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Improvement in municipal wastewater treatment alters lake nitrogen to phosphorus ratios in populated regions 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (21) : 11566-11572
作者:  Tong, Yindong;  Wang, Mengzhu;  Penuelas, Josep;  Liu, Xueyan;  Paerl, Hans W.;  Elser, James J.;  Sardans, Jordi;  Couture, Raoul-Marie;  Larssen, Thorjorn;  Hu, Hongying;  Dong, Xin;  He, Wei;  Zhang, Wei;  Wang, Xuejun;  Zhang, Yang;  Liu, Yi;  Zeng, Siyu;  Kong, Xiangzhen;  Janssen, Annette B. G.;  Lin, Yan
收藏  |  浏览/下载:12/0  |  提交时间:2020/05/13
nutrient balance  water quality change  anthropogenic source  wastewater treatment  aquatic ecosystem  
Electrical manipulation of a topological antiferromagnetic state 期刊论文
NATURE, 2020, 580 (7805) : 608-+
作者:  Chabon, Jacob J.;  Hamilton, Emily G.;  Kurtz, David M.;  Esfahani, Mohammad S.;  Moding, Everett J.;  Stehr, Henning;  Schroers-Martin, Joseph;  Nabet, Barzin Y.;  Chen, Binbin;  Chaudhuri, Aadel A.;  Liu, Chih Long;  Hui, Angela B.;  Jin, Michael C.;  Azad, Tej D.;  Almanza, Diego;  Jeon, Young-Jun;  Nesselbush, Monica C.;  Keh, Lyron Co Ting;  Bonilla, Rene F.;  Yoo, Christopher H.;  Ko, Ryan B.;  Chen, Emily L.;  Merriott, David J.;  Massion, Pierre P.;  Mansfield, Aaron S.;  Jen, Jin;  Ren, Hong Z.;  Lin, Steven H.;  Costantino, Christina L.;  Burr, Risa;  Tibshirani, Robert;  Gambhir, Sanjiv S.;  Berry, Gerald J.;  Jensen, Kristin C.;  West, Robert B.;  Neal, Joel W.;  Wakelee, Heather A.;  Loo, Billy W., Jr.;  Kunder, Christian A.;  Leung, Ann N.;  Lui, Natalie S.;  Berry, Mark F.;  Shrager, Joseph B.;  Nair, Viswam S.;  Haber, Daniel A.;  Sequist, Lecia V.;  Alizadeh, Ash A.;  Diehn, Maximilian
收藏  |  浏览/下载:37/0  |  提交时间:2020/07/03

Room-temperature electrical switching of a topological antiferromagnetic state in polycrystalline Mn3Sn thin films is demonstrated using the same protocol as that used for conventional ferromagnetic metals.


Electrical manipulation of phenomena generated by nontrivial band topology is essential for the development of next-generation technology using topological protection. A Weyl semimetal is a three-dimensional gapless system that hosts Weyl fermions as low-energy quasiparticles(1-4). It has various exotic properties, such as a large anomalous Hall effect (AHE) and chiral anomaly, which are robust owing to the topologically protected Weyl nodes(1-16). To manipulate such phenomena, a magnetic version of Weyl semimetals would be useful for controlling the locations of Weyl nodes in the Brillouin zone. Moreover, electrical manipulation of antiferromagnetic Weyl metals would facilitate the use of antiferromagnetic spintronics to realize high-density devices with ultrafast operation(17,18). However, electrical control of a Weyl metal has not yet been reported. Here we demonstrate the electrical switching of a topological antiferromagnetic state and its detection by the AHE at room temperature in a polycrystalline thin film(19) of the antiferromagnetic Weyl metal Mn3Sn9,10,12,20, which exhibits zero-field AHE. Using bilayer devices composed of Mn3Sn and nonmagnetic metals, we find that an electrical current density of about 10(10) to 10(11) amperes per square metre induces magnetic switching in the nonmagnetic metals, with a large change in Hall voltage. In addition, the current polarity along the bias field and the sign of the spin Hall angle of the nonmagnetic metals-positive for Pt (ref. (21)), close to 0 for Cu and negative for W (ref. (22))-determines the sign of the Hall voltage. Notably, the electrical switching in the antiferromagnet is achieved with the same protocol as that used for ferromagnetic metals(23,24). Our results may lead to further scientific and technological advances in topological magnetism and antiferromagnetic spintronics.


