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Accurate prediction of protein structures and interactions using a three-track neural network 期刊论文
Science, 2021
作者:  Minkyung Baek;  Frank DiMaio;  Ivan Anishchenko;  Justas Dauparas;  Sergey Ovchinnikov;  Gyu Rie Lee;  Jue Wang;  Qian Cong;  Lisa N. Kinch;  R. Dustin Schaeffer;  Claudia Millán;  Hahnbeom Park;  Carson Adams;  Caleb R. Glassman;  Andy DeGiovanni;  Jose H. Pereira;  Andria V. Rodrigues;  Alberdina A. van Dijk;  Ana C. Ebrecht;  Diederik J. Opperman;  Theo Sagmeister;  Christoph Buhlheller;  Tea Pavkov-Keller;  Manoj K. Rathinaswamy;  Udit Dalwadi;  Calvin K. Yip;  John E. Burke;  K. Christopher Garcia;  Nick V. Grishin;  Paul D. Adams;  Randy J. Read;  David Baker
收藏  |  浏览/下载:19/0  |  提交时间:2021/08/25
Analysis of multispectral imaging with the AstroPath platform informs efficacy of PD-1 blockade 期刊论文
Science, 2021
作者:  Sneha Berry;  Nicolas A. Giraldo;  Benjamin F. Green;  Tricia R. Cottrell;  Julie E. Stein;  Elizabeth L. Engle;  Haiying Xu;  Aleksandra Ogurtsova;  Charles Roberts;  Daphne Wang;  Peter Nguyen;  Qingfeng Zhu;  Sigfredo Soto-Diaz;  Jose Loyola;  Inbal B. Sander;  Pok Fai Wong;  Shlomit Jessel;  Joshua Doyle;  Danielle Signer;  Richard Wilton;  Jeffrey S. Roskes;  Margaret Eminizer;  Seyoun Park;  Joel C. Sunshine;  Elizabeth M. Jaffee;  Alexander Baras;  Angelo M. De Marzo;  Suzanne L. Topalian;  Harriet Kluger;  Leslie Cope;  Evan J. Lipson;  Ludmila Danilova;  Robert A. Anders;  David L. Rimm;  Drew M. Pardoll;  Alexander S. Szalay;  Janis M. Taube
收藏  |  浏览/下载:11/0  |  提交时间:2021/06/15
Haplotype-resolved diverse human genomes and integrated analysis of structural variation 期刊论文
Science, 2021
作者:  Peter Ebert;  Peter A. Audano;  Qihui Zhu;  Bernardo Rodriguez-Martin;  David Porubsky;  Marc Jan Bonder;  Arvis Sulovari;  Jana Ebler;  Weichen Zhou;  Rebecca Serra Mari;  Feyza Yilmaz;  Xuefang Zhao;  PingHsun Hsieh;  Joyce Lee;  Sushant Kumar;  Jiadong Lin;  Tobias Rausch;  Yu Chen;  Jingwen Ren;  Martin Santamarina;  Wolfram Höps;  Hufsah Ashraf;  Nelson T. Chuang;  Xiaofei Yang;  Katherine M. Munson;  Alexandra P. Lewis;  Susan Fairley;  Luke J. Tallon;  Wayne E. Clarke;  Anna O. Basile;  Marta Byrska-Bishop;  André Corvelo;  Uday S. Evani;  Tsung-Yu Lu;  Mark J. P. Chaisson;  Junjie Chen;  Chong Li;  Harrison Brand;  Aaron M. Wenger;  Maryam Ghareghani;  William T. Harvey;  Benjamin Raeder;  Patrick Hasenfeld;  Allison A. Regier;  Haley J. Abel;  Ira M. Hall;  Paul Flicek;  Oliver Stegle;  Mark B. Gerstein;  Jose M. C. Tubio;  Zepeng Mu;  Yang I. Li;  Xinghua Shi;  Alex R. Hastie;  Kai Ye;  Zechen Chong;  Ashley D. Sanders;  Michael C. Zody;  Michael E. Talkowski;  Ryan E. Mills;  Scott E. Devine;  Charles Lee;  Jan O. Korbel;  Tobias Marschall;  Evan E. Eichler
收藏  |  浏览/下载:26/0  |  提交时间:2021/04/06
Plant roots sense soil compaction through restricted ethylene diffusion 期刊论文
Science, 2021
作者:  Bipin K. Pandey;  Guoqiang Huang;  Rahul Bhosale;  Sjon Hartman;  Craig J. Sturrock;  Lottie Jose;  Olivier C. Martin;  Michal Karady;  Laurentius A. C. J. Voesenek;  Karin Ljung;  Jonathan P. Lynch;  Kathleen M. Brown;  William R. Whalley;  Sacha J. Mooney;  Dabing Zhang;  Malcolm J. Bennett
收藏  |  浏览/下载:10/0  |  提交时间:2021/01/22
Stretchable distributed fiber-optic sensors 期刊论文
Science, 2020
作者:  Hedan Bai;  Shuo Li;  Jose Barreiros;  Yaqi Tu;  Clifford R. Pollock;  Robert F. Shepherd
