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An intestinal zinc sensor regulates food intake and developmental growth 期刊论文
NATURE, 2020, 580 (7802) : 263-+
作者:  Wu, Thomas D.;  39;Gorman, William E.
收藏  |  浏览/下载:31/0  |  提交时间:2020/07/03

Hodor, an intestinal zinc-gated chloride channel, controls systemic growth in Drosophila by promoting food intake and by modulating Tor signalling and lysosomal homeostasis within enterocytes.


In cells, organs and whole organisms, nutrient sensing is key to maintaining homeostasis and adapting to a fluctuating environment(1). In many animals, nutrient sensors are found within the enteroendocrine cells of the digestive system  however, less is known about nutrient sensing in their cellular siblings, the absorptive enterocytes(1). Here we use a genetic screen in Drosophila melanogaster to identify Hodor, an ionotropic receptor in enterocytes that sustains larval development, particularly in nutrient-scarce conditions. Experiments in Xenopus oocytes and flies indicate that Hodor is a pH-sensitive, zinc-gated chloride channel that mediates a previously unrecognized dietary preference for zinc. Hodor controls systemic growth from a subset of enterocytes-interstitial cells-by promoting food intake and insulin/IGF signalling. Although Hodor sustains gut luminal acidity and restrains microbial loads, its effect on systemic growth results from the modulation of Tor signalling and lysosomal homeostasis within interstitial cells. Hodor-like genes are insect-specific, and may represent targets for the control of disease vectors. Indeed, CRISPR-Cas9 genome editing revealed that the single hodor orthologue in Anopheles gambiae is an essential gene. Our findings highlight the need to consider the instructive contributions of metals-and, more generally, micronutrients-to energy homeostasis.


  
More salt, please: global patterns, responses and impacts of foliar sodium in grasslands 期刊论文
ECOLOGY LETTERS, 2019, 22 (7) : 1136-1144
作者:  Borer, E. T.;  Lind, E. M.;  Firn, J.;  Seabloom, E. W.;  Anderson, T. M.;  Bakker, E. S.;  Biederman, L.;  La Pierre, K. J.;  MacDougall, A. S.;  Moore, J. L.;  Risch, A. C.;  Schutz, M.;  Stevens, C. J.
收藏  |  浏览/下载:20/0  |  提交时间:2019/11/27
Biogeography  herbivory  nitrogen  phosphorus  potassium  micronutrients  Nutrient Network (NutNet)  plant taxonomy  
Moving beyond calories and protein: Micronutrient assessment of UK diets and land use 期刊论文
GLOBAL ENVIRONMENTAL CHANGE-HUMAN AND POLICY DIMENSIONS, 2018, 52: 108-116
作者:  de Ruiter, Henri;  Macdiarmid, Jennie I.;  Matthews, Robin B.;  Smith, Pete
收藏  |  浏览/下载:17/0  |  提交时间:2019/04/09
Food security  Land use efficiency  Micronutrients  Agricultural metrics  Sustainability  
Bottom RedOx Model (BROM) general description and application for seasonal anoxia simulations 科技报告
来源:Center for International Climate and Environmental Research-Oslo (CICERO). 出版年: 2014
作者:  Yakushev, Evgeny;  Protsenko, E.A.;  Bruggeman, J.
收藏  |  浏览/下载:11/0  |  提交时间:2019/04/05
VDP::Matematikk og naturvitenskap: 400  VDP::Mathematics and natural scienses: 400  Biokjemi / Biochemistry  Mikronutrienter / mikronæringsstoffer / Micronutrients  Oseanografi / Oceanography  Redoksprosesser / Redox processes