  
A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds 期刊论文
NATURE, 2020, 580 (7803) : 409-+
作者:  Al-Shayeb, Basem;  Sachdeva, Rohan;  Chen, Lin-Xing;  Ward, Fred;  Munk, Patrick;  Devoto, Audra;  Castelle, Cindy J.;  Olm, Matthew R.;  Bouma-Gregson, Keith;  Amano, Yuki;  He, Christine;  Meheust, Raphael;  Brooks, Brandon;  Thomas, Alex;  Levy, Adi;  Matheus-Carnevali, Paula;  Sun, Christine;  Goltsman, Daniela S. A.;  Borton, Mikayla A.;  Sharrar, Allison;  Jaffe, Alexander L.;  Nelson, Tara C.;  Kantor, Rose;  Keren, Ray;  Lane, Katherine R.;  Farag, Ibrahim F.;  Lei, Shufei;  Finstad, Kari;  Amundson, Ronald;  Anantharaman, Karthik;  Zhou, Jinglie;  Probst, Alexander J.;  Power, Mary E.;  Tringe, Susannah G.;  Li, Wen-Jun;  Wrighton, Kelly;  Harrison, Sue;  Morowitz, Michael;  Relman, David A.;  Doudna, Jennifer A.;  Lehours, Anne-Catherine;  Warren, Lesley;  Cate, Jamie H. D.;  Santini, Joanne M.;  Banfield, Jillian F.
收藏  |  浏览/下载:37/0  |  提交时间:2020/07/03

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen and the causative agent of tuberculosis(1-3). Although Mtb can synthesize vitamin B-12 (cobalamin) de novo, uptake of cobalamin has been linked to pathogenesis of tuberculosis2. Mtb does not encode any characterized cobalamin transporter(4-6)  however, the gene rv1819c was found to be essential for uptake of cobalamin(1). This result is difficult to reconcile with the original annotation of Rv1819c as a protein implicated in the transport of antimicrobial peptides such as bleomycin(7). In addition, uptake of cobalamin seems inconsistent with the amino acid sequence, which suggests that Rv1819c has a bacterial ATP-binding cassette (ABC)-exporter fold1. Here, we present structures of Rv1819c, which reveal that the protein indeed contains the ABC-exporter fold, as well as a large water-filled cavity of about 7,700 angstrom(3), which enables the protein to transport the unrelated hydrophilic compounds bleomycin and cobalamin. On the basis of these structures, we propose that Rv1819c is a multi-solute transporter for hydrophilic molecules, analogous to the multidrug exporters of the ABC transporter family, which pump out structurally diverse hydrophobic compounds from cells(8-11).


