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Ecological insights from three decades of animal movement tracking across a changing Arctic 期刊论文
Science, 2020
作者:  Sarah C. Davidson;  Gil Bohrer;  Eliezer Gurarie;  Scott LaPoint;  Peter J. Mahoney;  Natalie T. Boelman;  Jan U. H. Eitel;  Laura R. Prugh;  Lee A. Vierling;  Jyoti Jennewein;  Emma Grier;  Ophélie Couriot;  Allicia P. Kelly;  Arjan J. H. Meddens;  Ruth Y. Oliver;  Roland Kays;  Martin Wikelski;  Tomas Aarvak;  Joshua T. Ackerman;  José A. Alves;  Erin Bayne;  Bryan Bedrosian;  Jerrold L. Belant;  Andrew M. Berdahl;  Alicia M. Berlin;  Dominique Berteaux;  Joël Bêty;  Dmitrijs Boiko;  Travis L. Booms;  Bridget L. Borg;  Stan Boutin;  W. Sean Boyd;  Kane Brides;  Stephen Brown;  Victor N. Bulyuk;  Kurt K. Burnham;  David Cabot;  Michael Casazza;  Katherine Christie;  Erica H. Craig;  Shanti E. Davis;  Tracy Davison;  Dominic Demma;  Christopher R. DeSorbo;  Andrew Dixon;  Robert Domenech;  Götz Eichhorn;  Kyle Elliott;  Joseph R. Evenson;  Klaus-Michael Exo;  Steven H. Ferguson;  Wolfgang Fiedler;  Aaron Fisk;  Jérôme Fort;  Alastair Franke;  Mark R. Fuller;  Stefan Garthe;  Gilles Gauthier;  Grant Gilchrist;  Petr Glazov;  Carrie E. Gray;  David Grémillet;  Larry Griffin;  Michael T. Hallworth;  Autumn-Lynn Harrison;  Holly L. Hennin;  J. Mark Hipfner;  James Hodson;  James A. Johnson;  Kyle Joly;  Kimberly Jones;  Todd E. Katzner;  Jeff W. Kidd;  Elly C. Knight;  Michael N. Kochert;  Andrea Kölzsch;  Helmut Kruckenberg;  Benjamin J. Lagassé;  Sandra Lai;  Jean-François Lamarre;  Richard B. Lanctot;  Nicholas C. Larter;  A. David M. Latham;  Christopher J. Latty;  James P. Lawler;  Don-Jean Léandri-Breton;  Hansoo Lee;  Stephen B. Lewis;  Oliver P. Love;  Jesper Madsen;  Mark Maftei;  Mark L. Mallory;  Buck Mangipane;  Mikhail Y. Markovets;  Peter P. Marra;  Rebecca McGuire;  Carol L. McIntyre;  Emily A. McKinnon;  Tricia A. Miller;  Sander Moonen;  Tong Mu;  Gerhard J. D. M. Müskens;  Janet Ng;  Kerry L. Nicholson;  Ingar Jostein Øien;  Cory Overton;  Patricia A. Owen;  Allison Patterson;  Aevar Petersen;  Ivan Pokrovsky;  Luke L. Powell;  Rui Prieto;  Petra Quillfeldt;  Jennie Rausch;  Kelsey Russell;  Sarah T. Saalfeld;  Hans Schekkerman;  Joel A. Schmutz;  Philipp Schwemmer;  Dale R. Seip;  Adam Shreading;  Mónica A. Silva;  Brian W. Smith;  Fletcher Smith;  Jeff P. Smith;  Katherine R. S. Snell;  Aleksandr Sokolov;  Vasiliy Sokolov;  Diana V Solovyeva;  Mathew S. Sorum;  Grigori Tertitski;  J. F. Therrien;  Kasper Thorup;  T. Lee Tibbitts;  Ingrid Tulp;  Brian D. Uher-Koch;  Rob S. A. van Bemmelen;  Steven Van Wilgenburg;  Andrew L. Von Duyke;  Jesse L. Watson;  Bryan D. Watts;  Judy A. Williams;  Matthew T. Wilson;  James R. Wright;  Michael A. Yates;  David J. Yurkowski;  Ramūnas Žydelis;  Mark Hebblewhite
收藏  |  浏览/下载:19/0  |  提交时间:2020/11/09
Influenza vaccine–induced human bone marrow plasma cells decline within a year after vaccination 期刊论文
Science, 2020
作者:  Carl W. Davis;  Katherine J. L. Jackson;  Megan M. McCausland;  Jaime Darce;  Cathy Chang;  Susanne L. Linderman;  Chakravarthy Chennareddy;  Rebecca Gerkin;  Shantoria J. Brown;  Jens Wrammert;  Aneesh K. Mehta;  Wan Cheung Cheung;  Scott D. Boyd;  Edmund K. Waller;  Rafi Ahmed
