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Field-resolved infrared spectroscopy of biological systems 期刊论文
NATURE, 2020, 577 (7788) : 52-+
作者:  Pupeza, Ioachim;  Huber, Marinus;  Trubetskov, Michael;  Schweinberger, Wolfgang;  Hussain, Syed A.;  Hofer, Christina;  Fritsch, Kilian;  Poetzlberger, Markus;  Vamos, Lenard;  Fill, Ernst;  Amotchkina, Tatiana;  Kepesidis, Kosmas V.;  Apolonski, Alexander;  Karpowicz, Nicholas;  Pervak, Vladimir;  Pronin, Oleg;  Fleischmann, Frank;  Azzeer, Abdallah;  Zigman, Mihaela;  Krausz, Ferenc
收藏  |  浏览/下载:32/0  |  提交时间:2020/07/03

The proper functioning of living systems and physiological phenotypes depends on molecular composition. Yet simultaneous quantitative detection of a wide variety of molecules remains a challenge(1-8). Here we show how broadband optical coherence opens up opportunities for fingerprinting complex molecular ensembles in their natural environment. Vibrationally excited molecules emit a coherent electric field following few-cycle infrared laser excitation(9-12), and this field is specific to the sample'  s molecular composition. Employing electro-optic sampling(10,12-15), we directly measure this global molecular fingerprint down to field strengths 10(7) times weaker than that of the excitation. This enables transillumination of intact living systems with thicknesses of the order of 0.1 millimetres, permitting broadband infrared spectroscopic probing of human cells and plant leaves. In a proof-of-concept analysis of human blood serum, temporal isolation of the infrared electric-field fingerprint from its excitation along with its sampling with attosecond timing precision results in detection sensitivity of submicrograms per millilitre of blood serum and a detectable dynamic range of molecular concentration exceeding 10(5). This technique promises improved molecular sensitivity and molecular coverage for probing complex, real-world biological and medical settings.


  
Construction of a human cell landscape at single-cell level 期刊论文
NATURE, 2020, 581 (7808) : 303-+
作者:  Han, Yan;  Reyes, Alexis A.;  Malik, Sara;  He, Yuan
收藏  |  浏览/下载:20/0  |  提交时间:2020/07/03

Single-cell analysis is a valuable tool for dissecting cellular heterogeneity in complex systems(1). However, a comprehensive single-cell atlas has not been achieved for humans. Here we use single-cell mRNA sequencing to determine the cell-type composition of all major human organs and construct a scheme for the human cell landscape (HCL). We have uncovered a single-cell hierarchy for many tissues that have not been well characterized. We established a '  single-cell HCL analysis'  pipeline that helps to define human cell identity. Finally, we performed a single-cell comparative analysis of landscapes from human and mouse to identify conserved genetic networks. We found that stem and progenitor cells exhibit strong transcriptomic stochasticity, whereas differentiated cells are more distinct. Our results provide a useful resource for the study of human biology.


Single-cell RNA sequencing is used to generate a dataset covering all major human organs in both adult and fetal stages, enabling comparison with similar datasets for mouse tissues.


  
Observations of grain-boundary phase transformations in an elemental metal 期刊论文
NATURE, 2020, 579 (7799) : 375-+
作者:  Valente, Luis;  Phillimore, Albert B.;  Melo, Martim;  Warren, Ben H.;  Clegg, Sonya M.;  Havenstein, Katja;  Tiedemann, Ralph;  Illera, Juan Carlos;  Thebaud, Christophe;  Aschenbach, Tina;  Etienne, Rampal S.
收藏  |  浏览/下载:30/0  |  提交时间:2020/07/03

Atomic-resolution observations combined with simulations show that grain boundaries within elemental copper undergo temperature-induced solid-state phase transformation to different structures  grain boundary phases can also coexist and are kinetically trapped structures.


The theory of grain boundary (the interface between crystallites, GB) structure has a long history(1) and the concept of GBs undergoing phase transformations was proposed 50 years ago(2,3). The underlying assumption was that multiple stable and metastable states exist for different GB orientations(4-6). The terminology '  complexion'  was recently proposed to distinguish between interfacial states that differ in any equilibrium thermodynamic property(7). Different types of complexion and transitions between complexions have been characterized, mostly in binary or multicomponent systems(8-19). Simulations have provided insight into the phase behaviour of interfaces and shown that GB transitions can occur in many material systems(20-24). However, the direct experimental observation and transformation kinetics of GBs in an elemental metal have remained elusive. Here we demonstrate atomic-scale GB phase coexistence and transformations at symmetric and asymmetric [111 over bar ] tilt GBs in elemental copper. Atomic-resolution imaging reveals the coexistence of two different structures at sigma 19b GBs (where sigma 19 is the density of coincident sites and b is a GB variant), in agreement with evolutionary GB structure search and clustering analysis(21,25,26). We also use finite-temperature molecular dynamics simulations to explore the coexistence and transformation kinetics of these GB phases. Our results demonstrate how GB phases can be kinetically trapped, enabling atomic-scale room-temperature observations. Our work paves the way for atomic-scale in situ studies of metallic GB phase transformations, which were previously detected only indirectly(9,15,27-29), through their influence on abnormal grain growth, non-Arrhenius-type diffusion or liquid metal embrittlement.