  
"Ancient pigs reveal a near-complete genomic turnover following their introduction to Europe (vol 116, pg17231, 2019) 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (25) : 14610-14611
作者:  Frantz, Laurent A. F.;  Haile, James;  Lin, Audrey T.;  Scheu, Amelie;  Geoerg, Christina;  Benecke, Norbert;  Alexander, Michelle;  Linderholm, Anna;  Mullin, Victoria E.;  Daly, Kevin G.;  Battista, Vincent M.;  Price, Max;  Gron, Kurt J.;  Alexandri, Panoraia;  Arbogast, Rose-Marie;  Arbuckle, Benjamin;  Balasescu, Adrian;  Barnett, Ross;  Bartosiewicz, Laszlo;  Baryshnikov, Gennady;  Bonsall, Clive;  Boric, Dian;  Boroneant, Adina;  Bulatovic, Jelena;  Cakirlar, Canan;  Carreterow, Jose-Miguel;  Chapman, John;  Church, Mike;  Crooijmans, Richard;  De Cupere, Bea;  Detry, Cleia;  Dimitrijevic, Vesna;  Dumitrascu, Valentin;  du Plessis, Louis;  Edwards, Ceiridwen J.;  Erek, Cevdet Merih;  Erim-Ozdogan, Ash;  Ervynck, Anton;  Fulgione, Domenico;  Gligor, Mihai;  Gotherstrom, Anders;  Gourichon, Lionel;  Groenen, Martien A. M.;  Helmer, Daniel;  Hongo, Hitomi;  Horwitz, Liora K.;  Irving-Pease, Evan K.;  Lebrasseur, Ophelie;  Lesur, Josephine;  Malone, Caroline;  Manaseryan, Ninna;  Marciniak, Arkadiusz;  Martlew, Holley;  Mashkour, Marjan;  Matthews, Roger;  Matuzeviciute, Giedre Motuzaite;  Maziar, Sepideh;  Meijaard, Erik;  McGovern, Tom;  Megens, Hendrik-Jan;  Miller, Rebecca;  Mohaseb, Azadeh Fatemeh;  Orschiedt, Jorg;  Orton, David;  Papathanasiou, Anastasia;  Pearson, Mike Parker;  Pinhasi, Ron;  Radmanovic, Darko;  Ricaut, Francois-Xavier;  Richards, Mike;  Sabin, Richard;  Sarti, Lucia;  Schier, Wolfram;  Sheikhi, Shiva;  Stephan, Elisabeth;  Stewart, John R.;  Stoddart, Simon;  Tagliacozzo, Antonio;  Tasic, Nenad;  Trantalidou, Katerina;  Tresset, Anne;  Valdiosera, Cristina;  van den Hurk, Youri;  Van Poucke, Sophie;  Vigne, Jean-Denis;  Yanevich, Alexander;  Zeeb-Lanz, Andrea;  Triantafyllidis, Alexandros;  Gilbert, M. Thomas P.;  Schibler, Jorg;  Rowley-Conwy, Peter;  Zeder, Melinda;  Peters, Joris;  Cucchi, Thomas;  Bradley, Daniel G.;  Dobney, Keith;  Burger, Joachim;  Evin, Allowen;  Girdland-Flink, Linus;  Larson, Greger
收藏  |  浏览/下载:18/0  |  提交时间:2020/02/17
Direct observation of bimolecular reactions of ultracold KRb molecules 期刊论文
SCIENCE, 2019, 366 (6469) : 1111-+
作者:  Hu, M. -G.;  Liu, Y.;  Grimes, D. D.;  Lin, Y. -W.;  Gheorghe, A. H.;  Vexiau, R.;  Bouloufa-Maafa, N.;  Dulieu, O.;  Rosenband, T.;  Ni, K. -K.
收藏  |  浏览/下载:7/0  |  提交时间:2020/02/17
A second source of repeating fast radio bursts 期刊论文
NATURE, 2019, 566 (7743) : 235-+
作者:  Amiri, M.;  Bandura, K.;  Bhardwaj, M.;  Boubel, P.;  Boyce, M. M.;  Boyle, P. J.;  Brar, C.;  Burhanpurkar, M.;  Cassanelli, T.;  Chawla, P.;  Cliche, J. F.;  Cubranic, D.;  Deng, M.;  Denman, N.;  Dobbs, M.;  Fandino, M.;  Fonseca, E.;  Gaensler, B. M.;  Gilbert, A. J.;  Gill, A.;  Giri, U.;  Good, D. C.;  Halpern, M.;  Hanna, D. S.;  Hill, A. S.;  Hinshaw, G.;  Hofer, C.;  Josephy, A.;  Kaspi, V. M.;  Landecker, T. L.;  Lang, D. A.;  Lin, H-H.;  Masui, K. W.;  Mckinven, R.;  Mena-Parra, J.;  Merryfield, M.;  Michilli, D.;  Milutinovic, N.;  Moatti, C.;  Naidu, A.;  Newburgh, L. B.;  Ng, C.;  Patel, C.;  Pen, U.;  Pinsonneault-Marotte, T.;  Pleunis, Z.;  Rafiei-Ravandi, M.;  Rahman, M.;  Ransom, S. M.;  Renard, A.;  Scholz, P.;  Shaw, J. R.;  Siegel, S. R.;  Smith, K. M.;  Stairs, I. H.;  Tendulkar, S. P.;  Tretyakov, I.;  Vanderlinde, K.;  Yadav, P.
