GSTDTAP

浏览/检索结果: 共14条,第1-10条 帮助

已选(0)清除 条数/页:   排序方式:
Expansion sequencing: Spatially precise in situ transcriptomics in intact biological systems 期刊论文
Science, 2021
作者:  Shahar Alon;  Daniel R. Goodwin;  Anubhav Sinha;  Asmamaw T. Wassie;  Fei Chen;  Evan R. Daugharthy;  Yosuke Bando;  Atsushi Kajita;  Andrew G. Xue;  Karl Marrett;  Robert Prior;  Yi Cui;  Andrew C. Payne;  Chun-Chen Yao;  Ho-Jun Suk;  Ru Wang;  Chih-Chieh Yu;  Paul Tillberg;  Paul Reginato;  Nikita Pak;  Songlei Liu;  Sukanya Punthambaker;  Eswar P. R. Iyer;  Richie E. Kohman;  Jeremy A. Miller;  Ed S. Lein;  Ana Lako;  Nicole Cullen;  Scott Rodig;  Karla Helvie;  Daniel L. Abravanel;  Nikhil Wagle;  Bruce E. Johnson;  Johanna Klughammer;  Michal Slyper;  Julia Waldman;  Judit Jané-Valbuena;  Orit Rozenblatt-Rosen;  Aviv Regev;  IMAXT Consortium19¶;  George M. Church;  Adam H. Marblestone;  Edward S. Boyden
收藏  |  浏览/下载:42/0  |  提交时间:2021/02/17
Proton-assisted growth of ultra-flat graphene films 期刊论文
NATURE, 2020, 577 (7789) : 204-+
作者:  Yuan, Guowen;  Lin, Dongjing;  Wang, Yong;  Huang, Xianlei;  Chen, Wang;  Xie, Xuedong;  Zong, Junyu;  Yuan, Qian-Qian;  Zheng, Hang;  Wang, Di;  Xu, Jie;  Li, Shao-Chun;  Zhang, Yi;  Sun, Jian;  Xi, Xiaoxiang;  Gao, Libo
收藏  |  浏览/下载:32/0  |  提交时间:2020/07/03

Graphene films grown by chemical vapour deposition have unusual physical and chemical properties that offer promise for applications such as flexible electronics and high-frequency transistors(1-10). However, wrinkles invariably form during growth because of the strong coupling to the substrate, and these limit the large-scale homogeneity of the film(1-4,11,12). Here we develop a proton-assisted method of chemical vapour deposition to grow ultra-flat graphene films that are wrinkle-free. Our method of proton penetration(13-17) and recombination to form hydrogen can also reduce the wrinkles formed during traditional chemical vapour deposition of graphene. Some of the wrinkles disappear entirely, owing to the decoupling of van der Waals interactions and possibly an increase in distance from the growth surface. The electronic band structure of the as-grown graphene films shows a V-shaped Dirac cone and a linear dispersion relation within the atomic plane or across an atomic step, confirming the decoupling from the substrate. The ultra-flat nature of the graphene films ensures that their surfaces are easy to clean after a wet transfer process. A robust quantum Hall effect appears even at room temperature in a device with a linewidth of 100 micrometres. Graphene films grown by proton-assisted chemical vapour deposition should largely retain their intrinsic performance, and our method should be easily generalizable to other nanomaterials for strain and doping engineering.


  
Evaluation of sea salt aerosols in climate systems: global climate modeling and observation-based analyses* 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2020, 15 (3)
作者:  Chen, Yi-Chun;  Li, Jui-Lin F.;  Lee, Wei-Liang;  Diner, David J.;  Garay, Michael J.;  Jiang, Jonathan H.;  Wang, Yi-Hui;  Yu, Jia-Yuh;  Kalashnikova, Olga, V
收藏  |  浏览/下载:32/0  |  提交时间:2020/07/02
global climate modeling  aerosols  sea salt  falling ice radiative effects  
Negative supercoil at gene boundaries modulates gene topology 期刊论文
NATURE, 2020, 577 (7792) : 701-+
作者:  Yuan, Guowen;  Lin, Dongjing;  Wang, Yong;  Huang, Xianlei;  Chen, Wang;  Xie, Xuedong;  Zong, Junyu;  Yuan, Qian-Qian;  Zheng, Hang;  Wang, Di;  Xu, Jie;  Li, Shao-Chun;  Zhang, Yi;  Sun, Jian;  Xi, Xiaoxiang;  Gao, Libo
收藏  |  浏览/下载:55/0  |  提交时间:2020/07/03

Transcription challenges the integrity of replicating chromosomes by generating topological stress and conflicts with forks(1,2). The DNA topoisomerases Top1 and Top2 and the HMGB family protein Hmo1 assist DNA replication and transcription(3-6). Here we describe the topological architecture of genes in Saccharomyces cerevisiae during the G1 and S phases of the cell cycle. We found under-wound DNA at gene boundaries and over-wound DNA within coding regions. This arrangement does not depend on Pol II or S phase. Top2 and Hmo1 preserve negative supercoil at gene boundaries, while Top1 acts at coding regions. Transcription generates RNA-DNA hybrids within coding regions, independently of fork orientation. During S phase, Hmo1 protects under-wound DNA from Top2, while Top2 confines Pol II and Top1 at coding units, counteracting transcription leakage and aberrant hybrids at gene boundaries. Negative supercoil at gene boundaries prevents supercoil diffusion and nucleosome repositioning at coding regions. DNA looping occurs at Top2 clusters. We propose that Hmo1 locks gene boundaries in a cruciform conformation and, with Top2, modulates the architecture of genes that retain the memory of the topological arrangements even when transcription is repressed.


