Brazil 期刊论文
ENERGY POLICY, 2019, 132: 1143-1154
作者:  Hoffmann, Alessandra Schwertner;  de Carvalho, Gabriel Henriques;  Felix Cardoso, Ricardo Abranches, Jr.
收藏  |  浏览/下载:19/0  |  提交时间:2019/11/27
Environmental aspects  Assessment criteria  Improving the permitting process  
Shining a Light on Electricity Governance 科技报告
来源:World Resources Institute (WRI). 出版年: 2013
作者:  Bharath Jairaj
收藏  |  浏览/下载:6/0  |  提交时间:2019/04/05
electricity  improving electricity governance  
2011 Global Forecast 科技报告
来源:Center for Strategic and International Studies (CSIS). 出版年: 2011
作者:  Craig Cohen;  Josiane Gabel
收藏  |  浏览/下载:15/0  |  提交时间:2019/04/05
2011 Global Security Forum  Africa Program  Africa’s Changing Economic Landscape  Americas Program  Analysis  Archived Project and Reports  Arctic  Asia Division  Central Asia  China Reality Check  Climate Change and Environmental Impacts  Counterterrorism and International Threats  Cybersecurity and Technology  DHS and the Homeland Security Enterprise  Defense Strategy and Capabilities  Defense and Security  Defense-Industrial Initiatives Group  Economics  Energy and National Security Program  Energy and Geopolitics  Energy and Sustainability  Europe Program  Evolving Partnership between DoD & Industry  Family Planning  Maternal and Child Health  and Immunizations  Freeman Chair in China Studies  Geopolitics and International Security  Global Aging Initiative  Global Food Security Project  Global Health  Global Health Policy Center  Homeland Security and Counterterrorism Program  Human Development  Human Rights Initiative  Human Rights and Counterterrorism  Impact of Budget Constraints  Improving Acquisition  International Development  International Security Program  Japan Chair  Kissinger Chair  Korea Chair  Leveraging Innovation  Markets  Trends  and Outlooks  Middle East Program  Middle East Program Publications  New Defense Approaches Project  New European Democracies Project  Program on Crisis  Conflict  and Cooperation (C3)  Project on Prosperity and Development  Proliferation Prevention Program  Publications  Regional Studies  Russia and Eurasia Program  Scholl Chair in International Business  Security and Conflict  Southeast Asia Program  Strategic Technologies Program  Trade and International Business  Transatlantic Relations  Transatlantic Security  Transnational Threats Project  Turkey Project  U.S. Development Policy  U.S. Policy towards Africa  Wadhwani Chair in U.S.-India Policy Studies