收藏  |  浏览/下载:14/0  |  提交时间:2019/11/27
Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior 期刊论文
SCIENCE, 2019, 365 (6456) : 882-+
作者:  Ganna, Andrea;  Verweij, Karin J. H.;  Nivard, Michel G.;  Maier, Robert;  Wedow, Robbee;  Busch, Alexander S.;  Abdellaoui, Abdel;  Guo, Shengru;  Sathirapongsasuti, J. Fah;  Lichtenstein, Paul;  Lundstrom, Sebastian;  Langstrom, Niklas;  Auton, Adam;  Harris, Kathleen Mullan;  Beecham, Gary W.;  Martin, Eden R.;  Sanders, Alan R.;  Perry, John R. B.;  Neale, Benjamin M.;  Zietsch, Brendan P.;  Agee, M.;  Alipanahi, B.;  Auton, A.;  Bell, R. K.;  Bryc, K.;  Elson, S. L.;  Fontanillas, P.;  Furlotte, N. A.;  Hicks, B.;  Huber, K. E.;  Jewett, E. M.;  Jiang, Y.;  Kleinman, A.;  Lin, K. -H.;  Litterman, N. K.;  McCreight, J. C.;  McIntyre, M. H.;  McManus, K. F.;  Mountain, J. L.;  Noblin, E. S.;  Northover, C. A. M.;  Pitts, S. J.;  Poznik, G. D.;  Shastri, A. J.;  Shelton, J. F.;  Shringarpure, S.;  Tian, C.;  Tung, J. Y.;  Vacic, V.;  Wang, X.;  Wilson, C. H.
收藏  |  浏览/下载:28/0  |  提交时间:2019/11/27
Large-scale ruminant genome sequencing provides insights into their evolution and distinct traits 期刊论文
SCIENCE, 2019, 364 (6446) : 1152-+
作者:  Chen, Lei;  Qin, Qiang;  Jiang, Yu;  Wang, Kun;  Lin, Zeshan;  Li, Zhipeng;  Bibi, Faysal;  Yang, Yongzhi;  Wang, Jinhuan;  Nie, Wenhui;  Su, Weiting;  Liu, Guichun;  Li, Qiye;  Fu, Weiwei;  Pan, Xiangyu;  Liu, Chang;  Yang, Jie;  Zhang, Chenzhou;  Yin, Yuan;  Wang, Yu;  Zhao, Yue;  Zhang, Chen;  Wang, Zhongkai;  Qin, Yanli;  Liu, Wei;  Wang, Bao;  Ren, Yandong;  Zhang, Ru;  Zeng, Yan;  da Fonseca, Rute R.;  Wei, Bin;  Li, Ran;  Wan, Wenting;  Zhao, Ruoping;  Zhu, Wenbo;  Wang, Yutao;  Duan, Shengchang;  Gao, Yun;  Zhang, Yong E.;  Chen, Chunyan;  Hvilsom, Christina;  Epps, Clinton W.;  Chemnick, Leona G.;  Doug, Yang;  Mirarab, Siavash;  Siegismund, Hans Redlef;  Ryder, Oliver A.;  Gilbert, M. Thomas P.;  Lewin, Harris A.;  Zhang, Guojie;  Heller, Rasmus;  Wang, Wen
收藏  |  浏览/下载:19/0  |  提交时间:2019/11/27
Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWPI inhibitory pathway 期刊论文
SCIENCE, 2019, 364 (6441) : 651-+
