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Rewetting does not return drained fen peatlands to their old selves 期刊论文
Nature Communications, 2021
作者:  Kreyling, J.;  Tanneberger, F.;  Jansen, F.;  van der Linden, S.;  Aggenbach, C.;  Blü;  ml, V.;  Couwenberg, J.;  Emsens, W-J;  Joosten, H.;  Klimkowska, A.;  Kotowski, W.;  Kozub, L.;  Lennartz, B.;  Liczner, Y.;  Liu, H.;  Michaelis, D.;  Oehmke, C.;  Parakenings, K.;  Pleyl, E.;  Poyda, A.;  Raabe, S.;  ;  hl, M.;  ;  cker, K.;  Schneider, A.;  Schrautzer, J.;  Schrö;  der, C.;  Schug, F.;  Seeber, E.;  Thiel, F.;  Thiele, S.;  Tiemeyer, B.;  Timmermann, T.;  Urich, T.;  van Diggelen, R.;  Vegelin, K.;  Verbruggen, E.;  Wilmking, M.;  Wrage-Mö;  nnig, N.;  Woł;  ejko, L.;  Zak, D.;  Jurasinski, G.
收藏  |  浏览/下载:32/0  |  提交时间:2021/10/22
Constraining the date of a seasonally ice-free Arctic using a simple model 期刊论文
Geophysical Research Letters, 2021
作者:  David B. Bonan;  Tapio Schneider;  Ian Eisenman;  Robert C.J. Wills
收藏  |  浏览/下载:15/0  |  提交时间:2021/08/30
Isobar Altitude Variations in the Upper Mesosphere Observed With IUVS-MAVEN in Response to Martian Dust Storms 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (12)
作者:  Gkouvelis, L.;  Gerard, J. -C.;  Gonzalez-Galindo, F.;  Hubert, B.;  Schneider, N. M.
收藏  |  浏览/下载:23/0  |  提交时间:2020/05/20
Mars dayglow  upper atmosphere  MAVEN  IUVS  dust storm  oxygen 297  2 nm  
Multispecific drugs herald a new era of biopharmaceutical innovation 期刊论文
NATURE, 2020, 580 (7803) : 329-338
作者:  Gallego, Laura D.;  Schneider, Maren;  Mittal, Chitvan;  Romanauska, Anete;  Carrillo, Ricardo M. Gudino;  Schubert, Tobias;  Pugh, B. Franklin;  Koehler, Alwin
收藏  |  浏览/下载:40/0  |  提交时间:2020/07/03

The modern biopharmaceutical industry traces its roots to the dawn of the twentieth century, coincident with marketing of aspirin-a signature event in the history of modern drug development. Although the archetypal discovery process did not change markedly in the first seven decades of the industry, the past fifty years have seen two successive waves of transformative innovation in the development of drug molecules: the rise of '  rational drug discovery'  methodology in the 1970s, followed by the invention of recombinant protein-based therapeutic agents in the 1980s. An incipient fourth wave is the advent of multispecific drugs. The successful development of prospectively designed multispecific drugs has the potential to reconfigure our ideas of how target-based therapeutic molecules can work, and what it is possible to achieve with them. Here I review the two major classes of multispecific drugs: those that enrich a therapeutic agent at a particular site of action and those that link a therapeutic target to a biological effector. The latter class-being freed from the constraint of having to directly modulate the target upon binding-may enable access to components of the proteome that currently cannot be targeted by drugs.


  
Spaceborne Measurements of Formic and Acetic Acids: A Global View of the Regional Sources 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (4)
作者:  Franco, B.;  Clarisse, L.;  Stavrakou, T.;  Mueller, J-F;  Taraborrelli, D.;  Hadii-Lazaro, J.;  Hannigan, J. W.;  Hase, F.;  Hurtmans, D.;  Jones, N.;  Lutsch, E.;  Mahieu, E.;  Ortega, I;  Schneider, M.;  Strong, K.;  Vigouroux, C.;  Clerbaux, C.;  Coneur, P-F
收藏  |  浏览/下载:23/0  |  提交时间:2020/07/02
Direct determination of mode-projected electron-phonon coupling in the time domain 期刊论文
SCIENCE, 2019, 366 (6470) : 1231-+
作者:  Na, M. X.;  Mills, A. K.;  Boschini, F.;  Michiardi, M.;  Nosarzewski, B.;  Day, R. P.;  Razzoli, E.;  Sheyerman, A.;  Schneider, M.;  Levy, G.;  Zhdanovich, S.;  Devereaux, T. P.;  Kemper, A. F.;  Jones, D. J.;  Damascelli, A.
收藏  |  浏览/下载:24/0  |  提交时间:2020/02/17
Global patterns and dynamics of climate-groundwater interactions 期刊论文
NATURE CLIMATE CHANGE, 2019, 9 (2) : 137-+
作者:  Cuthbert, M. O.;  Gleeson, T.;  Moosdorf, N.;  Befus, K. M.;  Schneider, A.;  Hartmann, J.;  Lehner, B.
收藏  |  浏览/下载:14/0  |  提交时间:2019/04/09
Evolution of Eastern Equatorial Pacific Seasonal and Interannual Variability in Response to Orbital Forcing During the Holocene and Eemian From Model Simulations 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2018, 45 (18) : 9843-9851
作者:  Khon, V. C.;  Schneider, B.;  Latif, M.;  Park, W.;  Wengel, C.
收藏  |  浏览/下载:13/0  |  提交时间:2019/04/09
annual cycle  ENSO  paleosimulations  tropical Pacific  orbital forcing  interglacial  
Urban influence on the concentration and composition of submicron particulate matter in central Amazonia 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2018, 18 (16) : 12185-12206
作者:  de Sa, Suzane S.;  Palm, Brett B.;  Campuzano-Jost, Pedro;  Day, Douglas A.;  Hu, Weiwei;  Isaacman-VanWertz, Gabriel;  Yee, Lindsay D.;  Brito, Joel;  Carbone, Samara;  Ribeiro, Igor O.;  Cirino, Glauber G.;  Liu, Yingjun;  Thalman, Ryan;  Sedlacek, Arthur;  Funk, Aaron;  Schumacher, Courtney;  Shilling, John E.;  Schneider, Johannes;  Artaxo, Paulo;  Goldstein, Allen H.;  Souza, Rodrigo A. F.;  Wang, Jian;  McKinney, Karena A.;  Barbosa, Henrique;  Alexander, M. Lizabeth;  Jimenez, Jose L.;  Martin, Scot T.
收藏  |  浏览/下载:36/0  |  提交时间:2019/04/09
Global Aurora on Mars During the September 2017 Space Weather Event 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2018, 45 (15) : 7391-7398
作者:  Schneider, N. M.;  Jain, S. K.;  Deighan, J.;  Nasr, C. R.;  Brain, D. A.;  Larson, D.;  Lillis, R.;  Rahmati, Ali;  Halekas, J. S.;  Lee, C. O.;  Chaffin, M. S.;  Stiepen, A.;  Crismani, M.;  Evans, J. S.;  Stevens, M. H.;  Lo, D. Y.;  McClintock, W. E.;  Stewart, A. I. F.;  Yelle, R. V.;  Clarke, J. T.;  Holsclaw, G. M.;  Lefevre, F.;  Montmessin, F.;  Jakosky, B. M.
收藏  |  浏览/下载:35/0  |  提交时间:2019/04/09
Mars  aurora  space weather  magnetic fields  ultraviolet  emission