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A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds 期刊论文
NATURE, 2020, 580 (7803) : 409-+
作者:  Al-Shayeb, Basem;  Sachdeva, Rohan;  Chen, Lin-Xing;  Ward, Fred;  Munk, Patrick;  Devoto, Audra;  Castelle, Cindy J.;  Olm, Matthew R.;  Bouma-Gregson, Keith;  Amano, Yuki;  He, Christine;  Meheust, Raphael;  Brooks, Brandon;  Thomas, Alex;  Levy, Adi;  Matheus-Carnevali, Paula;  Sun, Christine;  Goltsman, Daniela S. A.;  Borton, Mikayla A.;  Sharrar, Allison;  Jaffe, Alexander L.;  Nelson, Tara C.;  Kantor, Rose;  Keren, Ray;  Lane, Katherine R.;  Farag, Ibrahim F.;  Lei, Shufei;  Finstad, Kari;  Amundson, Ronald;  Anantharaman, Karthik;  Zhou, Jinglie;  Probst, Alexander J.;  Power, Mary E.;  Tringe, Susannah G.;  Li, Wen-Jun;  Wrighton, Kelly;  Harrison, Sue;  Morowitz, Michael;  Relman, David A.;  Doudna, Jennifer A.;  Lehours, Anne-Catherine;  Warren, Lesley;  Cate, Jamie H. D.;  Santini, Joanne M.;  Banfield, Jillian F.
收藏  |  浏览/下载：37/0  |  提交时间：2020/07/03

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen and the causative agent of tuberculosis(1-3). Although Mtb can synthesize vitamin B-12 (cobalamin) de novo, uptake of cobalamin has been linked to pathogenesis of tuberculosis2. Mtb does not encode any characterized cobalamin transporter(4-6)  however, the gene rv1819c was found to be essential for uptake of cobalamin(1). This result is difficult to reconcile with the original annotation of Rv1819c as a protein implicated in the transport of antimicrobial peptides such as bleomycin(7). In addition, uptake of cobalamin seems inconsistent with the amino acid sequence, which suggests that Rv1819c has a bacterial ATP-binding cassette (ABC)-exporter fold1. Here, we present structures of Rv1819c, which reveal that the protein indeed contains the ABC-exporter fold, as well as a large water-filled cavity of about 7,700 angstrom(3), which enables the protein to transport the unrelated hydrophilic compounds bleomycin and cobalamin. On the basis of these structures, we propose that Rv1819c is a multi-solute transporter for hydrophilic molecules, analogous to the multidrug exporters of the ABC transporter family, which pump out structurally diverse hydrophobic compounds from cells(8-11).


  
Red Sea corals under Artificial Light Pollution at Night (ALAN) undergo oxidative stress and photosynthetic impairment 期刊论文
GLOBAL CHANGE BIOLOGY, 2019
作者:  Ayalon, Inbal;  Marangoni, Laura F. de Barros;  Benichou, Jennifer I. C.;  Avisar, Dror;  Levy, Oren
收藏  |  浏览/下载：9/0  |  提交时间：2019/11/27
ALAN  corals  light pollution  photosynthesis  physiology  ROS  
Estimates of African Dust Deposition Along the Trans-Atlantic Transit Using the Decadelong Record of Aerosol Measurements from CALIOP, MODIS, MISR, and IASI 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2019, 124 (14) : 7975-7996
作者:  Yu, Hongbin;  Tan, Qian;  Chin, Mian;  Remer, Lorraine A.;  Kahn, Ralph A.;  Bian, Huisheng;  Kim, Dongchul;  Zhang, Zhibo;  Yuan, Tianle;  Omar, Ali H.;  Winker, David M.;  Levy, Robert C.;  Kalashnikova, Olga;  Crepeau, Laurent;  Capelle, Virginie;  Chedin, Alain
收藏  |  浏览/下载：10/0  |  提交时间：2019/11/27