作者:  Lee, Yu-Ru;  Chen, Ming;  Lee, Jonathan D.;  Zhang, Jinfang;  Lin, Shu-Yu;  Fu, Tian-Min;  Chen, Hao;  Ishikawa, Tomold;  Chiang, Shang-Yin;  Katon, Jesse;  Zhang, Yang;  Shulga, Yulia V.;  Bester, Assaf C.;  Fung, Jacqueline;  Monteleone, Emanuele;  Wan, Lixin;  Shen, Chen;  Hsu, Chil-Hung;  Papa, Antonella;  Clohessy, John G.;  Teruya-Feldstein, Julie;  Jain, Suresh;  Wu, Hao;  Matesic, Lydia;  Chen, Ruey-Hwa;  Wei, Wenyi;  Pandolfi, Pier Paolo
收藏  |  浏览/下载:14/0  |  提交时间:2019/11/27
Observation of two-neutrino double electron capture in Xe-124 with XENON1T 期刊论文
NATURE, 2019, 568 (7753) : 532-+
作者:  Aprile, E.;  Aalbers, J.;  Agostini, F.;  Alfonsi, M.;  Althueser, L.;  Amaro, F. D.;  Anthony, M.;  Antochi, V. C.;  Arneodo, F.;  Baudis, L.;  Bauermeister, B.;  Benabderrahmane, L.;  Berger, T.;  Breur, P. A.;  Brown, A.;  Brown, A.;  Brown, E.;  Bruenner, S.;  Bruno, G.;  Budnik, R.;  Capelli, C.;  Cardoso, J. M. R.;  Cichon, D.;  Coderre, D.;  Colijn, A. P.;  Conrad, J.;  Cussonneau, J. P.;  Decowski, M. P.;  de Perio, P.;  Di Gangi, P.;  Di Giovanni, A.;  Diglio, S.;  Elykov, A.;  Eurin, G.;  Fei, J.;  Ferella, A. D.;  Fieguth, A.;  Fulgione, W.;  Rosso, A. Gallo;  Galloway, M.;  Gao, F.;  Garbini, M.;  Grandi, L.;  Greene, Z.;  Hasterok, C.;  Hogenbirk, E.;  Howlett, J.;  Iacovacci, M.;  Itay, R.;  Joerg, F.;  Kaminsky, B.;  Kazama, S.;  Kish, A.;  Koltman, G.;  Kopec, A.;  Landsman, H.;  Lang, R. F.;  Levinson, L.;  Lin, Q.;  Lindemann, S.;  Lindner, M.;  Lombardi, F.;  Lopes, J. A. M.;  Fune, E. Lopez;  Macolino, C.;  Mahlstedt, J.;  Manfredini, A.;  Marignetti, F.;  Undagoitia, T. Marrodan;  Masbou, J.;  Masson, D.;  Mastroianni, S.;  Messina, M.;  Micheneau, K.;  Miller, K.;  Molinario, A.;  Mora, K.;  Murra, M.;  Naganoma, J.;  Ni, K.;  Oberlack, U.;  Odgers, K.;  Pelssers, B.;  Peres, R.;  Piastra, F.;  Pienaar, J.;  Pizzella, V.;  Plante, G.;  Podviianiuk, R.;  Priel, N.;  Qiu, H.;  Garcia, D. Ramirez;  Reichard, S.;  Riedel, B.;  Rizzo, A.;  Rocchetti, A.;  Rupp, N.;  dos Santos, J. M. F.;  Sartorelli, G.;  Sarcevic, N.;  Scheibelhut, M.;  Schindler, S.;  Schreiner, J.;  Schulte, D.;  Schumann, M.;  Lavina, L. Scotto;  Selvi, M.;  Shagin, P.;  Shockley, E.;  Silva, M.;  Simgen, H.;  Therreau, C.;  Thers, D.;  Toschi, F.;  Trinchero, G.;  Tunnell, C.;  Upole, N.;  Vargas, M.;  Wack, O.;  Wang, H.;  Wang, Z.;  Wei, Y.;  Weinheimer, C.;  Wenz, D.;  Wittweg, C.;  Wulf, J.;  Ye, J.;  Zhang, Y.;  Zhu, T.;  Zopounidis, J. P.
收藏  |  浏览/下载:14/0  |  提交时间:2019/11/27