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A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds 期刊论文
NATURE, 2020, 580 (7803) : 409-+
作者:  Al-Shayeb, Basem;  Sachdeva, Rohan;  Chen, Lin-Xing;  Ward, Fred;  Munk, Patrick;  Devoto, Audra;  Castelle, Cindy J.;  Olm, Matthew R.;  Bouma-Gregson, Keith;  Amano, Yuki;  He, Christine;  Meheust, Raphael;  Brooks, Brandon;  Thomas, Alex;  Levy, Adi;  Matheus-Carnevali, Paula;  Sun, Christine;  Goltsman, Daniela S. A.;  Borton, Mikayla A.;  Sharrar, Allison;  Jaffe, Alexander L.;  Nelson, Tara C.;  Kantor, Rose;  Keren, Ray;  Lane, Katherine R.;  Farag, Ibrahim F.;  Lei, Shufei;  Finstad, Kari;  Amundson, Ronald;  Anantharaman, Karthik;  Zhou, Jinglie;  Probst, Alexander J.;  Power, Mary E.;  Tringe, Susannah G.;  Li, Wen-Jun;  Wrighton, Kelly;  Harrison, Sue;  Morowitz, Michael;  Relman, David A.;  Doudna, Jennifer A.;  Lehours, Anne-Catherine;  Warren, Lesley;  Cate, Jamie H. D.;  Santini, Joanne M.;  Banfield, Jillian F.
收藏  |  浏览/下载：37/0  |  提交时间：2020/07/03

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen and the causative agent of tuberculosis(1-3). Although Mtb can synthesize vitamin B-12 (cobalamin) de novo, uptake of cobalamin has been linked to pathogenesis of tuberculosis2. Mtb does not encode any characterized cobalamin transporter(4-6)  however, the gene rv1819c was found to be essential for uptake of cobalamin(1). This result is difficult to reconcile with the original annotation of Rv1819c as a protein implicated in the transport of antimicrobial peptides such as bleomycin(7). In addition, uptake of cobalamin seems inconsistent with the amino acid sequence, which suggests that Rv1819c has a bacterial ATP-binding cassette (ABC)-exporter fold1. Here, we present structures of Rv1819c, which reveal that the protein indeed contains the ABC-exporter fold, as well as a large water-filled cavity of about 7,700 angstrom(3), which enables the protein to transport the unrelated hydrophilic compounds bleomycin and cobalamin. On the basis of these structures, we propose that Rv1819c is a multi-solute transporter for hydrophilic molecules, analogous to the multidrug exporters of the ABC transporter family, which pump out structurally diverse hydrophobic compounds from cells(8-11).


  
Mutations in topoisomerase II beta result in a B cell immunodeficiency 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Broderick, Lori;  Yost, Shawn;  Li, Dong;  McGeough, Matthew D.;  Booshehri, Laela M.;  Guaderrama, Marisela;  Brydges, Susannah D.;  Kucharova, Karolina;  Patel, Niraj C.;  Harr, Margaret;  Hakonarson, Hakon;  Zackai, Elaine;  Cowell, Ian G.;  Austin, Caroline A.;  Hugle, Boris;  Gebauer, Corinna;  Zhang, Jianguo;  Xu, Xun;  Wang, Jian;  Croker, Ben A.;  Frazer, Kelly A.;  Putnam, Christopher D.;  Hoffman, Hal M.
收藏  |  浏览/下载：9/0  |  提交时间：2019/11/27
US family forest management coupling natural and human systems: Role of markets and public policy instruments 期刊论文
LANDSCAPE AND URBAN PLANNING, 2019, 188: 43-53
作者:  Aguilar, Francisco X.;  Kelly, Matthew C.