收藏  |  浏览/下载:6/0  |  提交时间:2020/11/20
BTN3A1 governs antitumor responses by coordinating αβ and γδ T cells 期刊论文
Science, 2020
作者:  Kyle K. Payne;  Jessica A. Mine;  Subir Biswas;  Ricardo A. Chaurio;  Alfredo Perales-Puchalt;  Carmen M. Anadon;  Tara Lee Costich;  Carly M. Harro;  Jennifer Walrath;  Qianqian Ming;  Evgenii Tcyganov;  Andrea L. Buras;  Kristen E. Rigolizzo;  Gunjan Mandal;  Jason Lajoie;  Michael Ophir;  Julia Tchou;  Douglas Marchion;  Vincent C. Luca;  Piotr Bobrowicz;  Brooke McLaughlin;  Ugur Eskiocak;  Michael Schmidt;  Juan R. Cubillos-Ruiz;  Paulo C. Rodriguez;  Dmitry I. Gabrilovich;  Jose R. Conejo-Garcia
收藏  |  浏览/下载:11/0  |  提交时间:2020/08/25
Introductions and early spread of SARS-CoV-2 in the New York City area 期刊论文
Science, 2020
作者:  Ana S. Gonzalez-Reiche;  Matthew M. Hernandez;  Mitchell J. Sullivan;  Brianne Ciferri;  Hala Alshammary;  Ajay Obla;  Shelcie Fabre;  Giulio Kleiner;  Jose Polanco;  Zenab Khan;  Bremy Alburquerque;  Adriana van de Guchte;  Jayeeta Dutta;  Nancy Francoeur;  Betsaida Salom Melo;  Irina Oussenko;  Gintaras Deikus;  Juan Soto;  Shwetha Hara Sridhar;  Ying-Chih Wang;  Kathryn Twyman;  Andrew Kasarskis;  Deena R. Altman;  Melissa Smith;  Robert Sebra;  Judith Aberg;  Florian Krammer;  Adolfo García-Sastre;  Marta Luksza;  Gopi Patel;  Alberto Paniz-Mondolfi;  Melissa Gitman;  Emilia Mia Sordillo;  Viviana Simon;  Harm van Bakel
收藏  |  浏览/下载:12/0  |  提交时间:2020/07/21
A remnant planetary core in the hot-Neptune desert 期刊论文
NATURE, 2020, 583 (7814) : 39-+
作者:  David J. Armstrong;  Thé;  o A. Lopez;  Vardan Adibekyan;  Richard A. Booth;  Edward M. Bryant;  Karen A. Collins;  Magali Deleuil;  Alexandre Emsenhuber;  Chelsea X. Huang;  George W. King;  Jorge Lillo-Box;  Jack J. Lissauer;  Elisabeth Matthews;  Olivier Mousis;  Louise D. Nielsen;  Hugh Osborn;  Jon Otegi;  Nuno C. Santos;  ;  rgio G. Sousa;  Keivan G. Stassun;  Dimitri Veras;  Carl Ziegler;  Jack S. Acton;  Jose M. Almenara;  David R. Anderson;  David Barrado;  Susana C. C. Barros;  Daniel Bayliss;  Claudia Belardi;  Francois Bouchy;  ;  sar Briceñ;  o;  Matteo Brogi;  David J. A. Brown;  Matthew R. Burleigh;  Sarah L. Casewell;  Alexander Chaushev;  David R. Ciardi;  Kevin I. Collins;  Knicole D. Coló;  n;  Benjamin F. Cooke;  Ian J. M. Crossfield;  Rodrigo F. Dí;  az;  Elisa Delgado Mena;  Olivier D. S. Demangeon;  Caroline Dorn;  Xavier Dumusque;  Philipp Eigmü;  ller;  Michael Fausnaugh;  Pedro Figueira;  Tianjun Gan;  Siddharth Gandhi;  Samuel Gill;  Erica J. Gonzales;  Michael R. Goad;  Maximilian N. Gü;  nther;  Ravit Helled;  Saeed Hojjatpanah;  Steve B. Howell;  James Jackman;  James S. Jenkins;  Jon M. Jenkins;  Eric L. N. Jensen;  Grant M. Kennedy;  David W. Latham;  Nicholas Law;  Monika Lendl;  Michael Lozovsky;  Andrew W. Mann;  Maximiliano Moyano;  James McCormac;  Farzana Meru;  Christoph Mordasini;  Ares Osborn;  Don Pollacco;  Didier Queloz;  Liam Raynard;  George R. Ricker;  Pamela Rowden;  Alexandre Santerne;  Joshua E. Schlieder;  Sara Seager;  Lizhou Sha;  Thiam-Guan Tan;  Rosanna H. Tilbrook;  Eric Ting;  Sté;  phane Udry;  Roland Vanderspek;  Christopher A. Watson;  Richard G. West;  Paul A. Wilson;  Joshua N. Winn;  Peter Wheatley;  Jesus Noel Villasenor;  Jose I. Vines;  Zhuchang Zhan
收藏  |  浏览/下载:20/0  |  提交时间:2020/07/06