收藏  |  浏览/下载:18/0  |  提交时间:2020/10/12
Transcriptomic signatures across human tissues identify functional rare genetic variation 期刊论文
Science, 2020
作者:  Nicole M. Ferraro;  Benjamin J. Strober;  Jonah Einson;  Nathan S. Abell;  Francois Aguet;  Alvaro N. Barbeira;  Margot Brandt;  Maja Bucan;  Stephane E. Castel;  Joe R. Davis;  Emily Greenwald;  Gaelen T. Hess;  Austin T. Hilliard;  Rachel L. Kember;  Bence Kotis;  YoSon Park;  Gina Peloso;  Shweta Ramdas;  Alexandra J. Scott;  Craig Smail;  Emily K. Tsang;  Seyedeh M. Zekavat;  Marcello Ziosi;  Aradhana;  TOPMed Lipids Working Group;  Kristin G. Ardlie;  Themistocles L. Assimes;  Michael C. Bassik;  Christopher D. Brown;  Adolfo Correa;  Ira Hall;  Hae Kyung Im;  Xin Li;  Pradeep Natarajan;  GTEx Consortium;  Tuuli Lappalainen;  Pejman Mohammadi;  Stephen B. Montgomery;  Alexis Battle
收藏  |  浏览/下载:12/0  |  提交时间:2020/09/14
Using structured eradication feasibility assessment to prioritize the management of new and emerging invasive alien species in Europe 期刊论文
Global Change Biology, 2020
作者:  Olaf Booy;  Pete A. Robertson;  Niall Moore;  Jess Ward;  Helen E. Roy;  Tim Adriaens;  Richard Shaw;  Johan Van Valkenburg;  Gabrielle Wyn;  Sandro Bertolino;  Olivier Blight;  Etienne Branquart;  Giuseppe Brundu;  Joe Caffrey;  Dario Capizzi;  Jim Casaer;  Olivier De Clerck;  Neil E. Coughlan;  Eithne Davis;  Jaimie T. A. Dick;  Franz Essl;  Guillaume Fried;  Piero Genovesi;  Pablo Gonzá;  lez‐;  Moreno;  Frank Huysentruyt;  Stuart R. Jenkins;  Francis Kerckhof;  Lucy E. Frances;  Wolfgang Nentwig;  Jonathan Newman;  Wolfgang Rabitsch;  Sugoto Roy;  Uwe Starfinger;  Paul D. Stebbing;  Jan Stuyck;  Mike Sutton‐;  Croft;  Elena Tricarico;  Sonia Vanderhoeven;  Hugo Verreycken;  Aileen C. Mill
收藏  |  浏览/下载:12/0  |  提交时间:2020/09/08
Exploring movement patterns and changing distributions of baleen whales in the western North Atlantic using a decade of passive acoustic data 期刊论文
Global Change Biology, 2020
作者:  Genevieve E. Davis;  Mark F. Baumgartner;  Peter J. Corkeron;  Joel Bell;  Catherine Berchok;  Julianne M. Bonnell;  Jacqueline Bort Thornton;  Solange Brault;  Gary A. Buchanan;  Danielle M. Cholewiak;  Christopher W. Clark;  Julien Delarue;  Leila T. Hatch;  Holger Klinck;  Scott D. Kraus;  Bruce Martin;  David K. Mellinger;  Hilary Moors‐;  Murphy;  Sharon Nieukirk;  Douglas P. Nowacek;  Susan E. Parks;  Dawn Parry;  Nicole Pegg;  Andrew J. Read;  Aaron N. Rice;  Denise Risch;  Alyssa Scott;  Melissa S. Soldevilla;  Kathleen M. Stafford;  Joy E. Stanistreet;  Erin Summers;  Sean Todd;  Sofie M. Van Parijs
收藏  |  浏览/下载:16/0  |  提交时间:2020/07/14
How to build a more open justice system 期刊论文
Science, 2020
作者:  Adam R. Pah;  David L. Schwartz;  Sarath Sanga;  Zachary D. Clopton;  Peter DiCola;  Rachel Davis Mersey;  Charlotte S. Alexander;  Kristian J. Hammond;  Luís A. Nunes Amaral
收藏  |  浏览/下载:11/0  |  提交时间:2020/07/14
Limited and localized magmatism in the Central Atlantic Magmatic Province 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Marzen, R. E.;  Shillington, D. J.;  Lizarralde, D.;  Knapp, J. H.;  Heffner, D. M.;  Davis, J. K.;  Harder, S. H.