收藏  |  浏览/下载：6/0  |  提交时间：2019/11/27
Forest policy  Sustainable forest management  Ecosystem services  Extension forestry  Timber harvesting  Socio-ecological model  Family forests  
De novo design of tunable, pH-driven conformational changes 期刊论文
SCIENCE, 2019, 364 (6441) : 658-+
作者:  Boyken, Scott E.;  Benhaim, Mark A.;  Busch, Florian;  Jia, Mengxuan;  Bick, Matthew J.;  Choi, Heejun;  Klima, Jason C.;  Chen, Zibo;  Walkey, Carl;  Mileant, Alexander;  Sahasrabuddhe, Aniruddha;  Wei, Kathy Y.;  Hodge, Edgar A.;  Byron, Sarah;  Quijano-Rubio, Alfredo;  Sankaran, Banumathi;  King, Neil P.;  Lippincott-Schwartz, Jennifer;  Wysocki, Vicki H.;  Lee, Kelly K.;  Baker, David
收藏  |  浏览/下载：16/0  |  提交时间：2019/11/27
Amphibian fungal panzootic causes catastrophic and ongoing loss of biodiversity 期刊论文
SCIENCE, 2019, 363 (6434) : 1459-+
作者:  Scheele, Ben C.;  Pasmans, Frank;  Skerratt, Lee F.;  Berger, Lee;  Martel, An;  Beukema, Wouter;  Acevedo, Aldemar A.;  Burrowes, Patricia A.;  Carvalho, Tamilie;  Catenazzi, Alessandro;  De la Riva, Ignacio;  Fisher, Matthew C.;  Flechas, Sandra V.;  Foster, Claire N.;  Frias-Alvarez, Patricia;  Garner, Trenton W. J.;  Gratwicke, Brian;  Guayasamin, Juan M.;  Hirschfeld, Mareike;  Kolby, Jonathan E.;  Kosch, Tiffany A.;  La Marca, Enrique;  Lindenmayer, David B.;  Lips, Karen R.;  Longo, Ana V.;  Maneyro, Raul;  McDonald, Cait A.;  Mendelson, Joseph, III;  Palacios-Rodriguez, Pablo;  Parra-Olea, Gabriela;  Richards-Zawacki, Corinne L.;  Roedel, Mark-Oliver;  Rovito, Sean M.;  Soto-Azat, Claudio;  Toledo, Luis Felipe;  Voyles, Jamie;  Weldon, Che;  Whitfield, Steven M.;  Wilkinson, Mark;  Zamudio, Kelly R.;  Canessa, Stefano
收藏  |  浏览/下载：36/0  |  提交时间：2019/11/27
The Ozone Monitoring Instrument: overview of 14 years in space 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2018, 18 (8) : 5699-5745
作者:  Levelt, Pieternel F.;  Joiner, Joanna;  Tamminen, Johanna;  Veefkind, J. Pepijn;  Bhartia, Pawan K.;  Zweers, Deborah C. Stein;  Duncan, Bryan N.;  Streets, David G.;  Eskes, Henk;  van der A, Ronald;  McLinden, Chris;  Fioletov, Vitali;  Carn, Simon;  de laat, Jos;  DeLand, Matthew;  Marchenko, Sergey;  McPeters, Richard;  Ziemke, Jerald;  Fu, Dejian;  Liu, Xiong;  Pickering, Kenneth;  Apituley, Arnoud;  Abad, Gonzalo Gonzalez;  Arola, Antti;  Boersma, Folkert;  Miller, Christopher Chan;  Chance, Kelly;  de Graaf, Martin;  Hakkarainen, Janne;  Hassinen, Seppo;  Ialongo, Iolanda;  Kleipool, Quintus;  Krotkov, Nickolay;  Li, Can;  Lamsal, Lok;  Newman, Paul;  Nowlan, Caroline;  Suleiman, Raid;  Tilstra, Lieuwe Gijsbert;  Torres, Omar;  Wang, Huiqun;  Wargan, Krzysztof
收藏  |  浏览/下载：16/0  |  提交时间：2019/04/09
Loci associated with skin pigmentation identified in African populations 期刊论文
SCIENCE, 2017, 358 (6365) : 887-+
作者:  Crawford, Nicholas G.;  Kelly, Derek E.;  Hansen, Matthew E. B.;  Beltrame, Marcia H.;  Fan, Shaohua;  Bowman, Shanna L.;  Jewett, Ethan;  Ranciaro, Alessia;  Thompson, Simon;  Lo, Yancy;  Pfeifer, Susanne P.;  Jensen, Jeffrey D.;  Campbell, Michael C.;  Beggs, William;  Hormozdiari, Farhad;  Mpoloka, Sununguko Wata;  Mokone, Gaonyadiwe George;  Nyambo, Thomas;  Meskel, Dawit Wolde;  Belay, Gurja;  Haut, Jake;  Rothschild, Harriet;  Zon, Leonard;  Zhou, Yi;  Kovacs, Michael A.;  Xu, Mai;  Zhang, Tongwu;  Bishop, Kevin;  Sinclair, Jason;  Rivas, Cecilia;  Elliot, Eugene;  Choi, Jiyeon;  Li, Shengchao A.;  Hicks, Belynda;  Burgess, Shawn;  Abnet, Christian;  Watkins-Chow, Dawn E.;  Oceana, Elena;  Song, Yun S.;  Eskin, Eleazar;  Brown, Kevin M.;  Marks, Michael S.;  Loftus, Stacie K.;  Pavan, William J.;  Yeager, Meredith;  Chanock, Stephen;  Tishkoff, Sarah A.
