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全球仅0.18％的陆地面积PM2.5年均浓度未超安全限值 快报文章
资源环境快报，2023年第05期
作者:  廖琴
Microsoft Word(38Kb)  |  收藏  |  浏览/下载：606/0  |  提交时间：2023/03/15
PM2.5浓度  Population Exposure  Machine Learning  
Escalating global exposure to compound heat-humidity extremes with warming 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2020, 15 (6)
作者:  Li, Dawei;  Yuan, Jiacan;  Kopp, Robert E.
收藏  |  浏览/下载：12/0  |  提交时间：2020/07/02
heat stress  wet bulb globe temperature  heat-humidity extremes  population exposure  
Sialylation of immunoglobulin E is a determinant of allergic pathogenicity 期刊论文
NATURE, 2020, 582 (7811) : 265-+
作者:  Abdul-Masih, Michael;  Banyard, Gareth;  Bodensteiner, Julia;  Bordier, Emma;  Bowman, Dominic M.;  Dsilva, Karan;  Fabry, Matthias;  Hawcroft, Calum;  Mahy, Laurent;  Marchant, Pablo;  Raskin, Gert;  Reggiani, Maddalena;  Shenar, Tomer;  Tkachenko, Andrew;  Van Winckel, Hans;  Vermeylen, Lore;  Sana, Hugues
收藏  |  浏览/下载：17/0  |  提交时间：2020/07/03

A specific type of glycosylation-sialylation-is more common on immunoglobulin E from individuals with a peanut allergys than from non-atopic people, suggesting that it has a role in regulating anaphylaxis.


Approximately one-third of the world'  s population suffers from allergies(1). Exposure to allergens crosslinks immunoglobulin E (IgE) antibodies that are bound to mast cells and basophils, triggering the release of inflammatory mediators, including histamine(2). Although IgE is absolutely required for allergies, it is not understood why total and allergen-specific IgE concentrations do not reproducibly correlate with allergic disease(3-5). It is well-established that glycosylation of IgG dictates its effector function and has disease-specific patterns. However, whether IgE glycans differ in disease states or affect biological activity is completely unknown(6). Here we perform an unbiased examination of glycosylation patterns of total IgE from individuals with a peanut allergy and from non-atopic individuals without allergies. Our analysis reveals an increase in sialic acid content on total IgE from individuals with a peanut allergy compared with non-atopic individuals. Removal of sialic acid from IgE attenuates effector-cell degranulation and anaphylaxis in several functional models of allergic disease. Therapeutic interventions-including removing sialic acid from cell-bound IgE with a neuraminidase enzyme targeted towards the IgE receptor Fc epsilon RI, and administering asialylated IgE-markedly reduce anaphylaxis. Together, these results establish IgE glycosylation, and specifically sialylation, as an important regulator of allergic disease.


  
Increased population exposure to precipitation extremes under future warmer climates 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2020, 15 (3)
作者:  Chen, Huopo;  Sun, Jianqi;  Li, Huixin
收藏  |  浏览/下载：5/0  |  提交时间：2020/07/02
precipitation extremes  population exposure  climate change  CESM  1.5 degrees C  
Interacting implications of climate change, population dynamics, and urban heat mitigation for future exposure to heat extremes 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2019, 14 (8)
作者:  Vahmani, P.;  Jones, Andrew D.;  Patricola, Christina M.
收藏  |  浏览/下载：7/0  |  提交时间：2019/11/27
extreme heat exposure  climate change  population growth  urban climate adaptation  
Increased population exposure to extreme droughts in China due to 0.5 degrees C of additional warming 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2019, 14 (6)
作者:  Chen, Huopo;  Sun, Jianqi
收藏  |  浏览/下载：4/0  |  提交时间：2019/11/26
drought  population exposure  1.5 degrees C  2.0 degrees C  China  
Population exposed to drought under the 1.5 degrees C and 2.0 degrees C warming in the Indus River Basin 期刊论文
ATMOSPHERIC RESEARCH, 2019, 218: 296-305
作者:  Wen, Shanshan;  Wang, Anqian;  Tao, Hui;  Malik, Khalid;  Huang, Jinlong;  Zhai, Jianqing;  Jing, Cheng;  Rasul, Ghulam;  Su, Buda
收藏  |  浏览/下载：8/0  |  提交时间：2019/04/09
Drought  Population Exposure  Intensity-Area-Duration  Shared Socioeconomic Pathways  Indus River Basin  
Impact of the 2015 wildfires on Malaysian air quality and exposure: a comparative study of observed and modeled data 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2018, 13 (4)
作者:  Mead, M. I.;  Castruccio, S.;  Latif, M. T.;  Nadzir, M. S. M.;  Dominick, D.;  Thota, A.;  Crippa, P.
收藏  |  浏览/下载：1/0  |  提交时间：2019/04/09
air quality  transnational pollution  particulate matter  wildfires  population exposure  equatorial Asia  
Changing population dynamics and uneven temperature emergence combine to exacerbate regional exposure to heat extremes under 1.5 degrees C and 2 degrees C of warming 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2018, 13 (3)
作者:  Harrington, Luke J.;  Otto, Friederike E. L.
收藏  |  浏览/下载：2/0  |  提交时间：2019/04/09
climate change emergence  heat extremes  population exposure  paris agreement  
Good practice guide on noise exposure and potential health effects 科技报告
来源：European Environment Agency (EEA). 出版年： 2010
作者:  [null]
收藏  |  浏览/下载：26/0  |  提交时间：2019/04/05
noise indicators  health effects  noise  population exposure  noise exposure  health