The interiors of giant planets remain poorly understood. Even for the planets in the Solar System, difficulties in observation lead to large uncertainties in the properties of planetary cores. Exoplanets that have undergone rare evolutionary processes provide a route to understanding planetary interiors. Planets found in and near the typically barren hot-Neptune '  desert'  (1,2)(a region in mass-radius space that contains few planets) have proved to be particularly valuable in this regard. These planets include HD149026b(3), which is thought to have an unusually massive core, and recent discoveries such as LTT9779b(4)and NGTS-4b(5), on which photoevaporation has removed a substantial part of their outer atmospheres. Here we report observations of the planet TOI-849b, which has a radius smaller than Neptune'  s but an anomalously large mass of39.1-2.6+2.7Earth masses and a density of5.2-0.8+0.7grams per cubic centimetre, similar to Earth'  s. Interior-structure models suggest that any gaseous envelope of pure hydrogen and helium consists of no more than3.9-0.9+0.8 per cent of the total planetary mass. The planet could have been a gas giant before undergoing extreme mass loss via thermal self-disruption or giant planet collisions, or it could have avoided substantial gas accretion, perhaps through gap opening or late formation(6). Although photoevaporation rates cannot account for the mass loss required to reduce a Jupiter-like gas giant, they can remove a small (a few Earth masses) hydrogen and helium envelope on timescales of several billion years, implying that any remaining atmosphere on TOI-849b is likely to be enriched by water or other volatiles from the planetary interior. We conclude that TOI-849b is the remnant core of a giant planet.


Observations of TOI-849b reveal a radius smaller than Neptune'  s but a large mass of about 40 Earth masses, indicating that the planet is the remnant core of a gas giant.


  
Arctic-adapted dogs emerged at the Pleistocene–Holocene transition 期刊论文
Science, 2020
作者:  Mikkel-Holger S. Sinding;  Shyam Gopalakrishnan;  Jazmín Ramos-Madrigal;  Marc de Manuel;  Vladimir V. Pitulko;  Lukas Kuderna;  Tatiana R. Feuerborn;  Laurent A. F. Frantz;  Filipe G. Vieira;  Jonas Niemann;  Jose A. Samaniego Castruita;  Christian Carøe;  Emilie U. Andersen-Ranberg;  Peter D. Jordan;  Elena Y. Pavlova;  Pavel A. Nikolskiy;  Aleksei K. Kasparov;  Varvara V. Ivanova;  Eske Willerslev;  Pontus Skoglund;  Merete Fredholm;  Sanne Eline Wennerberg;  Mads Peter Heide-Jørgensen;  Rune Dietz;  Christian Sonne;  Morten Meldgaard;  Love Dalén;  Greger Larson;  Bent Petersen;  Thomas Sicheritz-Pontén;  Lutz Bachmann;  Øystein Wiig;  Tomas Marques-Bonet;  Anders J. Hansen;  M. Thomas P. Gilbert
收藏  |  浏览/下载:14/0  |  提交时间:2020/06/29
Designing optimal human‐modified landscapes for forest biodiversity conservation 期刊论文
Ecology Letters, 2020
作者:  ;  ctor Arroyo‐;  Rodrí;  guez;  Lenore Fahrig;  Marcelo Tabarelli;  James I. Watling;  Lutz Tischendorf;  Maí;  ra Benchimol;  Eliana Cazetta;  Deborah Faria;  Inara R. Leal;  Felipe P. L. Melo;  Jose C. Morante‐;  Filho;  Brá;  ulio A. Santos;  Ricard Arasa‐;  Gisbert;  Norma Arce‐;  Peñ;  a;  Martí;  n J. Cervantes‐;  ;  pez;  Sabine Cudney‐;  Valenzuela;  Carmen Galá;  n‐;  Acedo;  Miriam San‐;  José;  Ima C. G. Vieira;  J.W. Ferry Slik;  A. Justin Nowakowski;  Teja Tscharntke
收藏  |  浏览/下载:43/0  |  提交时间:2020/06/22