收藏  |  浏览/下载：13/0  |  提交时间：2019/11/27
Integrated genomic and molecular characterization of cervical cancer 期刊论文
NATURE, 2017, 543 (7645) : 378-+
作者:  Burk, Robert D.;  Chen, Zigui;  Saller, Charles;  Tarvin, Katherine;  Carvalho, Andre L.;  Scapulatempo-Neto, Cristovam;  Silveira, Henrique C.;  Fregnani, Jose H.;  Creighton, Chad J.;  Anderson, Matthew L.;  Castro, Patricia;  Wang, Sophia S.;  Yau, Christina;  Benz, Christopher;  Robertson, A. Gordon;  Mungall, Karen;  Lim, Lynette;  Bowlby, Reanne;  Sadeghi, Sara;  Brooks, Denise;  Sipahimalani, Payal;  Mar, Richard;  Ally, Adrian;  Clarke, Amanda;  Mungall, Andrew J.;  Tam, Angela;  Lee, Darlene;  Chuah, Eric;  Schein, Jacqueline E.;  Tse, Kane;  Kasaian, Katayoon;  Ma, Yussanne;  Marra, Marco A.;  Mayo, Michael;  Balasundaram, Miruna;  Thiessen, Nina;  Dhalla, Noreen;  Carlsen, Rebecca;  Moore, Richard A.;  Holt, Robert A.;  Jones, Steven J. M.;  Wong, Tina;  Pantazi, Angeliki;  Parfenov, Michael;  Kucherlapati, Raju;  Hadjipanayis, Angela;  Seidman, Jonathan;  Kucherlapati, Melanie;  Ren, Xiaojia;  Xu, Andrew W.;  Yang, Lixing;  Park, Peter J.;  Lee, Semin;  Rabeno, Brenda;  Huelsenbeck-Dill, Lori;  Borowsky, Mark;  Cadungog, Mark;  Iacocca, Mary;  Petrelli, Nicholas;  Swanson, Patricia;  Ojesina, Akinyemi I.;  Le, Xuan;  Sandusky, George;  Adebamowo, Sally N.;  Akeredolu, Teniola;  Adebamowo, Clement;  Reynolds, Sheila M.;  Shmulevich, Ilya;  Shelton, Candace;  Crain, Daniel;  Mallery, David;  Curley, Erin;  Gardner, Johanna;  Penny, Robert;  Morris, Scott;  Shelton, Troy;  Liu, Jia;  Lolla, Laxmi;  Chudamani, Sudha;  Wu, Ye;  Birrer, Michael;  McLellan, Michael D.;  Bailey, Matthew H.;  Miller, Christopher A.;  Wyczalkowski, Matthew A.;  Fulton, Robert S.;  Fronick, Catrina C.;  Lu, Charles;  Mardis, Elaine R.;  Appelbaum, Elizabeth L.;  Schmidt, Heather K.;  Fulton, Lucinda A.;  Cordes, Matthew G.;  Li, Tiandao;  Ding, Li;  Wilson, Richard K.;  Rader, Janet S.;  Behmaram, Behnaz;  Uyar, Denise;  Bradley, William;  Wrangle, John;  Pastore, Alessandro;  Levine, Douglas A.;  Dao, Fanny;  Gao, Jianjiong;  Schultz, Nikolaus;  Sander, Chris;  Ladanyi, Marc;  Einstein, Mark;  Teeter, Randall;  Benz, Stephen;  Wentzensen, Nicolas;  Felau, Ina;  Zenklusen, Jean C.;  Bodelon, Clara;  Demchok, John A.;  Yang, Liming;  Sheth, Margi;  Ferguson, Martin L.;  Tarnuzzer, Roy;  Yang, Hannah;  Schiffman, Mark;  Zhang, Jiashan;  Wang, Zhining;  Davidsen, Tanja;  Olaniyan, Olayinka;  Hutter, Carolyn M.;  Sofia, Heidi J.;  Gordenin, Dmitry A.;  Chan, Kin;  Roberts, Steven A.;  Klimczak, Leszek J.;  Van Waes, Carter;  Chen, Zhong;  Saleh, Anthony D.;  Cheng, Hui;  Parfitt, Jeremy;  Bartlett, John;  Albert, Monique;  Arnaout, Angel;  Sekhon, Harman;  Gilbert, Sebastien;  Peto, Myron;  Myers, Jerome;  Harr, Jodi;  Eckman, John;  Bergsten, Julie;  Tucker, Kelinda;  Zach, Leigh Anne;  