GSTDTAP

浏览/检索结果: 共15条,第1-10条 帮助

已选(0)清除 条数/页:   排序方式:
What Stars Are Made Of: The Life of Cecilia Payne-Gaposchkin 期刊论文
NATURE, 2020, 578 (7796) : 509-510
作者:  Clark, Michael David;  Contreras, Gustavo F.;  Shen, Rong;  Perozo, Eduardo
收藏  |  浏览/下载:12/0  |  提交时间:2020/07/03

Public acclaim escaped one of the twentieth century'  s most illustrious astronomers, Cecilia Payne-Gaposchkin  a new biography sets her in the firmament. By Giuseppina Fabbiano.


Public acclaim escaped one of the twentieth century'  s most illustrious astronomers, Cecilia Payne-Gaposchkin  a new biography sets her in the firmament. By Giuseppina Fabbiano.


  
A pause in Southern Hemisphere circulation trends due to the Montreal Protocol 期刊论文
NATURE, 2020, 579 (7800) : 544-548
作者:  Imai, Yu;  Meyer, Kirsten J.;  Iinishi, Akira;  Favre-Godal, Quentin;  Green, Robert;  Manuse, Sylvie;  Caboni, Mariaelena;  Mori, Miho;  Niles, Samantha;  Ghiglieri, Meghan;  Honrao, Chandrashekhar;  Ma, Xiaoyu;  Guo, Jason J.;  Makriyannis, Alexandros;  Linares-Otoya, Luis;  Boehringer, Nils;  Wuisan, Zerlina G.;  Kaur, Hundeep;  Wu, Runrun;  Mateus, Andre
收藏  |  浏览/下载:20/0  |  提交时间:2020/05/13

Observations show robust near-surface trends in Southern Hemisphere tropospheric circulation towards the end of the twentieth century, including a poleward shift in the mid-latitude jet(1,2), a positive trend in the Southern Annular Mode(1,3-6) and an expansion of the Hadley cell(7,8). It has been established that these trends were driven by ozone depletion in the Antarctic stratosphere due to emissions of ozone-depleting substances(9-11). Here we show that these widely reported circulation trends paused, or slightly reversed, around the year 2000. Using a pattern-based detection and attribution analysis of atmospheric zonal wind, we show that the pause in circulation trends is forced by human activities, and has not occurred owing only to internal or natural variability of the climate system. Furthermore, we demonstrate that stratospheric ozone recovery, resulting from the Montreal Protocol, is the key driver of the pause. Because pre-2000 circulation trends have affected precipitation(12-14), and potentially ocean circulation and salinity(15-17), we anticipate that a pause in these trends will have wider impacts on the Earth system. Signatures of the effects of the Montreal Protocol and the associated stratospheric ozone recovery might therefore manifest, or have already manifested, in other aspects of the Earth system.


  
Multispecific drugs herald a new era of biopharmaceutical innovation 期刊论文
NATURE, 2020, 580 (7803) : 329-338
作者:  Gallego, Laura D.;  Schneider, Maren;  Mittal, Chitvan;  Romanauska, Anete;  Carrillo, Ricardo M. Gudino;  Schubert, Tobias;  Pugh, B. Franklin;  Koehler, Alwin
收藏  |  浏览/下载:32/0  |  提交时间:2020/07/03

The modern biopharmaceutical industry traces its roots to the dawn of the twentieth century, coincident with marketing of aspirin-a signature event in the history of modern drug development. Although the archetypal discovery process did not change markedly in the first seven decades of the industry, the past fifty years have seen two successive waves of transformative innovation in the development of drug molecules: the rise of '  rational drug discovery'  methodology in the 1970s, followed by the invention of recombinant protein-based therapeutic agents in the 1980s. An incipient fourth wave is the advent of multispecific drugs. The successful development of prospectively designed multispecific drugs has the potential to reconfigure our ideas of how target-based therapeutic molecules can work, and what it is possible to achieve with them. Here I review the two major classes of multispecific drugs: those that enrich a therapeutic agent at a particular site of action and those that link a therapeutic target to a biological effector. The latter class-being freed from the constraint of having to directly modulate the target upon binding-may enable access to components of the proteome that currently cannot be targeted by drugs.


  
Coupling of Indo-Pacific climate variability over the last millennium 期刊论文
NATURE, 2020
作者:  Chow, Brian W.;  Nunez, Vicente;  Kaplan, Luke;  Granger, Adam J.;  Bistrong, Karina;  Zucker, Hannah L.;  Kumar, Payal;  Sabatini, Bernardo L.;  Gu, Chenghua
收藏  |  浏览/下载:34/0  |  提交时间:2020/05/13

Coral records indicate that the variability of the Indian Ocean Dipole over the last millennium is strongly coupled to variability in the El Nino/Southern Oscillation and that recent extremes are unusual but not unprecedented.


The Indian Ocean Dipole (IOD) affects climate and rainfall across the world, and most severely in nations surrounding the Indian Ocean(1-4). The frequency and intensity of positive IOD events increased during the twentieth century(5) and may continue to intensify in a warming world(6). However, confidence in predictions of future IOD change is limited by known biases in IOD models(7) and the lack of information on natural IOD variability before anthropogenic climate change. Here we use precisely dated and highly resolved coral records from the eastern equatorial Indian Ocean, where the signature of IOD variability is strong and unambiguous, to produce a semi-continuous reconstruction of IOD variability that covers five centuries of the last millennium. Our reconstruction demonstrates that extreme positive IOD events were rare before 1960. However, the most extreme event on record (1997) is not unprecedented, because at least one event that was approximately 27 to 42 per cent larger occurred naturally during the seventeenth century. We further show that a persistent, tight coupling existed between the variability of the IOD and the El Nino/Southern Oscillation during the last millennium. Indo-Pacific coupling was characterized by weak interannual variability before approximately 1590, which probably altered teleconnection patterns, and by anomalously strong variability during the seventeenth century, which was associated with societal upheaval in tropical Asia. A tendency towards clustering of positive IOD events is evident in our reconstruction, which-together with the identification of extreme IOD variability and persistent tropical Indo-Pacific climate coupling-may have implications for improving seasonal and decadal predictions and managing the climate risks of future IOD variability.