收藏  |  浏览/下载:9/0  |  提交时间:2020/07/09
Disturbance refugia within mosaics of forest fire, drought, and insect outbreaks 期刊论文
FRONTIERS IN ECOLOGY AND THE ENVIRONMENT, 2020, 18 (5) : 235-244
作者:  Krawchuk, Meg A.;  Meigs, Garrett W.;  Cartwright, Jennifer M.;  Coop, Jonathan D.;  Davis, Raymond;  Holz, Andres;  Kolden, Crystal;  Meddens, Arjan J. H.
收藏  |  浏览/下载:9/0  |  提交时间:2020/06/09
Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer's disease 期刊论文
NATURE, 2020, 577 (7790) : 399-+
作者:  Gate, David;  Saligrama, Naresha;  Leventhal, Olivia;  Yang, Andrew C.;  Unger, Michael S.;  Middeldorp, Jinte;  Chen, Kelly;  Lehallier, Benoit;  Channappa, Divya;  De Los Santos, Mark B.;  McBride, Alisha;  Pluvinage, John;  Elahi, Fanny;  Tam, Grace Kyin-Ye;  Kim, Yongha;  Greicius, Michael;  Wagner, Anthony D.;  Aigner, Ludwig;  Galasko, Douglas R.;  Davis, Mark M.;  Wyss-Coray, Tony
收藏  |  浏览/下载:6/0  |  提交时间:2020/07/03

Alzheimer'  s disease is an incurable neurodegenerative disorder in which neuroinflammation has a critical function(1). However, little is known about the contribution of the adaptive immune response in Alzheimer'  s disease(2). Here, using integrated analyses of multiple cohorts, we identify peripheral and central adaptive immune changes in Alzheimer'  s disease. First, we performed mass cytometry of peripheral blood mononuclear cells and discovered an immune signature of Alzheimer'  s disease that consists of increased numbers of CD8(+) T effector memory CD45RA(+) (T-EMRA) cells. In a second cohort, we found that CD8(+) T-EMRA cells were negatively associated with cognition. Furthermore, single-cell RNA sequencing revealed that T cell receptor (TCR) signalling was enhanced in these cells. Notably, by using several strategies of single-cell TCR sequencing in a third cohort, we discovered clonally expanded CD8(+) T-EMRA cells in the cerebrospinal fluid of patients with Alzheimer'  s disease. Finally, we used machine learning, cloning and peptide screens to demonstrate the specificity of clonally expanded TCRs in the cerebrospinal fluid of patients with Alzheimer'  s disease to two separate Epstein-Barr virus antigens. These results reveal an adaptive immune response in the blood and cerebrospinal fluid in Alzheimer'  s disease and provide evidence of clonal, antigen-experienced T cells patrolling the intrathecal space of brains affected by age-related neurodegeneration.


  
Agricultural risks from changing snowmelt 期刊论文
NATURE CLIMATE CHANGE, 2020, 10 (5) : 459-+
作者:  Qin, Yue;  Abatzoglou, John T.;  Siebert, Stefan;  Huning, Laurie S.;  AghaKouchak, Amir;  Mankin, Justin S.;  Hong, Chaopeng;  Tong, Dan;  Davis, Steven J.;  Mueller, Nathaniel D.
收藏  |  浏览/下载:10/0  |  提交时间:2020/05/13