  
Dualities and non-Abelian mechanics 期刊论文
NATURE, 2020, 577 (7792) : 636-+
作者:  Song, Xinyang;  Sun, Ximei;  Oh, Sungwhan F.;  Wu, Meng;  Zhang, Yanbo;  Zheng, Wen;  Geva-Zatorsky, Naama;  Jupp, Ray;  Mathis, Diane;  Benoist, Christophe;  Kasper, Dennis L.
收藏  |  浏览/下载:29/0  |  提交时间:2020/07/03

Dualities-mathematical mappings between different systems-can act as hidden symmetries that enable materials design beyond that suggested by crystallographic space groups.


Dualities are mathematical mappings that reveal links between apparently unrelated systems in virtually every branch of physics(1-8). Systems mapped onto themselves by a duality transformation are called self-dual and exhibit remarkable properties, as exemplified by the scale invariance of an Ising magnet at the critical point. Here we show how dualities can enhance the symmetries of a dynamical matrix (or Hamiltonian), enabling the design of metamaterials with emergent properties that escape a standard group theory analysis. As an illustration, we consider twisted kagome lattices(9-15), reconfigurable mechanical structures that change shape by means of a collapse mechanism(9). We observe that pairs of distinct configurations along the mechanism exhibit the same vibrational spectrum and related elastic moduli. We show that these puzzling properties arise from a duality between pairs of configurations on either side of a mechanical critical point. The critical point corresponds to a self-dual structure with isotropic elasticity even in the absence of spatial symmetries and a twofold-degenerate spectrum over the entire Brillouin zone. The spectral degeneracy originates from a version of Kramers'  theorem(16,17) in which fermionic time-reversal invariance is replaced by a hidden symmetry emerging at the self-dual point. The normal modes of the self-dual systems exhibit non-Abelian geometric phases(18,19) that affect the semiclassical propagation of wavepackets(20), leading to non-commuting mechanical responses. Our results hold promise for holonomic computation(21) and mechanical spintronics by allowing on-the-fly manipulation of synthetic spins carried by phonons.


  
Sustainability efficiency assessment of the electricity mix of the 28 EU member countries combining data envelopment analysis and optimized projections 期刊论文
ENERGY POLICY, 2019, 134
作者:  Zurano-Cervello, Patricia;  Pozo, Carlos;  Maria Mateo-Sanz, Josep;  Jimenez, Laureano;  Guillen-Gosalbez, Gonzalo
收藏  |  浏览/下载:15/0  |  提交时间:2020/02/17
Sustainability  Data envelopment analysis (DEA)  Electricity mix  Eco-efficiency  Optimization  Energy systems  
Review of indicators for comparing environmental effects across energy sources 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2019, 14 (10)
作者:  Doming, Monica A.;  Diffendorfer, Jay E.;  Loss, Scott R.;  Bagstad, Kenneth J.
收藏  |  浏览/下载:20/0  |  提交时间:2019/11/27
energy development  energy systems  multicriteria analysis  energy indicators  environmental effects  natural resources  
Direct and indirect seasonal rainfall forecasts for East Africa using global dynamical models 期刊论文
INTERNATIONAL JOURNAL OF CLIMATOLOGY, 2019
作者:  Colman, Andrew W.;  Graham, Richard J.;  Davey, Michael K.
收藏  |  浏览/下载:14/0  |  提交时间:2019/11/27
canonical correlation analysis  dynamical long-range forecast systems  Greater Horn of Africa  seasonal rainfall prediction  
Axisymmetric Potential Vorticity Evolution of Hurricane Patricia (2015) 期刊论文
JOURNAL OF THE ATMOSPHERIC SCIENCES, 2019, 76 (7) : 2043-2063
作者:  Martinez, Jonathan;  Bell, Michael M.;  Rogers, Robert F.;  Doyle, James D.
收藏  |  浏览/下载:12/0  |  提交时间:2019/11/27
Mesoscale systems  Potential vorticity  Tropical cyclones  Dropsondes  Radars  Radar observations  Variational analysis  
Exploratory analysis of high-resolution power interruption data reveals spatial and temporal heterogeneity in electric grid reliability 期刊论文
ENERGY POLICY, 2019, 129: 206-214
作者:  Dunn, Laurel N.;  Sohn, Michael D.;  LaCommare, Kristina Hamachi;  Eto, Joseph H.
收藏  |  浏览/下载:12/0  |  提交时间:2019/11/26
Electric power systems  Electric power interruptions  Grid reliability metrics  Big data  Data access  Exploratory data analysis  
Global overview of crude oil use: From source to sink through inter-regional trade 期刊论文
ENERGY POLICY, 2019, 128: 476-486
作者:  Wu, X. F.;  Chen, G. Q.
收藏  |  浏览/下载:23/0  |  提交时间:2019/11/26
Crude oil  Systems input-output analysis  Trade imbalance  World economy  International trade