  
STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion 期刊论文
NATURE COMMUNICATIONS, 2018, 9
作者:  Hsu, Jung-Mao;  Xia, Weiya;  Hsu, Yi-Hsin;  Chan, Li-Chuan;  Yu, Wen-Hsuan;  Cha, Jong-Ho;  Chen, Chun-Te;  Liao, Hsin-Wei;  Kuo, Chu-Wei;  Khoo, Kay-Hooi;  Hsu, Jennifer L.;  Li, Chia-Wei;  Lim, Seung-Oe;  Chang, Shih-Shin;  Chen, Yi-Chun;  Ren, Guo-Xin;  Hung, Mien-Chie
收藏  |  浏览/下载:31/0  |  提交时间:2019/11/27
Membrane protein-regulated networks across human cancers 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Lin, Chun-Yu;  Lee, Chia-Hwa;  Chuang, Yi-Hsuan;  Lee, Jung-Yu;  Chiu, Yi-Yuan;  Lee, Yan-Hwa Wu;  Jong, Yuh-Jyh;  Hwang, Jenn-Kang;  Huangq, Sing-Han;  Chen, Li-Ching;  Wu, Chih-Hsiung;  Tu, Shih-Hsin;  Ho, Yuan-Soon;  Yang, Jinn-Moon
收藏  |  浏览/下载:35/0  |  提交时间:2019/11/27
Thermodynamic and Dynamic Responses to Deforestation in the Maritime Continent: A Modeling Study 期刊论文
JOURNAL OF CLIMATE, 2019, 32 (12) : 3505-3527
作者:  Chen, Chu-Chun;  Lo, Min-Hui;  Im, Eun-Soon;  Yu, Jin-Yi;  Liang, Yu-Chiao;  Chen, Wei-Ting;  Tang, Iping;  Lan, Chia-Wei;  Wu, Ren-Jie;  Chien, Rong-You
收藏  |  浏览/下载:15/0  |  提交时间:2019/11/26
Land surface  Maritime Continent  Atmosphere-land interaction  Surface temperature  Climate models  Deforestation  
Warming up human body by nanoporous metallized polyethylene textile 期刊论文
NATURE COMMUNICATIONS, 2017, 8
作者:  Cai, Lili;  Song, Alex Y.;  Wu, Peilin;  Hsu, Po-Chun;  Peng, Yucan;  Chen, Jun;  Liu, Chong;  Catrysse, Peter B.;  Liu, Yayuan;  Yang, Ankun;  Zhou, Chenxing;  Zhou, Chenyu;  Fan, Shanhui;  Cui, Yi
收藏  |  浏览/下载:27/0  |  提交时间:2019/11/27
Large three-dimensional photonic crystals based on monocrystalline liquid crystal blue phases 期刊论文
NATURE COMMUNICATIONS, 2017, 8
作者:  Chen, Chun-Wei;  Hou, Chien-Tsung;  Li, Cheng-Chang;  Jau, Hung-Chang;  Wang, Chun-Ta;  Hong, Ching-Lang;  Guo, Duan-Yi;  Wang, Cheng-Yu;  Chiang, Sheng-Ping;  Bunning, Timothy J.;  Khoo, Iam-Choon;  Lin, Tsung-Hsien
收藏  |  浏览/下载:36/0  |  提交时间:2019/11/27
SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Yuan, Shuofeng;  Chu, Hin;  Chan, Jasper Fuk-Woo;  Ye, Zi-Wei;  Wen, Lei;  Yan, Bingpeng;  Lai, Pok-Man;  Tee, Kah-Meng;  Huang, Jingjing;  Chen, Dongdong;  Li, Cun;  Zhao, Xiaoyu;  Yang, Dong;  Chiu, Man Chun;  Yip, Cyril;  Poon, Vincent Kwok-Man;  Chan, Chris Chung-Sing;  Sze, Kong-Hung;  Zhou, Jie;  Chan, Ivy Hau-Yee;  Kok, Kin-Hang;  To, Kelvin Kai-Wang;  Kao, Richard Yi-Tsun;  Lau, Johnson Yiu-Nam;  Jin, Dong-Yan;  Perlman, Stanley;  Yuen, Kwok-Yung
收藏  |  浏览/下载:28/0  |  提交时间:2019/11/27