中文版 | English

在结果中检索

GSTDTAP

浏览/检索结果: 共17条，第1-10条 帮助

限定条件                        
已选(0)清除 条数/页：   排序方式：
Lagrangian-based Simulations of Hypervelocity Impact Experiments on Mars Regolith Proxy 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (13)
作者:  Froment, M.;  Rougier, E.;  Larmat, C.;  Lei, Z.;  Euser, B.;  Kedar, S.;  Richardson, J. E.;  Kawamura, T.;  Lognonne, P.
收藏  |  浏览/下载：13/0  |  提交时间：2020/05/25
Parametric study  Lagrangian numerical model  Shock wave  granular media  Mars regolith  Impact  
A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds 期刊论文
NATURE, 2020, 580 (7803) : 409-+
作者:  Al-Shayeb, Basem;  Sachdeva, Rohan;  Chen, Lin-Xing;  Ward, Fred;  Munk, Patrick;  Devoto, Audra;  Castelle, Cindy J.;  Olm, Matthew R.;  Bouma-Gregson, Keith;  Amano, Yuki;  He, Christine;  Meheust, Raphael;  Brooks, Brandon;  Thomas, Alex;  Levy, Adi;  Matheus-Carnevali, Paula;  Sun, Christine;  Goltsman, Daniela S. A.;  Borton, Mikayla A.;  Sharrar, Allison;  Jaffe, Alexander L.;  Nelson, Tara C.;  Kantor, Rose;  Keren, Ray;  Lane, Katherine R.;  Farag, Ibrahim F.;  Lei, Shufei;  Finstad, Kari;  Amundson, Ronald;  Anantharaman, Karthik;  Zhou, Jinglie;  Probst, Alexander J.;  Power, Mary E.;  Tringe, Susannah G.;  Li, Wen-Jun;  Wrighton, Kelly;  Harrison, Sue;  Morowitz, Michael;  Relman, David A.;  Doudna, Jennifer A.;  Lehours, Anne-Catherine;  Warren, Lesley;  Cate, Jamie H. D.;  Santini, Joanne M.;  Banfield, Jillian F.
收藏  |  浏览/下载：37/0  |  提交时间：2020/07/03

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen and the causative agent of tuberculosis(1-3). Although Mtb can synthesize vitamin B-12 (cobalamin) de novo, uptake of cobalamin has been linked to pathogenesis of tuberculosis2. Mtb does not encode any characterized cobalamin transporter(4-6)  however, the gene rv1819c was found to be essential for uptake of cobalamin(1). This result is difficult to reconcile with the original annotation of Rv1819c as a protein implicated in the transport of antimicrobial peptides such as bleomycin(7). In addition, uptake of cobalamin seems inconsistent with the amino acid sequence, which suggests that Rv1819c has a bacterial ATP-binding cassette (ABC)-exporter fold1. Here, we present structures of Rv1819c, which reveal that the protein indeed contains the ABC-exporter fold, as well as a large water-filled cavity of about 7,700 angstrom(3), which enables the protein to transport the unrelated hydrophilic compounds bleomycin and cobalamin. On the basis of these structures, we propose that Rv1819c is a multi-solute transporter for hydrophilic molecules, analogous to the multidrug exporters of the ABC transporter family, which pump out structurally diverse hydrophobic compounds from cells(8-11).