  
Investigation of the fine structure of antihydrogen 期刊论文
NATURE, 2020, 578 (7795) : 375-+
作者:  Zhang, Bing;  Ma, Sai;  Rachmin, Inbal;  He, Megan;  Baral, Pankaj;  Choi, Sekyu;  Goncalves, William A.;  Shwartz, Yulia;  Fast, Eva M.;  Su, Yiqun;  Zon, Leonard I.;  Regev, Aviv;  Buenrostro, Jason D.;  Cunha, Thiago M.;  Chiu, Isaac M.;  Fisher, David E.;  Hsu, Ya-Chieh
收藏  |  浏览/下载:25/0  |  提交时间:2020/07/03

At the historic Shelter Island Conference on the Foundations of Quantum Mechanics in 1947, Willis Lamb reported an unexpected feature in the fine structure of atomic hydrogen: a separation of the 2S(1/2) and 2P(1/2) states(1). The observation of this separation, now known as the Lamb shift, marked an important event in the evolution of modern physics, inspiring others to develop the theory of quantum electrodynamics(2-5). Quantum electrodynamics also describes antimatter, but it has only recently become possible to synthesize and trap atomic antimatter to probe its structure. Mirroring the historical development of quantum atomic physics in the twentieth century, modern measurements on anti-atoms represent a unique approach for testing quantum electrodynamics and the foundational symmetries of the standard model. Here we report measurements of the fine structure in the n = 2 states of antihydrogen, the antimatter counterpart of the hydrogen atom. Using optical excitation of the 1S-2P Lyman-alpha transitions in antihydrogen(6), we determine their frequencies in a magnetic field of 1 tesla to a precision of 16 parts per billion. Assuming the standard Zeeman and hyperfine interactions, we infer the zero-field fine-structure splitting (2P(1/2)-2P(3/2)) in antihydrogen. The resulting value is consistent with the predictions of quantum electrodynamics to a precision of 2 per cent. Using our previously measured value of the 1S-2S transition frequency(6,7), we find that the classic Lamb shift in antihydrogen (2S(1/2)-2P(1/2) splitting at zero field) is consistent with theory at a level of 11 per cent. Our observations represent an important step towards precision measurements of the fine structure and the Lamb shift in the antihydrogen spectrum as tests of the charge-parity-time symmetry(8) and towards the determination of other fundamental quantities, such as the antiproton charge radius(9,10), in this antimatter system.


Precision measurements of the 1S-2P transition in antihydrogen that take into account the standard Zeeman and hyperfine effects confirm the predictions of quantum electrodynamics.


  
Ocean heat content variability in an ensemble of twentieth century ocean reanalyses 期刊论文
CLIMATE DYNAMICS, 2018, 50: 3783-3798
作者:  de Boisseson, Eric;  Balmaseda, Magdalena Alonso;  Mayer, Michael
收藏  |  浏览/下载:6/0  |  提交时间:2019/04/09
Ocean reanalysis  Twentieth century record  Climate signals  Observing system changes  
High Arctic summer warming tracked by increased Cassiope tetragona growth in the world's northernmost polar desert 期刊论文
GLOBAL CHANGE BIOLOGY, 2017, 23 (11)
作者:  Weijers, Stef;  Buchwal, Agata;  Blok, Daan;  Loeffler, Joerg;  Elberling, Bo
收藏  |  浏览/下载:11/0  |  提交时间:2019/04/09
climate change  dendrochronology  dendroecology  dwarf shrubs  early twentieth-century warming  North Atlantic Oscillation  shrub expansion  soil moisture  temperature proxy  tundra  
Internal atmospheric noise characteristics in twentieth century coupled atmosphere-ocean model simulations 期刊论文
CLIMATE DYNAMICS, 2017, 49
作者:  Colfescu, Ioana;  Schneider, Edwin K.
收藏  |  浏览/下载:5/0  |  提交时间:2019/04/09
Internal variability  Atmospheric weather noise  Coupled general circulation modes  Twentieth century external forcing  Coupled atmosphere-ocean model simulations  Surface pressure variability  Coupled simulations  Stochastic atmospheric forcings  
The extraordinary windstorm of 7 December 1868 in the Czech Lands and its central European context 期刊论文
INTERNATIONAL JOURNAL OF CLIMATOLOGY, 2017, 37
作者:  Brazdil, Rudolf;  Szabo, Peter;  Stucki, Peter;  Dobrovolny, Petr;  Reznickova, Ladislava;  Kotyza, Oldrich;  Valasek, Hubert;  Melo, Marian;  Suchankova, Silvie;  Dolak, Lukas;  Chroma, Katerina
收藏  |  浏览/下载:7/0  |  提交时间:2019/04/09
windstorm of 7 December 1868  documentary data  Twentieth Century Reanalysis  meteorological situation  damage  forestry  Czech Lands  Central Europe  
Evidence of global warming impact on the evolution of the Hadley Circulation in ECMWF centennial reanalyses 期刊论文
CLIMATE DYNAMICS, 2017, 48
作者:  D&;  39;Agostino, Roberta
收藏  |  浏览/下载:0/0  |  提交时间:2019/04/09
ERA-20CM/C  ERA-Interim  Hadley Circulation  Global warming  Twentieth century  Trends