aerosol  dust deposition  long-range transport  satellite remote sensing  
AERONET Remotely Sensed Measurements and Retrievals of Biomass Burning Aerosol Optical Properties During the 2015 Indonesian Burning Season 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2019, 124 (8) : 4722-4740
作者:  Eck, T. F.;  Holben, B. N.;  Giles, D. M.;  Slutsker, I;  Sinyuk, A.;  Schafer, J. S.;  Smirnov, A.;  Sorokin, M.;  Reid, J. S.;  Sayer, A. M.;  Hsu, N. C.;  Shi, Y. R.;  Levy, R. C.;  Lyapustin, A.;  Rahman, Muhammad Arif;  Liew, Soo-Chin;  Cortijo, Santo V. Salinas;  Li, Tan;  Kalbermatter, Daniel;  Keong, Kwoh Leong;  Yuggotomo, Muhammad Elifant;  Aditya, Fanni;  Mohamad, Maznorizan;  Mahmud, Mastura;  Chong, Tan Kok;  Lim, Hwee-San;  Choon, Yeap Eng;  Deranadyan, Gumilang;  Kusumaningtyas, Sheila D. A.;  Aldrian, Edvin
收藏  |  浏览/下载：15/0  |  提交时间：2019/11/26
Exploring Aerosols Near Clouds With High-Spatial-Resolution Aircraft Remote Sensing During SEAC(4)RS 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2019, 124 (4) : 2148-2173
作者:  Spencer, Robert S.;  Levy, Robert C.;  Remer, Lorraine A.;  Mattoo, Shana;  Arnold, George T.;  Hlavka, Dennis L.;  Meyer, Kerry G.;  Marshak, Alexander;  Wilcox, Eric M.;  Platnick, Steven E.
收藏  |  浏览/下载：4/0  |  提交时间：2019/04/09
aerosol  AOD  eMAS  SEAC(4)RS  clouds  
Antarctic ice-sheet sensitivity to obliquity forcing enhanced through ocean connections 期刊论文
NATURE GEOSCIENCE, 2019, 12 (2) : 132-+
作者:  Levy, R. H.;  Meyers, S. R.;  Naish, T. R.;  Golledge, N. R.;  McKay, R. M.;  Crampton, J. S.;  DeConto, R. M.;  De Santis, L.;  Florindo, F.;  Gasson, E. G. W.;  Harwood, D. M.;  Luyendyk, B. P.;  Powell, R. D.;  Clowes, C.;  Kulhanek, D. K.
收藏  |  浏览/下载：10/0  |  提交时间：2019/04/09
Criteria for effective zero-deforestation commitments 期刊论文
GLOBAL ENVIRONMENTAL CHANGE-HUMAN AND POLICY DIMENSIONS, 2019, 54: 135-147
作者:  Garrett, R. D.;  Levy, S.;  Carlson, K. M.;  Gardner, T. A.;  Godar, J.;  Clapp, J.;  Dauvergne, P.;  Heilmayr, R.;  de Waroux, Y. le Polain;  Ayre, B.;  Barr, R.;  Dovre, B.;  Gibbs, H. K.;  Hall, S.;  Lake, S.;  Milder, J. C.;  Rausch, L. L.;  Rivero, R.;  Rueda, X.;  Sarsfield, R.;  Soarer-Filho, B.;  Villoria, N.
收藏  |  浏览/下载：11/0  |  提交时间：2019/04/09
Agriculture  Forestry  Supply chain  Conservation  Voluntary environmental policies  Sustainability standards  
Land Use Change Increases Streamflow Across the Arc of Deforestation in Brazil 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2018, 45 (8) : 3520-3530
作者:  Levy, M. C.;  Lopes, A. V.;  Cohn, A.;  Larsen, L. G.;  Thompson, S. E.
收藏  |  浏览/下载：5/0  |  提交时间：2019/04/09
Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection 期刊论文
SCIENCE, 2018, 359 (6382) : 1376-+
作者:  Thaiss, Christoph A.;  Levy, Maayan;  Grosheva, Inna;  Zheng, Danping;  Soffer, Eliran;  Blacher, Eran;  Braverman, Sofia;  Tengeler, Anouk C.;  Barak, Oren;  Elazar, Maya;  Ben-Zeev, Rotem;  Lehavi-Regev, Dana;  Katz, Meirav N.;  Pevsner-Fischer, Meirav;  Gertler, Arieh;  Halpern, Zamir;  Harmelin, Alon;  Aamar, Suhail;  Serradas, Patricia;  Grosfeld, Alexandra;  Shapiro, Hagit;  Geiger, Benjamin;  Elinav, Eran
收藏  |  浏览/下载：5/0  |  提交时间：2019/11/27