  
Global picophytoplankton niche partitioning predicts overall positive response to ocean warming 期刊论文
NATURE GEOSCIENCE, 2020, 13 (2) : 116-+
作者:  Flombaum, Pedro;  Wang, Wei-Lei;  Primeau, Francois W.;  Martiny, Adam C.
收藏  |  浏览/下载：6/0  |  提交时间：2020/05/13
Seasonal climatic effects and feedbacks of anthropogenic heat release due to global energy consumption with CAM5 期刊论文
CLIMATE DYNAMICS, 2019, 52 (11) : 6377-6390
作者:  Chen, Bing;  Wu, C.;  Liu, X.;  Chen, L.;  Wu, Jian;  Yang, H.;  Luo, Tao;  Wu, Xue;  Jiang, Yiquan;  Jiang, Lei;  Brown, H. Y.;  Lu, Z.;  Fan, W.;  Lin, G.;  Sun, Bo;  Wu, M.
收藏  |  浏览/下载：15/0  |  提交时间：2019/11/26
Anthropogenic heat release  Climatic effect  Climate feedback  Climate change  
Historical and genomic data reveal the influencing factors on global transmission velocity of plague during the Third Pandemic 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (24) : 11833-11838
作者:  Xu, Lei;  Stige, Leif C.;  Leirs, Herwig;  Neerinckx, Simon;  Gage, Kenneth L.;  Yang, Ruifu;  Liu, Qiyong;  Bramanti, Barbara;  Dean, Katharine R.;  Tang, Hui;  Sun, Zhe;  Stenseth, Nils Chr.;  Zhang, Zhibin
收藏  |  浏览/下载：15/0  |  提交时间：2019/11/27
Yersinia pestis  Third Pandemic  climate change  global transmission velocity  historical and genomic data  
Contrasting lake ice responses to winter climate indicate future variability and trends on the Alaskan Arctic Coastal Plain 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2018, 13 (12)
作者:  Arp, Christopher D.;  Jones, Benjamin M.;  Engram, Melanie;  Alexeev, Vladimir A.;  Cai, Lei;  Parsekian, Andrew;  Hinkel, Kenneth;  Bondurant, Allen C.;  Creighton, Andrea
收藏  |  浏览/下载：7/0  |  提交时间：2019/04/09
arctic  winter  climate change  lakes  freshwater ice  
Myofibroblast proliferation and heterogeneity are supported by macrophages during skin repair 期刊论文
SCIENCE, 2018, 362 (6417) : 909-+
作者:  Shook, Brett A.;  Wasko, Renee R.;  Rivera-Gonzalez, Guillermo C.;  Salazar-Gatzimas, Emilio;  Lopez-Giraldez, Francesc;  Dash, Biraja C.;  Munoz-Rojas, Andres R.;  Aultman, Krystal D.;  Zwick, Rachel K.;  Lei, Vivian;  Arbiser, Jack L.;  Miller-Jensen, Kathryn;  Clark, Damon A.;  Hsia, Henry C.;  Horsley, Valerie
收藏  |  浏览/下载：9/0  |  提交时间：2019/11/27
Rapid transition from continental breakup to igneous oceanic crust in the South China Sea 期刊论文
NATURE GEOSCIENCE, 2018, 11 (10) : 782-+
作者:  Larsen, H. C.;  Mohn, G.;  Nirrengarten, M.;  Sun, Z.;  Stock, J.;  Jian, Z.;  Klaus, A.;  Alvarez-Zarikian, C. A.;  Boaga, J.;  Bowden, S. A.;  Briais, A.;  Chen, Y.;  Cukur, D.;  Dadd, K.;  Ding, W.;  Dorais, M.;  Ferre, E. C.;  Ferreira, F.;  Furusawa, A.;  Gewecke, A.;  Hinojosa, J.;  Hofig, T. W.;  Hsiung, K. H.;  Huang, B.;  Huang, E.;  Huang, X. L.;  Jiang, S.;  Jin, H.;  Johnson, B. G.;  Kurzawski, R. M.;  Lei, C.;  Li, B.;  Li, L.;  Li, Y.;  Lin, J.;  Liu, C.;  Liu, Z.;  Luna, A. J.;  Lupi, C.;  McCarthy, A.;  Ningthoujam, L.;  Osono, N.;  Peate, D. W.;  Persaud, P.;  Qiu, N.;  Robinson, C.;  Satolli, S.;  Sauermilch, I;  Schindlbeck, J. C.;  Skinner, S.;  Straub, S.;  Su, X.;  Su, C.;  Tian, L.;  Van Der Zwan, F. M.;  Wan, S.;  Wu, H.;  Xiang, R.;  Yadav, R.;  Yi, L.;  Yu, P. S.;  Zhang, C.;  Zhang, J.;  Zhang, Y.;  Zhao, N.;  Zhong, G.;  Zhong, L.
收藏  |  浏览/下载：13/0  |  提交时间：2019/04/09
Evaluating Global Land Surface Models in CMIP5: Analysis of Ecosystem Water- and Light-Use Efficiencies and Rainfall Partitioning 期刊论文
JOURNAL OF CLIMATE, 2018, 31 (8) : 2995-3008
作者:  Li, Longhui;  Wang, Yingping;  Arora, Vivek K.;  Eamus, Derek;  Shi, Hao;  Li, Jing;  Cheng, Lei;  Cleverly, James;  Hajima, T.;  Ji, Duoying;  Jones, C.;  Kawamiya, M.;  Li, Weiping;  Tjiputra, J.;  Wiltshire, A.;  Zhang, Lu;  Yu, Qiang
收藏  |  浏览/下载：20/0  |  提交时间：2019/04/09
Ecological models  Hydrologic models  Land surface model  Model comparison  Model evaluation  performance  
Genome-wide identification of interferon-sensitive mutations enables influenza vaccine design 期刊论文
SCIENCE, 2018, 359 (6373) : 290-+
作者:  Du, Yushen;  Xin, Li;  Shi, Yuan;  Zhang, Tian-Hao;  Wu, Nicholas C.;  Dai, Lei;  Gong, Danyang;  Brar, Gurpreet;  Shu, Sara;  Luo, Jiadi;  Reiley, William;  Tseng, Yen-Wen;  Bai, Hongyan;  Wu, Ting-Ting;  Wang, Jieru;  Shu, Yuelong;  Sun, Ren
收藏  |  浏览/下载：9/0  |  提交时间：2019/11/27