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IL-17a promotes sociability in mouse models of neurodevelopmental disorders 期刊论文
NATURE, 2020, 577 (7789) : 249-+
作者:  Reed, Michael Douglas;  Yim, Yeong Shin;  Wimmer, Ralf D.;  Kim, Hyunju;  Ryu, Changhyeon;  Welch, Gwyneth Margaret;  Andina, Matias;  King, Hunter Oren;  Waisman, Ari;  Halassa, Michael M.;  Huh, Jun R.;  Choi, Gloria B.
收藏  |  浏览/下载:28/0  |  提交时间:2020/07/03

A subset of children with autism spectrum disorder appear to show an improvement in their behavioural symptoms during the course of a fever, a sign of systemic inflammation(1,2). Here we elucidate the molecular and neural mechanisms that underlie the beneficial effects of inflammation on social behaviour deficits in mice. We compared an environmental model of neurodevelopmental disorders in which mice were exposed to maternal immune activation (MIA) during embryogenesis(3,4) with mouse models that are genetically deficient for contactin-associated protein-like 2 (Cntnap2)(5), fragile X mental retardation-1 (Fmr1)(6) or Sh3 and multiple ankyrin repeat domains 3 (Shank3)(7). We establish that the social behaviour deficits in offspring exposed to MIA can be temporarily rescued by the inflammatory response elicited by the administration of lipopolysaccharide (LPS). This behavioural rescue was accompanied by a reduction in neuronal activity in the primary somatosensory cortex dysgranular zone (S1DZ), the hyperactivity of which was previously implicated in the manifestation of behavioural phenotypes associated with offspring exposed to MIA(8). By contrast, we did not observe an LPS-induced rescue of social deficits in the monogenic models. We demonstrate that the differences in responsiveness to the LPS treatment between the MIA and the monogenic models emerge from differences in the levels of cytokine production. LPS treatment in monogenic mutant mice did not induce amounts of interleukin-17a (IL-17a) comparable to those induced in MIA offspring  bypassing this difference by directly delivering IL-17a into S1DZ was sufficient to promote sociability in monogenic mutant mice as well as in MIA offspring. Conversely, abrogating the expression of IL-17 receptor subunit a (IL-17Ra) in the neurons of the S1DZ eliminated the ability of LPS to reverse the sociability phenotypes in MIA offspring. Our data support a neuroimmune mechanism that underlies neurodevelopmental disorders in which the production of IL-17a during inflammation can ameliorate the expression of social behaviour deficits by directly affecting neuronal activity in the central nervous system.


  
Global-scale human impact on delta morphology has led to net land area gain 期刊论文
NATURE, 2020, 577 (7791) : 514-+
作者:  Nienhuis, J. H.;  Ashton, A. D.;  Edmonds, D. A.;  Hoitink, A. J. F.;  Kettner, A. J.;  Rowland, J. C.;  Tornqvist, T. E.
收藏  |  浏览/下载:39/0  |  提交时间:2020/05/13

River deltas rank among the most economically and ecologically valuable environments on Earth. Even in the absence of sea-level rise, deltas are increasingly vulnerable to coastal hazards as declining sediment supply and climate change alter their sediment budget, affecting delta morphology and possibly leading to erosion(1-3). However, the relationship between deltaic sediment budgets, oceanographic forces of waves and tides, and delta morphology has remained poorly quantified. Here we show how the morphology of about 11,000 coastal deltas worldwide, ranging from small bayhead deltas to mega-deltas, has been affected by river damming and deforestation. We introduce a model that shows that present-day delta morphology varies across a continuum between wave (about 80 per cent), tide (around 10 per cent) and river (about 10 per cent) dominance, but that most large deltas are tide- and river-dominated. Over the past 30 years, despite sea-level rise, deltas globally have experienced a net land gain of 54 +/- 12 square kilometres per year (2 standard deviations), with the largest 1 per cent of deltas being responsible for 30 per cent of all net land area gains. Humans are a considerable driver of these net land gains-25 per cent of delta growth can be attributed to deforestation-induced increases in fluvial sediment supply. Yet for nearly 1,000 deltas, river damming(4) has resulted in a severe (more than 50 per cent) reduction in anthropogenic sediment flux, forcing a collective loss of 12 +/- 3.5 square kilometres per year (2 standard deviations) of deltaic land. Not all deltas lose land in response to river damming: deltas transitioning towards tide dominance are currently gaining land, probably through channel infilling. With expected accelerated sea-level rise(5), however, recent land gains are unlikely to be sustained throughout the twenty-first century. Understanding the redistribution of sediments by waves and tides will be critical for successfully predicting human-driven change to deltas, both locally and globally.