Karlan, Beth Y.;  Lester, Jenny;  Orsulic, Sandra;  Sun, Qiang;  Naresh, Rashi;  Pihl, Todd;  Wan, Yunhu;  Zaren, Howard;  Sapp, Jennifer;  Miller, Judy;  Drwiega, Paul;  Ojesina, Akinyemi I.;  Murray, Bradley A.;  Zhang, Hailei;  Cherniack, Andrew D.;  Sougnez, Carrie;  Pedamallu, Chandra Sekhar;  Lichtenstein, Lee;  Meyerson, Matthew;  Noble, Michael S.;  Heiman, David I.;  Voet, Doug;  Getz, Gad;  Saksena, Gordon;  Kim, Jaegil;  Shih, Juliann;  Cho, Juok;  Lawrence, Michael S.;  Gehlenborg, Nils;  Lin, Pei;  Beroukhim, Rameen;  Frazer, Scott;  Gabriel, Stacey B.;  Schumacher, Steven E.;  Leraas, Kristen M.;  Lichtenberg, Tara M.;  Zmuda, Erik;  Bowen, Jay;  Frick, Jessica;  Gastier-Foster, Julie M.;  Wise, Lisa;  Gerken, Mark;  Ramirez, Nilsa C.;  Danilova, Ludmila;  Cope, Leslie;  Baylin, Stephen B.;  Salvesen, Helga B.;  Vellano, Christopher P.;  Ju, Zhenlin;  Diao, Lixia;  Zhao, Hao;  Chong, Zechen;  Ryan, Michael C.;  Martinez-Ledesma, Emmanuel;  Verhaak, Roeland G.;  Byers, Lauren Averett;  Yuan, Yuan;  Chen, Ken;  Ling, Shiyun;  Mills, Gordon B.;  Lu, Yiling;  Akbani, Rehan;  Seth, Sahil;  Liang, Han;  Wang, Jing;  Han, Leng;  Weinstein, John N.;  Bristow, Christopher A.;  Zhang, Wei;  Mahadeshwar, Harshad S.;  Sun, Huandong;  Tang, Jiabin;  Zhang, Jianhua;  Song, Xingzhi;  Protopopov, Alexei;  Shaw, Kenna R. Mills;  Chin, Lynda;  Olabode, Oluwole;  Ojesina, Akinyemi I.;  DiSaia, Philip;  Radenbaugh, Amie;  Haussler, David;  Zhu, Jingchun;  Stuart, Josh;  Chalise, Prabhakar;  Koestler, Devin;  Fridley, Brooke L.;  Godwin, Andrew K.;  Madan, Rashna;  Ciriello, Giovanni;  Martinez, Cathleen;  Higgins, Kelly;  Bocklage, Therese;  Auman, J. Todd;  Perou, Charles M.;  Tan, Donghui;  Parker, Joel S.;  Hoadley, Katherine A.;  Wilkerson, Matthew D.;  Mieczkowski, Piotr A.;  Skelly, Tara;  Veluvolu, Umadevi;  Hayes, D. Neil;  Rathmell, W. Kimryn;  Hoyle, Alan P.;  Simons, Janae V.;  Wu, Junyuan;  Mose, Lisle E.;  Soloway, Matthew G.;  Balu, Saianand;  Meng, Shaowu;  Jefferys, Stuart R.;  Bodenheimer, Tom;  Shi, Yan;  Roach, Jeffrey;  Thorne, Leigh B.;  Boice, Lori;  Huang, Mei;  Jones, Corbin D.;  Zuna, Rosemary;  Walker, Joan;  Gunderson, Camille;  Snowbarger, Carie;  Brown, David;  Moxley, Katherine;  Moore, Kathleen;  Andrade, Kelsi;  Landrum, Lisa;  Mannel, Robert;  McMeekin, Scott;  Johnson, Starla;  Nelson, Tina;  Elishaev, Esther;  Dhir, Rajiv;  Edwards, Robert;  Bhargava, Rohit;  Tiezzi, Daniel G.;  Andrade, Jurandyr M.;  Noushmehr, Houtan;  Carlotti, Carlos Gilberto, Jr.;  Tirapelli, Daniela Pretti da Cunha;  Weisenberger, Daniel J.;  Van Den Berg, David J.;  Maglinte, Dennis T.;  Bootwalla, Moiz S.;  Lai, Phillip H.;  Triche, Timothy, Jr.;  Swisher, Elizabeth M.;  Agnew, Kathy J.;  Shelley, Carl Simon;  Laird, Peter W.;  Schwarz, Julie;  Grigsby, Perry;  Mutch, David
收藏  |  浏览/下载：15/0  |  提交时间：2019/04/09