A global study of river deltas shows a net increase in delta area by about 54 km(2) yr(-1) over the past 30 years, in part due to deforestation-induced sediment delivery increase.


  
Exposure to green areas: Modelling health benefits in a context of study heterogeneity 期刊论文
ECOLOGICAL ECONOMICS, 2020, 167
作者:  Chiabai, Aline;  Quiroga, Sonia;  Martinez-Juarez, Pablo;  Suarez, Cristina;  Garcia de Jalon, Silvestre;  Taylor, Tim
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/02
Green areas  Health risk reduction  Heckman Selection Model  Contextual factors  Health inequalities  Adaptation  
Spatioseasonal Variations of Atmospheric Ammonia Concentrations Over the United States: Comprehensive Model-Observation Comparison 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2019, 124 (12) : 6571-6582
作者:  Nair, Arshad Arjunan;  Yu, Fangqun;  Luo, Gan
收藏  |  浏览/下载:20/0  |  提交时间:2019/11/26
atmospheric ammonia  spatiotemporal variation  model-observation comparison  new particle formation  emission reduction  ecosystem  
Realizing China's goals on energy saving and pollution reduction: Industrial structure multi-objective optimization approach 期刊论文
ENERGY POLICY, 2018, 122: 300-312
作者:  Yu, Shiwei;  Zheng, Shuhong;  Zhang, Xuejiao;  Gong, Chengzhu;  Cheng, Jinhua
收藏  |  浏览/下载:18/0  |  提交时间:2019/04/09
Energy saving and pollutant reduction  Industrial restructuring  Dynamic input-output model  Multi-objective optimization  Reduction goals  
Implications of delaying transport decarbonisation in the EU: A systems analysis using the PRIMES model 期刊论文
ENERGY POLICY, 2018, 121: 48-60
作者:  Siskos, Pelopidas;  Zazias, Georgios;  Petropoulos, Apostolos;  Evangelopoulou, Stavroula;  Capros, Pantelis
收藏  |  浏览/下载:13/0  |  提交时间:2019/04/09
Transport sector decarbonisation  Power generation and transport systems analysis  Market and policy failure  Model based assessment  GHG emission reduction  
Advancing Graph-Based Algorithms for Predicting Flow and Transport in Fractured Rock 期刊论文
WATER RESOURCES RESEARCH, 2018, 54 (9) : 6085-6099
作者:  Viswanathan, H. S.;  39;Malley, D.
收藏  |  浏览/下载:18/0  |  提交时间:2019/04/09
discrete fracture networks  graph theory  subsurface flow and transport  fractured media  model reduction  multiscale modeling  
Assessing energy consumption, CO2 and pollutant emissions and health benefits from China's transport sector through 2050 期刊论文
ENERGY POLICY, 2018, 116: 382-396
作者:  Liu, Lei;  Wang, Ke;  Wang, Shanshan;  Zhang, Ruiqin;  Tang, Xiaoyan
收藏  |  浏览/下载:16/0  |  提交时间:2019/04/09
Energy demand  Emission reduction  LEAP model  Scenario analysis  Intake fraction method  Health benefits  
Carbon allowance auction design of China's emissions trading scheme: A multi-agent-based approach 期刊论文
ENERGY POLICY, 2017, 102
作者:  Tang, Ling;  Wu, Jiaqian;  Yu, Lean;  Bao, Qin
收藏  |  浏览/下载:13/0  |  提交时间:2019/04/09
Emissions trading scheme (ETS)  Carbon auction market  Allowance allocation  Emissions reduction  Multi-agent-based model  
Final Technical Report for DOE Award SC0006616 科技报告
来源:US Department of Energy (DOE). 出版年: 2015
作者:  Robertson, Andrew
收藏  |  浏览/下载:12/0  |  提交时间:2019/04/05
Centennial proxy records  Data-based closure models  Empirical model reduction (EMR)  Indus River discharge  Low-frequency variability (LFV)  Madden-Julian Oscillation (MJO)  Palmer Drought Severity Index (PDSI)  Singular-spectrum analysis (SSA)  Stochast